Emel Ergün

• Ankara University

Background Surfactant proteins A (SP-A) is integral components of the host defense system, known for their significant antimicrobial properties and diverse immunomodulatory functions, particularly within the lung alveolus. Although SP-A is expressed in the testis, its specific roles in testicular cells, especially in relation to spermatogenesis, re...

VEGF signaling has a crucial role in regulating the differentiation and proliferation of spermatogonial stem cells, as well as controlling vascular permeability in the epididymis. VEGF primarily exert their effects by binding to VEGFR-1, VEGFR-2, and VEGFR-3. The objective of this work was to assess the expression of VEGF, VEGFR-1, and VEGFR-2 in t...

The cell of Sertoli is a cell that initiates the development of testicular morphology and determines crucial parameters for spermatogenic function. The blood-testis barrier formed by Sertoli cells creates a unique microenvironment for developing spermatocytes that have exceeded into the adluminal compartment from the leptotene stage. It restricts t...

Calcium-binding proteins (CaBPs) have an essential role in male reproduction by modulating calcium ion metabolism. Although the brain and testis are structurally and functionally different, they show a high degree of transcriptomic and proteomic similarities. The purpose of the present study was to explore some CaBPs (Iba-1, Calbin-din, Calretinin...

Toll-like receptors take an essential part in innate immunity in response to invasion of the various harmful pathogens. We aimed to investigate TLR2, 7 and 8 expression in rat testis and epididymis throughout postnatal development. In the prepubertal period, TLR2 and 7 were variably localized to peritubular myoid cells, interstitial cells, blood ve...

Toll-like receptors take an essential part in innate immunity in response to invasion of the various harmful pathogens. We aimed to investigate TLR2, 7 and 8 expression in rat testis and epididymis throughout postnatal development. In the prepubertal period, TLR2 and 7 were variably localized to peritubular myoid cells, interstitial cells, blood ve...

Toll-like receptors (TLRs) belonging to pattern recognition receptors are involved in maintaining testicular and epididymal immune homeostasis. The purpose of the current study was to investigate TLR4 expression in rat testis and epididymis throughout postnatal development. Weak staining was detected in peritubular myoid cells and immature Sertoli...

Toll-like receptors (TLRs) family activated by endogenous host molecules or microbial components are pattern recognition receptors. Among all TLRs, TLR2 regulates intestinal inflammation, neuromuscular function, enteric nervous system structure, and neurochemical coding. In the present study, we aimed to investigate TLR2 expression on ovine ileum t...

Hibernation is characterized by marked suppression of renal function. Natriuretic peptides (NPs) are involved in the regulation of renal function. However, the role of NPs in the renal function during hibernation remains unclear. We aimed to investigate the distribution patterns of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) a...

Amaç: Bu çalışmada prenatal gelişim boyunca koyun ileumundaki kannabinoid reseptör 2 (CB2)'nin ekspresyonunu araştırmayı amaç-ladık. Gereç ve Yöntem: Çalışmamızda fötal yaşı 63 ile 147 gün arasın-da değişen 20 adet koyun fötüsünün ileum örnekleri kullanıldı. CB2 ekspresyonunu göstermek için Streptavidin-Biotin peroksidaz immunohistokimya yöntemin...

Anatolian ground squirrel (Spermophilus xanthoprymnus) is a true hibernator. This animal transiently reduces pulmonary function during hibernation. Continuance of pulmonary function is very important to survive ground squirrels during the hibernation. Natriuretic peptides may be key players in the modulation of pulmonary he-mostasis. However, NPs'...

Abstract: Oxidative stress interferes with oviduct functions including oocyte maturation, capacitation, fertilization, and embryo and gamete transport. This study aimed to determine activity of the antioxidants glutathione peroxidase (GPX-I), superoxide dismutase (SOD), and catalase (CAT) in bovine oviduct epithelial cells (BOEC) isolated from the...

Natriuretic peptide (NP) family is composed of atrial, brain and C‐type NP (NPPA, NPPB and NPPC). Here, we aimed to investigate NP expression in testis and epididymis during postnatal development. NPPA expression was observed in gonocytes at prepubertal period but in only spermatocytes in pachytene and leptotene/ zygotene stage at pubertal period....

The Anatolian ground squirrel ( Spermophilus xanthoprymnus ) is a typical example of true mammalian hibernators. In order to adapt to extreme external and internal environments during hibernation, they lower their body temperatures, heart rates and oxygen consumption; however, pathological events such as ischemia and ventricular fibrillation do not...

Galectins are a family of lectins-binding beta-galactosides involved in a variety of extracellular and intracellularprocesses, thereby contributing to homeostasis, cell adhesion, cellular turnover, and immunity. This study aimedto determine the localization and expression of galectin-1 (Gal-1) and galectin-3 (Gal-3) in the testis and epididymisof r...

The enteric nervous system (ENS) is a network of neurons and glia found in the gut wall and governs this gastrointestinal function independently from the central nervous system (CNS). ENS comprises the myenteric plexus (MP) and the submucous plexus (SP). In this study, we examined the expression profile of neurofilament heavy chain (NF-H), neuron-s...

The object of this study was to describe the prenatal development and histochemical properties of mucins in the sheep gastrointestinal tract. To determine changes in the mucin profile, the sections were stained with specific histochemical stains for carbohydrates. While neutral and mixed mucins were observed in the superficial epithelial cells of t...

Innate immunity constitutes the organism's first line of defense by initiating inflammatory response as well as phagocytosis to microbial attacks. This inflammatory response occurs as a consequence of induction of Pattern recognition receptors (PRR), which are germline-encoded in the organism. While PRRs primarily recognize microbial pathogen-assoc...

The largest pool of macrophages in the body is harboured by the intestinal mucosa. As the principal phagocytic component of the immune system, macrophages are essential for maintaining mucosal homeostasis as they prevent commensal bacteria from adhering to mucosal epithelial cells. This study provides a RAM11 immunohistochemical and electron micros...

Hibernation is an adaptive strategy to survive the winter under conditions of low ambient temperatures and limited or no food availability. The heart of hibernating Anatolian ground squirrels (Spermophilus xanthoprymnus) has the remarkable ability to fall to low temperatures without going into cardiac arrest. Natriuretic peptides possess potent nat...

Tis study aimed to determine the alpha-naphthyl acetate esterase (ANAE) activity of peripheral blood leukocytes in pregnant, kitten, and adult Angora cats. In each group 9 healthy pregnant, adult, and kitten Angora cats constituted the material of the study. Optimum reaction was achieved aſter a 3 h incubation period at pH 5.8, by ANAE staining. Tw...

In this study, 20 broilers were used to examine the effect of high-voltage electrical stimulation (HVES) on meat quality and the microstructure of the pectoralis muscle. After slaughter, carcasses were randomly distributed into 2 treatment groups (n = 10). In the first group, carcasses were electrically stimulated (500 V, 100 Hz) for 60 s. Carcasse...

The study was aimed to demonstrate the distribution, morphological and histochemical properties of BrunnerTs glands in the small intestine of the Angora rabbit. The duodenum of It) healthy animals of both sexes constituted the material of the study. The glands were composed of acini densely packed within the submucosa. The Brunner's glands containe...

The present study was undertaken to determine the morphology, histochemical properties, localization and quantitative distribution of Paneth cells in the small intestine of the Angora rabbit. Tissue samples taken from the duodenum,jejunum and ileum of 10 healthy adult Angora rabbits, obtained from private breeders, constituted the material of the s...

In this study, the exocrine pancreas of the Angora rabbits was examined by light and electron microscopical methods. Pancreas samples taken from rabbits were fixed in bouin and gluteraldehyde-paraformaldehyde solutions. Then, these tissues processed by histological methods were embedded in araldite M and paraphlast. In the light and electron micros...

The present study was undertaken to determine the morphology, histochemical properties, localization and quantitative distribution of Paneth cells in the small intestine of the Angora rabbit. Tissue samples taken from the duodenum. jejunum and ileum of 10 healthy Angora rabbits, obtained from private breeders, constituted the material of the study....

The present study was undertaken to investigate the histochemical properties and light and electron microscopic morphology of the oviduct of laying Pekin ducks and Pekin ducks in the quiescent phase of the reproductive Cycle. The oviducts of five healthy, two-year-old adult laying Pekin ducks and five five-month-old Pekin ducks in the quiescent pha...

This study was conducted with the objective of determining the staining properties and light and electron microscopic appearance of the corpus luteum during pregnancy and normal cyclic periods. The samples taken from the corpus luteum of 8 pregnant and 12 non-pregnant cows were used as materials in this study. The corpus luteum was found to be comp...

The present investigation was undertaken to assess the effects of aflatoxin (AF) on the exocrine pancreas in quails by means of light and electron microscopy. A total of 30 quails were divided into three groups, each composed of ten animals. Total AF was incorporated into the diet of these groups, at doses of 0, 2.5, and 5.0 mg of AF/kg feed, ppm,...

This study was conducted on cows in the estrual and luteal phases of the cycle to determine the staining properties, light and electron microscopic appearance and numerical distribution of mast cells from various areas of the ovary. The material for the study comprised ovarian specimen taken from 14 cows, 7 in the luteal phase and 7 in the estrual...

This study was carried out under both light and electron microscopy to investigate the effects on liver carbohydrate and lipid metabolism caused by aflatoxin (AF) fed to chicks. Twenty broiler chicks were used. The birds were housed in electrically heated battery cages and exposed to light for 24 h. Feed and water were provided ad libitum. The anim...

This study was conducted with the aim of examining the location, the morphology, and numerical distribution of mast cells in the different areas of the healthy adult dog skin. Skin samples taken from the cheek, pinna, thorax and thigh areas of 10 healthy dogs were used as the study material. The results show the existence of mast cell heterogeneity...

This study was carried out to investigate light and electron microscopic appearances and locations of the globule leukocytes in the small intestine of the sheep. In this study, the tissue samples taken from small intestine of 20 adult sheep were used as material. They are characterized by large eosinophilic globules, variable in number, size, shape...

This study was aimed at determining the alpha naphthyl acetate (ANAE) activity of T lymphocytes and the ratio of T lymphocytes in the peripheral blood leukocytes of healthy adult turkeys. Material for the study was obtained from blood samples of 20 adult American bronz breed turkeys. In the ANAE staining 51.8±0.62% of the lymphocytes were found to...

In this study, it has been aimed to modify the method to be used for the examination of synaptonemal complex between homolog chromo- somes at the pakiten stage of meiotic division in bull primary spermatocytes. Chromosome aberations have not been observed in metaphase stages in four bulls which were examined by modified micro spreading method of Co...