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Publications (16)
Organ initiation is often driven by extracellular signals that activate precursor cells competent to receive and respond to the signal, yet little is known about how dynamic competency is in space and time during development. Teeth are excellent organs to study organ initiation competency because they can be activated with the addition of a single...
Most vertebrate species undergo tooth replacement throughout adult life. This process is marked by the shedding of existing teeth and the regeneration of tooth organs. However, little is known about the genetic circuitry regulating tooth replacement. Here, we tested whether fish orthologs of genes known to regulate mammalian hair regeneration have...
Background
Vertebrate teeth exhibit a wide range of regenerative systems. Many species, including most mammals, reptiles, and amphibians, form replacement teeth at a histologically distinct location called the successional dental lamina, while other species do not employ such a system. Notably, a ‘lamina-less’ tooth replacement condition is found i...
Background
Vertebrate teeth exhibit a wide range of regenerative systems. Many species, including most mammals, reptiles, and amphibians, form replacement teeth at a histologically distinct location called the successional dental lamina, while other species do not employ such a system. Notably, a ‘lamina-less’ tooth replacement condition is found i...
Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons (Columba livia) are fundamentally one of four color pattern phenotypes, in decreasing order of melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identifi...
qRT-PCR source data represented in Figure 3A, and Figure 3—figure supplement 1.
Allele-specific expression assays source data represented in Figure 3B and Figure 3—figure supplement 3.
Numbers of SNPs between different pairwise combinations of homozygous bar, checker, and C. guinea represented in Figure 5C.
VISTA and REPTILE enhancer mapping hits on Scaffold 68.
Genotypes in the candidate region of individual birds in an F2 cross of domestic pigeons used to estimate recombination frequency.
Taqman copy number assay and phenotype quantification results represented in Figure 2C.
Primer sequences used in this study.
Combinations of bar and checker bird identifiers used to generate whole-genome D-statistics.
Taqman copy number assay results represented in Figure 2B.
Birds and other vertebrates display stunning variation in pigmentation patterning, yet the genes controlling this diversity remain largely unknown. Rock pigeons ( Columba livia ) are fundamentally one of four color pattern phenotypes, in decreasing order of melanism: T-check, checker, bar (ancestral), or barless. Using whole-genome scans, we identi...