Emma C Teeling

Emma C Teeling
University College Dublin | UCD · School of Biology and Environmental Science

About

172
Publications
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10,516
Citations
Additional affiliations
September 1999 - December 2001
University of California, Riverside
Position
  • PhD Student

Publications

Publications (172)
Preprint
Bats have evolved features unique amongst mammals, including flight, laryngeal echolocation, and certain species have been shown to have a unique immune response that may enable them to tolerate viruses such as SARS-CoVs, MERS-CoVs, Nipah, and Marburg viruses. Robust cellular models have yet to be developed for bats, hindering our ability to furthe...
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High-quality reference genomes for non-model species can benefit conservation.
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Seven species of the Asian torrent frogs (genus Amolops) have previously been reported from the eastern Himalayan country of Bhutan. Species identifications from the region have been largely based on photographed animals with few voucher specimens available and no molecular sampling. Understanding the taxonomic status of Bhutan’s torrent frogs has...
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This article talks about the Amolops species in Bhutan and also describes new to science species from Bhutan.
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Relationships among laurasiatherian clades represent one of the most highly disputed topics in mammalian phylogeny. In this study, we attempt to disentangle laurasiatherian interordinal relationships using two independent genome-level approaches: (1) quantifying retrotransposon presence/absence patterns, and (2) comparisons of exon datasets at the...
Preprint
The development of methods for individual identification in wild species and the refinement of Capture-Mark-Recapture (CMR) models during the past decades has greatly improved the assessment of population demographic rates to answer ecological and conservation questions. In particular, multistate models, with their flexibility for the analysis of c...
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Despite the global investment in One Health disease surveillance, it remains difficult and costly to identify and monitor the wildlife reservoirs of novel zoonotic viruses. Statistical models can guide sampling target prioritisation, but the predictions from any given model might be highly uncertain; moreover, systematic model validation is rare, a...
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Over 20% of all living mammals are bats (order Chiroptera). Bats possess extraordinary adaptations including powered flight, laryngeal echolocation and a unique immune system that enables them to tolerate a diversity of viral infections without presenting clinical disease symptoms. They occupy multiple trophic niches and environments globally. Sign...
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Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent lineages, reducing the...
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We present a genome assembly from an individual female Pipistrellus pipistrellus (the common pipistrelle; Chordata; Mammalia; Chiroptera; Vespertilionidae). The genome sequence is 1.76 gigabases in span. The majority of the assembly is scaffolded into 21 chromosomal pseudomolecules, with the X sex chromosome assembled.
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Autophagy maintains cellular homeostasis and its dysfunction has been implicated in aging. Bats are the longest-lived mammals for their size, but the molecular mechanisms underlying their extended healthspan are not well understood. Here, drawing on >8 years of mark-recapture field studies, we report the first longitudinal analysis of autophagy reg...
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Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately...
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Understanding antiviral immune responses in bats, which are reservoirs for many emerging viruses, could aid the response to future epidemics. Here, we discuss five key areas in which greater consensus among the bat research community is necessary to drive breakthroughs in the field. The COVID-19 pandemic has stressed the importance of understanding...
Preprint
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent l...
Preprint
Full-text available
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent l...
Preprint
Comprising more than 1400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity given small body size, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent l...
Article
Full-text available
The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of...
Article
Telomeres are used increasingly in ecology and evolution as biomarkers for ageing and environmental stress, and are typically measured from DNA extracted from nonlethally sampled blood. However, obtaining blood is not always possible in field conditions and only limited amounts can be taken from small mammals, such as bats, which moreover lack nucl...
Article
Despite a small genome size, bats have comparable diversity of retroviral and non-retroviral endogenous sequences to other mammals. These include Class I and Class II retroviral sequences, foamy viruses, and deltaretroviruses, as well as filovirus, bornavirus, and parvovirus endogenous viral elements. Some of these endogenous viruses are sufficient...
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To increase the applicability and success of physiological approaches in conservation plans, conservation physiology should be based on ecologically relevant relationships between physiological markers and environmental variation that can only be obtained from wild populations. Given their integrative and multifaceted aspects, markers of oxidative...
Preprint
Bats hold considerable potential for understanding exceptional longevity because some species can live eight times longer than other mammals of similar size [1]. Estimating their age or longevity is difficult because they show few signs of aging. DNA methylation (DNAm) provides a potential solution given its utility for estimating age [2-4] and lif...
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Significance The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a major pandemic that threatens millions of human lives and the global economy. We identified a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins. This can assist the identification of intermedia...
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Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity and unique immunity. High-quality genomes are crucial for understanding the molecular basis and evolution of these traits. Here we incorporated long-read sequencing and state-of-the-art scaffolding protocols¹ to generate, to our knowledge, the first reference-...
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Bats are the longest-lived mammals given their body size with majority of species exhibiting exceptional longevity. However, there are some short-lived species that do not exhibit extended lifespans. Here we conducted a comparative genomic and transcriptomic study on long-lived Myotis myotis (maximum lifespan = 37.1 years) and short-lived Molossus...
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Megophrys parva is currently considered to be among the most widely dispersed species within the genus, however, recent studies have provided compelling evidence that this species represents a complex of morphologically similar, deeply divergent taxa. The focus of this paper is to take a closer look at species from Northeast India (NEI) and Banglad...
Preprint
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The novel coronavirus SARS-CoV-2 is the cause of Coronavirus Disease-2019 (COVID-19). As for other coronaviruses, there is transmission between animals and humans. The main receptor of SARS-CoV-2, angiotensin I converting enzyme-2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different spec...
Article
Age related telomere shortening is considered a hallmark of the ageing process. However, a recent cross-sectional ageing study of relative telomere length (rTL) in bats failed to detect a relationship between rTL and age in the long-lived genus Myotis (M. myotis and M. bechsteinii), suggesting some other factors are responsible for driving telomere...
Preprint
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Bats account for ~20% of all extant mammal species and are considered exceptional given their extraordinary adaptations, including biosonar, true flight, extreme longevity, and unparalleled immune systems. To understand these adaptations, we generated reference-quality genomes of six species representing the key divergent lineages. We assembled the...
Article
Bats are one of the most widespread and speciose orders of mammals. Despite their huge biodiversity, little is known about the natural behaviour and ecology of many species given the difficulty in monitoring and studying them. Pipistrellus kuhlii is one of the most common bats of the Mediterranean biome but its ecology remains ambiguous given the s...
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Bats are the longest-lived mammals, given their body size. However, the underlying molecular mechanisms of their extended healthspans are poorly understood. To address this question we carried out an eight-year longitudinal study of ageing in long-lived bats (Myotis myotis). We deep-sequenced ~1.7 trillion base pairs of RNA from 150 blood samples c...
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Through their unique use of sophisticated laryngeal echolocation bats are considered sensory specialists amongst mammals and represent an excellent model in which to explore sensory perception. While several studies have shown that the evolution of vision is linked to ecological niche adaptation in other mammalian lineages, this has not yet been fu...
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The Megophrys major species group (MMSG) is composed of typically medium to large sized frogs. Within the genus, it is the most geographically widespread clade ranging from the western Himalayas to southern Indochina. In this study, we examined in detail the extent of cryptic diversity within the MMSG-Indian populations based on molecular data (up...
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Given their cryptic behaviour, it is often difficult to establish kinship within microchiropteran maternity colonies. This limits understanding of group formation within this highly social group. Following a concerted effort to comprehensively sample a Natterer’s bat (Myotis nattereri) maternity colony over two consecutive summers, we employed micr...
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Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The "Free Radical Theory of Ageing" (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals given their small size and high m...
Article
A number of limiting factors mean that traditional genome annotation tools either fail or perform sub-optimally when trying to detect coding sequences in poor quality genome assemblies/genome reports. This means that potentially useful data is accessible only to those with specific skills and expertise in assembly and annotation. We present an Asse...
Article
The olfactory receptor (OR) gene families, which govern mammalian olfaction, have undergone extensive expansion and contraction through duplication and pseudogenization. Previous studies have shown that broadly-defined environmental adaptations (e.g terrestrial vs aquatic) are correlated with the number of functional and non-functional OR genes ret...
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Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats on chromosome tips that shorten with cell division, potentially limiting life span. Bats are the longest-lived mammals for their size, but it is unknown whether their telo...
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A changing microbiome has been linked to biological aging in mice and humans, suggesting a possible role of gut flora in pathogenic aging phenotypes. Many bat species have exceptional longevity given their body size and some can live up to ten times longer than expected with little signs of aging. This study explores the anal microbiome of the exce...
Data
Hierarchical clustering of sample data Myotis myotis samples were grouped using hierarchical clustering based on the number of different OTUs found across each individual.
Data
Core microbiome in half of all samples Heatmap displaying the core microbiome across samples (OTUs present in 50% of all samples), highlighting some inter-individual diversity between specific OTUs.
Data
Core microbiome in 80% of all samples Heatmap displaying OTUs present in the majority (80%) of Myotis myotis samples.
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Bacteria abundances across samples Bacteria abundances, determined using QIIME and Greengenes for each sample are displayed. Classifications are resolved to genus level where possible.
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K-means clustering of mammalian taxa The different mammalian clusters identified using k-means clustering (k = 4, elbow criterion) on the first two principal components of bacteria abundance are displayed.
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Predicted microbiome functional content The functional gene pathways in the anal microbiome of Myotis myotis were predicted across all samples. Functional pathways are ranked from most to least.
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Analysis of metagenomic function across age groups The abundances of predicted metagenomic pathways between juveniles and adults were investigated to determine what functional categories were enhanced or diverged with age for (A) age dataset 2 and (B) age dataset 3.
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Rarefaction plots for data categories Rarefaction plots for age datasets 1 (A), 3 (B) and 4 (C), in addition to location (D), are displayed. Alpha diversity is measured using phylogenetic diversity (PD).
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Beta diversity before rarefaction Beta diversity across samples was investigated before rarefaction to determine if any separation of categorical data could be identified. (A) Beta diversity of male and female samples before rarefaction is displayed. (B) Beta diversity using weighted between adults and juveniles in age dataset 2 before rarefaction...
Data
Beta diversity for age dataset 3 and site before rarefaction Beta diversity across samples was investigated before rarefaction using PCoA and weighted Unifrac distances for (A) age dataset 3 and (B) sample collection site, representing 55% of variance.
Data
Principal Co-ordinate plot of beta diversity after rarefaction Similarity based on beta-diversity between samples was explored using PCoA and weighted Unifrac distances after rarefaction, explaining 60.59% variance for (A) age dataset 3 and (B) sample collection site.
Data
PCA of mammalian bacterial abundances Principal components analyses of nine highly abundance bacteria phyla across mammals, with the first three components displayed, highlighting the differential abundance across various mammalian microbiomes.
Data
Core microbiomes across samples The OTUs forming the core microbiomes across all bat samples are displayed. Core thresholds range from those present in 50% of samples to 90% of all individuals.
Data
SIMPER analysis of dissimilarity across site The percentage dissimilarity for classification levels 1 (phylum) to 6 (genus) across sample collection site is displayed both (A) before rarefaction and (B) after rarefaction are displayed.
Article
Bats are unique among mammals given their ability to fly, apparent tolerance of deadly viruses and extraordinary longevity. We propose that these traits are linked and driven by adaptations of the innate immune system. To explore this hypothesis we challenged macrophages from the greater mouse-eared bat, Myotis myotis and the house mouse, Mus muscu...