Eric de Groot

Eric de Groot
Imagelabonline & Cardiovascular · +31620062662

MD PhD

About

210
Publications
13,207
Reads
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9,972
Citations
Additional affiliations
February 2020 - present
Amsterdam UMC - Academic Medical Centre, University of Amsterdam.
Position
  • MD, PhD
September 2015 - present
Academisch Medisch Centrum Universiteit van Amsterdam
Position
  • MD, PhD
December 2012 - present
Imagelabonline & Cardiovascular
Position
  • Director, MD PhD

Publications

Publications (210)
Article
Familial hypercholesterolemia (FH) is a common genetic disorder of lipoprotein metabolism leading to premature atherosclerosis. From early onset, status and progression of atherosclerosis of the large peripheral arterial walls can be quantified by ultrasound intima-media thickness (IMT) measurements. Here we describe differences in IMT in treated a...
Article
Full-text available
Cognitive decline is associated with lifestyle-related factors such as overweight, blood pressure, and dietary composition. Studies have reported beneficial effects of dietary anthocyanins on cognition in older adults and children. However, the effect of anthocyanin-rich Aronia melanocarpa extract (AME) on cognition is unknown. Therefore, this stud...
Article
Background: To quantify the association between effects of interventions on carotid intimamedia thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum...
Article
Atherosclerosis - the pathophysiological mechanism shared by most cardiovascular diseases - can be directly or indirectly assessed by a variety of clinical tests including measurement of carotid intima-media thickness, carotid plaque, -ankle-brachial index, pulse wave velocity, and coronary -artery calcium. The Prospective Studies of Atherosclerosi...
Article
Full-text available
Hyperglycemia is linked to impaired arterial endothelial function (EF), an early sign of cardiovascular disease. We compared the efficacy of low-glycemic index isomaltulose (Palatinose™) with that of sucrose in modulating EF, as assessed by flow-mediated dilation (FMD). In this double-blinded cross-over study, 80 overweight mildly hypertensive subj...
Article
Background: Familial hypercholesterolemia is characterized by severely elevated low-density lipoprotein (LDL) cholesterol levels and premature cardiovascular disease. The short-term efficacy of statin therapy in children is well established, but longer follow-up studies evaluating changes in the risk of cardiovascular disease are scarce. Methods:...
Article
Full-text available
Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annual...
Article
We observed a positive correlation between cIMT and KD severity of coronary arteritis at the acute stage. Although initially increased, the cIMT in CAA-negative patients normalized at a later age. In contrast, patients with a history of KD complicated by giant CAA showed a trend toward persistently increased cIMT. These patients may need cardiovasc...
Article
Background: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid ath...
Article
Full-text available
Aims Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical fo...
Data
Data sharing restrictions, availability and contacts by study. (PDF)
Data
List of collaborators within the PROG-IMT study group, current from 10th June 2016. (PDF)
Data
Forest plots of the HR of MI in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for MI per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for MI per one SD of average mean CCA-IMT, adjusted for age, sex and annual mean CCA-IMT change...
Data
Forest plots of the HR of stroke in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for stroke per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for stroke per one SD of average mean CCA-IMT, adjusted for age, sex and annual mean CC...
Data
Meta-regression plots for the HR (combined endpoint) per SD of annual mean CCA-IMT change, by the year of the study start for group A cohorts. The size of each circle represents the precision of the log HR. Left panel: Model 1 (HR adjusted for age, sex, and average mean CCA-IMT): weighted regression line y = 7.07+0.004*x (p = 0.34). Right panel: Mo...
Data
Distribution of average mean CCA-IMT, annual change of mean CCA-IMT, and crude event rates by cohort and subgroup. *mean CCA-IMT not available, maximal CCA-IMT used instead. &combined endpoint not available, total mortality used instead. (DOCX)
Data
Forest plots of the HR of total mortality in group A (asymptomatic individuals with three or more CVD risk factors) with 95% Cls. Left panel: HR for total mortality per one SD of annual mean CCA-IMT change, adjusted for age, sex and average mean CCA-IMT (model 1). Right panel: HR for total mortality per one SD of average mean CCA-IMT, adjusted for...
Data
Forest plots of the HR of the combined endpoint in group A (asymptomatic individuals with three or more CVD risk factors) for maximal CCA-IMT with 95% Cls. Left panel: HR for the combined endpoint per one SD of annual maximal CCA-IMT change, adjusted for age, sex and average maximal CCA-IMT (model 1). Right panel: HR for the combined endpoint per o...
Data
Study-specific details of the ultrasound protocols. +plaques purposely included. #internal landmarks in computer aided navigation aid. ++2D images extracted from 3D dataset. n.s. = not specified. (DOCX)
Data
Flowchart on available studies. (DOCX)
Data
Forest plots of the HR of the combined endpoint per one SD of annual mean CCA-IMT change, grouped by IMT measurement protocol, with 95% Cls. Group B (asymptomatic individuals with carotid plaques), HR adjusted for age, sex and average mean CCA-IMT (model 1). (DOCX)
Article
Full-text available
Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and Results: From cohorts with two CIMT scans on average 3.6 years apart and clinical follow-up, subcohorts...
Article
Background: Endothelial dysfunction (ED) is involved in the development of atherosclerosis. Hesperidin, a citrus flavonoid with antioxidant and other biological properties, potentially exerts beneficial effects on endothelial function (EF). Objective: We investigated the effect of hesperidin 2S supplementation on EF in overweight individuals. D...
Chapter
Full-text available
With this summarized research report, AiREAS substantiates the wish and need to establish to a broadly supported Health Deal between the population of any region in the world and its executive governance. Since 2011, AiREAS has become functional as a formal cooperative multidisciplinary workgroup initiated by proactive civilians that invited the pa...
Chapter
Full-text available
In August 2015, one of our partners in the regional government pointed out to us that the Marathon of Eindhoven that year was subsidized based on an innovation clause.
Article
Full-text available
Background: Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima-media thickness (cIMT). Methods and results: We measured...
Article
Full-text available
Background: Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear. Objectives: We investigated the association of long-term exposure to PM10, PM2.5 (total mass, vehicular and crustal sources), and ultrafine particles (UFP) (pa...
Article
Slowing of progression and inducing the regression of atherosclerosis with medical therapy have been shown to be associated with an extensive reduction in risk of cardiovascular events. This proof of concept was obtained with invasive angiographic studies but these are, for obvious reasons, impractical for sequential investigations. Non-invasive im...
Article
Full-text available
Background: Kawasaki disease (KD) is an acute pediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. Concerns have been raised regarding the possibility of a predisposition of KD to premature cardiovascular disease (CVD) risk later in life. Our aim was to assess carotid intima-media thickness (cIMT), as a surrogate mar...
Article
Background: In sub-Saharan Africa, the number of persons living with human immunodeficiency virus (HIV) has increased immensely. In parallel, rates of noncommunicable diseases, especially cardiovascular disease, are rising rapidly in resource-limited settings. This study aims to evaluate the relation between subclinical atherosclerosis and HIV-rel...
Article
Full-text available
Different in-plane resolutions have been used for carotid 3T MRI. We compared the reproducibility, as well as the within- and between reader variability of high and routinely used spatial resolution in scans of patients with atherosclerotic carotid artery disease. Since no consensus exists about the optimal segmentation method, we analysed all imag...
Article
Full-text available
Introduction: Regular physical activity has been shown to reduce cardiovascular disease risk in the general population. While smaller studies in specified groups (highly trained versus untrained individuals) indicate a certain dose-dependent effect of physical activity on the reduction of carotid stiffness (an indicator of subclinical vascular dis...
Article
Nonalcoholic fatty liver disease (NAFLD) has been recognized as an independent risk factor for cardiovascular disease in adults. It has not been established whether NAFLD is related to early atherosclerotic changes in children. In a cross-sectional study, 78 non diabetic, non smoking children with severe obesity were evaluated for NAFLD. Proton mag...
Article
There is clinical trial evidence that only early, intensive risk factor control can reduce cardiovascular disease (CVD) morbidity and mortality in type 2 diabetes (T2DM). However, there is little information regarding preclinical atherosclerosis at diabetes diagnosis. We assessed carotid atherosclerosis in new-onset T2DM and control individuals wit...
Article
Aims: Kawasaki disease (KD) is an acute pediatric vasculitis with the development of coronary artery aneurysms (CAA) being recognized as a serious clinical complication of KD. It has been suggested that KD predisposes to premature cardiovascular disease (CVD) later in life, however, conflicting results have been reported. We therefore assessed the...
Article
Resumen Introducción y objetivos En estudios recientes se han identificado varias variantes genéticas asociadas a la enfermedad coronaria. Algunas de estas variantes genéticas no se asocian a factores de riesgo cardiovascular clásicos y no están claros los mecanismos por los que se producen tales asociaciones. El objetivo de este estudio es determ...
Article
Recent studies have identified several genetic variants associated with coronary artery disease. Some of these genetic variants are not associated with classical cardiovascular risk factors and the mechanism of such associations is unclear. The aim of the study was to determine whether these genetic variants are related to subclinical atheroscleros...
Article
Full-text available
Background Heparanase is the major enzyme involved in degradation of endothelial heparan sulfates, which is associated with impaired endothelial nitric oxide synthesis. However, the effect of heparan sulfate chain length in relation to endothelial function and nitric oxide availability has never been investigated. We studied the effect of heterozyg...
Article
Full-text available
Background: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. Methods: Information o...
Article
Full-text available
QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal association of the cardiovascular risk scores in the population-based cohort SAPALDIA with carotid intima media thickening (CIMT), an indicator of sub-clinical...
Article
Background Autosomal dominant hypercholesterolemias (ADH) are associated with high risk of premature cardiovascular disease (CVD). No data on progression of atherosclerosis in ADH population in clinical practice is available. Objective To investigate atherosclerosis progression in ADH patients and its relationship with CVD risk factors. Methods A...
Article
Background: Carotid intima-media thickness (CIMT) is a marker for atherosclerosis. Adult post-coarctectomy patients (CoA) demonstrate an increased cardiovascular risk and increased CIMT compared to controls. This study evaluates the effect of high dose statins on the change in CIMT and cardiovascular risk. Methods: We designed a multicenter, pro...
Article
Objective: Manifestation of cardiovascular disease (CVD) occurs with clear sex differences. Carotid stiffness (CS) parameters are increasingly used for CVD risk assessment but the sex-specific association with CVD risk factors as well as association patterns between CS parameters are largely unknown, which we investigated in SAPALDIA population-ba...
Article
Carotid intima media thickness (CIMT) and local stiffness are vascular biomarkers of atherosclerotic burden. We investigated the variability and reproducibility of clinically relevant structural (CIMT, lumen diameter) and functional parameters (strain, distensibility, compliance, β-stiffness index, Peterson's elastic modulus and Young's elastic mod...
Article
Cigarette smoking is a prevalent risk behavior among adolescents and tracks into adulthood. Little is known on the early impact of smoking on the vasculature in adolescence, although smoking is considered highly atherogenic in adults. We investigated the association between active smoking and Carotid artery Intima Media Thickness (CIMT), an early i...
Article
To improve carotid 3T magnetic resonance imaging (MRI) dimension measurements in patients with overt atherosclerotic carotid artery disease. In 31 patients with advanced atherosclerotic carotid artery disease, two high resolution (0.25 × 0.25 mm(2); HR) and two routinely used low resolution (0.50 × 0.50 mm(2); LR) carotid 3T MRI scans were performe...
Article
Full-text available
The aim of this study was to assess the reproducibility of flow-mediated dilatation (FMD) in a multicentre setting. This study was performed as part of the dal-VESSEL trial in which FMD was measured in 19 vascular imaging centres in six European countries. A subgroup of patients who were allocated in the placebo group and scanned twice at each tria...
Article
Full-text available
Background: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. Objective: We investigated the association of long-term exposure to traffic-related air pollution with subclinical atherosclerosis, measured by carotid intima media thickness (IMT) and ankle–brachial index...
Article
Introduction and objectivesCarotid intima-media thickness as measured with ultrasonography is an inexpensive and noninvasive predictor of cardiovascular events. The objectives of this study were to determine the population reference ranges of carotid intima-media thickness for individuals aged 35-84 years in Spain and to analyze the association of...
Article
Full-text available
AimsLow HDL-C is a potent risk factor for cardiovascular disease (CVD). Yet, mutations in ABCA1, a major determinant of circulating HDL-C levels, were previously not associated with CVD risk in cohort studies. To study the consequences of low plasma levels of high-density lipoprotein cholesterol (HDL-C) due to ATP-binding cassette transporter A1 (A...
Article
Introduction and objectives: Carotid intima-media thickness as measured with ultrasonography is an inexpensive and noninvasive predictor of cardiovascular events. The objectives of this study were to determine the population reference ranges of carotid intima-media thickness for individuals aged 35-84 years in Spain and to analyze the association...
Article
Fabry disease is an X-linked hereditary lysosomal storage disorder attributed to a deficiency of α-galactosidase A leading to increased plasma levels of globotriaosylsphingosine (lysoGb3). The disease presents as a vascular disease, with cerebral, cardiac, and renal complications. Carotid intima-media thickness (IMT), brachial flow-mediated dilatio...
Article
Background: Depressive and anxiety disorders are highly overlapping, heterogeneous conditions that both have been associated with an increased risk of cardiovascular disease (CVD). Cognitive vulnerability traits for these disorders could help to specify what exactly drives CVD risk in depressed and anxious subjects. Our aim is to examine sensitivi...
Article
Chronic low-grade inflammation is associated with atherosclerosis. Ultrasound imaging allows measurement of intima-media thickness (IMT) and plaque. We investigated the association between inflammatory markers and carotid and femoral atherosclerosis. We studied 554 subjects with primary dyslipidemia (57% men, median age 49 years) and 246 age- and s...
Article
The aim of this study was to investigate the role of reduced lecithin: cholesterol acyltransferase (LCAT) function on atherogenesis using 3.0-T carotid magnetic resonance imaging (MRI) and B-mode ultrasound. The role of low high-density lipoprotein cholesterol as a causal factor in atherogenesis has recently been questioned. LCAT plays a key role i...
Article
HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular ris...
Article
Hemophilia A patients have a lower cardiovascular mortality rate than the general population. Whether this protection is caused by hypocoagulability or decreased atherogenesis is unclear. To evaluate atherosclerosis and endothelial function in hemophilia A patients with and without obesity as well as in matched, unaffected controls. Fifty-one obese...
Article
The contribution of human cytomegalovirus (HCMV) to vascular disease may depend on features of the immune response not reflected by the detection of specific antibodies. Persistent HCMV infection in healthy blood donors has been associated with changes in the distribution of NK cell receptors (NKR). The putative relationship among HCMV infection, N...