Emanuel Vamanu

Emanuel Vamanu
University of Agricultural Sciences and Veterinary Medicine of Bucharest | USAMV Bucuresti · Faculty of Biotechnology

Professor
Bioavailability and bioactivity (in vivo studies) of functional compounds. Microbiota modulation - in vitro studies

About

150
Publications
31,830
Reads
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1,132
Citations
Introduction
Microbiota restoration and modulation by functional products. In vitro bladder system and phenolic compounds to prevent urinary microbial infections. Probiotic yeasts as in vivo tool for antioxidant and cytotoxic effects evaluation.
Additional affiliations
March 2016 - present
University of Agricultural Sciences and Veterinary Medicine
Position
  • Professor (Associate)
October 2006 - March 2016
University of Agricultural Sciences and Veterinary Medicine of Bucharest
Position
  • Professor (Assistant)
October 1999 - March 2006
University of Agronomical Sciences and Veterinary Medicine
Position
  • Professor
Description
  • I am one of the founding members of Biotehnol Center Bucharest. The areas of competence are related to the domains of microbial biotechnologies, fermentation technologies and functional products obtaining.

Publications

Publications (150)
Article
Full-text available
Postbiotics are non-viable probiotic preparations that confer a health benefit on the host. In the last years, scientific literature has proved that postbiotics have health-promoting features and technological advantages compared to probiotics, augmenting their full potential application in the food and pharmaceutical industries. The current work c...
Article
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Cancer is defined as a multifactorial disease because it exhibits the continuous proliferation of malignant cells. It is one of the principal causes of death worldwide, with breast cancer occurrence being the highest among women and lung cancer being the highest among men. Hydroxyflavanones come under the category of flavonones and are further clas...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronavirus (HCoV) that has created a pandemic situation worldwide as COVID-19. This virus can invade human cells via angiotensin-converting enzyme 2 (ACE2) receptor-based mechanisms, affecting the human respiratory tract. However, several reports of neurological symptoms sugge...
Article
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Natural antioxidants derived from plants have been proven to have significant inhibitory effects on the free radicals of living organisms during actively metabolization. Excessive production of free radicals increases the risk of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and motor sclerosis. This study aimed to c...
Article
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Disposable personal care products are part of modern life, but these products could become a biological hazard in case of improper disposal. Therefore, our study compared the biodeterioration of plant-based woven materials (cotton, linen), animal materials (wool, leather), disposable hygiene products with cellulose fibers (sanitary pads, cosmetic p...
Book
Full-text available
The study of bioactive compounds represents a new and innovative section of biotech�nology, with applications to the well-being of humans. The therapeutic potential of natural health products could be demonstrated by in vitro and/or in vivo biological activities, because the primary aim is to prevent or alleviate different chronic/degenerative dise...
Article
Full-text available
The study of bioactive compounds represents a new and innovative section of biotechnology, with applications to the well-being of humans. The therapeutic potential of natural health products could be demonstrated by in vitro and/or in vivo biological activities, because the primary aim is to prevent or alleviate different chronic/degenerative disea...
Article
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Urinary tract infections (UTI) represent one of the most widespread infections, and frequent recurrent episodes, induced mostly by uropathogenic Escherichia coli, make them increasingly difficult to treat. Long-term antibiotic therapy is an effective approach to treat recurrent UTI but generates adverse effects, including the emergence of pathogeni...
Article
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Banana peel, a little-used waste, contains a high amount of biologically active compounds. The aim of the study is to demonstrate in vitro, the antioxidant, cytotoxic, and antimicrobial effects of hydroalcoholic extracts from yellow (BP) and red (BPR) banana peels. The analysis of the extracts by Capillary Zone Electrophoresis (CZE) has confirmed t...
Article
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Autophagy is an important cellular self-digestion and recycling pathway that helps in maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and endolysosomal pathway has been reported in several neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington disease (HD) and is cit...
Article
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Aquiring the recommended daily allowance of vitamins is crucial for maintaining homeo�static balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abno...
Article
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Inonotus obliquus, a parasite of the birch tree, is also a well-known medicinal mushroom. Its sterile conk is highly sought for its bioactive compounds such as phenols, polysaccharides, triterpenoids, and steroids. It was traditionally used to treat various gastrointestinal diseases, viral and parasitic infections, to counteract the progression of...
Article
Background Polyhydroxyalkanoates (PHAs) are bacteria-synthetized biopolymers under unbalanced growth conditions. These biopolymers are considered potential biomaterials for future applications for their biocompatibility and biodegradable features and potential biomaterials for future applications for their biocompatibility and biodegradable charact...
Article
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Current research in medicine in several parts of the world has attempted to establish a link between the occurrence of neurodegenerative pathologies, microbiota dysbiosis, and the incidence of obesity. The body’s response to different physicochemical factors has also been influenced by the proper assimilation of bioactive compounds contained in the...
Article
Full-text available
This scientific research focused on the production of hydroethanolic extract of the plant species Lycopodium selago L. (L. selago) by the ultrasound-assisted extraction (USAE) and the identification of biocompounds with high antioxidant activity is of interest for possible phytotherapeutic treatment against Alzheimer’s disease (AD). The extract was...
Article
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Hericium erinaceus (H. erinaceus) is a rare and appreciated fungal species belonging to the division Basidiomycota used for centuries in traditional Chinese medicine for its medicinal value. This species of mushrooms brings the most diverse benefits for the human body, and can have beneficial effects for treating Alzheimer's disease (AD). This stud...
Article
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Edible mushrooms are functional foods and valuable but less exploited sources of biologically active compounds. Herbal teas are a range of products widely used due to the therapeutic properties that have been demonstrated by traditional medicine and a supplement in conventional therapies. Their interaction with the human microbiota is an aspect tha...
Article
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Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal re...
Conference Paper
Plants are a valuable source of secondary metabolites, which due to their biological activity, are widely used in various industries, such as cosmetology, pharmaceutical, and food. For this purpose, the plants from the flora of Romania are collected. We can say that both in vivo and in vitro plant culture remains a world ar research topic. The rese...
Article
Full-text available
Bioactive compounds and phenolic compounds are viable alternatives to antibiotics in recurrent urinary tract infections. This study aimed to use a natural functional product, based on the bioactive compounds’ composition, to inhibit the uropathogenic strains of Escherichia coli. E. coli ATCC 25922 was used to characterize the IVCM (new in vitro cat...
Article
Full-text available
Submerged culturing of mycelium is an efficient technique used to increase biomass yields, more so when employed with naturally slow-growing species of mushrooms. This paper is concerned with optimizing nutrient broth components used in Inonotus obliquus cultures for achieving high biomass yields. We modeled the effect of seven biotechnological par...
Article
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The effect of stevioside on human health is still insufficiently highlighted by recent research. The total or partial replacement of sugar with sweeteners influences the general state of health, especially the human microbiota’s response as a determining factor in the onset of type 2 diabetes. The present study aimed to present the long-term (one-y...
Article
Full-text available
Neurodegenerative diseases (NDs) represent a common neurological pathology that determines a progressive deterioration of the brain or the nervous system. For treating NDs, comprehensive and alternative medicines have attracted scientific researchers' attention recently. Edible mushrooms are essential for preventing several age-based neuronal dysfu...
Article
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Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limita...
Book
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Agricultura biologică are la bază o cunoaştere în detaliu a sistemelor de producţie care valorifică la maximum resursele locale și nutriționale din sol. Unul dintre principiile agriculturii biologice este menţinerea şi sporirea fertilităţii solului prin intensificarea activităţii microbiologice a acestuia. Acest domeniu are ca scop reducerea riscur...
Article
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Coffee grounds are a valuable source of bioactive compounds. In Romania, most of the amount obtained is lost through non-recovery; the rest is occasionally used as organic fertilizer. The coffee grounds were selected according to the roasting degree: blonde roasted (BR), medium roasted (MR), and dark roasted (DR). The study aimed to evaluate three...
Cover Page
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REVISTA DE CHIMIE Cite as: Rev. Chim. https://doi.org/10.37358/Rev.Chim.1949 OSIM Nr. R102355 ISSN Print 0034-7752 ISSN Online 2668-8212 Journal Metrics * Impact Factor 2019: 1.755 * 5-Year IF: 1.351 * CiteScore: 2.2 * H index: 28 (InCites Journal Citation Reports) Revista de Chimie REVISTA DE CHIMIE Revista de Chimie is internationally rec...
Article
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The expression of bioactivity depends on the assimilation of different classes of natural substances (e.g., phenolic compounds) in vivo. Six functional extracts (Aspalathus linearis, leaves; Paullinia cupana, seeds; Aristotelia chilensis, berries; Ilex paraguariensis, leaves; Syzygium aromaticum, cloves, and wild berries) were analyzed in vitro and...
Article
Full-text available
Infections with Escherichia (E.) coli is an important problem in clinical practice. Finding natural, non-toxic ways to prevent infections or control the proliferation of these strains is a current topic. The purpose of this study was the antioxidant analysis and the inhibition of E. coli multiplication of the extract of four species of common edibl...
Conference Paper
Full-text available
Natural ingredients have been used for skin care since centuries. Nowadays, they are becoming increasingly popular in specific products due to consumers' concerns about the toxic action of chemical compounds. As a result, there has been a high demand for the use of natural ingredients in cosmetics. The main benefits of the use of herbal extracts in...
Article
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Numerous studies have demonstrated the role of the microbiota in supporting the physiological functions, owing to its metabolomic component. The presence of biocomponents generally leads to the correction of the microbial pattern correlated with the reduction of oxidative pressure. This study aims to present the main processes that correlate the bi...
Thesis
Human skin pigmentation is a complex process, and solar radiation is known to be the main factor for this. The majority of known effects of solar exposure of the skin are tied to UV radiations, it refers to inducing skin cancer. Blue light, part of the visible light, represents almost half of the solar spectrum, and its effects on the skin are stil...
Conference Paper
Full-text available
Objective Early prevention of obesity is based on a clear understanding of the role that the intestinal microbiota plays in the development of this pathology. Diet is important in the evolution of microbiota, but the health effects are also important in disease management and interactions with associated pathologies. This study, therefore, is aimed...
Article
Full-text available
In recent years, there has been significant interest in the reduction of health risks due to diseases caused by oxidative stress. Many plants contain compounds that mitigate such decay, and there are many studies that attempt to increase the availability of these phytochemicals using gamma radiation. This paper reviews 14 such studies, in attempt t...
Article
Full-text available
Non-nutritive sweeteners represent an ingredient class that directly affects human health, via the development of inflammatory processes that promote chronic diseases related to microbiota dysbiosis. Several in vitro tests were conducted in the static GIS1 simulator. The aim of the study was to highlight the effect of sweeteners on the microbiota p...
Conference Paper
Full-text available
I. obliquus, known as the Chaga mushroom, is regarded as excellent source of many therapeutic compounds such as Triterpenes (including Betulinic Acid, Lanosterol-type Triterpenes), Beta Glucans, Polysaccharides, Tripeptides, Sterols, and many other phytonutrients. Chaga mushrooms are a good source of antioxidants, like superoxide dismutase (SOD) wh...
Conference Paper
Full-text available
In recent years, there has been significant interest in the reduction of health risks due to diseases caused by oxidative stress. Many plants contain compounds which mitigate such decay, and there are many studies which attempt to increase the availability of these phytochemicals using gamma radiation. This paper reviews 14 such studies, in attempt...
Article
Full-text available
The multiple causes of cardiovascular diseases signify a major incidence and developmental risk of this pathology. One of the processes accountable for this pathologic development is the instauration of dysbiosis and its connection with an inflammatory process. Low antioxidant colonic protection encourages the progression of inflammation, with card...
Article
Full-text available
Due to their direct relationship with the activity of the gut microbiota, nutraceuticals are, at present, an effective alternative for the mitigation and alleviation of the dysfunctions governed by oxidative stress. The escalation in the number of the target group patients (diabetes, cardiovascular dysfunction, cancer, etc.) has spurred the quest f...
Method
Full-text available
The purpose of the research was to identify the in vivo protection of the Matcha tea hydroalcoholic extract to oxidative stress by using S. boulardii probiotic yeast as a biological model. The research was based on identifying the critical point of resistance to action of hydrogen peroxide on viability, correlated with phenolic level and antioxidan...
Article
Full-text available
Inonotus obliquus (chaga) is a birch phytoparasitic mushroom with an irregular shape that represents dark-colored mycelial agglomeration. It has a high pharmaceutical value because of its rich content in bioactive compounds, polysaccharides, phenols, or triterpene (betulin, for example). The purpose of this study was to determine the composition of...
Article
Full-text available
The purpose of the present study was to assess the antioxidant effect, antibiofilm activity, and partial characterization of the main groups of bioactive compounds of mushrooms, under the influence of the composition of the relevant culture environment and different fermentation parameters of the Pleurotus (P.) ferulae mushroom mycelium. One used f...
Article
Full-text available
Background: Two pathologies commonly associated with gut microbiota dysbiosis are type 2 diabetes and cardiovascular diseases. A disturbance in microbial balance translates into the occurrence of degenerative dysfunctions that are also associated with other pathologies, such as obesity, colon cancer. Methods: Thus, the aim of this review was to...
Conference Paper
Full-text available
Introduction: The microbiota fingerprint of cardiovascular target group is characterized by a specific pattern. Compared with the normal group, the decrease of favorable strains may be associated to a development of cardiovascular risk [1]. The major bioactive compound from Curcuma longa, curcumin, represents a natural protector in inflammatory pro...
Article
Full-text available
This study presents the effect of two new products based on atomized extracts from edible wild mushrooms (RoBioMush1, RoBioMush2) on the microbiota of three target groups: clinically healthy (NG) individuals, individuals with nutritional disorders (ND), and individuals with cardiovascular diseases (CVD). The microbiota fingerprints were determined...
Conference Paper
Full-text available
Fermentation is a facile process for obtaining natural products with therapeutic properties, especially used to inhibit the high rate of oxidative stress in human body. After Pleurotus ferulae mycelium submerged cultivation, fermentation broth becomes a rich substrate in phenolic compounds. The aim of the study was to investigate in vitro and ex...
Article
Full-text available
The aim of this research was to present in vitro and ex vivo biological activities for three different Matcha teas and a juice based on Matcha tea, lingonberry and bacterial probiotic strain (as a control) and one commercial green tea. The results demonstrated a strong correlation between major bioactive compounds and three biological activities. A...
Conference Paper
Full-text available
Inonotus obliquus (chaga) is a birch phytoparasitic mushroom with an irregular shape that represents dark-colored mycelial agglomeration. It has a high pharmaceutical value because of its rich content in bioactive compounds, polysaccharides, phenols, or triterpene (betulin, for example). The purpose of this study was to determine the composition of...
Conference Paper
Full-text available
The aim of this research was to present in vitro and ex vivo biological activities for two different Matcha teas and a juice based on Matcha tea, lingonberry and bacterial probiotic strain (as a control). The results demonstrated a strong correlation between major bioactive compounds and three biological activities. Antioxidant potential was correl...
Article
Full-text available
in vivo conditions. The purpose of this study was to describe a green AgNP synthesis process, using aqueous extract from Lactarius piperatus mushroom, and to characterize the nanomaterial. We determined its antimicrobial and antioxidant effects in vitro in the microbiota of healthy individuals via the GIS1 system—a colon transit simulator. Per the...
Article
Full-text available
Many compounds in mushrooms are biologically active; however, the in vivo actions of their metabolites are poorly understood. An in vitro system, GIS1, was used to simulate the fermentation action of microbiota in each colon region. We used MycoPo, a natural product obtained from the lyophilized mycelia of different Pleurotus ostreatus species to d...
Patent
The invention relates to a method for testing the viability of certain strains of Lactobacillus sp., Which synthesizes exopolysaccharides for the production of probiotic and synbiotic products, by using an experimental method of in vitro simulation of the human gastric and intestinal level.
Article
Full-text available
Wild edible mushrooms are considered as a cheap food source, but rich in bioactive compounds, especially in phenolic compounds. The purpose of the study was to determine the antioxidant and antimicrobial activity and the content of polyphenolcarboxylic acids in 10 species of mushrooms commonly used (consumed) in Romania and two controls. The effect...
Presentation
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Conference Paper
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The aim of the study was the determination of in vitro effect on the microbiome fingerprint in the case of two target groups (diabetes and cardiovascular diseases) after the administration of freeze dried triple extracts from 10 species of wild edible mushrooms harvested from the spontaneous flora of Romania. The results were correlated with the nu...
Conference Paper
Full-text available
The in vitro effect of digestion on the quantity of phenols and on the antioxidant status after consuming three types of alcoholic (bilberry brandy from commerce, cherry brandy from craft production and a topinambur distillate supplemented with natural extracts) was determined. A high stability was found at gastric level, of the total polyphenol co...
Article
Full-text available
The selection of probiotic strains resistant to gastrointestinal transit is an important stage when developing supplements that contain viable biomass. A total of six strains belonging to different genotypes were tested and compared with both a positive and negative control (Lactobacillus plantarum 5s). Significant differences were found between st...
Article
Full-text available
This study determined the effect of the consumption of six edible wild mushroom species (Boletus edulis, Boletus pinophilus, Boletus aureus, Armillari amellea, Lactarius piperatus, Pleurotus eryngii, Pleurotus djamor - positive control, Amanita rubescens - negative control) on the microbiota of three target groups: clinically healthy (NM) individua...