Eray Atalay

Eray Atalay
Eskisehir Osmangazi University Faculty of Medicine · Ophthalmology

MD & MSc (BMTE - UCL)

About

87
Publications
14,069
Reads
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753
Citations
Citations since 2016
61 Research Items
707 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
My research interests relate to anterior segment of the eye mainly focusing on cornea, ocular surface disorders and glaucoma. I also have an MSc background on biomaterials and tissue engineering obtained from UCL.
Additional affiliations
October 2017 - February 2021
Eskisehir Osmangazi University
Position
  • Professor (Assistant)
October 2015 - February 2017
Singapore Eye Research Institute
Position
  • Fellow
March 2015 - August 2015
Istanbul Medipol University
Position
  • Ophthalmologist
Education
September 2020 - September 2021
University College London
Field of study
  • Biomaterials and Tissue Engineering
February 2014 - October 2014
Harvard Medical School
Field of study
  • Principles and Practice of Clinical Research - Distance Learning Program
January 2009 - February 2013
Istanbul University Cerrahpasa Medical School
Field of study
  • Ophthalmology

Publications

Publications (87)
Article
PURPOSE: To develop a combined biomechanical and tomographic model for identifying eyes with subclinical keratoconus (SKC) that are categorized as normal or borderline in the Pentacam Belin/Ambrósio Enhanced Ectasia Display. METHODS: This case-control study comprised 62 eyes with SKC and randomly selected eyes of 186 age-matched healthy controls. S...
Article
Introduction Optical coherence tomography (OCT) has revolutionized patient care in ophthalmology within the last two decades. Initially conceptualized as a means to visualize the posterior segment, advances in OCT technology now allows enhanced, high-resolution imaging of the anterior segment (AS-OCT). Areas covered In this review, we begin by rev...
Article
Full-text available
Importance Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness. Objective To determine if exfoliation syndrome i...
Article
Purpose: This study aimed to determine the prevalence of keratoconus (KC) in the students and faculty members (aged ≥18 and ≤30 years) studying/working at the Medical and Health Sciences faculties of Eskişehir Osmangazi University. Setting: Eskişehir Osmangazi University Design: Prevalence study Methods: Subjects were randomly selected to un...
Article
Purpose: To compare the progression rate and time-to-progression determined using the Belin ABCD Progression Display (BAPD) with the conventional metrics in keratoconus (KC) patients. Design: Retrospective comparison of progression assessment. Methods: Patients aged ≥18 and ≤35 years, with at least one-year follow-up and three Pentacam visits, we...
Article
Objectives: To evaluate the performance of convolutional neural network (CNN) architectures to distinguish eyes with glaucoma from normal eyes. Materials and methods: A total of 9,950 fundus photographs of 5,388 patients from the database of Eskişehir Osmangazi University Faculty of Medicine Ophthalmology Clinic were labelled as glaucoma, glaucoma...
Article
Bu çalışmanın amacı TRK-2P cihazı (Topcon Medical Systems Inc., Oakland NJ) ile elde edilen keratometri ve kornea kalınlık değerlerini, Pentacam-HR cihazı (Oculus; Optikgeräte GmbH, Wetzlar, Almanya) ile elde edilen ön kornea keratometrisi ve pakimetri değerleri ile karşılaştırmaktır. Veri tabanlarımızda her iki cihazın tam kayıtlarına sahip olan h...
Article
Full-text available
Introduction: To evaluate the corneal epithelial thickness (CET) profiles and their correlations with axial length (AL) and anterior corneal radius of curvature (Rm F) across different refractive error groups. Methods: A total of 1225 eyes of 616 normal patients were included. CET mapping, AL, and Rm F were obtained using spectral-domain optical c...
Article
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Purpose: To investigate the risk factors and the clinical characteristics of the hypertensive phase (HP) after Ahmed glaucoma valve (AGV) implantation. Methods: This retrospective study included 60 eyes of 57 patients who underwent AGV implantation and with at least 1-year follow-up. HP was defined as intraocular pressure (IOP) > 21 mmHg in the fi...
Article
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Objectives: To determine corneal biomechanical and tomographic factors associated with keratoconus (KC) progression. Materials and methods: This study included 111 eyes of 111 KC patients who were followed-up for at least 1 year. Progression was defined as the presence of progressive change between the first two consecutive baseline visits in an...
Article
Full-text available
Glaucoma leads to permanent vision disability by damaging the optical nerve that transmits visual images to the brain. The fact that glaucoma does not show any symptoms as it progresses and cannot be stopped at the later stages, makes it critical to be diagnosed in its early stages. Although various deep learning models have been applied for detect...
Article
Objectives: With low supply and high demand for donor corneas, we surveyed Turkish participants on level of knowledge, awareness, and willingness toward cornea donation. Materials and methods: Our prepared internet-based questionnaire on awareness and attitudes toward cornea donation was structured into 6 parts (parts 1-2 examined socio-demograp...
Article
Full-text available
Keratoconus had traditionally been considered a rare disease at a time when the imaging technology was inept in detecting subtle manifestations, resulting in more severe disease at presentation. The increased demand for refractive surgery in recent years also made it essential to more effectively detect keratoconus before attempting any ablative pr...
Article
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Background Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of hypoxemia and hypercapnia during sleep. The aim of this study was to determine whether OSAS causes significant changes in corneal endothelium detectable by specular microscopy. Methods This prospective, cross-sectional study compared the specular microscopi...
Article
Prcis: Reduction of intraocular pressure by latanoprost in treatment-naïve eyes is significantly correlated to an increase in vessel density at the optic nerve head. Purpose: To evaluate the effect of topical latanoprost on ocular microvasculature using optical coherence tomography angiography (OCTA). Patients and methods: In this prospective...
Chapter
ÖZET Teknolojik gelişmelerle birlikte son yıllarda çok yüksek çözünürlükte ve hızlı bir şekilde ön segment görüntülemesi yapabilen cihazlar geliştirilmekte olup bu cihazların oftalmoloji kliniğinde kullanım alanlarının her geçen gün yaygınlaştığı görülmektedir. Kornea ektazilerinde ön segment görüntüleme patolojinin teşhisinde, ayırıcı tanısında v...
Article
Full-text available
Purpose: Fabry disease (FD) is characterized by a deficiency in α-galactosidase A activity that leads to the cumulative deposition of unmetabolized glycosphingolipids within organs, including the vascular endothelium and the eyes. The purpose of this study was to assess the effects of FD on the retinal microvasculature, foveal avascular zone (FAZ),...
Article
Purpose: To investigate the effect of oral isotretinoin use on refractive error, axial length and anteroposterior segment parameters Materials and methods: In this prospective study, 50 eyes of 50 patients using isotretinoin with a diagnosis of acne vulgaris and 50 eyes of 50 healthy control subjects were included. After detailed biomicroscopy, me...
Article
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Objectives: The aim of this study was to investigate the distribution of microbial agents in the early and late postoperative periods in patients with microbial keratitis (MK) after penetrating keratoplasty (PK). Materials and Methods: The records of 36 patients who were clinically diagnosed as having MK after PK were retrospectively reviewed. Cul...
Article
Full-text available
Purpose To identify the effect of corneal geometrical and biomechanical parameters on the intraocular pressure (IOP) measurements obtained by Goldmann Applanation Tonometer (GAT), non-contact tonometer, iCare Pro Rebound Tonometer (IRT), Tonopen and Ocular Response Analyzer (ORA, Goldmann-correlated IOP: IOPg, corneal compensated IOP: IOPcc). Meth...
Article
PurposeTo investigate the associations between mean ocular perfusion pressure (MOPP) and several variables including body mass index (BMI), comorbid medical conditions and various ocular parameters in a population-based sample.Study designCross-sectional.Methods Data of 2091 healthy participants from a previous population based cross-sectional stud...
Poster
ORA waveform parameters derived from the second applanation signal were significantly different in progressing eyes. Parameters derived from the second applanation signal of ORA may be predictive of keratoconus progression.
Article
Full-text available
Vasoproliferative retinal tumor (VPRT) is a rare, benign lesion with a variable clinical course depending on the individual. Favorable outcomes are obtained with early diagnosis and treatment of patients with VPRT. In this case report, we present a case of concomitant VPRT and multiple sclerosis along with our management of uveitis and secondary gl...
Article
Aims: To present the results of our case series with a technique we defined as “modified viscotrabeculotomy” which incorporates the benefits of 360° of trabeculotomy and viscodilation and viscodissection of canal of Schlemm using a microcatheter. Materials and methods: This study was designed as a prospective interventional case series and was cond...
Article
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Aim: To report an unusual case of a newly diagnosed bilateral superior keratoconus in an elderly patient. Background: We report a case of bilateral superior keratoconus in a 64-year-old woman who was diagnosed after having presented with hydrops in one eye. Case description: Uncorrected visual acuity was counting fingers from 3 and 1 meter for the...
Article
Full-text available
Objectives: To assess phosphate and osmolarity levels of chronically administered eye drops commercially available in Turkey. Materials and methods: A total of 53 topical eye drops including 18 antiglaucoma drugs, 4 nonsteroidal anti-inflammatory drugs (NSAIDs), 10 corticosteroids, 7 antihistaminics, and 14 artificial tears identified using the...
Article
This case presented with a hegzapodic herpetic dendritic ulcer that developed on the background of band keratopathy. The etiology for band keratopthy was history of multiple intraocular surgery, aphakia and silicone oil injection.
Article
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Chromatic pupillometry is an emerging modality in the assessment of retinal and optic nerve disorders. Herein, we evaluate the effect of low and moderate refractive errors on pupillary responses to blue- and red-light stimuli in a healthy older population. This study included 139 participants (≥50 years) grouped by refractive error: moderate myopes...
Article
Background: To assess pointwise corneal elevation changes after forced eyelid closure test (FECT) in the eyes of healthy subjects and in eyes with keratoconus. Methods: Twenty‐nine subjects with keratoconus and 31 healthy volunteers were evaluated. Patients with keratoconus who had corneal hydrops, apical scarring, corneal thickness ≤ 400 μm, ocul...
Article
Full-text available
Objectives: To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. Materials and methods: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an...
Article
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Purpose: To evaluate the ability of chromatic pupillometry to reveal abnormal pupillary responses to light in patients with early-stage primary open-angle glaucoma (POAG) and to test whether the degree of pupillometric impairment correlates with structural hallmarks of optic nerve damage in the disease. Design: Cross-sectional study. Participan...
Article
Full-text available
Importance The acute biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) elevations may serve as a biomarker for the development and progression of glaucoma. Objective To evaluate the association between visual field loss and the biomechanical response of the ONH to acute transient IOP elevations. Design, Setting, a...
Article
Full-text available
Chromatic pupillometry is an emerging method for evaluating ocular health that relies upon the differential stimulation of rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). Although it has been investigated in conditions affecting the outer or inner retina, there is a paucity of studies in conditions where the anterior...
Article
Purpose: We previously identified three distinct subgroups of patients with primary angle closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging. Group 1 was characterized by a large iris area with deepest anterior chambers, group 2 by a large lens vault (LV) and shallow anterior chamber depth (ACD), and gro...
Article
Full-text available
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previo...
Article
Full-text available
Purpose: Our objective was to evaluate the diagnostic value of a handheld pupillometer in differentiating eyes with pseudoexfoliation syndrome (PXS) from healthy controls. Methods: This population-based, cross-sectional study was conducted in the province of Eskisehir, Turkey. Subjects 40 years of age and older were randomly recruited using stra...
Article
Purpose To evaluate the intraocular pressure (IOP) change and associated factors 6 months after phacoemulsification in eyes with primary angle-closure suspect (PACS) and eyes with primary angle closure (PAC) that had no medical therapy. Setting Singapore National Eye Center, Singapore, Singapore. Design Retrospective case series. Methods Patient...
Article
Full-text available
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previo...
Article
Full-text available
Background: To estimate and compare changes in the Bruch's membrane opening-minimum rim width (BMO-MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP). Methods: The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) w...
Article
Purpose: To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG) using pointwise linear regression (PLR) trend analysis. Design: Clinic-based retrospective study. Participants: Primary angle-closure glaucoma patients with 5 or more reliable VF tests and with 5 years or m...
Article
Full-text available
Importance: Baseline anterior segment imaging parameters associated with incident gonioscopic angle closure, to our knowledge, are unknown. Objective: To identify baseline quantitative anterior segment optical coherence tomography parameters associated with the development of incident gonioscopic angle closure after 4 years among participants wi...
Article
Full-text available
Importance: The evaluation of anterior chamber scan (ACS) of Cirrus optical coherence tomography (OCT) for routine clinical use BACKGROUND: To assess the variability of anterior chamber angle (ACA) measurements using the ACS DESIGN: Cross-sectional observational study PARTICIPANTS: Forty subjects aged 40-80 years METHODS: One randomly selected eye...
Article
Full-text available
PurposeThe purpose of this study was to identify whether it was possible to subdivide subjects with primary angle-closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging, and to determine the characteristics of such subgroups.Methods We evaluated 210 subjects with PACG. All subjects underwent gonioscopy and AS...
Article
Full-text available
Purpose: To compare ocular biometric and anterior segment parameters between the affected and fellow eye in subjects with acute primary angle closure (APAC). Methods: We evaluated 76 subjects with unilateral APAC who had undergone bilateral laser peripheral iridotomy before enrollment. Imaging was done using anterior segment optical coherence to...
Conference Paper
Purpose : Chromatic pupillometry has been recently reported as a potential tool for detecting primary open angle glaucoma (POAG), especially at moderate and advanced stages. The aim of our study was to evaluate the capability of this technique to reveal abnormal pupillary responses to light in early-stage POAG. Methods : In this cross-sectional st...
Article
Purpose: To investigate the patterns of visual field (VF) defects in primary angle-closure glaucoma (PACG) across different severity levels and to assess hemifield differences within each severity level. Design: Cross-sectional study. Participants: Three hundred four patients diagnosed with PACG were recruited from glaucoma clinics at a Singap...
Article
Full-text available
A 51-year-old man with high intraocular pressure on the left eye was referred to our clinic. A laser iridotomy was performed with full anti-glaucoma medication prior to the referral. There was a fixed dilated irregular pupil of the left eye, accompanied with mild corneal edema, a paracentral stromal corneal haze, patchy iris atrophy, fine keratic p...
Article
Full-text available
Objectives: To compare the differences in intraoperative complications rates by the number of resident-performed sequential phacoemulsification surgeries. Materials and Methods: Preoperative and postoperative ophthalmological examination records and intraoperative data of 180 eyes of 140 patients who underwent cataract surgery by two residents betw...
Article
PURPOSE: To perform a quadrantwise comparison of the minimum distance between the posterior iris and the anterior lens in eyes with pseudoexfoliation syndrome (PXS) and age-matched controls. PATIENTS AND METHODS: This study was designed as a prospective cross-sectional study. The study population consisted of 60 patients with PXS and 50 age-matched...
Article
Full-text available
We report two cases of severe thermal burns on the ocular surface and its adnexal appendages that developed secondary to exposure to molten heavy metal with a melting temperature of near-thousand degree Celsius. Despite aggressive intervention and strict monitoring, the profound inflammation caused significant damage to the ocular surface, ending u...
Article
We report four consecutive cases of photokeratitis that presented to the emergency department, interestingly after having watched the same theatre performance in the same school. The patients’ ages (3 male, 1 female) ranged from 9 to 13 years. All patients presented with similar complaints consisting of pain, tearing, foreign body sensation, photop...
Article
Full-text available
We report four consecutive cases of photokeratitis that presented to the emergency department, interestingly after having watched the same theatre performance in the same school. The patients’ ages (3 male, 1 female) ranged from 9 to 13 years. All patients presented with similar complaints consisting of pain, tearing, foreign body sensation, photop...
Article
Full-text available
Phthiriasis palpebrarum is an uncommon cause of blepharoconjunctivitis in which Pthirus pubis infest the eyelashes. We report a case of unilateral phthiriasis palpebrarum with crab louse. A 45-year-old man presented with conjunctival hyperaemia and moderate itching associated with irritation, and crusty excretions of the eyelashes in the left eye....
Article
To evaluate the agreement between the reading values of the Goldmann applanation tonometer (GAT), Icare Pro rebound tonometer (IRT) and noncontact tonometer (NCT) in glaucoma patients. This cross-sectional study comprised 292 eyes of 292 patients selected from a glaucoma outpatient clinic. The intraocular pressure (IOP) was measured sequentially, a...
Article
We report two cases of severe thermal burns on the ocular surface and its adnexal appendages that developed secondary to exposure to molten heavy metal with a melting temperature of near-thousand degree Celsius. Despite aggressive intervention and strict monitoring, the profound inflammation caused significant damage to the ocular surface, ending u...
Article
Full-text available
We aimed to report a rarely observed case of unilateral epicapsular star and the visual impairment developed secondary to it. A 8-year-old girl presented with a complaint of blurred vision in the right eye; best-corrected visual acuity was 0.7 in the right eye and 1.0 in the left eye. Near visual acuity was J1 in the right eye and J1+ in the left e...
Article
Full-text available
We report a case of peripheral corneal ulceration associated with Graves ophthalmopathy that was treated with corneal lamellar graft surgery. A 36-years-old man with graves ophthalmopathy had severe corneal stromal thinning and a crescent shaped corneal ulcer in the inferior periphery. Corneal lamellar grafting was performed to avoid the risk of sp...
Article
Full-text available
Aim: To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP). Methods: In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). T...
Article
Purpose: To investigate the change in pre- and post-dilation anterior segment parameters and intraocular pressure (IOP) of patients with and without pseudoexfoliation, after topical application of phenylephrine HCl 10% and tropicamide 1%. Materials and methods: Totally 129 eyes of 129 patients were included in the study. Of the 129 eyes; 31 had ps...
Article
Purpose: The aim of this study was to present a novel technique to avoid the open-sky condition in pediatric and adult penetrating keratoplasty (PK). Methods: Seventy-two eyes of 65 infants and children and 44 eyes of 44 adult patients were operated on using this technique. After trephining the recipient cornea up to a depth of 50% to 70%, the a...
Article
Full-text available
The aim of this study was to investigate the association between choroidal thickness (CT) and sex, age, refractive error (RE), and axial length in healthy subjects. This is a study of 154 eyes in 154 healthy subjects. CT measurements were performed by the same experienced technician using a spectral domain optical coherence tomography device. CT wa...
Article
We report a case of fungal endophthalmitis in a 73-year-old woman secondary to Fusarium keratitis, which developed 1 week after complicated cataract surgery. The culture of corneal scrap-ing specimens revealed isolated methicillin-resistant coagulase-negative staphylococci, whereas vitreous culture results identified Fusarium solani, which had a hi...
Article
Full-text available
Context: Congenital glaucoma is a potentially blinding ocular disease of the childhood. Identification of the possible associated risk factors and may be helpful for prevention or early detection of this public health problem. Aims: To demonstrate the demographic features of congenital glaucoma subjects. Setting and design: The charts of conge...
Article
To evaluate the change in intraocular pressure (IOP) after pharmacologic dilation in eyes with primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), and eyes of normal subjects. This cross-sectional study was conducted in a university hospital-based setting. Patients with PXG, POAG, and normal subjects were consecutively selected an...