Emmanuel Orman- Doctor of Philosophy
- Lecturer at University of Health and Allied Sciences
Emmanuel Orman
- Doctor of Philosophy
- Lecturer at University of Health and Allied Sciences
Quality & Safety Analytics of Medicines and Healthcare Products
About
54
Publications
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Introduction
I am an analytical chemist & researcher specializing in Quality & Safety Analytics of Medicines and Healthcare Products. My work focuses on phytochemistry, pharmaceutical quality, developing innovative analytical methodologies, & addressing critical challenges in medicine safety, counterfeit, impurities & adulteration detection, & regulatory compliance.
Currently, I am involved in projects that aim to enhance public health through improved healthcare product quality and innovative diagnostics.
Current institution
Additional affiliations
January 2017 - October 2018
Education
September 2019 - June 2023
September 2012 - November 2014
Publications
Publications (54)
Soil-transmitted helminthiases continue to present a huge economic burden on animal and human health resulting in significant morbidity and mortality. Plant polyphenols have recently been recognised as sustainable means for helminth control. This study, therefore, sought to investigate the anthelmintic effects of tannin-containing extracts against...
Some tannin-rich plants such as Combretum mucronatum and Phyllanthus urinaria are widely used in Africa for the control of parasitic nematodes in both humans and livestock. Tannins have been recognized as an alternative source of anthelmintic therapies, and hence, recent studies have focused on both the hydrolyzable and condensed tannins. These gro...
Background
Soil-transmitted helminths (STH) infect more than a quarter of the world’s human population. In the absence of vaccines for most animal and human gastrointestinal nematodes (GIN), treatment of infections primarily relies on anthelmintic drugs, while resistance is a growing threat. Therefore, there is a need to find alternatives to curren...
Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it is distributed in the tropics. This plant is widely grown in West Africa for its ornamental and medicinal purposes. There are two varieties of P. longifolia which are commonly distinguishable by the direction of their branches. One has spreading perpend...
Introduction
Malaria is a parasitic disease that is endemic in tropical areas and can be life-threatening. There has been a decrease in the prevalence of malaria in Ghana but the burden of the disease is still high in the country. Many Ghanaians depend on herbal products for malaria treatment. This study aimed to survey and evaluate commercial herb...
Moringa oleifera is one plant that is multi-purposefully used for the prevention and treatment of numerous diseases. This study analyzed the phytochemical and elemental contents of M. oleifera leaf extract, and evaluated its effect on fibroblast proliferation, which is crucial for wound healing. M. oleifera leaf samples were collected, identified,...
Diabetes is a disease characterized by high post-prandial glucose levels, which lead to other complications such as peripheral end organ damage. The use of enzyme inhibitors in the management of Type-2 diabetes ensure the control of blood glucose levels via the control of carbohydrate metabolism. The use of standard agents such as acarbose is assoc...
The aerial parts of Phyllanthus urinaria are used in traditional medicine in West Africa against helminthiasis, but their anthelmintic potential has not been evaluated until now. Within the current study, a hydroacetonic extract (AWE) and fractions and isolated ellagitannins from P. urinaria were, therefore, tested in vitro against Caenorhabditis e...
Background
Antimicrobial resistance threatens adequate healthcare provision against infectious diseases. Antibiograms, combined with patient clinical history, enable clinicians and pharmacists to select the best empirical treatments prior to culture results.
Objectives
To develop a local antibiogram for the Ho Teaching Hospital.
Methods
This was...
Soil-transmitted helminthiasis affects more than 1.5 billion people globally and largely remains a sanitary problem in Africa. These infections place a huge economic burden on poor countries and affect livestock production, causing substantial economic losses and poor animal health. The emergence of anthelmintic resistance, especially in livestock,...
Herbal medicines are invaluable in African medicine, but quality and safety are not documented in many cases. Besides controlled farming, validated quality control methods are needed to ensure identity, purity, and content. Analytical specifications within modern monographs are needed for consistent batch quality. Combretum mucronatum leaves are wi...
![Representative UPLC fingerprint profile for ESB extract
[A]–Stack...](publication/365822069/figure/fig2/AS:11431281276472404@1725650741371/Representative-UPLC-fingerprint-profile-for-ESB-extract-A-Stack-illustration-of_Q320.jpg)
The antifungal activity of the 70% ethanol stem bark extract of Erythrina senegalensis (ESB) against different strains and drug resistant clinical isolates of Candida albicans and Candida glabrata were evaluated in the study. The effect of ESB on biofilms as well as its activity in combination with fluconazole, nystatin or caspofungin against the C...
In this study, we consider pyridine-N-oxide alkaloids from Allium stipitatum and their synthetic disulfide analogs (PDAs) as candidates for next-generational antimycobacterial agents, in light of growing resistance to existing conventional therapies. In silico studies involving molecular docking simulations of 12 PDAs were carried out against 7 Myc...
A library of six compounds with new hybrids in a single molecule triazole ring attached to the phosphonium salts was synthesized. Click chemistry was, however, used to synthesize the 1-, 2-, and 3-triazole intermediates as a tether for the hybrid phosphonium salts. Their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus a...
4-(2-(2,4-Dinitrophenyl) hydrazone) methyl)-2 methoxy phenol (IND-X) and 4-(2-(2, 4-dinitrophenylhydrazono) methyl) benzene-1,3-diol (IND-Y) were synthesised by condensation reactions with 2,4-dinitrinophenylhydrazine and were observed to possess acid-base indicator properties. e study was conducted to explore and verify their use in di erent analy...
![Fig. 4. Stability of 5-HMF Solutions [A] -Investigatiing the stability...](profile/Cedric-Amengor-2/publication/362948365/figure/fig4/AS:11431281098344788@1668863927669/Stability-of-5-HMF-Solutions-A-Investigatiing-the-stability-of-the-stock-solution_Q320.jpg)
Processing of food products makes them palatable, edible, provides options to consumers and prolong their life spans. Irrespective of these benefits, some of these processes have also shown to increase the build-up of potential toxic metabolites, for example, 5-hydroxymethylfurfural (5-HMF). 5-HMF production results from caramelization and/or Maill...
Background
In Africa, herbalism supplements allopathic medicine's efforts to ensure Universal Health Coverage attainment. This review was conducted to identify and to summarise current literature on methodological approaches used for quality control of herbal medicines in Africa, to evaluate the gaps associated with existing strategies within conte...
Introduction: Antimicrobial resistance has increasingly been a global health concern over the past decades and that has necessitated the quest to increase the pool of antibiotics. Methods: Five (5) azo compounds were synthesised by diazotization and coupling procedures with yields of 60-92%. They were characterized by melting point determination, U...
Introduction: Antimicrobial resistance has increasingly been a global health concern over the past decades and that has necessitated the quest to increase the pool of antibiotics.
Methods: Five (5) azo compounds were synthesised by diazotization and coupling procedures with yields of 60 – 92%. They were characterized by melting point determination...
The study evaluated the antifungal activities of the 70% ethanol extracts of Sclerocarya birrea leaves (SBL) and stem bark (SBB) against C. albicans strains and fluconazole-resistant isolates, their antifungal effects in combination with conventional antifungals as well as their effects on the biofilms of the C. albicans strains and isolates. UPLC-...
Quinine- and cryptolepine-based antimalarials serve as valuable alternatives to artemisinin-based combination therapies (ACTs) in Ghana. Their use, however, is associated with adulteration and substandard quality challenges. An HPLC method targeting quinoline and indoloquinoline antimalarial alkaloids was developed, validated, and applied to evalua...
Background
Zingiber officinale Roscoe (ginger) rhizome is a global spice with marked pharmacological activities and industrial application. The demand for the powdered spice soared in the wake of the COVID-19 global pandemic. The present study sought to assess powdered ginger products on the Ghanaian market for some quality parameters and compare t...
Common cold medicines usually present as multi-component products and constitute one of the largest groups of ‘over-the-counter’ medicines marketed in Ghana. Due to their wide patronage and easy accessibility, their quality control is of utmost importance to medicine consumers. In this study, the Design of Experiment (DOE) concept is adopted to dev...
Antimicrobial resistance threatens infectious disease management outcomes, especially in developing countries. In this study, the occurrence of resistant coagulase-negative staphylococci (rCoNS) and antibiotic residues in urine samples of 401 healthy individuals from Korle-Gonno (KG) and Dodowa (DDW) in Ghana was investigated. MALDI-ToF/MS with gra...
![The Behaviour Change Wheel and COM-B model, adapted from ref. [13].](publication/357261363/figure/fig1/AS:11431281329006231@1743151500304/The-Behaviour-Change-Wheel-and-COM-B-model-adapted-from-ref-13_Q320.jpg)
Antimicrobial resistance (AMR) is a significant problem in global health today, particularly in low- and middle-income countries (LMICs) where antimicrobial stewardship programmes are yet to be successfully implemented. We established a partnership between AMR pharmacists from a UK NHS hospital and in Ho Teaching Hospital with the aim of enhancing...
: Antimicrobial resistance (AMR) is a significant problem in global health today, particularly in Low- and Middle-Income Countries (LMICs) where antimicrobial stewardship programmes are yet to be successfully implemented. We established a partnership between AMR pharmacists leads from a UK NHS hospital and in Ho Teaching Hospital with the aim to by...
The recommended doses of antacids by some manufacturers are in ranges. However, dosing decisions on antacids should be based on acid-neutralizing capacities (ANCs). This study evaluated the ANCs of different doses of antacids. Twenty-two antacids (3 granular, 5 tablet and 14 suspension formulations) were evaluated for their ANCs at half, minimum, a...
![Fig. 1. Some physicochemical parameters of the antacids. [A]...](profile/Emmanuel-Orman/publication/354366378/figure/fig1/AS:1068387966918661@1631734949171/Some-physicochemical-parameters-of-the-antacids-A-Viscosities-and-flow-times-B_Q320.jpg)
Antacids are over-the-counter medications that neutralize stomach acid and inhibit pepsin activity. They are used to relieve symptoms associated with some upper gastrointestinal disorders. Several antacids are available in Ghana; therefore, comparative data on dose volume, efficacy, and cost are needed. This study investigated the properties of ant...
The aim of the study is to investigate the anti-inflammatory property of the different parts of Adansonia digitata (Malvaceae) extracts. A. digitata is an important medicinal plant to West Africa including Ghana. The plant is used effectively in folk medicine to treat inflammatory diseases such as joint disorders, asthma, toothache and painful swel...
There has always been a strong human dependency on plants for health purposes and such an important relationship should be sustained. Plants remain a repository of drug leads for discovering new pharmaceutical agents for prevention, treatment and improving the quality of health for many people globally. In the effort to improve healthcare services,...
A standardised Global Point Prevalence Survey (PPS) tool was used to determine the an-timicrobial prescription pattern in the Ho Teaching Hospital on two separate occasions in a total of 14 wards in the hospital, including dedicated wards for paediatrics and neonates. Manually collected and anonymised data were entered, validated, analysed and repo...
In the Abstract of the initial online publication an incorrect analyte was specified as not having been detected and quantified. The original article has been corrected.
The study was conducted to evaluate the antibacterial, antioxidant, and wound healing properties of the stem bark of Khaya grandifoliola (Welw) CDC (Meliaceae). A preliminary phytochemical screening conducted showed the presence of tannins, alkaloids, saponins, reducing sugars, flavonoids, terpenoids, and phenols in the stem bark (KG) as well as it...
The role of unregulated and inappropriate dispensing, and use of antibiotics remains significant in the development of antimicrobial resistance in infectious disease endemic regions of developing countries. The exposure to antibiotics from unfamiliar and unsuspecting sources such as drinking water and food, and adulterated herbal medicines remains...
An accurate and rapid reverse HPLC method has been developed and validated for the simultaneous quantification of lamivudine, nevirapine, and tenofovir disoproxil fumarate. Suitable separation was achieved on Phenomenex Synergi C18 (250 × 4.6 mm, 4 μm) using mobile phase, methanol (50%): ammonium acetate buffer (adjusted to pH 2.80) (40%): acetonit...
Objective
To assess the quality of antibiotics sampled from authorised sales outlets (ATs) (i.e. hospitals/health centres, pharmacies and licensed chemical shops) and unauthorised sales outlets (UATs) (mainly street vendors) in Ghana and to explore the health‐seeking behaviour of medicine consumers.
Methods
The contents of 14 active pharmaceutical...
This study was conducted to comparatively assess the anthelminthic activity of leaves, stem bark, and seeds of Carica papaya, in order to identify which of the plant parts possess the highest anthelminthic activity. Three concentrations of ethanolic and hydroethanolic extracts of the plant parts (1 mg/ml, 2.5 mg/ml, and 5 mg/ml) were prepared and t...
Cholesterol plays a key role in the synthesis of bile acids and steroid hormones in the human body. However, excessively high levels are usually implicated in cardiovascular diseases. For this reason, it is essential to monitor exposure to high levels of it in products meant for human consumption, and this calls for the need to develop analytical m...
A simple, rapid, accurate, and less expensive spectrophotometric method has been developed for the quantitation of 5-hydroxymethyl furfural (5-HMF) levels in canned malt drinks and fruit juice drinks sampled in the Kumasi Metropolis, Ghana. e quantitation is based on the selective maximum absorption of ultraviolet radiation by 5-HMF at the waveleng...
![Figure 5: Determination of the accuracy of the method [A] – [C] –...](profile/Abraham-Mensah-3/publication/303339561/figure/fig1/AS:363398807212034@1463652436553/Determination-of-the-accuracy-of-the-method-A-C-Comparing-the-percentage_Q320.jpg)
The main objective of the study was to develop and validate a novel radical scavenging antioxidant assay using KMnO4. In this method tannic acid at concentration 6.25 μg/ml – 200 μg/ml was used as the standard antioxidant. KMnO4 solution (80.00 μg/L) in phosphate buffer (pH= 9) was developed as the prooxidant. Absorbances of KMnO4 both in the prese...
Aim: To evaluate the indicator properties of a synthesized azo compound to be used as a suitable substitute for standard indicators
Methodology: Compound, [4-((4-hydroxynaphthalen-1yl)diazenyl) benzoic acid] (p-ABAαN) was synthesized using standard diazotization and coupling procedures. Initial evidence indicated that [4-((4-hydroxynaphthalen-1-yl)...
Aim: The objective of this study was to develop a reliable, accurate and precise Titrimetric - UV spectrophotometric method for the assay of fixed dose combination formulations involving Paracetamol, Caffeine and Ibuprofen.
Study Design: Experimental.
Place and Duration of Study: Quality Control Department of SALOM Pharmacy Limited between June, 20...
Aim: The study investigated Moringa oleifera Lam (Moringaceae), for its in-vivo antiplasmodial properties, using a murine model involving Plasmodium berghei.
Study Design: Experimental.
Places of Study and Duration: Department of Pharmaceutical Chemistry, KNUST, Department of Immunology, NMIMR and Department of Animal Experimentation, NMIMR, May –...
Questions
Questions (4)
I am conducting a study to assess the quality of selected parts of some herbal materials and also develop acceptance criteria for their quality attributes. I am supposed to sample these materials from across the length and breadth of the country and I am hoping to stratify the country into strata and further divide each stratum into clusters, and then randomly sample the materials from each of the clusters picked up through systematic sampling.
My challenge is with the calculation of a 'realistic' sample size that can then be used to determine the number of clusters and the number of samples from each cluster. Very often what I see in literature tends to be convenient sampling, which may not be representative of the population. The focus of my study however requires that my sampling is representative of the population in the country (and also realistic), especially because of the part that has to do with setting acceptance criteria.
I would be very grateful for your technical assistance. Thank you.
If i used different general purpose media, Tryptone Soy Agar, Nutrient Agar and Plate Count Agar to culture microbial contaminants in a product, how significant will the enumerations be from each other?
Having reviewed literature on the use of chemometric approaches in quality assessments of medicines (including herbal medicines), I realised that several approaches are adopted. For example, in preprocessing of the data for further analysis, literature reports of methods like normalisation, peak centering, warping, smoothing among others.
Having in mind that the way you preprocess the data may affect the final outcome of the multivariate analysis, I want to find out if there exist any protocol guiding the adoption of any of these tools. For instance, when analysing chromatographic data from HPLC, you may have to correct baseline, then warp and normalise or something. Also, when dealing with FTIR data, you may have to first correct baseline, normalise and smooth (how do you determine the smoothing points?) among others. Are there specific preprocessing tools for specific datasets (that is from different instruments like FTIR, HPLC, LC-MS, etc) and are there specific procedures for the use of such, so that irrespective of who is conducting such analysis, the outcome may always be reproducible?
Thank you.
Having reviewed literature on the use of chemometric approaches in quality assessments of medicines (including herbal medicines), I realised that several approaches are adopted. For example, in preprocessing of the data for further analysis, literature reports of methods like normalisation, peak centering, warping, smoothing among others.
Having in mind that the way you preprocess the data may affect the final outcome of the multivariate analysis, I want to find out if there exist any protocol guiding the adoption of any of these tools. For instance, when analysing chromatographic data from HPLC, you may have to correct baseline, then warp and normalise or something. Also, when dealing with FTIR data, you may have to first correct baseline, normalise and smooth (how do you determine the smoothing points?) among others. Are there specific preprocessing tools for specific datasets (that is from different instruments like FTIR, HPLC, LC-MS, etc) and are there specific procedures for the use of such, so that irrespective of who is conducting such analysis, the outcome may always be reproducible?
Thank you.
