Emilie Caron

Emilie Caron
French Institute of Health and Medical Research | Inserm · Institute of Circulation, Metabolism and Nutrition

About

27
Publications
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Publications

Publications (27)
Article
Full-text available
Background/Objectives Alteration of the perinatal nutritional environment is an important risk factor for the development of metabolic diseases in later life. The hormone leptin plays a critical role in growth and development. Previous studies reported that postnatal overnutrition increases leptin secretion during the pre-weaning period. However, a...
Article
Full-text available
Alzheimer’s disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose homeostasis alterations observed in AD patients. However, the links between tau impairments and glucose ho...
Article
Full-text available
The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis in peripheral organs. Indeed, enterohepatic-expressed FXR controls metabolic processes (BA, glucose and lipid metabolism, fat mass, body weight). The central nervous system (CNS) regulates energy homeostasis in close interaction with...
Article
Full-text available
Metabolic health depends on the brain’s ability to control food intake and nutrient use versus storage, processes that require peripheral signals such as the adipocyte-derived hormone, leptin, to cross brain barriers and mobilize regulatory circuits. We have previously shown that hypothalamic tanycytes shuttle leptin into the brain to reach target...
Article
Hypothalamic glucose sensing enables an organism to match energy expenditure and food intake to circulating levels of glucose, the main energy source of the brain. Here, we established that tanycytes of the hypothalamic arcuate nucleus, specialized glia that line the wall of the third ventricle, convert brain glucose supplies into lactate that they...
Article
Full-text available
Objectives Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this study, we investigated the distribution of GCK-expressing tanycytes in mice and their role in the regulation of energy balance. Methods In situ hybridization, reporter gen...
Preprint
Full-text available
Background and Prupose: The nuclear bile acid (BA) receptor farnesoid X receptor (FXR) is a major regulator of metabolic/energy homeostasis in peripheral organs. Indeed, enterohepatic-expressed FXR controls metabolic processes (BA, glucose and lipid metabolism, fat mass, body weight). The central nervous system (CNS) regulates energy homeostasis in...
Article
Full-text available
Parkinson’s disease is a progressive neurodegenerative disorder characterized by loss of dopaminergic neurons, pathological accumulation of alpha-synuclein and motor symptoms, but also by non-motor symptoms. Metabolic abnormalities including body weight loss have been reported in patients and could precede by several years the emergence of classica...
Article
Full-text available
Objectives: Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk. Yet the causal relationship between this gene and defective energy homeostasis remains elusive. Here we sought to understand the contribution of Cdkn2a to metabolic hom...
Data
Pathway analysis of diseases and/or biological functions affected in Cdkn2a+/+ and Cdkn2a−/− primary adipocytes related to differential peptide phosphorylation. Related to Figure 4.
Data
List of diseases and/or biological functions associated to gene expression profiling of Cdkn2a+/+ and Cdkn2a−/− primary adipocytes. Related to Results section.
Data
List of peptides differentially phosphorylated in Cdkn2a+/+ and Cdkn2a−/− primary adipocytes. Related to Figure 4.
Data
List of transcripts differentially regulated in Cdkn2a+/+ and Cdkn2a−/− primary adipocytes identified by RNA-sequencing (download at https://drop-good.egid.fr/index.php/s/Pu8IB6dYCFR1N6T). Related to Results section.
Data
Oligonucleotides sequences used in this study.
Article
Full-text available
The molecular pathways underlying tau pathology–induced synaptic/cognitive deficits and neurodegeneration are poorly understood. One prevalent hypothesis is that hyperphosphorylation, misfolding, and fibrillization of tau impair synaptic plasticity and cause degeneration. However, tau pathology may also result in the loss of specific physiological...
Article
Full-text available
Excess nutrient supply and rapid weight gain during early life are risk factors for the development of obesity during adulthood. This metabolic malprogramming may be mediated by endocrine disturbances during critical periods of development. Ghrelin is a metabolic hormone secreted from the stomach that acts centrally to promote feeding behavior by b...
Article
Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased arachidonic acid and decreased DHA concentrations, is known to play a critical role in chronic inflam...
Article
In restrictive type anorexia nervosa (AN) patients, physical activity is usually associated with food restriction but its physiological consequences remain poorly characterized. In female mice, we evaluated the impact of voluntary physical activity with/without chronic food restriction on metabolic and endocrine parameters that might contribute to...
Article
Leptin secreted by adipocytes acts on the brain to reduce food intake by regulating neuronal activity in the mediobasal hypothalamus (MBH). Obesity is associated with resistance to high circulating leptin levels. Here, we demonstrate that peripherally administered leptin activates its receptor (LepR) in median eminence tanycytes followed by MBH neu...
Article
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. We previously showed that Perilipin 2 (Plin2), a member of lipid droplet protein family, is markedly increased in fatty liver, and its reduction in the liver of diet-induced obese mice by anti-sense oligonucleotide (ASO) decreased steatosis and enhanced insulin se...
Article
Full-text available
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that changes in growth and nutrition during childhood and adolescence can impair reproductive function. However, the precise biological mechanisms that under...
Chapter
Energy homeostasis requires a balance between food intake and energy expenditure. Neurons in the hypothalamus and brainstem detect signals from the gastrointestinal tract, adipose tissue, and other peripheral organs and integrate this information to provide appropriate responses to ensure energy balance. This chapter will examine the central neuron...
Article
Leptin plays a pivotal role in the regulation of energy homeostasis and neuroendocrine functions, and increasing evidence indicates that leptin acts on the brain to mediate many of these effects. Recent data have also suggested that leptin influences brain development during early postnatal life. Here we examined the distribution of cells that expr...
Article
Fertility is gated by nutrition and the availability of stored energy reserves. Thus, the adipocyte-derived hormone leptin appears to play a pivotal role in the onset and regulation of reproductive function. In addition to its direct action at the pituitary and gonad levels, recent data has defined a core circuitry in the hypothalamus that appears...

Projects

Project (1)