Emmanuel Bassene

• Professor
• Chef de Service at Cheikh Anta Diop University

Cocos nucifera L. (Arecaceae) est une plante de la pharmacopée traditionnelle sénégalaise, dont les fibres sont utilisées au Sénégal dans le traitement du diabète. Afin de prouver et de valoriser l'activité antidiabétique des fibres de la noix de Cocos nucifera, des extraits obtenus à partir de cette drogue ont été testés sur des rats de souche wis...

Antioxidants used to protect unstable unsaturated fatty acids from oxidation are toxic or lose their potential in fats. The aim of this work was to investigate the protective effect of Ocimum essential oils against auto-oxidation of flaxseed oil. Essential oils were extracted from leaves of cultivated Ocimum basilicum, Ocimum canum, Ocimum gratissi...

Borassus aethiopum est une plante de la famille des Arécacées. C’est un géant palmier qui présente un tronc dur appelé stipe, des racines fasciculées et des feuilles longues en forme d’éventail. Elle est presque cosmopolite et ses différentes parties sont utilisées dans nombreux domaines : économiques, écologiques, alimentaires et sanitaire. En eff...

La présente étude a pour but d’évaluer l’activité anti-inflammatoire de Morinda geminata DC, plante de la famille des Rubiaceae largement répandue dans la sous-région d’Afrique de l’Ouest. Des rats de souche wistar ont été répartis en 2 lots de 5 puis gavés aux extraits aqueux de racines de Morinda geminata DC aux doses de 100 mg/kg (n=5) et 300 mg...

Full Title: Étude de quelques caractéristiques des bois raméaux fragmentés (BRF) de Guiera senegalensis J. F. Gmel et de Piliostigma reticulatum (DC) Hochst et de leur influence sur des propriétés chimiques et biologiques des sols ferrugineux tropicaux du Bassin arachidier, Sénégal.Objectif : Cette étude, réalisée en laboratoire, visait à évaluer l...

La mise à profit d’espèces ligneuses buissonnantes présentes dans les systèmes agroforestiers comme sources d’engrais verts, peut contribuer à rehausser le statut organique des sols agricoles, augmenter leur productivité et assurer leur exploitation durable. L’objectif de la présente étude est d’évaluer l’influence des bois raméaux fragmentés (BRF)...

Drug combinations against candidiasis and other fungal infections have been considered as alternatives for mono-therapy. However, there are no data available on the combination of essential oils from Ocimum genus.The aim of this work is the optimization of essential oils derived from Cameroon-grown Ocimum against four Candida albicans. The essentia...

En Afrique, l’espèce Zanthoxylum zanthoxyloides est largement utilisée dans le traitement de nombreuses affections comme la drépanocytose, les maladies inflammatoires et les douleurs. Les racines restent les parties de la plante les plus utilisées, ce qui pose le problème de la survie et de l’exploitation durable de l’espèce. Cette présente étude t...

Drug combinations against candidiasis and other fungal infections have been considered as alternatives for mono-therapy. Howev-er, there are no data available on the combination of essential oils from Ocimum genus.The aim of this work is the optimization of essential oils derived from Cameroon-grown Ocimum against four Candida albicans. The essenti...

Résumé : Les jeunes feuilles de Icacina senegalensis Juss (Icacinaceae) récoltées en février 2012 dans l'enceinte de l'Université Assaue Seck de Ziguinchor (Sénégal) sont mis en décotion pendant 4heures dans des solvants de polarités croissantes (hexane, dichlorométhane, éthanol, et eau). Après évaporation à sec le résidu d'éthanol est fractionné p...

Le rônier est un palmier très utilisé dans la pharmacopée traditionnelle ; Le calcinât des feuilles est utilisé en boisson dans l’eau pour traiter la bilharziose viscérale. La tigelle de la noix germée en décoction lutte contre l’impuissance sexuelle, une activité anti-inflammatoire avec une inhibition de 70% de l’oedème induite par la carragénine...

Adansonia digitata L. is a multi-purpose species which plays an important role in the socio-economic and cultural life of Sub-Saharan populations. In Senegal, peasants distinguish various morphotypes of baobab according to their fruit traits. This study evaluates the morpho-biochemical significance of these local morphotypes using a scientific appr...

The root of B. ferrugineais traditionnally used as a treatment for type 2 diabetes. The present study was investigated to evaluate the preventive effect of B. ferruginea on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesity and oxidative stress) induced by high fructose and fat diet in male Wistar ra...

Fall M, Boukandou M, Fall AD, Cabral M, Diatta W, Gueye PM, Faye M, Bakou SN , , Mendes V, Bassene E, Diouf A. Toxicité aiguë et subaiguë d'extrait aqueux de feuilles d'Aphania senegalensis (Juss. Ex Poir.) sur des rats Wistar.

The analgesic and anti-inflammatory activity of Cassia sieberiana roots were investigated. Analgesic activity had been investigated using acetic acid induced contortions in mice. The aqueous root extract of C. sieberiana at 300 mg/kg per os showed similar analgesic activity than 100 mg/kg of acetylsalicylic acid (20 ± 1.14 vs 26 ± 1.79 contortions)...

Abstract Leaves of Adansonia digitata are currently ingested by certain west African populations, especially those whose diet is based on millet couscous. These leaves contain an important amount of mucilage (12%) that is supposed to have a harmful effect on food adsorption. As source of calcium, a fraction devoid of mucilage is proposed. RESUME Le...

The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a significant decrease of blood glucose on glucose-loaded no...

Against cough activity from Guiera senegalensis' leaves has been previously scientifically studied. However, to the best of our knowledge, active principles responsible of this activity were not yet identified. Thus, we undertook this work with the aim to evaluate the effect of total alkaloids from plant's leaves in cough induced in guinea pig by a...

Cassia sieberiana DC (CAESALPINIACEAE) is a plant which grows in Southern Senegal. Its roots are used by traditional medicinal practitioners for its s pasmolytic and antiparasitic properties. The objective of our study was to investigate the myorelaxant and antispasmodic activity of the roots of C. sieberiana on the isolated Wistar rat ileum. The p...

Lyophilised aqueous extract and alcaloidic totum (basic form) from roots of Tinospora bakis (Miers) have been tested with hyperthermic rabbits by sub-cutaneous administration of Saccharomyces cerevisiae mixture at 2g/kg. Total aqueous extract had been orally administrated at three doses: 150, 300 and 600 mg/kg and we obtained significant antipyreti...

The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity. Indeed, when it was used at a dose o...

To assess the efficacy and tolerance of chemoprophylaxis with cotrimoxazole compared with placebo among HIV-1-infected adults. Randomized, double-blind, placebo-controlled clinical trial in the urban community of Dakar, Senegal. Eligibility criteria were age greater than 15 years, HIV-1 or HIV-1 and HIV-2 dual seropositivity, CD4 cell count lower t...

The study was based on an aqueous extract derived from a 60 degrees ethanolic tincture containing 0.032 g of dry matter per ml. The leaves of Guiera senegalensis Lam (Combretaceae) were collected in December 1991 at Nguekhokh a village within 20 km from Mbour (Senegal). The extract was administered for six months through daily forced-feeling at 2 g...

Phytotherapy is a medicinal and ancestral practice in Africa. It deals with all the fields of human pathology. We wanted to ascertain the efficacy of some plants used in odontology as Euphorbia balsamifera traditionally used as antalgic treatment of acute dental pulpitis. The latex of the plant was caught and treated as to get enough stable paste....

Three species of the Mentha gender are found in Senegal under the name of "Nana", and are essentially used in tea and juices as flavour. The aerial parts of the three species (common mint, mentholated mint and "fass" mint) have been harvested two months after they have been sown and the extraction of the essential oils was done by carrying them awa...

Twenty guinea pigs were used to study the effects of Cassia italica leaves and pods extracts on intestinal motricity in vitro. The results obtained showed that the plant stimulate intestinal contractions with dose-dependent relation. Moreover, Cassia italica contractile activity was comparable to the acetylcholine one and was inhibited by atropine....

The seeds of Parinarium excelsum and P. macrophyllum (Rosaceae or Chrysobalanaceae) yield about 65-66% of oil. 13C NMR and gas chromatographic analyses show that these two oils have a high content in α-eleostearic acid, about 62% for P. excelsum and 33% for P. macrophyllum. These results indicate that α-eleosteatic acid can be used as chemotaxonomi...

Hundred white Wistar rats have been used to evaluate the antihypertensive effects of entire seeds and decorticated, fermented seeds of a soudanian plant, Parkia biglobosa. The arterial blood pressure was measured by using bloody method in anesthizied animals. The Pham Huu Chanh method was used to determine type plant's antihypertensive activity. Ac...

We confirmed the innocuity of different extracts (leaves and stem bark) of Calotropis procera (Asclepiadaceae), a plant widely used in Asian and West African traditional therapy in dermatological and bronchal affections. We proved the against cough activity of the aqueous stem bark extract after administration, per os, upon bronchal irritation by a...

Fifty rats weighing average 200 g were used to study choleretic activity of Cassia alata LINN extract. Bile was collected according to acute biliarly fistula technic on animals anesthetized with 1.5g/kg of ethyle carbamate (Urethane ND). After determination of the minimal active dose (15 mg/kg) and lethal dose (100mg/kg) of the extract, rats were a...

Seed oils of S. tomentosa and S. tragacantha (Sterculiaceae) were found to contain malvalic (5.8 and 5.1%), sterculic (11.3 and 30.2%) and dihydrosterculic (0.9 and 0.5%) acids. The total amt. of these two cyclopropenoid fatty acids was established by 1H NMR and their co-occurrence by gas chromatog. Besides these unusual compds., the main common fa...

We proved the cardiac toxicity of Nauclea latifolia Sm on frog isolated heart by Fuhner modified test. The screening was realized with hydro-alcoholic extract of dryied stem bark and its different fractions obtained by 'flash' chromatography. The higher toxicity of fraction F6-4 was shown; 0.15 mg dosis of this fraction provoqued deep cardiac depre...

Chemical research of alkaloids met in Combretum micranthum has been carried on in order to solve some contradictions we have found about them in several previous authors. Presence of hydroxy-stachydrin has been confirmed, cholin and stachydrin clearly identified, whereas betain has not been isolated. Structures of all compounds have been determined...