Emine Baydan

• Professor of veterinary pharmacology and toxicology
• Ankara University

In this research was aimed to investigate the sensitivity to drug (ivermectin) in Kangal and Akbaş breed dogs, which are dog breeds native to Turkey, via the MDR1 gene mutation. For the research, blood, hair and intraoral swap samples were taken from 30 Kangal and 20 Akbaş breed dogs (male female mixed, adult) with ethical permission and approval f...

In this study, it was aimed to determine the kinetics of florfenicol (FF) given intramuscularly and gavage in a single dose (10 mg/kg) in Black Sea Turbot (Psetta maxima), whose growing possibilities were investigated in Turkey in recent years. The study was carried out in black sea water, in closed system pools within the Trabzon Fisheries Central...

Günümüzde COVID-19 pandemisi nedeniyle özellikle egzotik hayvan kaynaklı zoonotik hastalıkların önemi ve küresel ölçekte yaptıkları olumsuz etkiler tekrar gündeme gelmiştir. Bu derlemede, pandemi şeklinde gelişen zoonotik hastalıkların nedenleri, hastalık etkenleri ve muhtemel tedavi metotları hakkında bilgi verilmeye çalışılmıştır.

İçme suyundaki organik maddelerin insan ve hayvan sağlığı açısından zarar vermeyecek düzeyde olması önem arz etmektedir. Bu çalışma, Kırıkkale İli sınırları içerisindeki 59 büyükbaş hayvan işletmesinden temin edilen sularda, bazı inorganik maddelerin (nitrat, nitrit, amonyum) seviyelerinin belirlenmesi ve bu materyalleri tüketen hayvanların sağlığı...

The aim of this study was to determine, muscle residue level (MRL) and withdrawal time (WT) of florfenicol (FF), in healthy and infected rainbow trout (Oncorhynchus mykiss) with Lactococcus garvieae. Fish were divided into the four groups, Group I (Infected fish fed with FF free diet, n = 10), Group II (Healthy fish fed with FF free diet, n = 10),...

Bu çalışmanın amacı, etlik piliçlerde kursağa ve damar içine (Dİ) 100 mg/kg miktarında tek dozda verilen sülfadiazinin farmakokinetiğini belirlemek ve bu farmakokinetik değişkenlerden yararlanarak aynı miktarda sülfadiazinin çinko içeren yemle birlikte verildiğinde çinko ve sülfadiazin arasında etkileşim olup olmadığını ortaya koymaktır. Çalışmada...

Türkçe Bildiri : Broylerlerde Florfenikolun Hematolojik Parametreler Üzerine Etkisi Giriş ve Amaç: Florfenikol, Gram pozitif ve negatif bakterilere etki eden bir tiamfenikol türevidir. Çalışmanın amacı broylerlerde yüksek dozlarda verilen florfenikolun hematolojik parametreleri üzerine etkilerini araştırmaktır. Yöntemler: Etik onay Yerel Etik Kurul...

Biyolojik sistemlerin işleyişinde ve patolojisinde reseptörler önemlidir. Belirtilen nedenle reseptör ve reseptör alt tiplerini tanımlama, anatomik dağılımları, hastalık durumundaki sıklığı, reseptörlere özgü ligand geliştirme, geliştirilen ligandların farmakokinetik ve farmakodinamik çalışmalarının yapılması gibi birçok alanda reseptör analiz yönt...

Cannabinoid receptor 2 (CB2) has a role in the pathology of some liver diseases. Cypermethrin (CYP) is a synthetic pyrethroid insecticide used commonly for the control of pests and vectors, and for protection of foodstuffs. In this study, the involvement of CB2 in CYP-induced liver damage in rats was investigated. CYP was applied to rats orally at...

Organic and conventional animal products may include residues of veterinary drugs and environmental contaminant. Food contaminants can cause consumer illness such as allergy, immunosuppression, cancer, teratogenicity, mutagenicity and genotoxicity. Therefore, their control is an important issue in terms of public health. In this article, informatio...

In the last century, drug development researches presented a great contribution to the progress of medicine through advancements of pharmacology, clinical and especially chemistry sciences. In drug development studies, especially discovery of transmembrane receptors and production of ligands specific to these resectors provide important development...

In the current study, organic and conventionally produced rice and lentil samples purchased from the supermarkets in Ankara, Turkey were analyzed for their nutritional composition, nitrate/nitrite content and aflatoxin contamination. Nitrate/nitrite concentrations were found to be significant (p<0.05) only for nitrate (higher in organic) and nitrit...

zet Geleneksel (Konvansiyonel) yetiştiricilikte öncelikli amaç az maliyetle yüksek miktar-da ürün elde etmektir. Bu sebeple, bitki ve hayvan yetiştiriciliğinde koruyucu ve sağaltıcı amaçla antibiyotik, hormon, pestisit gibi maddelerin kullanımı söz konusu olabilmektedir. Yapılan bilinçsiz uygulamalar kanser sıklığında artışa, tanımlanamayan hastalı...

Veterinary drug residues and their metabolites in food are regularly investigated by local authorities; however their fate in the environment is still unknown. Despite the importance of the aquaculture industry and the widespread use of antibiotics; limited scientific information regarding their residue in natural fish, sediment and sea water are a...

Öz: Üretimi gittikçe artan ve toksikolojik yönden incelenmeden sofralarımıza daha sık giren GDO’lu ürünlerin sağlığımıza ne gibi etkileri olacağı da belirsizdir. Alerjik tepkimelere yol açabileceği, besin zinciri içinde birikebileceği, toksik etkiler yapabileceği ve antibiyotik direnci oluşturabileceği gibi etkiler bunların arasında en önemlileridi...

This study was conducted to investigate the effects of frying, boiling and freezing processes on sulfamethazine (SMZ) residues in chick breast meat and liver. Chicks were fed with feed not containing sulfonamide residues for 30 days. After 30 days, the suspensions of SMZ (110 mg/kg) were given to 10 chicken by gavage to craw once daily for 5 days....

The pharmacological activity of the aerial (EKA) and root (EKR) parts of the endemic plant, Eryngium kotschyi Boiss., on rat isolated ileum and detrusor muscle was investigated. Plant extracts alone and with the presence of agonist (acethylcholine) and antagonist (atropin, verapamile, oxybutinine-detrusor muscle, and papaverine-ileum) drugs, along...

This study was conducted to determine the effects frying, boiling and freezing processes on the levels of sulfachlorpyridazine (SCP) and trimethoprim (TMP) in broiler chest meat and liver. Male broiler chicks were assigned to two groups as control and treatment groups. Animals were fed on commercial diet not containing SCP and TMP for 35 days. At 3...

Eryngium species have widely been used in folk medicine with their antiinflammatory and antinociceptive activities. The objective of the study was to determine the antibacterial and the antioxidant activities of the aereal and the root parts of the lyophilized extracts of Eryngium maritimum L. and Eryngium kotschyi Boiss. Antibacterial activity of...

Abstract The toxicity of etephon and maleic hydrazide, used as plant growth regulators in agriculture, were reported as low in mammals in previous studies. However, in vitro cytotoxicity studies in mammalian cells are currently missing to understand their toxicity at molecular level. In the current study, the cytotoxicity of these compounds, were s...

In this research, residues of certain veterinary drugs (florfenicol (FF) and florfenicol amine (FFA)) were screened in natural fish, sediment, and seawater samples of the Aegean Sea, while only chloramphenicol (CAP) was searched for in the sediment. Samples were collected from fish farming cages in selected coordinates (Bodrum, Salihli Region, Turk...

Context: Eryngium maritimum L. and the endemic Eryngium kotschyi Boiss. of the Apiaceae family are used for antiinflammatory, antivenom, antinociceptive and diuretic purposes in folk medicine in Turkey. Objective: This study investigated the cytotoxic effects of the plant extracts belonging to Eryngium L. genus on various cell lines. Materials...

Lead, cadmium, copper, zinc and iron levels were determined in organically and conventionally produced wheat, green lentils, flower honey and eggs that are supplied on different markets in Ankara, Turkey. Their toxicological and nutritional values were compared with national and international limits and literature data. The levels of cadmium and le...

This study investigated the effect of chlorpyrifos on thoracic aorta and on the level of NO in plasma and aorta. The effect of chlorpyrifos on thoracic aorta in organ bath was determined in 10 rats. Another 45 rats were assigned to 3 groups with 15 rats each: control group 1 received distilled water, control group 2 was given corn oil, and the last...

This study was carried out to investigate the effect of various cooking and freezing processes on the levamisole residues in poultry tissues, which is one of most commonly used antiparasiter drug, has been frequently using in Turkey as well. For this purpose, 10 of Ross PM-3 breed chicks were given levamisole by oral gavage at 36 mg/kg/2 ml. After...

The subacute toxic effects of separate and combined use of piperonyl butoxide and resmethrin (cismethrin) on the liver and kidneys of male mice were investigated. It is known that when given alone, pyrethroids are toxic and their toxicity becomes more complicated when they are co-formulated with piperonyl butoxide. In the present study, macroscopic...

A range of pesticides is widely used in pest management and the chances of exposure to multiple organophosphorus (OP) compounds simultaneously are high, especially from dietary and other sources. Although health hazards of individual OP insecticides have been relatively well characterized, there is lesser information on the interactive toxicity of...

The aim of this study was conducted to subchronic toxic effects separate and combined using of maleic hydrazide and ethephon in female mice. Treatment group divided into 9 groups according to chemicals' doses and compared with controls. Three separate maleic hydrazide doses (100-200-400 mg/kg/day, in feed) and ethephon (50-100-150 mg/kg/day, in wat...

The aim of this study is to determine the effect of levamisole and levamisole-trichlorfon combination on isolated sheep trachea. Contraction was achieved with levamisole concentrations (10(-8)-10(-3) M) on tracheal strips of adult sheep (> 1 year of age). Pretreatment with trichlorfon (10(-7) M)-levamisole (10(-7) M) decreased the pD2 and E(max) of...

The consumption and production of organic food has been increasing all over the world gradually. Organic foods are commonly represented as food grown without pesticides; grown without artificial fertilizers and has not been treated with hormones, antibiotics etc. The aim of this review was to evaluate the nutritional value and the residue content o...

Double divisor-ratio spectra derivative (graphical method), classical least-squares and principal component regression (two numerical methods) methods were developed for the spectrophotometric multicomponent analysis of soft drink powders and synthetic mixtures containing three colorants without any chemical separation. The graphical method is base...

The pharmacokinetics of conventional and long-acting oxytetracycline (OTC) formulation were evaluated in sheep at a single dosage of 20 mg-kg-1 body weight (bw). Conventional formulation was injected by intravenous (IV) route and long-acting formulation of oxytetracycline was administered by intramuscular (IM) route. Then blood samples were taken a...

Summary: The effects of tetramisole and trichlorphon which are administred seperately and together were investigated clinically and haematological. In this study, 24 half breed dogs of both sex aging months to two years, weighing six to 28 kg bodyweight were used. They were divided into three group. The first group of eight dogs were given tetramis...

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Teratogenic effects of heavy metals on chick embryos: i. Effects of sepe- rate and combined use of arsenic and lead. Summary: In this study, effects of seperate and combined use of arsenic and lead were examined on chick embryos. Two-day-old Ross-PM 3 embryos were administered different dose levels of arsenic trioxide (1.44-1.44 'g as Aslegg), lead...