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Emanuele Crocetti

Emanuele Crocetti
www.emanuelecrocetti.com

www.emanuelecrocetti.com, MD, PhD (Epidemiology&Public Health)
Consultant epidemiologist

About

412
Publications
41,393
Reads
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13,050
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Introduction
www.emanuelecrocetti.com (for further details) June 2017- Consultant epidemiologist June 2015 - May 2017 epidemiologist at the European Commission JRC 1993-2015 Epidemiologist at ISPO Florence (I)- Director Tuscany Cancer Registry - 2013-6 President Italian Network of Cancer Registries 2016- President GRELL www.grell-network.org Steering committee ENCR 2020 PhD (Epidemiology&Public Health) 2001 specialist Medical Statistics 1990 specialist Public Health 1986 MD
Additional affiliations
June 2017 - present
Epidemiology Consultant
Position
  • Epidemiologist
June 2015 - May 2017
JRC - Institute for Health and Citizen Protection
Position
  • GH 40
February 1993 - May 2015
Istituto per lo Studio e la Prevenzione Oncologica (ISPO)
Position
  • Senior Epidemiologist
Education
September 2017 - June 2020
University College Cork
Field of study
  • Epidemiology&Public Health
July 2017 - July 2017
British Council Milan
Field of study
  • IELTS, band 7
September 1986 - July 2001
University of Pavia
Field of study
  • Statistics

Publications

Publications (412)
Article
Full-text available
Background: The objectives of this study were to quantitatively assess the geographic heterogeneity of cancer prevalence in selected Western Countries and to explore the associations between its determinants. Methods: For 20 cancer sites, 5-year cancer prevalence, incidence, and survival were observed and age standardised for the mid 2000s in the...
Article
Full-text available
Due to changes in cancer-related risk factors, improvements in diagnostic procedures and treatments, and the aging of the population, in most developed countries cancer accounts for an increasing proportion of health care expenditures. The analysis of cancer-related costs is a topic of several economic and epidemiological studies and represents a r...
Article
Formal indicators for the evaluation of the quality of melanoma care are needed. We identified 13 process indicators, which encompassed early diagnosis, pathology reporting and surgical treatment. We evaluated the adherence to these indicators using a population-based series on incident skin melanomas (only primary melanomas) for the year 2004 (687...
Article
Purpose: Diabetes is associated with increased risk of developing colorectal cancer (CRC), but its effect on overall and cancer-specific mortality in CRC patients has been little investigated. The aim of this study was to assess the influence of diabetes on overall and cancer-specific mortality in Italian CRC patients. Methods: Cases of adult (≥...
Technical Report
Full-text available
Objectives Revision of the priority list for incidence date to incorporate modern diagnostic methods, including but not limited to flow cytometry, molecular testing, screening tests and new radiological/imaging techniques. The revision should not preclude comparison of survival estimates with tumours registered using the existing priority list, to...
Article
Background: We determined the relative contribution of decreased tumour thickness to the favourable trend in survival from cutaneous malignant melanoma (CMM) in Italy. Methods: Eleven local cancer registries covering a population of 8 056 608 (13.4% of the Italian population in 2010) provided the records of primary CMM cases registered between 2...
Technical Report
Full-text available
https://www.ars.toscana.it/2-articoli/4707-geotermia-e-salute-in-toscana-presentato-il-rapporto-2021-di-ars.html In Italia la produzione di energia elettrica da fonte geotermica è interamente concentrata in Toscana, dove si raggiunge una capacità installata globale di più di 900 MW, pari a circa il 34% del fabbisogno elettrico regionale. Fu propri...
Article
Full-text available
Variation in cancer incidence between countries and groups of countries has been well studied. However cancer incidence is linked to risk factors that may vary within countries, and may subsist in localized geographic areas. In this study we investigated between- and withincountry variation in the incidence of all cancers combined for countries bel...
Chapter
With over one million new cases (n = 1,033,701) and 782,685 deaths in 2018, gastric cancer (GC) ranks fifth for incidence and third for mortality among cancers worldwide. Most cancers have sporadic origin (90%) while a small proportion (10%) show a family component or hereditary syndromes. GC arises, in most cases, from the interaction of genetic a...
Article
interpretation of the effect of multiple variables is not straightforward. Classification and Regression Trees Analysis (CART), which allows a more friendly data evaluation, could be a valid integration of the message from Cox model. METHODS: The CART algorithm splits up data, creating a “tree” of groups of patients with different profiles for the...
Article
Full-text available
Background: New oral anticoagulant agents (NOACs) are valid alternatives for vitamin K antagonists (VKA) in patients with non-valvular atrial fibrillation (NVAF) for stroke prevention. In clinical practice, NOACs users may differ from patients enrolled in clinical trials in age or comorbidities, and thus it is a critical issue to evaluate the effe...
Article
Full-text available
Abstract: Variation in cancer incidence between countries and groups of countries has been well studied. However cancer incidence is linked to risk factors that may vary within ountries, and may subsist in localized geographic areas. In this study we investigated between- and within country variation in the incidence of all cancers combined for cou...
Article
Full-text available
Background The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC. Methods We analyzed two population-based cohorts of individuals with TC or other neoplasms diagnosed between...
Article
The study presented in this article aims at investigating the clinical usefulness of a novel test, called T-PEC, for the diagnosis of Developmental Language Disorder in Italian preschool children. The instrument exploits the production of clitic pronouns, in particular third person direct object clitics (3PDO-CL), as a clinical marker for the disor...
Presentation
Full-text available
Abstract: Aims: The number of patients living after a cancer diagnosis is increasing, especially after thyroid cancer (TC). This study aims at evaluating both the risk of a second primary cancer (SPC) in TC patients and the risk of TC as a SPC. Methods: Two population-based cohorts of cancer patients aged up to 84 years were identified from 28 Ita...
Presentation
Full-text available
Abstract: Objectives: Survival from cutaneous malignant melanoma (CMM) has increased for years in most western countries. So far, this has commonly been attributed to a trend towards lower Breslow tumour thickness. This study aimed to determine the relative role that the improvement in tumour thickness has played in the favourable trend in survival...
Article
Full-text available
Objective: A reliable measure of the burden of inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are essential to monitor their epidemiology and plan appropriate health services. Methods: This is a population-based study carried out in the Milan Agency for Health Protection. Incident and prevalent cases were i...
Article
Full-text available
This corrects the article DOI: 10.23736/S0392-0488.17.05584-5.
Article
Background: Few studies have estimated the probability of being cured for cancer patients. This study aims to estimate population-based indicators of cancer cure in Europe by type, sex, age and period. Methods: 7.2 million cancer patients (42 population-based cancer registries in 17 European countries) diagnosed at ages 15-74 years in 1990-2007 wi...
Article
Background: Few studies have estimated the probability of being cured for cancer patients. This study aims to estimate population-based indicators of cancer cure in Europe by type, sex, age and period. Methods: 7.2 million cancer patients (42 population-based cancer registries in 17 European countries) diagnosed at ages 15-74 years in 1990-2007 wit...
Article
In Oceania, North America and north‐western Europe, after decades of increase, cutaneous malignant melanoma rates began to stabilise or decline before 2000. Anecdotal evidence suggests that the reversal of the incidence trend is extending to southern Europe. In order to obtain a formal confirmation, this nationwide study from Italy investigated the...
Thesis
Full-text available
Introduction The activity of cancer registries represents a multistep process that starts by gathering information from a variety of sources. Such information is checked, linked, enriched and handled to produce high-quality original data capable of being informative enough to prove useful in answering specific epidemiological and clinical questions...
Article
Full-text available
Introduction: Chronic infections and infestations represent one of the leading causes of cancer. Eleven agents have been categorized by the International Agency for Research on Cancer (IARC) in Group 1, 3 in Group 2A and 4 in Group 2B. We previously estimated that the incidence of cancers associated with infectious agents accounted for the 8.5% of...
Article
Background: An increased risk of death by suicide in cancer patients has been documented since decades. We evaluated the risk of death by suicide in an Italian population-based cancer case series and added the results to a systematic review and meta-analysis of the literature. Methods: The Italian series, including 127,042 primary cancer patient...
Article
Cancer registries (CRs) produce original and reliable data on cancer frequency and prognosis, document individual clinical paths, and represent a privileged real-world setting for quality of care and effectiveness evaluation. To reach their aim, CRs use many sources of information (hospital discharge notes, pathology reports, death certificates, an...
Presentation
Full-text available
Epidemiologia del melanoma: stato dell'arte e prospettive
Article
Background The basic scope of population-based cancer registries (CRs) is to collect data that enable computation of cancer incidence. In addition to this, nowadays most registries can provide more extensive information such as data on stage and treatment, which could be used to assess and compare different care pathways. The current analysis repor...
Article
Full-text available
EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...
Article
The prolonged use of drugs such as beta-blockers, acetylsalicylic acid, omeprazole, statins, oral contraceptives and hormone replacement therapy might have some role in melanocytic nevi development and be ultimately linked to melanoma risk. Aims of the study were to evaluate a possible association between the above-mentioned drugs and features such...
Article
Nel 2008 è pervenuta alla direzione aziendale (DA) della ASL 11 di Empoli (oggi Azienda Usl Toscana Centro) la segnalazione da parte di alcuni MMG di una inusuale mortalità per leucemie tra i loro assistiti in un comune. La Direzione aziendale della ASL ha quindi deciso di effettuare un approfondimento epidemiologico formalizzando la costituzione d...
Article
In the past two decades, the treatment landscape for patients with metastatic renal cell carcinoma has significantly changed thanks to the approval of several targeted molecular therapies (VEGF and mTOR inhibitors) and recently immune-checkpoint inhibitors. The Italian Association of Medical Oncology (AIOM) Renal Cell Cancer (RCC) Guidelines Panel...
Article
In 2008, some general practitioners (GPs) in the area of Empoli (Tuscany Region, Central Italy), reported to the Local Health Authority (LHA), an unusually high frequency of leukemia deaths among their patients residing in a one of the municipalities of the area. The LHA decided to carry out an epidemiological investigation. An interdepartmental wo...
Article
Full-text available
Background: Increasing evidence of cure for some neoplasms has emerged in recent years. The study aimed to estimate population-based indicators of cancer cure. Methods: Information on more than half a million cancer patients aged 15-74 years collected by population-based Italian cancer registries and mixture cure models were used to estimate the...
Article
BACKGROUND: Prognostic factors in cutaneous melanoma are commonly evaluated by the Cox proportional hazard model. However, the interpretation of the effect of multiple variables is not straightforward. Classification and Regression Trees Analysis (CART), which allows a more friendly data evaluation, could be a valid integration of the message from...
Presentation
Full-text available
Recent evidence in melanoma and trends
Article
Objectives: Prognostic definition and treatment of breast cancer are supported by multigene testing. A recent trial (TAILORx) provided evidence against the use of adjuvant chemotherapy in early breast cancer (HR+ HER2-) with an intermediate result (11-25) in a multigene test (Oncotype DX). These results consequently fueled great discussion among o...
Article
http://www.toscanamedica.org/87-toscana-medica/qualita-e-professione/836-i-numeri-del-cancro-in-toscana-2018
Article
Abstract Background: Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factor...
Article
Full-text available
Background: Breast cancer is the most common cancer and the leading cause of cancer-related death in females, with a large societal and economic impact. Decisions regarding its treatment are largely affected by the categorization into different subtypes with hormone receptor status and HER2 status being the most important predictive factors. Other...
Article
Background: the employment relationship with a public health service foresees a remuneration that in many cases is the main income, it takes place within a hierarchical structure, whose top management is nominated by politics. Therefore, objectives and priorities can change according to the prevailing policy. Objectives: to verify the existence...
Article
Objective To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy. Methods Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates,...
Presentation
Full-text available
The development and diffusion of automation puts at risk traditional cancer registries but it also offers the opportunity to exploit their potentialities. It seems necessary to redefine some cornerstones of our activity to be part of the ongoing change and to sharing our wealth of knowledge on data and their interpretation.
Poster
Full-text available
Il Disturbo del Linguaggio (DL) è il disturbo del neurosviluppo più frequente in età evolutiva: colpisce circa 5-7% dei bambini in età prescolare, riducendo la sua incidenza all’1-2% in età scolare [Lindsay & Strand, 2016]; può ledere aspetti diversi dell’elaborazione del linguaggio (fonologia, morfosintassi, sintassi, semantica lessicale e frasale...
Chapter
Full-text available
https://www.aiom.it/wp-content/uploads/0208/11/2018_carcinoma_mammella.pdf
Article
After a long-term increase, the incidence of cutaneous malignant melanoma has stabilized recently or even decreased in several populations of North-western Europe, USA, Canada, Australia and New Zealand, but not in southern Europe. The incidence trends of primary invasive cutaneous malignant melanoma (International Classification of Diseases, 10th...
Article
The aim was to evaluate changes in skin melanoma incidence and mortality at a population level in central Italy over the past two decades. Skin melanoma incidence rate from 1994 to 2014, were retrieved from the Umbrian Cancer Registry (about 900 000 inhabitants). Changes from 1994–1999 to 2010–2014 in tumour and patient characteristics– sex, age (0...
Presentation
Full-text available
Article
Background The 8th edition of TNM has introduced new rules for staging cutaneous melanoma. Objective To compare TNM 7th and 8th editions in defining pathological stages of melanoma. Methods A population‐based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003‐2012 has been used to measure the agreement (with Co...
Presentation
Full-text available
Effects of automation on cancer registries's future
Book
Full-text available
https://www.aiom.it/wp-content/uploads/2018/10/2018_NumeriCancro-operatori.pdf
Article
Una sessione del recente Convegno dell’Associazione italiana di epidemiologia tenutosi a Mantova ha affrontato la questione del conflitto d’interesse. Nella discussione ho fatto notare come nessuno dei relatori delle molte relazioni presentate in precedenza avesse dichiarato di avere conflitti d’interesse, pur lavorando (come dipendenti o precari)...
Article
Purpose: Breast is the leading site of cancer onset and death in Italy. Cases diagnosed in stage IV or that progress in metastatic phase represent a specific and challenging task for oncologists. Estimates on the burden of breast cancer (BC) in stage IV in Italy are not available. Methods: We applied mortality-incidence age-specific ratios measure...
Presentation
Full-text available
Il ruolo del disegno dello studio nella ricerca scientifica
Article
full-text view-only version: https://www.nature.com/articles/ajg2016172.epdf?author_access_token=9X5NxlqlQGvj2aeFglWME9RgN0jAjWel9jnR3ZoTv0P8bTHB53po23LnoSSf9MHaRnB8qfXIqGHZf2IQnNXCbeu2InwtnQcZ0mzmoA9aLLRa9ybGymc7goGSZhCL0JMx
Presentation
Full-text available
IL BURDEN DELLA MALATTIA ONCOLOGICA: prospettive e sostenibilità
Article
Purpose of the study: The usefulness of sentinel lymph node biopsy in thick melanomas is debated. The aim of this study was to evaluate the possible prognostic significance of sentinel lymph node biopsy in T4 melanoma patients and to verify whether this was a homogeneous group of patients with similar poor behavior. Materials and Methods: A retrosp...
Presentation
Full-text available
IL BURDEN DELLA MALATTIA ONCOLOGICA: prospettive e sostenibilità