Ephraim Marondedze

Ephraim Marondedze
University of Johannesburg | uj · Department of Chemistry

Doctor of Philosophy

About

5
Publications
330
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14
Citations
Introduction
Ephraim Marondedze currently works at the Department of Chemical Sciences, University of Johannesburg. Ephraim does research in Computational Medicinal chemistry and Organic Chemistry.

Publications

Publications (5)
Article
Salmonella typhi (S. typhi), a gram-negative bacterium responsible for gastroenteritis – typhoid – has continually evolved into drug-resistant strains with the most recent being the haplotype H58 strain. The haplotype H58 strain has spread across the globe causing outbreaks in countries such as Pakistan, Zimbabwe, and several underdeveloped regions...
Article
Full-text available
Rimegepant is a new medicine developed for the management of chronic headache due to migraine. This manuscript is an attempt to study the various structural, physical, and chemical properties of the molecules. The molecule was optimized using B3LYP functional with 6-311G + (2d,p) basis set. Excited state properties of the compound were studied usin...
Preprint
Full-text available
Rimegepant is a new medicine developed for the management of chronic headache due to migraine. This manuscript is an attempt to study the various structural, physical and chemical properties of the molecules. The molecule was optimised using B3LYP functional with 6-311G+(2d,p) basis set. Excited state properties of the compound were studied using C...
Article
Currently, only three molecules, flutemetamol, florbetaben and florbetapir, have been approved for clinical use towards the definitive diagnosis of Alzheimer’s disease (AD). Despite the clinically approved drugs’ advantages, there still exists a need for new diagnostic molecules with improved properties (physicochemical and pharmacokinetic) in comp...
Article
Timely and accurate diagnosis of Alzheimer's disease (AD) remains a major challenge in the medical arena. β-amyloid (Aβ) imaging techniques such as positron emission tomography and single photon emission computed tomography require the use of an imaging probe. To date, only flutemetamol, florbetaben and florbetapir have been approved for clinical u...

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