Emmanuel Laffitte

Hôpitaux Universitaires de Genève | HUG · Service de dermatologie et vénéréologie

Background Cutaneous reactions, mostly on injection site after mRNA-based COVID-19 vaccines have been reported but not with detailed histopathological characterization. Objectives Characterization and classification of these reactions in a clinical and pathological point of view. Methods Monocentric case series of 11 patients with cutaneous manif...

Introduction Le syndrome des ongles jaunes ou « yellow nail syndrome » (YNS) est une entité rare qui correspond à l’association de dystrophies unguéales (ongles épaissis, jaunes, de croissance ralentie), d’une atteinte des voies respiratoires hautes et basses (sinusites, bronchopneumopathies, pleurésies, bronchectasies) et d’un lymphœdème. Nous rap...

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Importance: Treatment of pityriasis rubra pilaris (PRP) is solely based on its resemblance to psoriasis rather than any knowledge of its pathomechanism. Insight into pathogenic mediators of inflammation is essential for targeted and valid treatment options that could replace previous serendipitous therapeutic approaches in refractory PRP. Objecti...

Background: Randomized controlled trials have shown the efficacy of systemic treatments in moderate-to-severe psoriasis. Clinical outcomes in psoriasis patients under real-world conditions are less well understood. Objective: This study compared Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI) improvement in...

Background: The Swiss psoriasis registry SDNTT (Swiss Dermatology Network for Targeted Therapies) records the long-term safety and effectiveness of systemic treatment regimens for psoriasis. Patients and methods: Patients with moderate to severe psoriasis are included in the SDNTT when treatment with a conventional systemic agent or biologic is...

Introduction Les IgE jouent probablement un rôle important dans la physiopathologie de la pemphigoïde bulleuse (PB). Nous rapportons le cas d’une patiente souffrant d’une PB chez qui l’implication d’auto-anticorps IgE était fortement suspectée, et traitée par omalizumab, un anticorps monoclonal humanisé dirigé contre les IgE au niveau de la partie...

Introduction Le syndrome de Grzyboswki (SG) est une entité rare associant éruption généralisée de papules étiquetées kératoacanthomes et atteinte du visage avec un ectropion sévère. Nous rapportons un cas de SG, dont l’analyse nous a fait plutôt considérer la lésion élémentaire comme une prolifération folliculaire bénigne plutôt qu’un réel kératoac...

Patients undergoing immunosuppressive therapy are at increased risk of infection. Community-acquired pneumonia and invasive pneumococcal disease account for substantial morbidity and mortality in this population and may be prevented by vaccination. Ideally, immunization to pneumococcal antigens should take place before the start of immunosuppressiv...

Interleukin (IL)-17A, a proinflammatory cytokine, is increased in biological fluids and skin of systemic sclerosis (SSc) individuals. Our aim was to investigate whether IL-17 family members other than IL-17A were expressed in the skin of SSc and Morphea patients compared to healthy donors (HD). Skin biopsies were obtained from the involved skin of...

Solid organ transplant recipients (SOTRs) have an increased risk of skin cancer due to their long-term immunosuppressed state. These patients should benefit from pre- and post-transplant screening and management of skin cancer by a dermatologist. The frequency of the dermatological consultations mainly depends on the previous history of skin cancer...

Thalidomide has several mechanisms of action: several immuno-modulatory properties, an anti-angiogenic action and a hypnosedative effect. Thalidomide has been used in several cutaneous inflammatory disorders (such as erythema nodosum leprosum in lepromatous leprosy, cutaneous lupus erythematosus, severe aphtosis), cancers (relapsed/refractory multi...