Emma K Adam

Northwestern University | NU · Ph.D. Programm in Human Development and Social Policy

Importance High levels of anxiety and depression were documented shortly after the arrival of the COVID-19 pandemic and were more prevalent in younger adults than in older adults. Knowing whether these age disparities persisted throughout multiple years of the COVID-19 pandemic and identifying associated factors will help guide health policy. Obje...

The COVID-19 pandemic resulted in adolescents' increased exposure to daily experiences of risk factors for depression and anxiety (e.g., loneliness). Intensive longitudinal studies examining daily experiences during the pandemic have revealed short-term and long-term consequences on youth mental health. Although evidence suggests small average incr...

The current study investigates whether prepregnancy maternal posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, and stress predict children's cortisol diurnal slopes and cortisol awakening responses (CARs) adjusting for relevant variables. Mothers were enrolled after delivering a baby and followed through their subsequent pregnancy...

The cortisol awakening response (CAR) is frequently assessed in psychobiological (stress) research. Obtaining reliable CAR data, however, requires careful attention to methodological detail. To promote best practice, expert consensus guidelines on the assessment of the CAR were published (Stalder et al., 2016, PNEC). However, it is unclear whether...

Background Immigrants from Turkey experience health disadvantages relative to non-immigrant populations in Germany that are manifest from the earliest stages of the lifespan onwards and are perpetuated across generations. Chronic stress and perturbations of stress-responsive physiological systems, including the hypothalamus-pituitary-adrenal (HPA)-...

Early life adversity influences the diurnal cortisol rhythm, yet the relative influence of different characteristics of adversity remains unknown. In this study, we examine how developmental timing (childhood vs. adolescence), severity (major vs. minor), and domain of early life adversity relate to diurnal cortisol rhythms in late adolescence. We a...

OBJECTIVE Inflammation as a risk factor for preterm birth is well-established. The primary objective of this analysis was to examine whether individual cytokines versus a composite indicator of mid-pregnancy inflammation are significantly associated with risk for adverse birth outcomes. STUDY DESIGN A multi-site prospective study was conducted in...

Purpose The COVID-19 pandemic has brought dramatic changes to the daily lives of U.S. adolescents, including isolation from friends and extended family, transition to remote learning, potential illness and death of loved ones, and economic distress. This study’s purpose is to measure changes in adolescents’ perceived stress and mood early in the pa...

The present study examines the longitudinal association between cortisol (dys)regulation – mean cortisol awakening response (CAR) and area under the curve with respect to ground (AUCg) for total daily cortisol – and autobiographical memory. 135 participants (mean age at baseline = 16.1; Females = 78.5%) provided cortisol samples (T1). Seven months...

Problem The immune system represents a leading pathway of interest in the pathophysiology of preterm birth. The majority of human clinical studies interrogating this pathway have utilized circulating immune biomarkers; however, these concentrations typically reflect only basal production but not key functional properties of the immune system, parti...

Objectives Alterations in adult hypothalamic–pituitary–adrenal (HPA) axis activity have increasingly been linked with early life stress and adult depression, but a limited number of studies have used longitudinal data to explore HPA axis dysregulation as an underlying mechanism driving the long‐term depressive impacts of early stressors. Here we ad...

Stress during pregnancy affects maternal health and well‐being, as well as the health and well‐being of the next generation, in part through the hypothalamic‐pituitary‐adrenal (HPA) axis. Although most studies have focused solely on proximal experiences (i.e., during the pregnancy) as sources of prenatal stress, there has been a recent surge in stu...

Cigarette smoking and alcohol consumption during pregnancy can have detrimental effects on the developing fetus, including fetal alcohol syndrome and low birth weight. Surprisingly little is known about the association of personality traits with smoking and alcohol consumption in the specific subpopulation of pregnant women. This study analyzed dat...

Context Across pregnancy, maternal serum cortisol levels increase up to 3-fold. It is not known whether maternal peripheral cortisol metabolism and clearance change across pregnancy or influence fetal cortisol exposure and development. Objectives The primary study objective was to compare maternal urinary glucocorticoid metabolites, as markers of...

We examine how students' physiological stress differs between a regular school week and a highstakes testing week, and we raise questions about how to interpret high-stakes test scores. A potential contributor to socioeconomic disparities in academic performance is the difference in the level of stress experienced by students outside of school. Chr...

Objective Higher rates of adverse outcomes have been reported for early term (37 0 to 38 6 weeks) versus full term (≥ 39 0 weeks) infants, but differences in breastfeeding outcomes have not been systematically evaluated. This study examined breastfeeding initiation and exclusivity in early and full term infants in a large US based sample. Methods...

This study examined whether parental and adolescent stress act as mediators between socio-economic status (SES) and adolescent executive functioning (EF) in urban youth. Two hundred and sixty-seven 6th-11th grade students (ages 11-16, 55.4% female; 49.1% Black/African American) attending racially and socioeconomically diverse schools in Chicago, Il...

Background The serotonin system and hypothalamic pituitary‐adrenal (HPA)‐axis are each implicated in the pathway to depression; human and animal research support these systems’ cross‐talk. Our work implicates a 5‐variant additive serotoninergic multilocus genetic profile score (MGPS) and separately the cortisol awakening response (CAR) in the prosp...

Individuals' social experiences are associated with their mental health, physical health, and even mortality. Over the last 30 years, researchers have examined the ways in which these social experiences might be associated with chronic inflammation—a component underlying many of the chronic diseases of aging. Little research, however, has examined...

Objective Allostatic load (AL) represents multisystem physiological “wear-and-tear” reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities. Methods The Eunice Kennedy Shriver National Institute for Child Health and Human Development Community Child Health...

To evaluate the association between psychotropic medication and inflammatory biomarkers in women with antenatal depressive symptoms (ADS). In this cross-sectional secondary analysis of a prospective multicenter observational study, 723 pregnant women underwent a depression screen using the Center for Epidemiologic Studies Depression Scale (CES-D) b...

Objective: To evaluate the association between prenatal stress and gestational weight gain (GWG). Study design: This was an analysis of women recruited between 2013-2015 from four sites in the US. We tested associations between responses at 32-35 weeks to the Life Experiences Survey (LES), a 37-item measure of events and perceived stress, and GW...

We investigated how meaning in life affects the link between stress and depression symptoms in adolescents. Adolescents (N = 177; 58.4% female, mean age = 14.75 years) reported on their meaning in life, exposure to stressors, and depression symptomatology. Higher meaning in life predicted lower depression symptoms. Importantly, meaning in life mode...

Following the birth of an infant, decreases in testosterone and increases in depressive symptoms have been observed in fathers. Paternal testosterone may reflect fathers' investment in pair-bonding and paternal caregiving and, as such, may be associated with maternal and familial well-being. This study tests associations between paternal testostero...

Investigators are increasingly beginning to examine racial/ethnic and cultural processes in psychobiological research. In this chapter we provide a broad overview of the newly emerging field of cultural neurobiology. First, we highlight important theoretical perspectives that contribute to our motivation for understanding cultural neurobiology. Nex...

The data combine objectively measured sleep and thrice-daily salivary cortisol collected from a 4-day diary study in a large Midwestern city with location data on all violent crimes recorded during the same time period for N = 82 children (Mage = 14.90, range = 11.27–18.11). The primary empirical strategy uses a within-person design to measure the...

Stress exposure, and subsequent biological responses to stress exposure, can negatively affect cognitive functioning and test performance. Stress exposure affects multiple biological systems, including sleep and the activity of the hypothalamic-pituitary-adrenal (HPA) axis and its primary hormonal product, cortisol. Sleep and cortisol interact with...

Objectives: The present study examined both within- and between-person associations between adolescents' time use (technology-based activities and face-to-face interactions with friends and family) and sleep behaviors. We also assessed whether age moderated associations between adolescents' time use with friends and family and sleep. Design: Ado...

Research suggests the health consequences of economic hardship can be transmitted across generations. Some of these disparities are thought to be passed to offspring during gestation. But this hypothesis has not been tested in contemporary American samples, and the mechanisms of transmission have not been characterized. Accordingly, this study had...

Childhood and adolescent adversity have been shown to predict later mental and physical health outcomes. Understanding which aspects and developmental timings of adversity are important, and the mechanisms by which they have their impact may help guide intervention approaches. A large subset of adolescents (N = 457; Female 68.9 %) from the 10-year...

Objectives: This 10-day study aimed to (1) assess the effectiveness of a text message-based sleep intervention and (2) determine whether the intervention was equally effective for non-Hispanic whites and racial-ethnic minority adolescents. Participants: Participants were 46 (50% female) adolescents (13-18 years; mean=15.75 years old, SD=0.98) fr...

Despite a growing understanding that the social determinants of health have an impact on body mass index (BMI), the role of fatherhood on young men's BMI is understudied. This longitudinal study examines BMI in young men over time as they transition from adolescence into fatherhood in a nationally representative sample. Data from all four waves of...

Maladaptive emotion regulation and dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning are characteristic of depression and anxiety. However, little research examines whether and how emotion regulation affects HPA axis functioning. We utilized an experience sampling methodology to examine associations between three emotion regulation...

Objectives Prior studies have shown significant racial disparities in psychosocial stressors for pregnant women. One physiological mechanism by which prenatal stress is expressed is via the stress-sensitive hormone cortisol, which itself differs by race. In this study, we examine differences in cortisol awakening response (CAR) for African-American...

Within the field of relationship science there is increasing interest in the connections between close relationships and physical health. In the present study, we examined whether adolescents’ (∼12 years old) and young adults’ (∼20 years old) perceptions of their parents as a secure base prospectively predict C-reactive protein (CRP), a commonly us...

The cortisol awakening response (CAR), the marked increase in cortisol secretion over the first 30–45 min after morning awakening, has been related to a wide range of psychosocial, physical and mental health parameters, making it a key variable for psychoneuroendocrinological research. The CAR is typically assessed from self-collection of saliva sa...

We present the race-based disparities in stress and sleep in context model (RDSSC), which argues that racial/ethnic disparities in educational achievement and attainment are partially explained by the effects of race-based stressors, such as stereotype threat and perceived discrimination, on psychological and biological responses to stress, which,...

Problem: Maternal inflammation undergoes adaptations during pregnancy, and excessive inflammation has been associated with adverse outcomes. One mechanism may be maternal inflammation transmission to the fetal compartment. Links between maternal pregnancy inflammation and fetal inflammation are poorly characterized. Method: Principal components...

Objective To assess the relationship between cortisol slope, a biologic marker of stress, and postpartum weight retention. Methods We included 696 women in a secondary analysis from a multi-site study conducted using principles of community-based participatory research to study multi-level sources of stress on pregnancy outcomes. As a stress marker...

Despite the increasing popularity of incorporating salivary cortisol measurement into health and social science research, relatively little empirical work has been conducted on the number of saliva samples across the day required to capture key features of the diurnal cortisol rhythm, such as the diurnal cortisol slope, the area under the curve (AU...

Cortisol is the primary output of the hypothalamic-pituitary-adrenal (HPA) axis and is central to the human biological stress response, with wide-ranging effects on physiological function and psychiatric health. In both humans and animals, cortisol is frequently studied as a biomarker for exposure to environmental stress. Relatively little attentio...

Cortisol, the major physiological end product of the hypothalamic-pituitary-adrenal axis, is usually associated with stress and negative affect. However, a new body of research highlights the complex, adaptive significance of elevated cortisol within individuals in everyday life. Whereas most studies do not have the power to test the dynamic transa...

Objective: Elevated maternal psychosocial stress during pregnancy and accompanying changes in stress hormones may contribute to risk of adverse birth outcomes such as low birth weight and preterm birth. Relatedly, research on fetal programming demonstrates intriguing associations between maternal stress processes during pregnancy and outcomes in o...

Purpose: With a growing focus on the importance of men's reproductive health, including preconception health, the ways in which young men's knowledge, attitudes, and beliefs (KAB) predict their reproductive paths are understudied. To determine if reproductive KAB predicts fatherhood status, timing and residency (living with child or not). Methods...

Variation in the CD38 gene, which regulates secretion of the neuropeptide oxytocin, has been associated with several social phenotypes. Specifically, rs3796863 A allele carriers have demonstrated increased social sensitivity. In 400 older adolescents, we used trait-state-occasion modeling to investigate how rs3796863 genotype, baseline ratings of c...

Behavioral genetic research supports polygenic models of depression in which many genetic variations each contribute a small amount of risk, and prevailing diathesis-stress models suggest gene-environment interactions (G x E). Multilocus profile scores of additive risk offer an approach that is consistent with polygenic models of depression risk. I...

Prior studies have found that close mother-child sleep proximity helps increase rates of breastfeeding, and breastfeeding itself is linked to better maternal and infant health. In this study, we examine whether breastfeeding and infant bed-sharing are related to daily rhythms of the stress-responsive hormone cortisol. We found that bed-sharing was...

Adolescence is a sensitive period for changes in both sleep and affect. Although past research has assessed the association between affect and sleep among adolescents, few studies have examined both trait (typical) and day-to-day changes in affect, and fewer still have specifically examined negative social evaluative emotions (e.g. embarrassment) i...

Depression is a prevalent and debilitating illness facing many adolescents, especially adolescent girls, whose risk for this disorder is approximately twice that of boys. Many studies have identified mechanisms that place girls at higher risk for depression during adolescence. Few, however, have examined differences in the everyday emotional experi...

Psychobiological research with adolescent populations tends to focus on negative mood, stress, and psychopathology, but the role of positive emotions is insufficiently understood. The current study examines the relative contributions of both negative and positive affective experiences to the basal activity of the hypothalamic-pituitary-adrenal axis...

Researchers have identified cross-sectional links between interpersonal stress and inflammation. Little is known, however, about how these dynamics unfold over time, what underlying immune pathways might exist, or whether moderators such as race could alter the strength of the connection between interpersonal stress and inflammatory processes. We e...

Low socioeconomic status (SES) is associated with increased psychosocial stress among low-income persons, which could contribute to differences in activity of the HPA axis (assessed by diurnal cortisol profiles). The current article investigates associations of SES from different developmental stages with cortisol profiles. Using data from a large,...

Objective: This study was designed to examine whether family and peer relationships in adolescence predict the emergence of metabolic risk factors in young adulthood. Method: Participants from a large, nationally representative cohort study (N = 11,617 for these analyses) reported on their relationship experiences with parents and close friends...

Prior research indicates that blacks and Hispanics/Latinos have flatter diurnal cortisol declines across the day, a profile associated with poorer health. The stability of racial and ethnic differences in cortisol levels over time is not well understood, and additional research is needed to establish racial and ethnic differences in psychosocial st...

Background: To examine overweight/obesity in young males over time as they transition to fatherhood in a nationally representative, longitudinal sample. Methods: We combined all 4 waves of the National Longitudinal Study of Adolescent Health to support a 20-year longitudinal analysis of 10,623 men and then created a "fatherhood-year" data set, ca...

Discrimination is theorized to set in motion a neuroendocrine response, which includes cortisol secretion from the hypothalamic-pituitary-adrenal axis. Repeated exposure to perceived discrimination is thought to contribute to alterations in diurnal cortisol rhythms and to have implications for health. Discrimination may have particularly strong eff...

Reduced autobiographical memory specificity (AMS) is an important cognitive phenomenon in major depressive disorder (MDD), but knowledge about mechanisms is lacking. The CaR-FA-X model of Williams and colleagues (2007) proposed that 3 processes contributed to reduce AMS: capture and rumination (CaR), functional avoidance (FA), and impaired executiv...

Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated...

Stress and immune function may be important mediators of the strong association between social factors and health over the life course, but previous studies have lacked the data to fully explore these links in a population-based sample. This study utilizes data from Waves I-IV of the U.S. National Longitudinal Study of Adolescent Health (Add Health...

Chronic inflammation is a potentially important physiological mechanism linking early life environments and health in adulthood. Elevated concentrations of C-reactive protein (CRP)-a key biomarker of inflammation-predict increased cardiovascular and metabolic disease risk in adulthood, but the developmental factors that shape the regulation of infl...

Cross-sectional associations have been found between anxiety disorders (ADs) and hypothalamic-pituitary-adrenal (HPA) axis functioning, as measured by levels of salivary cortisol, but prospective data are lacking, as are studies examining specific ADs. We have previously shown that one aspect of the diurnal rhythm of cortisol, the cortisol awakenin...

Childhood and adolescent adversity is of great interest in relation to risk for psychopathology, and interview measures of adversity are thought to be more reliable and valid than their questionnaire counterparts. One interview measure, the Childhood Trauma Interview (CTI; Fink et al., 1995), has been positively evaluated relative to similar measur...

Meta-analytic evidence has supported a gene-environment interaction between life stress and the serotonin transporter-linked polymorphism (5-HTTLPR) on depression, but few studies have examined factors that influence detection of this effect, despite years of inconsistent results. We propose that the candidate environment (akin to a candidate gene)...