Enrique Rojas-Campos

Enrique Rojas-Campos
Mexican Institute of Social Security | IMSS · Unidad de Investigación Médica en Enfermedades Renales

About

108
Publications
9,331
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
962
Citations

Publications

Publications (108)
Article
Full-text available
Gut microbiota disturbances may influence cognitive function, increasing uremic toxins and inflammation in dialysis patients; therefore, we aimed to evaluate the association of the gut microbiota profile with cognitive impairment (CI) in patients on automated peritoneal dialysis (APD). In a cross-sectional study, cognitive function was evaluated us...
Article
Full-text available
Background. Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is associated with clinical outcomes. It is necessary to identify the phenotype to make clinical decisions that optimize resources and follow-up. Objective. To determine the frequency of the CKD-MBD phenotype in dialysis patients and the associated factors. Methods. Cross-sectio...
Article
Antecedentes: La enfermedad renal crónica (ERC), tiene muchos retos: el diagnóstico temprano, atención especializada, aspectos económicos, sin embargo el aspecto nutricional es de la misma relevancia. No se conoce el número de especialistas en nutrición renal en muchos países (entre ellos México). El derecho a la salud, a la nutrición y a la nutric...
Article
Full-text available
Evidence supporting a starting dose of 2 g/day of mycophenolate mofetil (MMF) in combination with tacrolimus (TAC) for renal transplantation (RT) is still limited, but maintaining a dose of <2 g could result in worse clinical outcomes in terms of acute rejection (AR). This study aimed to determine the association between AR and infectious and nonin...
Article
Full-text available
Background There are many clinical practice guidelines (CPGs) in Nephrology; however, there is no evidence that their availability has improved the clinical competence of physicians or the outcome of patients with chronic kidney disease (CKD). This study was aimed to evaluate the effect of implementation of CPGs for early CKD on family physicians (...
Preprint
Background The evidence supporting a starting dose of 2 g/day of mycophenolate mofetil (MMF) in combination with tacrolimus (TAC) in renal transplant (RT) is still limited but maintaining the dose of less than 2g could result in worse clinical outcomes in terms of acute rejection (AR). Research Question This study’s aim was to determine the associ...
Article
Full-text available
To evaluate individual and combined effect of captopril and telmisartan on systemic inflammation markers of hemodialysis (HD) patients. Randomized, double-blinded, controlled clinical trial. Patients on HD at least 2 months, with arteriovenous fistula, were randomly allocated to groups: (1) captopril/placebo (N 13); (2) telmisartan/placebo (N 13);...
Article
Full-text available
Background: Acute kidney injury (AKI) is associated with poor outcomes in patients infected with SARS-CoV-2. Sepsis, direct injury to kidney cells by the virus, and severe systemic inflammation are mechanisms implicated in its development. We investigated the association between inflammatory markers (C-reactive protein, procalcitonin, D-dimer, lac...
Preprint
Full-text available
Background Acute kidney injury (AKI) is associated with poor outcomes in patients infected with SARS-CoV-2. Sepsis, direct injury to kidney cells by the virus, and severe systemic inflammation are mechanisms implicated in its development. We investigated the association between inflammatory markers (C-reactive protein, procalcitonin, D-dimer, lacta...
Article
Full-text available
Contexto: la procalcitonina (PCT) podría ser útil en la evaluación de la función del injerto renal (IR) en el postrasplante inmediato, ya que sus niveles se incrementan posterior a la elevación de citocinas inflamatorias (IL-6, TNF-?) durante eventos de disfunción renal. Objetivo: determinar la asociación de la PCT sérica con la función del injert...
Article
Full-text available
The mycetoma is a granulomatous chronic disease, subcutaneous disease is the common presentation, very few cases are reported affecting central nervous system, but there are not cases in Renal Transplant (RT). Renal transplant recipients have increased risk of invasive fungal infections. Transplant centers in geographic endemic risk areas should su...
Article
Full-text available
The clinical and biochemical improvement observed in kidney transplant (RT) recipients is remarkable. The correct functioning of the allograft depends on various factors such as the donor’s age, the alloimmune response, the ischemia-reperfusion injury, arterial hypertension, and the interstitial fibrosis of the allograft, among others. Antihyperten...
Article
Full-text available
Background Malnutrition and inflammation are highly prevalent and associated with poor outcomes in continuous ambulatory peritoneal dialysis (CAPD). Nutritional supplements are commonly used; however, presence of systemic inflammation could limit their effect. Aim To evaluate the impact of systemic inflammation on nutritional status of CAPD patien...
Article
Full-text available
Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL acc...
Article
Full-text available
The aim of the present study was to develop and validate a test to evaluate dietitian's clinical competence (CC) about nutritional care in patients with early chronic kidney disease (CKD). The study was conducted through five steps: (1) CC and its dimensions were defined; (2) test items were elaborated, and choice of response format and scoring sys...
Article
Full-text available
Introduction: Acute Kidney Injury (AKI) is a common complication associated with SARS-CoV-2 infection and its incidence ranges from 7.3% in hospitalized patients to 19.9% in critically ill patients with repercussion in high mortality. Sepsis, direct cellular injury due to the tropism of the virus, and systemic inflammation are mechanisms involved i...
Article
Full-text available
Background & aims Evidence suggests that multiple-behavior interventions (with a specialist) have a greater impact on public health than single-behavior interventions, particularly in a chronic patient. However, there is little understanding of some very basic principles concerning multiple health behavior change, especially in situations such as k...
Article
Full-text available
Patients with end-stage renal disease (ESRD) present alterations in mineral and bone metabolism. Hyperphosphatemia in ESRD is considered an independent risk factor for cardiovascular disease (CVD), increasing morbidity, and mortality. Sevelamer hydrochloride is a calcium-free, non-absorbable phosphate-chelating polymer. Calcium carbonate chelator i...
Article
Full-text available
Background & Aims Mexico has one of the highest mortality rates by COVID-19 worldwide. This may be partially explained by the high prevalence of overweight/obesity found in general population; however, there is limited information in this regard. Furthermore, acute kidney injury (AKI) and need for renal replacement therapy (RRT) associated to obesi...
Article
Full-text available
Background: Cognitive deterioration decreases quality of life, self-care and adherence to treatment, increasing mortality risk. There is scarce information of cognitive impairment in peritoneal dialysis, and data are controversial. Objective: To determine the frequency and associated factors of cognitive impairment in patients on automated perit...
Article
Triggering receptor expressed on myeloid cells (TREM)-1 is a potent and early amplifier of the inflammatory response expressed on neutrophils and monocytes/macrophages. TREM-1, and its soluble form (sTREM-1), are increased in sepsis and other noninfectious inflammatory conditions. However, virtually no data are available in kidney disease. To deter...
Article
Full-text available
Objective To describe mortality of in-hospital patients with COVID-19 and compare risk factors between survivors and non-survivors. Design Prospective cohort of adult inpatients. Setting Tertiary healthcare teaching hospital in Guadalajara, Mexico. Participants All patients with confirmed COVID-19 hospitalised from 25 March to 7 September 2020 w...
Article
Full-text available
Protein-energy wasting (PEW) and poor health-related quality of life (HRQoL) are independently associated with morbi-mortality in continuous ambulatory peritoneal dialysis (CAPD). PEW may reduce HRQoL; however, we hypothesized HRQoL is affected differentially by PEW degrees or by individual criteria of nutritional status. Aim To evaluate HRQoL acc...
Article
Full-text available
A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. Renal transplant from a living related...
Article
Full-text available
Background In our population, anti-thymocyte globulin (ATG) of 1 mg/Kg/day for 4 days is used; which permits not using valgancyclovir (VGC) prophylaxis in some renal transplant recipients (RTR) of moderate risk (R+), to reduce costs. Our objective was to determine the incidence and risk for the development of cytomegalovirus (CMV) with or without p...
Article
Full-text available
Minimization in immunosuppression could contribute to the appearance the donor-specific HLA antibodies (DSA) and graft failure. The objective was to compare the incidence of DSA in renal transplantation (RT) in recipients with immunosuppression with and without steroids. A prospective cohort from March 1st, 2013 to March 1st, 2014 and follow-up (1...
Article
Full-text available
Donors have a higher risk of developing chronic kidney disease than the general population. Some mechanisms mediated by pro-inflammatory cytokines and oxidative stress may be involved as risk factors. The objective of the study was to evaluate the behavior of pro-inflammatory cytokines and oxidative stress markers in living renal donors with a 6-mo...
Article
Full-text available
Background and Aims The main precursor of suicidal ideation is depression, which is the most common psychiatric disorder in dialysis patients. Studies have shown an association of depression with nutritional alterations and systemic inflammation; however, in patients with kidney disease there is no data about a possible relation between malnutritio...
Article
Full-text available
Background and Aims Risk factors for chronic kidney disease (CKD) such as type 2 diabetes mellitus (DM2), high blood pressure (HBP) and obesity are strongly related to negative lifestyle and nutritional habits. The aim of this study was to estimate the proportion of patients with and without risk factors for CKD who meet recommendations for food co...
Article
Full-text available
Background and Aims Cognitive impairment is very common in dialysis patients, with negative effects on quality of life and mortality. In neurodegenerative conditions (Alzheimer, Parkinson) a gut-brain axis has been identified; however, there is no information about the relationship of gut microbiota alterations and presence of cognitive impairment...
Article
Objective: The aim of this study was to validate a direct taste perception test (TPT) and evaluate its performance in patients on dialysis. Methods: This cross-sectional study was carried out in a tertiary-care hospital. A TPT was validated on 112 healthy subjects and applied on 43 patients on hemodialysis and 32 patients on peritoneal dialysis....
Article
Full-text available
Objective: Pica could be strongly implicated in nutritional status of patients on dialysis; however, very scarce data are currently available. The objective of this study was to evaluate the prevalence of pica and its association with nutritional status in dialysis patients. Design and methods: This is a cross-sectional study in a tertiary care...
Article
Full-text available
Background: Acute renal graft dysfunction (AGD) is one of the primary complications after kidney transplantation. The aim of this study was to identify the systemic oxidative DNA damage and apoptosis markers in patients with AGD, which will aid the understanding of the underlying processes of the complication.
Article
Full-text available
Background: Acute renal graft dysfunction (AGD) is one of the primary complications after kidney transplantation. The aim of this study was to identify the systemic oxidative DNA damage and apoptosis markers in patients with AGD, which will aid the understanding of the underlying processes of the complication. Methods: A cross-sectional analytical...
Article
Full-text available
Background. There is always the possibility of acute renal graft dysfunction (AGD) after renal transplantation (RT). AGD is suspected because of a decrease in urine volume, an increase in baseline serum creatinine (SCr) or proteinuria. Tacrolimus (TAC) is a calcineurin inhibitor (CI) with immunosuppressive function. Aim. To analyze the association...
Chapter
Chronic kidney disease (CKD) is a worldwide epidemic, especially in disadvantaged populations. Lack of economic resources is a clear constraint for improving kidney health in low-income countries and disadvantaged populations; therefore the employment of systematic strategies for prevention, screening, and treatment of CKD in the primary health-car...
Article
Full-text available
Multidisciplinary attention models include the joined and coordinated participation of different professionals within the health team (physicians, nurses, social workers, dietitians, physical trainers, among others). A multidisciplinary approach facilitates and improves management of patients from early chronic kidney disease (CKD) in the primary h...
Article
Full-text available
Vascular calcification (VC), it is a clinical condition highly associated to Chronic Kidney Disease (CKD), CKD patients had as a primary death cause, the cardiovascular disease (CVD), among many non-traditional factors for CKD appears VC. The pathogenesis of VC it´s multifactorial and it´s in short terms a change of muscle vessels cells to a bone c...
Article
Full-text available
Objective. To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus. Methods. Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up). Patients with AGD and without AGD were included. Serum IL-6, TNF- α , 8-isoprostanes (8-IP), and Nitric Oxide (NO) were deter...
Article
Full-text available
Renal transplantation (RT), has been considered the best therapeutic option for end stage renal disease (ESRD). Objective . To determine the effect of RT on the evolution of oxidative DNA status. Methods . Prospective cohort ( N = 50 receptors of RT); genotoxic damage, 8-hydroxy-2′-deoxyguanosine (8-OHdG), and DNA repair enzyme, human 8-oxoguanine-...
Article
Full-text available
The peritoneal equilibration test (PET) is a common test used in the adequacy of peritoneal dialysis (PD). To determine the frequency of presentation of different types of peritoneal transport in patients on PD ranking with Twardowski, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) and Hospital de Especialidades del I...
Article
Full-text available
Background and aims: One strategy to prevent and manage chronic kidney disease (CKD) is to offer screening programs. The aim of this study was to determine the percentage prevalence and risk factors of CKD in a screening program performed in an adult general population. Methods: This is a cross-sectional study. Six-hundred ten adults (73% women,...
Article
Full-text available
Background: Acute rejection and graft function have not been completely clarified in early-steroid-withdrawal (ESW) patients. The objective of this study was to compare the effect of early steroid withdrawal on GFR, graft survival/rejection in recipients in a cohort treated with tacrolimus/mycophenolate mofetil compared to a control cohort. Mater...
Article
Background: The peritoneal equilibration test (PET) is a common test used in the adequacy of peritoneal dialysis (PD). Aim: To determine the frequency of presentation of different types of peritoneal transport in patients on PD ranking with Twardowski, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ) and Hospital de Esp...
Article
Chronic kidney disease (CKD) is a worldwide epidemic especially in developing countries, with clear deficiencies in identification and treatment. Better care of CKD requires more than only economic resources, utilization of health research in policy-making and health systems changes that produce better outcomes. A multidisciplinary approach may fac...
Article
Full-text available
Inflammation is highly prevalent in patients on dialysis. Statins have anti-inflammatory actions but their use has been scarcely studied in continuous ambulatory peritoneal dialysis (CAPD). We undertook this study to compare the effect of pravastatin vs. placebo on the serum concentrations of C-reactive protein (CRP) in patients on CAPD. In a doubl...
Article
Vascular calcification (VC) is a predictor of poor survival and cardiovascular outcome in end-stage renal disease (ESRD) patients; however, there is scarce information of VC in Latin America, and virtually no data in our setting. We undertook this study to evaluate the prevalence and characteristics of VC in a hemodialysis (HD) population from west...
Article
Full-text available
The aim of this study was to compare the effect of pentoxifylline versus placebo on serum concentrations of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and C-reactive protein (CRP) of hemodialysis (HD) patients. This is a randomized double-blind, controlled clinical trial. HD patients without infection or drugs with anti-inflammatory...
Article
Full-text available
To compare dietary intake of micronutrients by peritoneal dialysis (PD) patients according to their nutrition and inflammatory statuses. This cross-sectional study evaluated 73 patients using subjective global assessment, 24-hour dietary recall, and markers of inflammation [C-reactive protein (CRP), tumor necrosis factor α, and interleukin 6]. Half...