Emmanuel Simon

University of Calicut · Department of Life Sciences

Curcumin is a polyphenol derived from the herb Curcuma longa, which has been extensively studied in terms of its antitumour, antioxidant, and chemopreventive activity as well as various other effects. In the present work we compared curcumin with its synthetic analogue dimethoxycurcumin (dimc) in terms of its antioxidant enzyme-modulating effects i...

Dimethoxycurcumin (Dimc), a synthetic analogue of curcumin, that has been reported to exhibit better in vivo stability and anti-tumour activity, was investigated for its interaction with DNA, employing spectroscopic methods based on absorption, fluorescence, circular dichroism (CD), ethidium bromide (EtBr) competitive binding assay, 4'-6-diamidino-...

Dimethoxycurcumin(DIMC) a synthetic analogue of curcumin is reported to exhibit higher anticancer activity and metabolic stability over curcumin and has the potential to be developed into an anticancer drug. In the present work we have studied the interaction of DiMC with calf thymus dna (ct-DNA) employing UV absorption and flurescence spectroscopy...

Interaction of curcumin analogue bis-dimethoxycurcumin with DNA Emmanuel Simon1, U. Singh1, A. Kunwar1, S. Santosh Kumar, K. I. Priyadarsini1 1Radiation & Photochemistry Division, 2Radiation Biology & Health Sciences Division, Bhabha Atomic Research Center, Mumbai-400085, India Bis-dimethoxycurcumin (BDMC) a synthetic analogue of curcumin is repo...