Eni-Yimini Agoro

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• P.hD. MNSBMB. FMLSCN. FWAPCMLS.
• Reader (Chemical Pathology and Forensic Toxicology) at Federal University Otuoke

Background and Objective: Oryctes rhinoceros larvae is a special cuisine heavily patronized in Bayelsa State and neighboring states of Delta and Rivers in Nigeria. The preparation mode and exposure during sales call for empirical investigation into its chemical and toxicological status. Heavy metals and polycyclic hydrocarbons (PCHs) were the major...

Background and Objective: Paracetamol overdose can cause severe liver, heart and kidney damage due to oxidative stress and glutathione depletion. Phyllanthus amarus, known for its hepatoprotective properties, may offer therapeutic benefits in mitigating such toxicity. This study evaluates the antioxidative effects of Phyllanthus amarus on biochemic...

This research studied the bacterial and fungal microbial ecologies on dichlorvos-treated carrions and their effects on post-mortem microbial clock for post-mortem interval (PMI) estimation during death investigations. Carrion-soil, skin, oral and rectal samples were aseptically collected, cultured and microbes isolated from both dichlorvos-treated...

Background and aims: Rape as a crime is on the increase despite various punitive measures put in place by governments. The major handicaps to the containment of rape are due to societal discriminatory outlooks, poor investigative tools, and expensive empirical evidential biomarkers. Evolving cheap and measurable biochemical biomarkers to bridge the...

This study was designed to examine the phytochemical composition of Pentaclethra macrophylla and its consumption effect on hepato-renal chemistries. The fermented seeds of Pentaclethra macrophylla were pulverized into fine powder and a portion of it was extracted with water to get the aqueous extract. The phytochemical constituents of fermented P....

Prostate cancer (PC) represents one of the most commonly diagnosed cancers, and the over-expression of cell survival genes has been described to underlie castration-resistant prostate cancer (CRPC) emergence and resistance to chemotherapies post-andro-gen withdrawal. Although several patients initially respond well to standard treatments but later...

The rate of rape and other sexually induced crimes is rapidly on the increase worldwide with weak empirical confirmational tools, and expensive financial implications This is further compounded by poor proof of the time of the committal of the crime and its attendant effect on the parameter of interest. This called for a cheap and accurate approach...

Pregnancy is known to create profound metabolic, hormonal, and physiological changes in the body. Lipid profile and some parameters associated with lipid peroxidation play crucial roles in the sustenance of pregnancy and delivery. The biochemical changes resulting from pregnancy could be physiological or pathological depending on the parameter's co...

Soccer is a worldwide game played for health, entertainment and economic purposes. The effect of soccer activities on homeostatic, glucolytic and lipolytic biochemical parameters were estimated before and after 90 minutes of a full-time game. Twenty-two (22) male soccer players from a second-tier squad took part in the investigation. The biochemica...

The effect of 50, 100 and 200 mg/kg of combined ethanol extract of S. calycina and C. lutea were investigated on mating behavioural parameters and sex/reproductive hormone boosting potentials in both non-bonny light crude oil (NBLCO) and bonny light crude oil (BLCO) environmentally challenged rats. Forty sexually experienced rats weighing 120-135g...

The rate of rape and other sexually induced crimes is rapidly on the increase worldwide with weak empirical confirmational tools, and expensive financial implications This is further compounded by poor proof of the time of the committal of the crime and its attendant effect on the parameter of interest. This called for a cheap and accurate approach...

Background and Objective: Okra (Abelmoschus esculentus) is one of the most popular and commonly used members of the Malvaceae family. The study investigated the phytochemical content of okra and its attendant metabolic role on the liver in maintaining the optimal concentrations of glucose and lipids in the body. Materials and Methods: Thirty albino...

Background and Objective: There is an unrestrained dumping of wastes and chemicals into water bodies of communities in the South East of Nigeria due to the increasing industrialization. This has led to

Background and Objective: Okra (Abelmoschus esculentus) is one of the most popular and commonly used members of the Malvaceae family. The study investigated the phytochemical content of okra and its attendant metabolic role on the liver in maintaining the optimal concentrations of glucose and lipids in the body. Materials and Methods: Thirty albino...

The translocation capacity of metals (Cd, Cr, As, Pb, and Hg) was determined in water and fish, and in the serum and vitreous humor harvested from New Zealand White (albino) rabbits fed with the processed fish. The sample size comprised 12 male rabbits divided equally into control and experimental groups. Both groups were fed with normal rabbit mea...

In most developing countries, stores, where chemical substances are sold, are poorly ventilated, and best practices are not followed. This can result in the contamination of the ambient air inside the stores with toxicological implications for the lungs. This work aimed at determining the risk of pulmonary disease in chemical storekeepers in the Ar...

Introduction: Body Mass Index (BMI) is a nutritional index used to measure the level of obesity in individuals and other weight associated abnormalities. This study was intended to investigate the effect of the various BMI classifications on total cholesterol (TCHOL), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL),...

Introduction: Typhoid fever infection is one of the most prevalent diseases in developing countries. It is caused by Salmonella species and can affect multiple organs in the body if left untreated. The purpose of this study was to determine the biochemical patterns of renal and liver biochemical parameters in patients admitted with typhoid fever. M...

Hormonal contraceptives induce changes in the hypothalo-pituitary-ovarian loop and this eventually results in their therapeutic effects. The study aimed to investigate the level of changes induced in the pituitary gland and the ovary by hormonal contraceptive agents. The sample size was 200. One hundred and fifty (150) women desirous of contracepti...

Background: This research was carried out to investigate the potential bioaccumulation and translocation of heavy metals in plantain cultivation-consumption chain using the serum and vitreous humour as the final reservoirs. Soil, plantain, serum and vitreous humour were analyzed for heavy metals (HM) (Cr, Pb, Cd, As, Hg). Methods: Twelve male albin...

Background: Trevo is a nutritional supplement with numerous bioactive natural products, with detoxifying and antioxidant properties. The purpose of this study was to investigate the ability of Trévo to protect against oxidative stress induced by lead in the kidneys of male Wistar rats. Methods: Thirty-five healthy male Wistar rats were divided int...

Anaemia in pregnancy has remained a universal public health issue, causing maternal and fetal morbidity and mortality. This prospective cross-sectional analytic study aimed to determine the prevalence of anaemia in pregnancy at booking and other related determinants. It was carried out at the antenatal booking clinic, Federal Medical Centre Yenagoa...

This study was conducted to assess the concentrations of some Heavy Metals (HM) and their translocation capacity in the various milieus of plantain cultivation-consumption chain using a rabbit as an animal model. Twelve male albino rabbits divided into control and treatment groups constituted the sample size. Both groups were fed with normal rabbit...

The development of male infertility is increasing rapidly worldwide with numerous causative agents and idiopathic causes. Infertility conundrum coincides with the epidemic of abnormal body weight which holds sway to countless pathological cond the relationship between low body mass index (BMI), sperm counts and seminal electrolyte concentrations in...

Methaemoglobin (Met-Hb) is a type of the oxygen-carrying metalloproteinhemoglobin. The heme group iron exists as ferric (Fe3+) iron, rather than the ferrous (Fe2+) iron of typical hemoglobin. Met-Hb is unable to perform the function of binding to oxygen like oxyhaemoglobin does. The aim of this study was to compare methaemoglobin levels between AA...

Bioaccumulation and Translocation of Some Heavy Metals in Cultivation-Consumption Chain of Plantain Grown in Crude Oil exposed Community in Bayelsa State, Nigeria

OTU based Microbial Diversity of Microbiota in the GUT of Diarrheic Patients in Rivers State, Nigeria.

Purpose: A study on the impact of carbon monoxide (CO) on eye and vision is still nascent especially in the area of vitreous chemistry. This study was therefore set out to evaluate the impact of CO on some serum and vitreous chemistry parameters. Method: A total of twenty rabbits were used for the study comprising equal age and weight-matched contr...

Abstract: Tramadol intoxication is rapidly on the increase in Nigeria with unestablished short-term and long-term effects. The study was aimed at elucidating the dose-dependent effect of acute or chronic tramadol intoxication on some immunological parameters using male rats (Rattus norvegicus). A total of fifty adult rats were used for the stud...

Aim: The aim of this study was to evaluate the effects of three commonly marketed herbal cosmetics in Port Harcourt on the renal parameters in rabbits. Methodology: A total of 48 rabbits were used for the study. They were divided into four groups with twelve rabbits in each group. Four rabbits from each group were treated for thirty, sixty and nine...

This is an interventional study

Aim: The aim of this study was to assess some biochemical parameters in the vitreous humor of Rabbits exposed to sodium cyanide. Study Design: This study is an interventional study. Place and Duration of Study: This study was carried out at Animal House, Applied and Environmental Biology Department, Rivers State University, Port Harcourt, Rivers St...

Objectives This study was conducted to estimate the heavy metal (HM) content of water sources from oil contaminated area, HM and hepato-renal functions of residents and to determine association between consumption of crude oil contaminated water and development of multiple organ toxicities. Methods Heavy metals (Pb, Cd, As, Hg) content of 20 surfa...

Background The World Health Organization (WHO) has estimated drowning as the leading cause of unintentional death in the world, with 372,000 deaths reported annually. Not all drowning are unintentional; some could be disguised to cover up an act of heinous criminality. This study was aimed at using some vitreous renal function biochemical parameter...

Methaemoglobin (Met-Hb) is a type of the oxygen-carrying metalloproteinhemoglobin. The heme group iron exists as ferric (Fe 3+) iron, rather than the ferrous (Fe 2+) iron of typical hemoglobin. Met-Hb is unable to perform the function of binding to oxygen like oxyhaemoglobin does. The aim of this study was to compare methaemoglobin levels between A...

Objective: To study the incidence, pattern and treatment of anaemia amongst gynaecological in-patients at the University of Benin Teaching Hospital. Methods: The data of all patients admitted into the gynaecology ward from 1 st January to 31 st December 2019 were prospectively obtained, employing a self-designed study proforma. The haemoglobin leve...

Objective: To study the incidence, pattern and treatment of anaemia amongst gynaecological in-patients at the University of Benin Teaching Hospital. Methods: The data of all patients admitted into the gynaecology ward from 1 st January to 31 st December 2019 were prospectively obtained, employing a self-designed study proforma. The haemoglobin leve...

The serum concentrations of C-reactive protein (CRP), zinc and copper in type 2 diabetic mellitus patients were assessed in this study. Serum obtained from blood samples of 50 non-diabetic and 50 diabetic patients was used in determining serum CRP, zinc and copper concentrations. Results showed that the mean concentration of CRP was significantly (...

The serum concentrations of C-reactive protein (CRP), zinc and copper in type 2 diabetic mellitus patients were assessed in this study. Serum obtained from blood samples of 50 non-diabetic and 50 diabetic patients was used in determining serum CRP, zinc and copper concentrations. Results showed that the mean concentration of CRP was significantly (...

Carbon monoxide (CO) is a toxic gas produced as a result of incomplete combustion of organic materials. The source of CO production is very common especially in nations that depend on power generating sets for electricity. Chronic disease is non-communicable and usually takes a longer time to manifest. Examples are kidney failure, diabetes mellitus...

Introduction Tramadol is a synthetic centrally acting analgesic used worldwide for pain relief but now abused as a euphoria generating substance. The short- and long-term implications of tramadol intoxication on blood cells and its components are still hazy and controversial. Aim Our primary aim was to evaluate the alterative pattern of haematologi...

Malaria has for century's defiled eradication due to pathophysiological and environmental complexities. The study was aimed at revealing the effect of malaria parasitaemia on hepatic synthetic fidelity and oxidative stress markers individually and synergistically. A total of five hundred subjects constituted the sample size, out of which two hundre...

Sniper, whose active ingredient is dichlorvos, is one of the leading causes of pesticide poisoning and death. Sniper induced death is suggested to be increasing in Nigeria without a scientific basis for discriminating ante-mortem from postmortem intoxication. The study is aimed at using vitreous biochemical parameters such as proteins, lipids, elec...

Carbon monoxide (CO) intoxication is the inhalation of CO concentration above the tolerant threshold of the body. The quantity of CO concentration inhaled determines the level of damage which is proportional to either morbidity or mortality. The euphoria and rapidity of the mechanism of action of CO ranked it as a deleterious gas that could cause r...

Alcohol intoxication is associated with a significant mortality rate including accidents, suicide and murder. The study investigated the concentration of sodium, potassium, chloride, glucose, creatinine and urea in vitreous humor of rabbits that died of alcohol intoxication. A total of twelve (12) rabbits divided into three (3) groups of four (4) c...

Background Drowning is the leading cause of unintentional death in the world, with about 372,000 drowning deaths reported annually. Forensic opinion of drowning is considered one of the most difficult tasks in confirming the exact cause of death. Drowning is now possibly patronized to cover up intentional crimes. This study was aimed at utilizing c...

Hypertensive disorders of pregnancy are an important cause of severe acute feto-maternal morbidity, lasting disability and mortality. In Africa, about one-tenth of all maternal deaths are associated with hypertensive disorders of pregnancy. The majority of deaths attributable to preeclampsia can be circumvented by instituting appropriate and effect...

Carbon monoxide (CO) is a toxic gas that escapes easy detection due to its euphoric nature. It utilizes hypoxia in causing mortality or morbidity. The study was aimed at evaluating the effect of chronic CO concentration (>200 ppm) in some liver biochemical parameters utilizing rabbit as a choice animal model. A total twenty (20) apparently health a...

Carbon monoxide (CO) is a colorless gas that can cause cellular damage in exposed hosts depending on the levels inhaled. There is an increase in idiopathic diseases without a known cause. In Nigeria, this has led to a call for profi ling of CO, a gas routinely inhaled by its population. This study was designed to assess the effect of chronic CO inh...

Cite this article: Agoro ES, Wankasi MM, Zebedee UL. The Effects of Chronic Carbon Monoxide Intoxication on Some Haematological Parameters and Films in Rabbits. Adv J Toxicol Curr Res. 2019;3(1): 001-005. Carbon Monoxide (CO) is a poisonous non-irritant gas produced by incomplete combustion of organic materials due to insuffi cient oxygen supply [1...

Carbon monoxide is a euphoric toxic gas with the propensity of causing death within a short time interval. In this study, eighteen (18) rabbits of same sex and age were divided into three groups thus: Carbon monoxide Death (CD) group was made up of animals exposed to high levels of Carbon monoxide (CO) till death, while Disguised Death (DD) group c...

Carbon monoxide (CO) is a colorless gas that can cause cellular damage in exposed hosts depending on the levels inhaled. There is an increase in idiopathic diseases without a known cause. In Nigeria, this has led to a call for profi ling of CO, a gas routinely inhaled by its population. This study was designed to assess the effect of chronic CO inh...

Carbon monoxide is a known notorious gas with a high preponderance of causing either morbidity or mortality depending on the concentration inhaled or administered. The study was aimed to determine whether chronic CO intoxication could stimulate lipid peroxidation. A total of twenty albino rabbits of same sex, age and weight constituted the sample s...

Carbon monoxide is a known notorious gas with a high preponderance of causing either morbidity or mortality depending on the concentration inhaled or administered. The study was aimed to determine whether chronic CO intoxication could stimulate lipid peroxidation. A total of twenty albino rabbits of same sex, age and weight constituted the sample s...

Carbon monoxide is a known notorious gas with a high preponderance of causing either morbidity or mortality depending on the concentration inhaled or administered. The study was aimed to determine whether chronic CO intoxication could stimulate lipid peroxidation. A total of twenty albino rabbits of same sex, age and weight constituted the sample s...

Venous blood sampling is usually performed using a tourniquet to help locate and define peripheral veins to achieve successful and safe venipuncture. Despite widespread usage of tourniquets for venipuncture by phlebotomists, very few are aware of the effects of tourniquet application on laboratory parameters. This study was set out to determine the...

Aging has been defined as "a progressive unfavourable loss of adaption, leading to increased vulnerability, decreased viability, and decreased life expectancy. Enablers of aging could be retarded as a result of proper medical intervention of the old aged. The aim of the research is to provide interventions that could also serve a retarder to aging...

Sperm count, or sperm concentration measures the concentration of sperm in a man's ejaculate, distinguished from total sperm count, which is the sperm count multiplied with volume. Over 15 million sperm per milliliter is considered normal, according to the WHO in 2010. Older definitions state 20 million. Sperm count is the focal factor of conceptio...

This study was designed to assess the chronic effect of CO inhalation on vitreous and serum protein and lipid panels. A total of twenty four (24) rabbits as indicated by mead’s formula constituted the sample size. The study was divided into four groups including the controls. With exception of the control rabbits, others were treated daily with not...

In this study, acute carbon monoxide (CO) was used to cause the death of experimental animals through inhalation. The sample size of the study was made up of 18 rabbits divided into the control group (CG), disguised death (DD) and carbon monoxide death (CD) groups respectively. Vitreous humours were extracted using standard methodologies and bioche...

Oral glucose tolerance test (OGTT) is a medical test utilized mostly to resolve border results involving glucose concentrations. This study is aimed at establishing an existence of relationship of OGTT glucose concentrations between glucose oxidase and glucometer methods. Blood samples were collected from hundred (100) pregnant women with risk fact...

Storage of samples at a given temperature for future Laboratory investigation is a routine due to several technical constraints. This study was designed to determine the effect, reliability and accuracy of studied biochemical parameters upon prolonged sample storage at a given temperature. A total of hundred apparently healthy subjects of equal sex...

This study was designed to assess the chronic effect of CO inhalation on vitreous and serum protein and lipid panels. A total of twenty four (24) rabbits as indicated by mead's formula constituted the sample size. The study was divided into four groups including the controls. With exception of the control rabbits, others were treated daily with not...

Carbon monoxide (CO) is a euphoric poisonous gas with the predisposition of causing death depending on its concentration. This study was designed to assess the effects of acute CO poisoning on oxidative stress indicators and other ancillary biochemical parameters. Eighteen (18) rabbits divided into three groups of six each constituted the sample si...

Vitreous humor is an inert, transparent, jelly like substance that fills the posterior four fifths of the cavity of eyeball which offers shape to the eye. Vitreous humour were collected from the eyes of 50 dead bodies (28 males and 22 females) at the Federal Medical Center Yenagoa morgue. The vitreous supernatant was analyzed for glucose, total pro...

Vitreous humor is an inert, transparent, jelly like substance that fills the posterior four fifths of the cavity of eyeball which offers shape to the eye. Vitreous humour were collected from the eyes of 50 dead bodies (28 males and 22 females) at the Federal Medical Center Yenagoa morgue. The vitreous supernatant was analyzed for glucose, total pro...

Background Study: Vitreous humor is an inert, transparent, jelly like substance that fills the posterior four fifths of the cavity of the eyeball. It is the choice sample in post-mortem investigation and analysis. Objective of study: To determine vitreous biochemical parameters suitable for postmortem interval (PMI) extrapolation. Material and Meth...

Introduction: Protein profile is an important investigation utilized for the diagnosis and management of arrays of diseases such as diabetes mellitus. Нe measurement of protein profile is basically carried out through invasive sample blood which inflicts pain and is financiall\ cumbersome. Нe study is aimed at generating an alternative noninvasive...

Vitreous humor is understood to be bacterial free and not prone to contamination even at advanced stage of putrefaction. The research was tailored to validate the bacterial status of the vitreous and the attendant effect of carbon monoxide on bacterial population in the vitreous. In this study, thirty six (36) rabbits of same sex and age were divid...

Diabetes mellitus is the most common metabolic disorder occasioned by derangement in glucose equilibration between the ECF and ICF. The derangement is known to affect the appropriate bal- ance of electrolytes that serves as a buffer in the body. In this study anion gap was evaluated among outpatient diabetics as compared to non-diabetics control gr...

Background Premarital screening is fast gaining ground as a prerequisite for the solemnization of holy matrimony by many faith-based organizations in Nigeria, yet there is no literature on the subject in Yenagoa, Bayelsa State. Methods One hundred and five (105) premarital heterosexual couples (105 males and105 females) were screened for the presen...

Background: ABO, Rhesus blood groups and Haemoglobin variants are known to vary from one population to another. This study therefore sought to study the frequency of these indices among residents of Yenagoa and Environ, Bayelsa State, Nigeria. Objectives: The study was designed for the purpose of updating information on the prevalence of abnormal h...

In this study we measured white blood cells count and haematoccrits of 300 subjects. The study was divided into two groups. Group A constituted the controls of 100 subjects with normal leukocyte counts. The group B constituted the study group with a sample size of 200 subjects. The study group showed an elevated white blood cells count (leukocytosi...

The effect of soccer on routine urinalysis and some biochemical indices measured in laboratories has been studied, in order to review the changes that may result from such contact exercise. A total of 40 amateur soccer players were used for this study in which urine and arterial blood samples were collected before and after soccer. The mean pH of u...