Emanuel V. Capela

Emanuel V. Capela
University of Aveiro | UA · CICECO - Aveiro Institute of Materials

PhD in Chemical Engineering

About

15
Publications
7,344
Reads
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184
Citations
Additional affiliations
March 2018 - May 2018
University of Twente
Position
  • Researcher
April 2017 - January 2022
University of Aveiro
Position
  • PhD Student
April 2017 - September 2017
Technical University of Lisbon
Position
  • PhD Student
Education
April 2017 - January 2022
University of Aveiro
Field of study
  • Chemical Engineering
September 2014 - July 2016
University of Aveiro
Field of study
  • Biochemistry - Biomolecular Methods
September 2011 - June 2014
University of Aveiro
Field of study
  • Biochemistry

Publications

Publications (15)
Article
Full-text available
Cholinium-based ionic liquids ([Ch]-based ILs) were investigated as electrolytes in the formation of aqueous biphasic systems (ABS) composed of polyethylene glycol (PEG) and sodium polyacrylate (NaPA) polymers. Both enhancement and decrease in the liquid-liquid demixing ability induced by electrolytes in PEG-NaPA aqueous biphasic systems were obser...
Article
Full-text available
Monoclonal antibodies (mAbs) are of crucial interest for therapeutic purposes, particularly in vaccination and immunization, and in the treatment of life-threatening diseases. However, their downstream processing from the complex cell culture media in which they are produced still requires multiple steps, making mAbs extremely high-cost products. T...
Article
Full-text available
In this work, an experimental protocol to determine liquid-liquid phase diagrams of aqueous two-phase systems (ATPS) in a chemical engineering course is described. Throughout this laboratory set of experiments, students will determine liquid-liquid ternary phase diagrams, comprising the solubility curves, tie-lines, tie-line lengths and critical po...
Chapter
Full-text available
Research on the extraction and separation of value-added products from biomass has been a hot topic in the framework of biorefinery aiming a sustainable conversion of biomass into chemicals, materials, energy, and fuels. However, a complete use of the biomass potential is still limited by the lack of cost-effective extraction and separation process...
Chapter
Full-text available
Research on the extraction and separation of value-added products from biomass has been a hot topic in the framework of biorefinery aiming a sustainable conversion of biomass into chemicals, materials, energy, and fuels. However, a complete use of the biomass potential is still limited by the lack of cost-effective extraction and separation process...
Article
Full-text available
In the past decade it has been demonstrated the remarkable potential of ionic-liquid-based aqueous biphasic systems (IL-based ABS) to extract and purify a large range of valued-added biocompounds. However, the transposal of lab-experiments to an industrial scale has been precluded by a poor understanding of the molecular-level mechanisms ruling the...
Chapter
Monoclonal antibodies (mAbs) were firstly described by Köhler and Milstein in 1975, and their potential as powerful therapeutic agents recognized in the following years. Currently, the US Food and Drug Administration (FDA) has already approved 56 monoclonal antibodies for the treatment of several diseases, including cancer (e.g. breast cancer, leuk...
Article
Full-text available
Aqueous biphasic systems (ABS) composed of polypropylene glycol and carbohydrates, two benign substances are proposed to separate two food colorants (E122 and E133). ABS are promising extractive platforms, particularly for biomolecules, due to their aqueous and mild nature (pH and temperature), reduced environmental impact and processing costs. Ano...
Article
Full-text available
Monoclonal antibodies are becoming a leading class of biopharmaceuticals but to increase their accessibility by the general population, new production processes must be developed in particular for the downstream processing. In this work, we propose an alternative and innovative affinity chromatographic method using quaternary amine matrices. Separa...
Article
Deep eutectic solvents (DES) have been studied in a wide range of applications, and despite their potential as sustainable solvents, detailed knowledge on their solvatochromic parameters is still lacking. To overcome this problem, in this work, the Kamlet Taft (KT) solvatochromic parameters, namely the hydrogen-bond acidity, hydrogen-bond basicity...
Article
Full-text available
Based on the particular ability of aliphatic amino acids to form aqueous biphasic systems with ionic liquids, it is here shown how these systems can be used to selectively and efficiently separate mixtures of aliphatic and aromatic amino acids usually present in protein hydrolysates or fermentation broths.
Article
Full-text available
BACKGROUND - Self-buffered aqueous biphasic systems (ABS) are prepared with ionic liquids (ILs) based in Good's buffers (GB-ILs) and used to purify proteins. RESULTS - A set of new GB-ILs based on the tetrabutylphosphonium cation ([P4444]+) was here synthesized and characterized. The self-buffering behaviour of the GB-ILs was asserted by measuring...
Article
Full-text available
Solubility experimental data of six monosaccharides, viz. D-(+)-glucose, D-(+)-mannose, D-(-)-fructose, D-(+)-galactose, D-(+)-xylose and L-(+)-arabinose, in four ionic liquids (ILs), at temperatures ranging from 288.2 to 348.2 K, were here determined aiming at gathering a better understanding on their solvation aptitude and molecular-level mechani...

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