Enrique Velasco SernaKU Leuven | ku leuven · Department of Cellular and Molecular Medicine
Enrique Velasco Serna
Doctor in Neuroscience
About
22
Publications
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Citations
Introduction
Enrique Velasco Serna currently works at the Instituto de Neurociencias, Universidad Miguel Hernández de Elche. Enrique does research in Neuroscience
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Additional affiliations
September 2016 - September 2017
Publications
Publications (22)
Peripheral sensory neurons transduce physicochemical stimuli affecting somatic tissues into the firing of action potentials that are conveyed to the central nervous system. This results in conscious perception, adaptation and survival, but alterations of the firing patterns can result in pain and hypersensitivity conditions. Thus, understanding the...
The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral ner...
“Nasal hyperreactivity” is a key feature in various phenotypes of upper airway diseases, whereby reactions of the nasal epithelium to diverse chemical and physical stimuli are exacerbated. In this review we illustrate how nasal hyperreactivity can result from at least three types of mechanisms: 1) impaired barrier function, 2) hypersensitivity to e...
Background:
Electrical stimulation of skin afferents can induce somatosensory plasticity in humans. Nevertheless, it is unknown if this is possible to do through percutaneous stimulation of a peripheral nerve, which will allow for regional anaesthesia interventions. Furthermore, potentiation protocols applied over mainly non-nociceptive fibers inh...
Abstract: The purpose of this double-blinded randomized controlled trial was to investigate whether
percutaneous electrolysis (PE) is able to activate endogenous pain modulation and whether its effects
are dependent on the dosage of the galvanic current. A total of 54 asymptomatic subjects aged
18–40 years were randomized into three groups, receivi...
Background:
The vasculature function is mainly regulated by the autonomic nervous system. Importantly, the sensory-motor nervous system also innervates peripheral vessels and has the capacity to modulate vascular tone. Here we investigated the effects of electrical stimulation of a mixed nerve trunk on blood flow in deep arteries and muscle perfus...
The role of TRPA1 in the thermosensitivity of the corneal cold thermoreceptor nerve endings was studied in young and aged mice. The contribution of the TRPA1-dependent activity to basal tearing and thermally-evoked blink was also explored. The corneal cold thermoreceptors’ activity was recorded extracellularly in young (5-month-old) and aged (18-mo...
Mechanisms and neuroscientific substrate of nociception and pain generation in physiological and pathophysiological conditions adapted to physical therapists
Perfluorohexyloctane (F6H8) eyedrops have been recently introduced in Europe as a product to treat dry eye disease, based on its ability to reduce tear film instability in Meibomian gland dysfunction and evaporative dry eye disease, although its mechanism of action is still unknown. In the present pilot study, we evaluated the effects of the ocular...
The class IIa histone-deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express HDAC4, 5 and 7 but not HDCA9. Here we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negative regulators of myelination ensuring peripheral ner...
Percutaneous electrolysis consists of the application of a galvanic electrical current throughout an acupuncture needle. It has been previously hypothesized that needling procedures’ neurophysiological effects may be related to endogenous pain modulation (EPM). This protocol study describes the design of a double-blind (participant, assessor) rando...
Transcranial direct current stimulation (tDCS) has been investigated as a way of improving motor learning. Our purpose was to explore the reversal bilateral tDCS effects on manual dexterity training, during five days, with the retention component measured after 5 days to determine whether somatosensory effects were produced. In this randomized, tri...
Objective
To systematically review the literature on the use of the transcranial static magnetic stimulation (tSMS) technique in humans and animals, its effects on different areas of the central nervous system (CNS), its influence on neural excitability and on the subject’s behavior, and its biological effects and future possibilities. All static m...
Typically, studies characterizing the response of cold thermoreceptor neurons use high-intensity cooling stimuli, far from the normal range of temperature oscillation under physiological conditions. In the present work, we studied the changes in impulse activity of cold thermosensitive trigeminal ganglion (TG) neurons in response to small temperatu...
Purpose
TRPA1 and TRPM8 channels provide cold sensitivity to cold thermoreceptor neurons, being activated by high‐ and low‐intensity cooling stimuli respectively. Corneal cold sensory nerve terminals (CSNTs) encode both corneal surface temperature reductions and tear osmolarity increases associated with tear evaporation, acting as `dryness detector...
Questions
Question (1)
I'm trying to get a distance matrix between my different datapoints in a bidimensional space (one variable in X axis, another in Y, simple). To get the distance forming the matrix, i will use euclidean distances, and, due to X and Y variable being in different scale/units, I want to standardize them (for example, using a rank between 0 and 1, or using the mean as 1, doesn't matter).
Until here, everything is okey. But when I'm about to request this normalization in SPSS, the programme asks me if I want to perform this standardization "by variable" or "by case". I don't understand the difference between this two procedures and the help in the programme doesn't look very helpful.
Kindest regards,
Quique
