Eric Ansoborlo

Eric Ansoborlo
Atomic Energy and Alternative Energies Commission | CEA · Département de recherche sur les procédés pour la Mine et le Recyclage des Combustibles (DMRC)

About

136
Publications
15,050
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2,305
Citations
Additional affiliations
January 2017 - June 2017
Atomic Energy and Alternative Energies Commission
Position
  • International Expert
January 2013 - December 2017
Atomic Energy and Alternative Energies Commission
Position
  • International Expert
January 2002 - July 2017
Atomic Energy and Alternative Energies Commission
Position
  • International Expert

Publications

Publications (136)
Article
Full-text available
When focusing on environmental tritium measurement, water is the most common matrix, and monitoring is mainly concerned by tissue free water tritium (TFWT) and organically bound tritium (OBT) analysis. Moreover, in order to improve knowledge on tritium behaviour and migration, TFWT and OBT determinations are performed at low activity level. TFWT an...
Book
Abstract –: The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series (ICRP, 1979, 1980, 1981, 1988b) and Publication 68 (I...
Article
The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30series (ICRP, 1979, 1980, 1981, 1988b) and Publication 68(ICRP, 1994b). In...
Article
Full-text available
From secretive beginnings to serving in missions on Mars, Rebecca J. Abergel and Eric Ansoborlo take a look at the glowing mark curium has left on contemporary science and technology.
Article
Full-text available
Predictive modelling of uranium speciation in natural waters can be achieved using equilibrium thermodynamic data and adequate speciation software. The reliability of such calculations is highly dependent on the equilibrium reactions that are considered as entry data, and the values chosen for the equilibrium constants. The working group “Speciatio...
Article
Full-text available
Eric Ansoborlo and Richard Wayne Leggett discuss the chemical and radiological characteristics that make caesium a captivating element but also a troublesome contaminant.
Article
Full-text available
Many methods allow analysing the various forms of tritium in environmental samples; however, there are no published standard methods for measuring organically bound tritium (OBT). Furthermore, there are no certified reference materials of OBT for environmental samples. In environmental samples (plants and animals), the measurement of the various tr...
Article
Full-text available
Uranium represents a unique case for an element naturally present in the environment, as its chemical guideline value in drinking water significantly increased from 2μg/L in 1998 up to 15μg/L in 2004 and then to 30μg/L in 2011, to date corresponding to a multiplication factor of 15 within a period of just 13years. In this commentary we summarize th...
Article
Full-text available
Eric Ansoborlo considers the disproportionate potency of polonium compared with its relative scarcity on Earth.
Article
Full-text available
This paper presents a comprehensive survey of the tritium content of "reference waters" in real working conditions by French laboratories involved in environmental monitoring. Reference waters are virtually tritium-free waters used to determine blanks for the analytical system and to check for any contamination. It is therefore crucial to be sure o...
Article
Purpose: This paper reviews data related to the behavior of the lanthanoid elements (lanthanum through lutetium, atomic numbers 57-71) in the human body and proposes biokinetic models for internally deposited radio-lanthanoids in workers. Materials and methods: Published data on the following topics are reviewed and analyzed: Physico-chemical pr...
Article
The knowledge of the speciation of elements at trace and ultra-trace level, in biological and environmental media is essential to acquire a better understanding of the mechanisms of toxicity, transport and accumulation in which they are involved. Determining the speciation of an element in a given medium is challenging and requires the knowledge of...
Article
Cobalt is used in numerous industrial sectors, leading to occupational diseases, particularly by inhalation. Cobalt-associated mechanisms of toxicity are far from being understood and information that could improve knowledge in this area is required. We investigated the impact of a soluble cobalt compound, CoCl(2)·6H(2)O, on the BEAS-2B lung epithe...
Article
Full-text available
Within the last ten years there has been increasing interest in tritium behaviour and distribution in the environment. This is based partly on empirical findings that tritium discharged mostly as HTO can become transformed into organic forms in environmental samples. An international workshop was convened in France in 2012 to gather the scientific...
Chapter
This chapter aims to describe the lessons learned from the studies of radionuclide behaviour in the vicinity of the Chernobyl Nuclear Power Plant, as an example of radionuclide migration in a contaminated surface site. Thus, the Chernobyl Pilot Site (1999-2003) and Experimental Platform In Chernobyl (2004-2008) projects have improved our understand...
Article
The knowledge of the speciation of elements at trace and ultra-trace level in biological and environmental media is essential to gather information on their action mode and their fate in the biosphere and geosphere. Determining the speciation of an element in a given medium is a great challenge and requires the knowledge of the different methodolog...
Chapter
To meet the growing demands in the field of toxicology for evaluation and management of environmental and health risks, it is important to understand rationally and effectively both geochemical and biological processes involved in the accumulation of radioactive trace elements and their toxic effects. In this chapter we review these issues by treat...
Article
The discovery of polonium (Po) was first published in July, 1898 by P. Curie and M. Curie. It was the first element to be discovered by the radiochemical method. Polonium can be considered as a famous but neglected element: only a few studies of polonium chemistry have been published, mostly between 1950 and 1990. The recent (2006) event in which (...
Conference Paper
Natural samples of soil, sediment and natural water were collected in the “Parc National du Mercantour” in France. Soil and sediment samples were studied to better understand the behaviors of radionuclides (RNs) in different natural compartments. Considering 137 Cs and 241 Am activities in depth (measured by α- and γ-spectrometries), two types of...
Article
The understanding of radionuclides (RN) action modes in the living organisms in case of contamination is a major aim in nuclear toxicology studies. The mechanisms of RN-involved toxicity at the molecular level are critically dependent on their speciation. In this framework, the calculating and experimental approaches of speciation determination are...
Article
A review on specific parameter measurements to calculate doses per unit of incorporation according to recommendations of the International Commission of Radiological Protection has been performed for inhaled actinide oxides. Alpha activity distribution of the particles can be obtained by autoradiography analysis using aerosol sampling filters at th...
Article
Full-text available
La mesure du tritium sous ses différentes formes (gaz (HT), eau (HTO), ou solide (hydrures)), est une étape importante pour l’évaluation des risques sanitaires et environnementaux associés et in fine son estimation dosimétrique. Dans les échantillons du règne végétal ou animal, le tritium est associé à la fraction eau libre et est inclus dans les c...
Article
In order to optimise the monitoring of potentially exposed workers, it is desirable to determine specific values of absorption for the compounds handled. This study derives specific values of absorption rates for different chemical forms of plutonium from in vitro and animal (monkeys, dogs, mice, rats) experiments, and from human contamination case...
Article
Full-text available
Purpose: To improve the dosimetry of incorporated americium (Am) and to contribute to radiation protection by characterizing the absorption kinetics of inhaled Am compounds. Material and methods: In vitro dissolution tests, animal experiments and human contamination cases published in the literature were reviewed. The data were analyzed with bio...
Chapter
Full-text available
Cet ouvrage collectif a mobilisé plus de cent chercheurs, principalement du CEA et de l'IRSN. Il constitue une mise en commun sans précédent des connaissances et des approches méthodologiques et expérimentales de physiciens, de chimistes, de biologistes et de médecins. Toxicologie nucléaire environnementale et humaine développe plus spécifiquement...
Article
Exceptionally high concentrations of natural uranium have been found in drinking water originating from drilled wells in Southern Finland. However, no clear clinical symptoms have been observed among the exposed population. Hence a question arose as to whether uranium speciation could be one reason for the lack of significant adverse health effects...
Article
Full-text available
This paper deals with plutonium and key factors related to impact assessment. It is based on recent work performed by CEA which summarize the main features of plutonium behaviour from sources inside installations to the environment and man, and to report current knowledge on the different parameters used in models for environmental and radiological...
Book
Proceedings of the 2008 International Liquid Scintillation Conference, Davos, Switzerland, 25-30 May 2008
Article
A library of bisphosphonate-based ligands was prepared using solution-phase parallel synthesis and tested for its uranium-binding properties. With the help of a screening method, based on a chromophoric complex displacement procedure, 23 dipodal and tripodal chelates bearing bisphosphonate chelating functions were found to display very high affinit...
Chapter
Full-text available
This document deals with the different isotopes of plutonium. It intends to summarize the main features of plutonium behaviour from sources inside installation to the environment and man, and is expected to report the current knowledge about the different parameters used in models for environmental and radiological impact assessment. The objective...
Article
Full-text available
In case of accidental release of radionuclides in a nuclear facility or in the environment, internal contamination (inhalation, ingestion or wound) with actinides represents a severe health risk to human beings. It is therefore important to provide effective chelation therapy or decorporation to reduce acute radiation damage, chemical toxicity, and...
Article
In the framework of the French Environmental Nuclear Toxicology program, additional experiments related to the decorporation of actinides are planned. Decorporation is the removal or release from target organs (bones, liver, kidney …), tissues or cells of radioactive material previously incorporated in them, using chelating agents or other administ...
Article
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The ICRP Task Group on Internal Dosimetry is developing new Occupational Intakes of Radionuclides (OIR) documents. Application of the Human Respiratory Tract Model (HRTM) requires a review of the lung-to-blood absorption characteristics of inhaled compounds of importance in radiological protection. Where appropriate, material-specific absorption pa...
Article
Full-text available
Dosimetric impact studies aim at evaluating potential radiological effects of chronic or acute releases from nuclear facilities. A methodology for ranking radionuclides (RN) in terms of their health-related impact on the human population was first developed at CEA with specific criteria for each RN that could be applied to a variety of situations....
Article
Full-text available
Radionuclides may be released into the environment accidentally or incidentally, which could raise health risks when ingested or inhaled by humans. In order to study the behaviour of radionuclides in the human organism (metabolism, retention, excretion), knowledge of radionuclide speciation is indispensable: speciation governs the transfer, bioavai...
Article
A didactic software, MEthodes DOsimètriques de REférence (MEDOR), is being developed to provide help in the interpretation of biological data. Its main purpose is to evaluate the pertinence of the application of different models. This paper describes its first version that is focused on inhalation exposure to actinide aerosols. With this tool, sens...
Article
Cesium-137 (137Cs) is one of the most important nuclear fission elements that contaminated the environment after the explosion of the Chernobyl nuclear power plant in Ukraine (1986). The aim of the study was to compare the efficacy of two chelating agent, Prussian blue and apple-pectin on 137cesium decorporation in rats. Rats were intravenously inj...
Article
Full-text available
Since in nuclear power plants, risks of skin contact contamination by radiocobalt are significant, we focused on the impact of cobalt on a human cutaneous cell line, i.e. HaCaT keratinocytes. The present paper reports an interdisciplinary approach aimed at clarifying the biochemical mechanisms of metabolism and toxicity of cobalt in HaCaT cells. Fi...
Article
Full-text available
In case of accidental release of radionuclides into the environment, actinides represent a severe health risk to human beings following internal contamination (inhalation, ingestion or wound). For a better understanding of the actinide behaviour in man (in term of metabolism, retention, excretion) and in specific biological systems (organs, cells o...
Article
The presence of heavy metal(loid)s in soils and waters is an important issue with regards to human health. Taking into account speciation problems, in the first part of this report, we investigated under identical growth conditions, yeast tolerance to a set of 15 cytotoxic metal(loid)s and radionuclides. The yeast cadmium factor 1 (YCF1) is an ATP-...
Article
Radionuclides can occur in the environment either through chronic releases of nuclear facilities, or due to incidents or accidents. In order to study there behaviors in the environment (migration, retention, transfer, ...) and in human organisms (metabolism, retention, excretion), it is of prime importance to know their solution chemistry, and more...
Article
Although of major impact in terms of biological and environmental hazards, interactions of actinide cations with biological molecules are only partially understood. Human serum transferrin (Tf) is one of the major iron carriers in charge of iron regulation in the cell cycle and consequently contamination by actinide cations is a critical issue of n...
Article
Full-text available
An intercomparison exercise was led in order to study the impact of thermodynamic database (TDB) on the speciation of americium(III) in biochemical media. A first exercice was led, considering only the americium(III) species in solution. Even with different data sets, all the exercises are in relatively good agreement, concluding to successive comp...
Article
To compare specific absorption parameter values obtained from in vitro dissolution studies (this paper) and in vivo experiments (data published by Ramounet et al, 2000) and to determine their influence on Dose Per Unit Intake (DPUI) calculations. Experiments were performed on plutonium oxide (PuO2) and two Mixed Oxide (MOx) preparations containing...
Article
Uranium is a naturally occurring heavy metal. Its extensive use in the nuclear cycle and for military applications has focused attention on its potential health effects. Acute exposures to uranium are toxic to the kidneys where they mainly cause damage to proximal tubular epithelium. The purpose of this study was to investigate the biological conse...
Article
Full-text available
The main activity of the RBDATA-EULEP project is the development of an electronic database of information on the biokinetics of radionuclides after intake by inhalation, ingestion or injection. It consists of linked tables of publications and experiments, with details and comments on the materials, procedures and results. By March 2004 it contained...
Article
Decorporation of radionuclides is of continuous interest in order to reduce doses in case of occupational or accidental human exposure. In the present study, insights into the non-covalent interactions that hold the well-known chelating agent DTPA (diethylenetriaminepentaacetic acid) with inorganic elements of interest, such as europium and stronti...
Article
Full-text available
Results of an inter-laboratory round-robin study of the application of time-resolved emission spectroscopy (TRES) to the speciation of uranium(VI) in aqueous media are presented. The round-robin study involved 13 independent laboratories, using various instrumentation and data analysis methods. Samples were prepared based on appropriate speciation...
Article
A detailed study, using a panel of spectroscopic analytical methods, of the complexation between 1-hydroxyethane-1,1'-diphosphonic acid (HEDP) and uranyl ion (UO(2)(2+)) is reported. Results suggest that the metal complex is present as only 1:1 (metal/ligand) species at low concentration (<10(-)(4) M). The conditional constants of this complex were...
Article
The ICRP Publication 66 Human Respiratory Tract Model (HRTM) has been applied to calculate dose coefficients and bioassay functions using default values of parameters relating to the material and the subjects. The ICRP Task Group on Internal Dosimetry (INDOS) has developed a guidance document on application of the HRTM in situations where using spe...
Article
This paper provides guidance on the most appropriate monitoring procedures and intervals, the likely uncertainties in the assessment of intake and recommendations on appropriate investigation levels for repeated exposures to uranium trioxide, octoxide and dioxide of natural composition.
Article
The aim of this work was to investigate the biokinetics of thorium dioxide in animals for the purpose of assessing intakes of the compound by workers and the resulting doses. The results imply that measurements of the decay products in the chest or extrapolations from urine analysis data are unlikely to be of value for doses below 20 mSv. Even high...
Article
The aim of this study was to compare dissolution parameter values for Pu from industrial MOX with different Pu contents. For this purpose, preliminary results obtained after inhalation exposure of rats to MOX containing 2.5% Pu are reported and compared to those obtained previously with MOX containing 5% Pu. Dissolution parameter values appear to i...
Article
Exposure limits for workers and the public are based on both chemical toxicity and radiation dose. As a consequence of the different procedures used in their calculation they are incompatible, and adherence to one limit may result in a serious breach of the other. This paper explores the background to these limits, the problems posed by their appli...
Article
Uranium is a heavy metal which, following accidental exposure, may potentially be deposited in human tissues and target organs, the kidneys and bones. A few published studies have described the distribution of this element after chronic exposure and one of them has demonstrated an accumulation in the brain. In the present study, using inductively c...
Article
Internal dose determination is an essential component of individual monitoring programmes for workers or members of the public exposed to radionuclides, and methods and computer programs are required for dose assessment. A recent international European Radiation Dosimetry Group (EURADOS) intercomparison has shown unacceptably large ranges in the re...