Enrique Soto-Perez-de-Celis

• MD
• Associate Professor at University of Colorado Anschutz

e13848 Background: Africa is witnessing an increase in its older population and in cancer incidence, but little is known about the regional status of geriatric oncology. We conducted a cross-sectional survey among African physicians managing older adults with cancer to understand African geriatric oncology practices. Methods: A 30-item survey on th...

11013 Background: Preference-concordant care improves quality of life (QoL) and reduces healthcare utilization. However, limited research exists on how preferences impact clinical outcomes in older adults with advanced cancer. Our study explores differences in outcomes between patients (pts) prioritizing extending survival versus maintaining QoL. W...

9018 Background: The Common Sense Oncology (CSO) movement advocates for high-quality, patient-centered cancer care by emphasizing evidence-based, patient-relevant outcomes and equitable access to care through improved evidence generation, interpretation, and communication. A key part of CSO’s mission is training oncologists to incorporate these pri...

1629 Background: Exercise offers significant benefit for patients with cancer, improving physical function, quality of life, and treatment-related outcomes. However, barriers such as limited referral practices and insufficient knowledge hinder its integration into care. This study compared referral practices, exercise assessment, and physicians’ pe...

1624 Background: Prognostic awareness plays a key role in patient outcomes, particularly among older adults with metastatic cancer. This secondary analysis of a randomized controlled trial (RCT) evaluated the effect of a Geriatric Assessment-guided Intervention (GAIN-S) on patient responses to prognosis items over time between two arms. Methods: El...

1618 Background: DPD deficiency is the most important risk factor for developing fluoropyrimidine-related adverse events. Genetic variants causing DPD deficiency are found in 6-8% of Caucasian patients. However, there is limited information on their prevalence in underrepresented ethnic groups, such as Hispanics and Latinos, and testing for these v...

Background: Older patients with cancer face challenges in accessing high-quality cancer care, especially in resource-limited settings. We assessed the impact of a telehealth-adapted Geriatric Assessment–Guided Intervention (GAIN-S) among older Brazilians with metastatic cancer. Patient and Methods: This randomized clinical trial enrolled adults age...

Introduction Financial toxicity from cancer treatment is a significant barrier to equitable care and an important clinical and public health concern. This scoping review systematically review the financial toxicity assessment pattern in cancer care across global settings and generate an inventory of domains and sub-domains of questions used to asse...

PURPOSE Integrating palliative care into oncology is essential, yet disparities in access and quality persist, particularly in low- and middle-income countries (LMICs). The ASCO guidelines advocate for early, routine, interdisciplinary palliative care for patients with advanced cancer. Barriers to implementing these recommendations include resource...

Background Given the rising cancer burden, the capacity of Mexico’s healthcare system to effectively address cancer care through its current available infrastructure becomes increasingly critical. Limited availability of diagnostic and therapeutic infrastructure leads to delays in diagnosis and treatment. Countries like Mexico, should undertake com...

Importance Lung cancer management involves navigating a complex pathway from symptom onset to treatment initiation, where delays can compromise outcomes. Objective To identify the length of treatment intervals among Mexican lung cancer patients, compare treatment intervals to results from other countries, and identify determinants of delays. Desi...

130 Background: Patients with metastatic prostate cancer (mPCa) undergoing treatment often experience declines in health-related quality of life (HRQoL) and increased symptom burden. Exercise interventions are known to mitigate these effects, but adherence to such programs remains a challenge. This study aimed to assess the impact of adherence to a...

The COVID-19 pandemic provided an ideal scenario for studying the care of the elderly population, we implemented a tool named the Geriatric Measure (GM) tool to determine the severity and need for hospitalization. The objective of the study is to evaluate if the results of a brief Geriatric Measure tool are associated with mortality and other outco...

PURPOSE Trimodal therapy (TMT) is the standard treatment for patients with nonmetastatic inflammatory breast cancer (IBC). TMT consists of neoadjuvant systemic therapy, modified radical mastectomy (MRM), and postmastectomy radiation therapy. Although broadly considered the best approach for IBC, in the United States, only a third of patients receiv...

Purpose Despite exercise’s known benefits for cancer patients, little is understood about combining it with immune checkpoint inhibitors (ICI). This study aims to assess the feasibility and acceptability of a personalized physical activity program for cancer patients on ICI treatment and to investigate its effects on quality of life, ICI-related si...

Background The global population aged 80 years or older is expected to triple by 2050, leading to an increased cancer burden in the oldest population. This study describes the estimated cancer incidence and mortality in 2022 and projections for 2050 in the oldest old, analyzed globally and by world regions and World Bank income levels, for all sexe...

Background Despite the increasing integration of wearable technology in oncology, its application in the care of older adults, representing most patients with cancer, is poorly defined. Objective This systematic review aimed to summarize the current use of wearables in studies in older adults with cancer. Methods This systematic review was conduc...

PURPOSE To develop and implement a continuing professional development (CPD) activity focused on geriatric assessment (GA) in oncology for oncologists and geriatricians. We evaluated the impact of this activity on knowledge, skills, and performance regarding GA in oncology, as well as its feasibility and acceptability. METHODS We included teams co...

HER2-positive breast cancer accounts for 10% to 20% of all breast cancer diagnoses. The mAb trastuzumab is crucial in treating this disease, significantly improving survival outcomes. Despite its inclusion in the World Health Organization’s Model List of Essential Medicines, access to trastuzumab remains limited worldwide. In this issue of the jour...

112 Background: Immune checkpoint inhibitors are unavailable or unaffordable to many patients in LMIC, including Mexico. Some proposed strategies to improve access include weight-based dosing, vial sharing, or using low-dose IO (immunotherapy) schedules. Despite the potential advantages of low-dose IO to increase access and improve outcomes, there...

This review explores current guidelines for integrating psychosocial support, nutrition, and physical activity into cancer care and examines the resources available to deliver comprehensive care effectively and equitably, with a focus on telehealth solutions. A review of current guidelines related to psychosocial support, nutrition, and exercise in...

Background The global cancer burden is rising, particularly in low‐ and middle‐income countries (LMIC), highlighting a critical research gap in understanding disparities in supportive care access. To address this, the Multinational Association of Supportive Care in Cancer (MASCC) Health Disparities Committee initiated a global survey to investigate...

Purpose The time toxicity of anticancer therapy, defined as days spent with healthcare contact during treatment, represents a critical but understudied outcome. This study aims to quantify time toxicity among older patients with cancer receiving palliative systemic treatment. Methods All patients aged ≥ 65 years with metastatic cancer receiving cy...

Molecular and cellular characterization of tumors is essential due to the complex and heterogeneous nature of cancer. In recent decades, many bioinformatic tools and experimental techniques have been developed to achieve personalized characterization of tumors. However, sample handling continues to be a major challenge as limitations such as prior...

Addressing ageism in clinical practice & research: #awareness #education #language and #geriassessment

PURPOSE The study aims to explore unmet social needs and sources of financial toxicities in patients as noted by health care professionals and researchers in cancer supportive care, shedding light on potential health disparities. METHODS In this cross-sectional survey, we anonymously surveyed active members of the Multinational Association of Supp...

Introduction The time toxicity of anticancer therapy, defined as the number of days spent with healthcare contact during treatment, represents a critical but understudied outcome. This study aims to quantify time toxicity among older patients with cancer receiving palliative systemic treatment and identify predictors for a high burden of time toxic...

The increasing rate of the older adult population across the world over the next 20 years along with significant developments in the treatment of oncology will require a more granular understanding of the older adult population with cancer. The ASCO Geriatric Oncology Community of Practice (COP) herein provides an outline for the field along three...

While some recent drug treatments have been transformative for patients with cancer, many treatments offer small benefits despite high clinical toxicity, time toxicity and financial toxicity. Moreover, treatments that do provide substantial clinical benefits are not available to many patients globally due to issues with availability and affordabili...

1623 Background: Leading organizations, including ASCO, recommend physical activity for patients with cancer. However, numerous barriers hinder patients from maintaining regular physical activity, particularly among older adults, who have lower participation in exercise programs. This study aims to evaluate the effects of a 12-week supervised remot...

e24040 Background: Cancer is a common cause of death among Hispanics. Estimating patient survival is critical in cancer care since it allows better shared decision-making and avoids use of futile therapy. Palliative Performance Scale (PPS) has been widely used for survival prediction among patients with cancer. However, its performance has not been...

1514 Background: Older adults with cancer often present unique geriatric and supportive care needs. We sought to evaluate the impact of a telehealth-based multimodal geriatric assessment (GA)-guided supportive care interventions (GAIN-S) program among older patients with metastatic cancer in a Brazilian cancer center. Methods: This is a randomized...

1515 Background: Older adults receiving chemotherapy (CT) are at a high risk of toxicity (Tox) and of functional decline. Promptly acting upon CT Tox in older adults is difficult, particularly in developing countries where triage systems and personnel are limited. We previously showed that monitoring older patients using an accelerometer-equipped s...

Communication in oncology has always been challenging. The new era of precision oncology creates prognostic uncertainty. Still, person-centered care requires attention to people and their care needs. Living with cancer portends an experience that is life-altering, no matter what the outcome. Supporting patients and families through this unique expe...

9020 Background: Geriatric assessment (GA) is recommended as part of the standard of care for older adults with cancer. However, the GA has not been fully adopted as part of routine practice in oncology in Mexico, mainly due to lack of qualified personnel and limited knowledge. We designed an interprofessional case-based educational intervention to...

Breast cancer is the most common neoplasia, with the highest mortality in women worldwide. The tenth update of the Me-xican Consensus on Diagnosis and Treatment of Breast Cancer (2023) is published by its authors in different articles. This article includes the management of advanced breast cancer, the adjuvant systemic treatment, the role of surge...

Introduction Older adults with cancer facing competing treatments must prioritize between various outcomes. This study assessed health outcome prioritization among older adults with cancer starting chemotherapy. Methods Secondary analysis of a randomized trial addressing vulnerabilities in older adults with cancer. Patients completed three validat...

Equity, diversity, and inclusion (EDI) are essential for healthcare organizations since they allow for the development of programs and initiatives that bring together diverse perspectives and knowledge. Global multidisciplinary organizations, such as the Multinational Association for Supportive Care in Cancer (MASCC), need to understand the perspec...

It is relevant to study the financial toxicity of cancer to address it. However, the existing tools fail to capture the financial destruction of cancer on patients and their families in resource-limited countries. The authors discuss the need for a new tool in this article.

Breast cancer, in early stages, has specific surgical, radiotherapy, and systemic management. This type of cancer includes ductal carcinoma in situ and breast cancers in stages I, IIA, IIB, and IIIA. This tenth update of the Mexican Breast Cancer Consensus addressed the management of early stages. The dissemination of this consensus contributes to...

Introduction: Older adults with metastatic prostate cancer (mPC) experience high symptom burden associated with treatment. Frailty may exacerbate treatment toxicity. The aim of this study was to explore short-term treatment toxicity in patients with metastatic prostate cancer. Materials and Methods: Older adults with metastatic prostate cancer sta...

267 Background: Immunotherapy has revolutionized cancer treatment, but immune-related side effects can significantly impact patients' quality of life and treatment outcomes. Physical activity and exercise have been shown to be beneficial in managing these adverse events. This study aims to investigate the effects of a low-cost and accessible remote...

215 Background: Older adults with cancer in developing countries often encounter obstacles in accessing specialized medical services. We conducted a randomized clinical trial to investigate the feasibility and preliminary efficacy of integrating telehealth-based multimodal geriatric assessment (GA)-guided supportive care interventions (GAIN) for ol...

Background The US-Mexico border is the busiest in the world, with millions of people crossing it daily. However, little is known about cross-border utilization of cancer care, or about the reasons driving it. We designed a cross sectional online survey to understand the type of care patients with cancer who live in the US and Mexico seek outside th...

This letter to the editor remarks on results of a recently published study and highlights the need for multinational and interinstitutional registries so health departments in the US and Latin American countries can accurately capture cancer incidence and mortality data.

No hay ninguna duda de que en las últimas décadas la oncología médica ha tenido extraordinarios éxitos en el tratamiento del cáncer. Estos avances se han visto impulsados por el descubrimiento, la innovación y, sobre todo, por la investigación clínica rigurosa, que ha llevado al desarrollo de nuevos protocolos terapéuticos y a la optimización de su...

Antecedentes: Los retrasos en la atención de personas con cáncer impactan negativamente su calidad de vida y aumentan los costos al sistema de salud. Objetivo: Describir las fases del proyecto Código Cáncer y sus resultados preliminares. Métodos: Se organizaron siete grupos de investigación para: a) entender las causas de los retrasos que enfrent...

The use of geriatric assessment (GA) by oncology specialists in Mexico is low. We aimed to explore factors associated with the evaluation of individual GA domains by Mexican oncology specialists. We performed an exploratory analysis of a sequential explanatory mixed-methods study consisting of an online cross-sectional survey of Mexican oncology sp...

Previous studies have shown a disproportionate rise in cancer incidence in low-and-middle-income countries (LMICs) due to rapid population ageing. This study aims to describe the cancer incidence in adults aged 60 years and older in LMICs to inform cancer control planning. Using the latest GLOBOCAN estimates for 2020, we describe the cancer inciden...

Central America and the Caribbean is a highly heterogeneous region comprising more than 30 countries and territories with more than 200 million inhabitants. Although recent advances in the region have improved access to cancer care, there are still many disparities and barriers for obtaining high-quality cancer treatments, particularly for those fr...

Simple Summary Advanced cancer represents the most common reason for needing palliative care among older adults worldwide. Unfortunately, older adults face several barriers when trying to obtain high-quality palliative care partly due to a lack of data regarding the best way to treat them and to limited geriatric expertise among clinicians. Providi...

Introduction: Physical activity may be associated with cancer treatment toxicity, but generalizability to geriatric oncology is unclear. As many older adults have low levels of physical activity and technology use, this area needs further exploration. We evaluated the feasibility of daily step count monitoring and the association between step coun...

Purpose: To estimate the cost-effectiveness of adding a CDK4/6 inhibitor to standard endocrine therapy in the first-line setting for advanced HR+/HER2- breast cancer in postmenopausal and premenopausal women, from the perspective of the Mexican public healthcare system. Methods: We used a partitioned survival model to simulate relevant health ou...

e18575 Background: Healthcare utilization is a common reason for bidirectional travel across the US-Mexico border. We surveyed Mexican oncologists to understand why patients with cancer in the US and Mexico seek care outside their home country and what barriers they face. Methods: Approval was obtained from Instituto Nacional de Ciencias Médicas y...

12055 Background: Accelerometry research suggests physical activity may be associated with treatment toxicity, but generalizability to geriatric oncology is unclear. As many older adults have low levels of physical activity and technology use, further exploration is warranted. This study explores the feasibility of daily physical activity monitorin...

e18574 Background: Transnational healthcare utilization between US and Mexico border states is well described for specific medical conditions; however, little is known regarding the trans-border use of diagnostic imaging and invasive studies in cancer care in this region. We aimed at identifying patterns of diagnostic testing use among US- and Mexi...

12122 Background: Exercise has been shown to ameliorate the side effects of cancer therapy, improve quality of life, and may even enhance treatment response. Since immunotherapy is widely used and approved for over 18 indications, studies are needed to determine the effect of exercise on immunotherapy outcomes Additionally, there is a crucial need...

e18592 Background: In Latin America (LatAm), cancer is a major public health issue with high mortality rates. Patient navigation (PN) programs have emerged as a strategy to improve access to cancer care for underserved populations. Unfortunately, there is a lack of educational opportunities for those willing to become patient navigators in LatAm. T...

e18576 Background: Crossing the US-Mexico border to seek healthcare is common, but limited data is available regarding cross-border cancer care. Since access and availability differs between Mexico and the US, we investigated which therapies were sought by Mexico and US-based patients crossing the border to receive cancer care. Methods: An online s...

12033 Background: Malnutrition is a predictor of cancer survival independent of cancer site. However, routine screening for malnutrition is underutilized. Advanced cancer accounts for 60% of cancer cases in developing countries of which approximately 52 % have malnutrition. This study aimed to describe factors associated with risk of malnutrition a...

12054 Background: Advancements in metastatic prostate cancer (mPC) treatments have increased survival, but using multiple lines of therapy has increased the prevalence and severity of toxicities. Older men and those living with frailty experience higher symptom burden associated with treatment. Although toxicities have been described in previous tr...

Cancer is a disease of older adults, with 60% of cancer diagnoses and 70% of cancer deaths occurring in individuals ≥ 65 years. Normal oral aging may transition to disease in the presence of one or more potential modifiers, such as a new oncological diagnosis or a new treatment. Oral conditions in patients with cancer cause significant morbidity. P...

Background: When treating older women with breast cancer, life expectancy is an important consideration. ASCO recommends calculating 10-year mortality probabilities to inform treatment decisions. One useful tool is the Schonberg index, which predicts risk-based all-cause 10-year mortality. We investigated the use of this index in women aged ≥65 ye...

Purpose To compare supportive care needs between older adults with cancer (age ≥ 65 years) and their younger counterparts. Methods We conducted a retrospective analysis of a prospective cohort of patients with newly diagnosed metastatic solid tumors. Supportive care needs were assessed at baseline and at 3-month follow-up. Patients were divided in...