Emilia Barcia

Emilia Barcia
Complutense University of Madrid | UCM · Department of Pharmaceutics and Food Technology

Doctor of Pharmacy

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64
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855
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Publications

Publications (64)
Article
Full-text available
Objectives: The objectives of this study were to characterize the population pharmacokinetics of vancomycin in trauma patients and to propose dosing schemes to optimize therapy. Patients and methods: Trauma patients from Hospital Universitario Severo Ochoa (Spain) receiving intravenous vancomycin and routine therapeutic drug monitoring were incl...
Article
Objective: To evaluate the predictive performance of population pharmacokinetic models for piperacillin (PIP) available in the software MwPharm, TDMx and ID-ODs for initial dosing selection and therapeutic drug monitoring (TDM) purposes. Methods: This is a prospective observational study in adult patients with severe infections receiving PIP treatm...
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Inhalation therapy is gaining increasing attention for the delivery of drugs destined to treat respiratory disorders associated with cytokine storms, such as COVID-19. The pathogenesis of COVID-19 includes an inflammatory storm with the release of cytokines from macrophages, which may be treated with anti-inflammatory drugs as celecoxib (CXB). For...
Article
Neurodegenerative diseases are still a challenge for effective treatments. The high cost of approved drugs, severity of side effects, injection site pain, and restrictions on drug delivery to the Central Nervous System (CNS) can overshadow the management of these diseases. Due to the chronic and progressive evolution of neurodegenerative disorders...
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Full-text available
Objective The aim of this study was to characterize the population pharmacokinetics of amikacin in elderly patients by means of nonlinear mixed effects modelling and to propose initial dosing schemes to optimize therapy based on PK/PD targets. Method A total of 137 elderly patients from 65 to 94 years receiving intravenous amikacin and routine the...
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To date there is no cure for Parkinson’s disease (PD), a devastating neurodegenerative disorder with levodopa being the cornerstone of its treatment. In early PD, levodopa provides a smooth clinical response, but after long-term therapy many patients develop motor complications. Tolcapone (TC) is an effective adjunct in the treatment of PD but has...
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Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. To...
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Rheumatoid arthritis (RA) is a chronic inflammatory disease with sulfasalazine (SSZ) extensively used for long-term treatment of both juvenile and adult RA. Its use is associated with adverse effects and toxicity due to its non-selective biodistribution. Macrophages play an important role in inflammatory processes. In order to target SSZ to macroph...
Article
Background Morin flavonoid exerts neuroprotective effects with potential interest in neurodegenerative disorders. For this, the use of surface-modified polymeric nanoparticles loaded with morin is an interesting approach. Objective To develop and validate an HPLC method for the quantification of morin released from a new delivery system consisting...
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The World Health Organization has listed migraine as the sixth most disabling disorder globally and the most disabling of all neurological disorders. Flunarizine (FZ) is considered a first-line prophylactic treatment for migraine in several guidelines. For this purpose, treatment courses of 2-3 months are necessary and once proven effective, the co...
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Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and represents one of the leading causes of mortality worldwide due to multidrug-resistant TB (MDR-TB). In our work, a new formulation of biodegradable PLGA microparticles was developed for pulmonary administration of gatifloxacin, using a surface modifier agent to acti...
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Background and Objectives Uncertainty exists regarding the optimal dosing regimen for vancomycin in different patient populations, leading to a plethora of subgroup-specific pharmacokinetic models and derived dosing regimens. We aimed to investigate whether a single model for vancomycin could be developed based on a broad dataset covering the extre...
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A new drug delivery system is developed for ropinirole (RP) for the treatment of Parkinson’s disease (PD) consisting of biodegradable poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). The formulation selected was prepared with 8 mg RP and 50 mg PLGA 502. This formulation exhibited mean encapsulation efficiency of 74.8 ± 8.2%, mean particl...
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Pathophysiological changes involved on drug disposition in critically ill patients, should be considered on the dosing optimization of vancomycin administered by continuous infusion, and certain strategies must be applied to reach therapeutic targets on the first day of treatment. The aim of this study was to develop a population pharmacokinetic mo...
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Full-text available
Patricia Marcianes,1 Sofia Negro,1,2 Luis García-García,3 Consuelo Montejo,4 Emilia Barcia,1,2 Ana Fernández-Carballido1,2 1Department of Pharmaceutics, School of Pharmacy, University Complutense of Madrid, Madrid, Spain; 2Institute of Pharmaceutical Technology, University Complutense of Madrid, Madrid, Spain; 3Multidisciplinary Institute of Cerebr...
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In the present study, the influence of gamma-irradiation was evaluated on the physicochemical characteristics and in vitro release of rasagiline mesylate (RM), a selective MAO-B inhibitor used in Parkinson's disease, from poly(D,L-lactide-co-glycolide) (PLGA) microspheres. Microspheres were prepared using PLGA 50:50 by the solvent evaporation techn...
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A new controlled delivery system is developed for ropinirole (RP) for the treatment of Parkinson´s disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs are evaluated in SKN-AS cells after exposure to rotenone (20...
Article
A simple HPLC-UV method was developed and validated for the quantitation of RP free base encapsulated into two new multiparticulate systems (microparticles and nanoparticles), as well as for the quantification of RP hydrochloride when given as a loading dose together with the new delivery system developed. HPLC separation was achieved using a C18 K...
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The aim of this study is to characterize and validate the population pharmacokinetics of gentamicin in infants and to determine the influence of clinically relevant covariates to explain the inter- and intra-individual variability associated to this drug. Infants receiving IV gentamicin and with routine therapeutic drug monitoring were consecutivel...
Article
Treatment of malignant gliomas consists of resection followed by radiotherapy and chemotherapy. Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells. Two new delivery systems for CXB are developed: microspheres (MPs) f...
Article
To treat hypertension around 75% of patients will require combination therapy for which administration of lisinopril and indapamide could be of practical use. Lisinopril has a low oral bioavailability (around 25%) with large intersubject variability (6-60%), due to slow absorption. In order to improve drug permeability, encapsulation of the drugs w...
Article
In the present study, we have developed and validated an analytical method for the determination of meloxicam in liposomes using high-performance liquid chromatography-ultraviolet (HPLC-UV). Chromatographic separation was carried out on an Ascentis RP amide C16 column selecting a mobile phase composed of acetonitrile-0.3% formic acid solution (40:...
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Microencapsulation of rasagiline mesylate (RM) into PLGA microspheres was performed by method A (O/W emulsion) and method B (W/O/W double emulsion). The best formulation regarding process yield, encapsulation efficiency and in vitro drug release was that prepared with method A, which exhibited constant drug release for two weeks (K(0)=62.3μg/day/20...
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This is the first report on the efficacy of a new controlled release system developed for rasagiline mesylate (RM) in a rotenone-induced rat model of Parkinson's disease (PD). PLGA microspheres in vitro released RM at a constant rate of 62.3 μg/day for two weeks. Intraperitoneal injection of rotenone (2 mg/kg/day) to Wistar rats produced typical PD...
Article
We report the synthesis and characterization as well as cytotoxicity and biocompatibility studies of a poly(magnesium acrylate) hydrogel (PAMgA) developed for drug delivery applications. Two hydrogels with different mesh sizes, large and short, were synthesized (L-C PAMgA and S-C PAMgA). The hydrogels were characterized through swelling, FT-IR and...
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Clioquinol (CQ), a metal chelator, has gained renewed attention due to its ability to modulate metal homeostasis in neurodegenerative disorders such as Alzheimer's disease. To investigate the protective effects of a wide range of concentrations of CQ on two human neuroblastoma cell lines (IMR-32 and SKN-AS) and to develop and characterize a new con...
Article
Combination of drugs for subcutaneous infusion is common practice in palliative medicine, however, there is no information pertaining to the compatibility and stability of tramadol combined in ternary admixtures and no information exists regarding its clinical performance. Tramadol hydrochloride, haloperidol lactate, and hyoscine N-butyl bromide ha...
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Introduction: knowledge of the learning styles of Pharmacy students is an important tool that can be used to improve teaching thereby reinforcing the use of appropriate and transferable teaching strategies. For this, the use of the Technologies of Information and Communication (TIC) may facilitate the implementation of the European Space for Higher...
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Recent studies have shown that COX-2 inhibitors, such as meloxicam, have demonstrated promising results when used with chemotherapy. Based on these findings, this is the first study in which the antiproliferative effect of meloxicam is investigated on two prostate cancer cell lines (PC3 and DU-145). We have also evaluated if this antiproliferative...
Article
We tested the short- and long-term ability of polylactic-glycolic acid (PLGA) microspheres loaded with dexamethasone to reduce ocular inflammation in rabbits elicited by intravitreal lipopolysaccharide (LPS) injection. PLGA microspheres loaded with dexamethasone were prepared by the solvent evaporation technique from an oil/water emulsion and steri...
Article
In the present study, a reverse phase high performance liquid chromatographic method was developed and validated for the determination of rasagiline mesylate in biodegradable microspheres. Chromatographic separation was carried out on a RP-18 column using a mobile phase consisting of acetonitrile:water (5:95, v/v) adjusted at pH 3.1. Flow rate was...
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The incorporation of additives such as polyoxyethylated oleic acid glycerides (PEG-derivative) can modify the release of drugs from microparticles. PEG-derivative decreases the release rate of drugs that are dissolved in PLGA matrices but if un-dissolved the initial release rate slightly increases. To clarify this behaviour the influence of adding...
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Delivery of drug admixtures by continuous subcutaneous infusion is common practice in palliative medicine, but analytical confirmation of their compatibility and stability is not always available. To study the compatibility and stability of tramadol hydrochloride and dexamethasone sodium phosphate combined in solution and to report on its use in te...
Article
More than two-thirds of patients with metastatic cancer experience pain. Tramadol is one of the most interesting and useful weak opioids used by palliative care units to treat moderate to moderately severe pain. Relief of distressful symptoms in terminally ill patients is of prime importance; a common practice is to administer opioid analgesics in...
Article
Full-text available
To determine the pharmacokinetic parameters of gentamicin in a population of 200 premature newborns and to investigate the influence of several clinical and physiopathological covariates on the pharmacokinetics of the drug. To validate the pharmacokinetic analysis performed in another population of 50 premature newborns. A total of 200 premature ne...
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The goal of palliative care is the achievement of the best quality of life for patients and their families. For this, the administration of drugs by subcutaneous infusion is frequently used since many patients have great difficulties in taking drugs orally and regular intramuscular injections are painful. Usually, drugs are combined in infusion sol...
Article
The administration of drugs by subcutaneous infusion is routinely practiced in palliative medicine for the management of patients who are no longer able to take oral medication. It is common for two or more drugs to be combined in subcutaneous solutions. The combination of an opioid with other drugs (haloperiol lactate and hyoscine N-butyl bromide)...
Article
The aim of this study was to obtain biodegradable indomethacin microspheres for intra-articular administration in rheumatoid arthritis, where angiogenic processes are involved. Indomethacin concentrations to achieve an anti-angiogenic effect would be five-times higher than an anti-inflammatory. Microspheres were prepared by solvent evaporation usin...
Article
Terminally ill cancer patients commonly suffer from several symptoms at the same time, such as pain, nausea, anxiety, cognitive failure, bowel obstruction, and fatigue. To obtain optimal symptom control, the simultaneous administration of more than one drug by continuous subcutaneous (SC) infusion is often required. Tramadol is considered an effect...
Article
Drug interactions can be beneficial and valuable, but their consequences are usually adverse/undesirable, thus compromising the efficacy of drugs and enhancing their toxicity. Interactions can be divided into pharmaceutical incompatibilities, and pharmacokinetic and pharmacodynamic interactions. Unexpected drug responses can result from drug-excipi...
Article
The aim of this study was to determine the compatibility and stability of morphine hydrochloride and hyoscine-N-butyl bromide combined in solution at three different concentrations and stored in polypropylene syringes at 4 degrees C and 25 degrees C over a period of 15 days. The doses assayed were 20, 60 and 120 mg/day for morphine hydrochloride an...
Article
Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders where oral administration is not possible. In these circumstances, PRO can be administered in physiologic or glucose soluti...
Article
Human cytomegalovirus (HCMV) retinitis treated with frequent intraocular injections of ganciclovir is associated with complications such as endophthalmitis, retinal detachment and vitreous haemorrhage. Several formulations of biodegradable injectable PLGA microspheres with ganciclovir have been previously investigated as a possible alternative for...
Article
In this study we compare the oral bioavailability difference between sulphadiazine administered 1 h after an oral dose of guar gum, to the administration of the sulphonamide taken alone, by means of monitoring the drug and metabolite levels in urine up to 24 h. Twelve healthy volunteers received, in a two-way cross-over design, two treatments; trea...
Article
The administration of drugs by s.c. infusion is routinely practiced in palliative medicine for the management of patients who are no longer able to take oral medication. It is not uncommon for two or more drugs to be combined in s.c. infusion solutions. Unfortunately, the compatibility and stability of haloperidol and hyoscine- N-butyl bromide has...
Article
The objectives of this study were first to investigate the compatibility and physical stability of drug admixtures destined for s.c. administration through elastomeric infusion pumps to terminally ill cancer patients followed up at home by staff of the Palliative Care Unit (AECC), "La Paz" Hospital, Madrid and secondly, to evaluate the local side-e...
Article
The purpose of this work was to study the effect of storage time and temperature on the in vitro release kinetics of a commercial sustained-release dosage form of theophylline, at different pHs of the dissolution medium. The formulation was stored at 35 degrees C for 16 months and at 45 degrees C for 8 months, with a relative humidity of 60%. The i...
Article
In the majority of cases, drugs have to be chemically transformed that is, metabolised to more polar compounds before they can be excreted into the urine. The rate of drug metabolism may be affected by numerous factors such as age, gender, foreign and environmental factors, diet, other drugs, genetic and pathological factors... Independently of the...
Article
The main objectives of this work were to determine the effect of storage time, temperature and pH of the medium on the in vitro release kinetics and morphology of a commercial sustained-release dosage form of theophylline. The formulation was stored at 35°C for 16 months and at 45°C for 8 months. The in vitro release tests were performed at pH 2, 4...
Article
An intraocular biodegradable implant of ganciclovir was developed from poly(D,L-lactic-co-glycolide) of inherent viscosity 0.2 dl/g. Microspheres were prepared using a solvent evaporation technique from an o/o emulsion. The formulation was improved by adding fluorosilicone oil to the polymeric solution. The influence of two fluorosilicone oil visco...
Article
In this work, the swelling index is determined for various vegetable fibers (wheat bran. orange fibre and lemon fibre), and several granulated formulations to which different binding agents are added. The formulation that presents the highest swelling index (14.5 ml/g) was found to be composed of orange fibre, lemon fibre and pectin in a 1:1:1 prop...
Article
In this work a biopharmaceutic study is performed on two nitrafurantoin oral dosage forms which are commercialized in Spain : coated tablets (formulation A) and conventional tablets (formulation B). The in vitro dissolution tests are performed at different pH. The dissolution profiles corresponding to formulation Bare satisfactorily fitted to a fir...
Article
A comparative study is done on the swelling capacity of various vegetable fibres: orange fibre, lemon fibre and psyllium husk (USP 23) as well as two new granulated formulations: one prepared with orange fibre, lemon fibre and pectin (OF + LF + P) and the other, with psyllium husk and excipients (PS + E). To evaluate their swelling capacity the swe...
Article
Nowadays, dietary fibre represents the most adequate method for the prevention and treatment of functional constipation. Its laxative effect is due to the capacity of the fibre to retain water in its matrix structure. In this work, a study is carried out on the water-holding capacity of various individual vegetable fibres (wheat bran, orange and le...
Article
The present study describes the pharmacokinetic behaviour of a new dosage form of etodolac not available in the Spanish market: suppositories. Rectal administration was chosen as an alternative for the oral route. The dose used was 200 mg. The pharmacokinetic parameters of the drug are estimated by means of two possible methods i.e., model-independ...
Article
The study of the dissolution behaviour of guanyl-cysteine is presented. The drug was assayed as a pure non-formulated product and formulated in hard gelatine capsules. Aqueous solutions buffered at different pH were used as dissolution fluids. The dissolution rate constant of the drug in this formulation was estimated. Our results show that dissolu...
Article
A new method is presented for estimating the rate constants for the one-compartment open model with first-order absorption in a data-sparse environment. It is based on the principles of matrix algebra and system theory and requires only three to four plasma samples drawn at equal time intervals (a minimum of at least one sample in the absorption ph...

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