Emmanuel Kofi Kumatia

Centre for Plant Medicine Research,Ghana · Phytochemistry

Background: Tieghemella heckelii stem bark is used in African traditional medicine to treat inflammatory pain conditions. However, these biological actions of the plant have not been proven. This study investigates the phytochemical composition and the mechanisms of analgesic and anti-inflammatory actions of the hydroethanolic stem bark extract of...

Mist Nibima is an essential herbal medicine used to treat malaria, bacterial, yeast, and COVID-19 infections. However, the drug has not been standardized and its active chemical ingredients are also not known. This study employed physicochemical, organoleptic, qualitative, and quantitate phytochemical analysis to established standards for Mist Nibi...

Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) are complex inflammatory disorders of the digestive tract. Dysfunctional intestinal epithelial barrier, uncontrolled neutrophil recruitment into the colon, and oxidative stress are major features of IBD. IBD cannot be cured, but symptoms can be alleviated w...

Abstract Ethnopharmacological relevance Pain and inflammation are the major symptoms of almost every human disease. Herbal preparations from Morinda lucida are used to treat pain and inflammation in traditional medicine. However, the analgesic and anti-inflammatory activities of some of its chemical constituents are not known. Aim of the study Th...

The root bark of Capparis erythrocarpos (CERB) is employed to treat rheumatoid arthritis (RA) in Africa, particularly in Ghana. However, there was no isolation and characterization of the bioactive constituents responsible for the pharmacological actions of this plant. The aim of this study is to isolate, characterize and evaluate the anti-arthriti...

Background The erythrocytic stage of the life cycle of the malaria parasite, Plasmodium falciparum , consists of trophozoite, schizont and gametocyte stages in humans. Various anti-malarial agents target different stages of the parasite to produce treatment outcomes. This study reports on the stage-specific anti-malarial activity of heptaphylline a...

Background: The erythrocytic stage life cycle of the malaria parasite, Plasmodium falciparum, consists of trophozoite, schizont and gametocyte stages in humans. Various antimalarial agents target different stages of the parasite to produce treatment outcomes. This study reports on the stage specific antimalarial activity of heptaphylline and impera...

Rheumatoid arthritis (RA) is an incurable debilitating disease which attack the joints and impair quality of life. Antrocaryon micraster is used to treat RA in African traditional medicine. However, its anti-arthritic activity has not been pharmacologically studied. This study therefore, reports the anti-arthritic and anti-oxidant activities of A....

Ethnopharmacological relevance Pain and inflammation are the major symptoms of almost every human disease. Herbal preparations from Morinda lucida are used to treat pain and inflammation in traditional medicine. However, the analgesic and anti-inflammatory activities of some of the plant's chemical constituents are not known. Aim of the study The...

Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (female Anopheles mosquito and tsetse fly) abound. Various medicinal plants are used to treat these parasitic diseases. However, the scientific basis of their use and toxicologic...

Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (Female Anopheles mosquito and tsetse fly) abound. Various medicinal plants are used to treat these parasitic diseases. However, the scientific basis of their use and toxicologic...

Mist Nibima is an essential herbal medicine used to treat malaria, bacterial, yeast and Covid-19 infections. However, the drug has not been standardized and its active chemical ingredients are also not known. This study employed physicochemical, organoleptic, qualitative and quantitate phytochemical analysis to established standards for Mist Nibima...

Introduction: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract with an increasing incidence worldwide. IBD consists of Crohn’s disease (CD) and ulcerative colitis (UC) and is characterized by intestinal epithelial barrier dysfunction, excessive neutrophil recruitment, and oxidative stress. Current tr...

Anthonotha macrophylla leaf (AML) is employed in the management of pain, inflammation, and some diseases associated with oxidative stress in African traditional medicine. This study investigated the anti-inflammatory and analgesic activities, the acute toxicity and anti-oxidant properties of AML, characterised the phytochemical constituents, and qu...

In Ghana, the encapsulated blend of the powdered stem and root bark of Cassia sieberiana is prescribed and dispensed to patients at the Centre for Plant Medicine Research (CPMR), for the management of dysmenorrhea and gastric ulcer pain. This current formulation has significant challenges in manufacturing and optimization of therapeutic outcomes du...

Ethnopharmacological relevance: Malaria is caused by infection with some species of Plasmodium parasite which leads to adverse alterations in physical and hematological features of infected persons and ultimately results in death. Antrocaryon micraster is used to treat malaria in Ghanaian traditional medicine. However, there is no scientific valid...

Ethnopharmacological relevance Malaria is a global public health burden due to large number of annual infections and casualties caused by its hematological complications. The bark of Annickia polycarpa is an effective anti-malaria agent in African traditional medicine. However, there is no standardization parameters for A. polycarpa. The anti-malar...

Background: Malaria is an infectious disease that is spread through the bite of female anopheles mosquito resulting in the death of hundreds of thousands of people per year. Medicinal plants provide crude extracts and purified compounds for malaria treatment. Annickia polycarpa is one of such plants whose bark is used for this purpose. However, the...

Mist Antiaris is a herbal decoction for treatment of nervous disorders. Safety and efficacy were evaluated in Sprague-Dawley rats and human patients, respectively. Acute toxicity was assessed by administration of a single 5000 mg/kg oral dose of decoction to a group of six rats. For subchronic toxicity, four groups of six rats each received water (...

Clausena anisata is a medicinal plant use to treat diseases including inflammatory, pain and oxidative stress conditions. Nonetheless, these activities have not been evaluated for its stem. This study aimed to evaluate and compared analgesic, anti-inflammatory and anti-oxidant activities of ethanol extracts of leaf (CLE) and stem (CSE) of C. anisat...

The in vivo antiinflammatory and analgesic activities of the crude ethanol extract and chemical constituents of Clausena anisata roots were investigated. The crude extract, which was devoid of any visible acute toxicity, displayed significant antiinflammatory effect at the dose of 1000 mg/kg (p.o.) when assessed using the carrageenan-induced oedema...

Annickia polycarpastem bark is used in West Africa to treat ailments related to pain and inflammation in traditional medicine. Yet, these biological activities of the plant have not been investigated. To investigate the anti-inflammatory and analgesic activities of A. polycarpa stem bark (ASE) and its constituents. The compounds were isolated using...