Emmanuel Dugrenot

• PhD
• Senior Researcher at DAN - Divers Alert Network

Decompression sickness can occur in divers even when recommended decompression procedures are followed. Furthermore, the physiological state of individuals can significantly affect bubbling variability. These informations highlight the need for personalized input to improve decompression in SCUBA diving. The main objective of this study is to propo...

Susceptibility to decompression sickness (DCS) is characterized by a wide inter-individual variability, the origins of which are still poorly understood. We selectively bred rats with at least a 3-fold greater resistance to DCS than standard rats after 6 generations. In order to better understand DCS mechanisms, we compared the static genome expres...

Background: Scuba diving is an increasingly popular activity that involves the use of specialized equipment and compressed air to breathe underwater. Scuba divers are subject to the physiological consequences of being immersed in a high-pressure environment, including, but not limited to, increased work of breathing and kinetic energy expenditure,...

Introduction / Background: Susceptibility to decompression sickness is characterized by a wide interindividual variability which origin is still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with at least a 3-fold greater resistance to DCS than standard ones after 6 gener...

Introduction: The use of closed-circuit rebreather (CCR) and helium-mixed-gases allows deeper and longer dives. Many factors as the breathing gas properties and or equipment itself challenge the cardiopulmonary system and inflammatory responses that could trigger diving related injuries. The aim of this study was to evaluate the influence of helium...

Introduction / Background: Susceptibility to decompression sickness is characterized by a wide interindividual variability which origin is still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with at least a 3-fold greater resistance to DCS than standard ones after 6 gener...

Decompression sickness (DCS) with neurological disorders includes an inappropriate inflammatory response which degenerates slowly, even after the disappearance of the bubbles. There is high inter-individual variability in terms of the occurrence of DCS that could have been mastered by the selection and then the breeding of DCS-resistant rats. We hy...

Introduction / Background: Susceptibility to decompression sickness is characterized by a wide interindividual variability which origin is still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with at least a 3-fold greater resistance to DCS than standard ones after 6 gener...

Introduction / Background: Susceptibility to decompression sickness is characterized by a wide interindividual variability which origin is still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with at least a 3-fold greater resistance to DCS than standard ones after 6 gener...

Background: Scientific underwater exploration could benefit from professional diving facilities. This could allow marine research for durations far exceeding anything currently possible. The closed-circuit rebreather expansion provides new perspectives by unleashing divers and their diving bell. "Under the Pole Expeditions" developed an innovative...

Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some diving risks. “Deep” divers (n = 8) dove once to mean (±SD) 102.5 ± 1.2 m of sea water (msw) for 167.3 ± 11.5 min. “Shallow” divers (n = 6) dove 3 times on day 1, and then repeti...

Background and Objectives: The use of closed-circuit rebreathers (CCRs) in recreational diving is gaining interest. However, data regarding its physiological effects are still scarce. Immersion, cold water, hyperoxia, exercise or the equipment itself could challenge the cardiopulmonary system. The purpose of this study was to examine the impact of...

Diving into epigenetic regulations of gene expression in decompression sickness resistant rats: a study of circulating micrornas (miRs). E Dugrenot, A Guernec, J. Orsat, F Guerrero. Bull. MEDSUBHYP 2022, 22 (2) : 37-50. Introduction / Background: We conducted a selective breeding process of Wistar rats, which after 6 generations led to animals disp...

Diving into Decompression Sickness resistant rats gene expression through a miRnome / transcriptome crossed approach.

Introduction: Susceptibility to decompression sickness (DCS) is characterised by a wide inter-individual variability whose origins are still poorly understood. This hampers reliable prediction of DCS by decompression algorithms. We previously selectively bred rats with a 3-fold greater resistance to DCS than standard rats. Based on its previously r...

Capsule Project : a physiological survey during 3 days shallow saturation dives in a very limited space.

Capsule Project : a physiological survey during 3 days shallow saturation dives in a very limited space.

Diving into Decompression Sickness resistant rats gene expression through a miRnome / transcriptome crossed approach

PurposeDeep diving using mixed gas with closed-circuit rebreathers (CCRs) is increasingly common. However, data regarding the effects of these dives are still scarce. This preliminary field study aimed at evaluating the acute effects of deep (90–120 msw) mixed-gas CCR bounce dives on lung function in relation with other physiological parameters.Met...

On one side, decompression sickness (DCS) with neurological disorders lead to a reshuffle of the fecal metabolome from rat caecum. On the other side, there is high inter-individual variability in terms of occurrence of DCS. One could wonder whether the fecal metabolome could be linked to the DCS-susceptibility. We decided to study male and female r...

Decompression sickness (DCS) is a complex and poorly understood systemic disease with wide inter-individual resistance variability. We selectively bred rats with a 3-fold greater resistance to DCS than standard ones. To investigate possible physiological mechanisms underlying the resistance to DCS, including sex-related differences in these mechani...

In this article, we propose and study a new form of admissible pressure in the Haldanian framework. We then use it to study the surjectivity of the Gradient Factors on the space of the reachable decompression profiles, and investigate a particular case. This case leads to the proposition of a decompression strategy, whose crucial parameter is the a...

Introduction: Few studies are available to appreciate the broad spectrum of dive-related injuries (DI), which are not limited to decompression illness (DCI) and fatalities. Studies supporting injury-management efficacy from early recognition to first-aid, final treatment and outcome are also lacking. This study aims at making an epidemiologic inve...

Introduction: Few studies are available to appreciate the broad spectrum of dive-related injuries (DI), which are not limited to decompression illness (DCI) and fatalities. Studies supporting injury-management efficacy from early recognition to first-aid, final treatment and outcome are also lacking. This study aims at making an epidemiologic inven...

Introduction: Commercial divers, high altitude pilots, and astronauts are exposed to some inherent risk of decompression sickness (DCS), though the mechanisms that trigger are still unclear. It has been previously showed that diving may induce increased levels of serum angiotensin converting enzyme. The renin angiotensin aldosterone system (RAAS) i...

Introduction: Decompression sickness (DCS) is a complex and poorly understood systemic disease caused by inadequate desaturation following a decrease of ambient pressure. Strong variability between individuals is observed for DCS occurrence. This raises questions concerning factors that may be involved in the inter-individual variability of DCS oc...