Emeline Mullier

Seenel Imaging

Across development, experience has a strong impact on the way we think and adapt. School experience affects academic and social-emotional outcomes, yet the extent to which pedagogy modulates underlying brain network development is still unknown. In this study, we compared brain network dynamics of students with different pedagogical backgrounds. Sp...

Connectome Mapper 3 (CMP3) is an open-source processing pipeline software, written in Python 3, for multi-scale multi-modal connectome mapping of the human brain. It provides researchers with a unique workflow, implemented in accordance with the Brain Imaging Data Structure (BIDS) App framework, that leverages a number of widely adopted software to...

Background Dysconnectivity has been consistently proposed as a major key mechanism in psychosis. Indeed, disruptions in large-scale structural and functional brain networks have been associated with psychotic symptoms. However, brain activity is largely constrained by underlying white matter pathways and the study of function-structure dependency,...

Autism Spectrum Disorders are accompanied by atypical brain activity and impairments in brain connectivity. In particular, dynamic functional connectivity approaches highlighted aberrant brain fluctuations at rest in individuals with autism compared to a group composed of typically developed individuals, matched in age and gender. However, the char...

Objective Epilepsy diagnosis can be difficult in the absence of interictal epileptic discharges (IED) on scalp EEG. We used high-density EEG to measure connectivity in large‐scale functional networks of patients with focal epilepsy (Temporal and Extratemporal Lobe Epilepsy, TLE and ETLE) and tested for network alterations during resting wakefulness...

Recently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Functional connectivity (FC) reflecting genuine functional relationships is impossible to disentangle...

Recently, EEG recording techniques and source analysis have improved, making it feasible to tap into fast network dynamics. Yet, analyzing whole-cortex EEG signals in source space is not standard, partly because EEG suffers from volume conduction: Functional connectivity (FC) reflecting genuine functional relationships is impossible to disentangle...

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying white matter networks in neurodevelopment is largely unknown. In this study, we focused on how t...

Background: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal...

Error monitoring allows us to adapt to an inherently dynamic environment. Error monitoring relies mainly on the anterior cingulate cortex (ACC). Its protracted maturation suggests a window for experience-dependent plasticity. To investigate this possibility, we measured error-related response-locked potentials components with morphometric magnetic...

Early in the course of psychosis, alterations in brain connectivity accompany the emergence of psychiatric symptoms and cognitive impairments, including processing speed. The clinical-staging model is a refined form of diagnosis that places the patient along a continuum of illness conditions, which allows stage-specific interventions with the poten...

The thalamus has a central role in the pathophysiology of schizophrenia. Formed by several nuclei, it is mainly constituted by partial volume (PV) of grey and white matter. We hypothesize that a PV segmentation will be better in measuring subtle changes in schizophrenia than total thalamus volume or local measurements that do not consider PV. We co...

Background In schizophrenic patients, increasing evidence suggests that oxidative stress is involved on the disease pathophysiology. Estimation of the level of glutathione (GSH), main actor of the brain redox dysregulation, has revealed a decreased GSH levels in early psychosis patients (EPP). N-Acetyl-Cysteine (NAC) is an antioxidant and precursor...