Eman Helal

• Ph D
• Professor (Full) at Al-Azhar University

Background: Cisplatin is a widely used chemotherapeutic agent effective against various cancers, but its use is often limited by its nephrotoxic and hepatotoxic side effects. Objective: This study aims to evaluate the protective effects of Matcha and Chia seeds on Cisplatin-induced liver and kidney damage in male albino rats. Methods: Male albino r...

Background: Cisplatin is a widely used chemotherapeutic agent with significant hepatotoxic and nephrotoxic side effects. Objective: This study aimed to investigate the protective effects of parsley oil (PO) and pumpkin seed oil (PSO) against cisplatin-induced organ toxicity in male albino rats. Methods: A batch of male albino rats weighing between...

ackground: Phytoestrogens are non-estradiol molecules categorized as endocrine-disrupting chemicals, which means they can alter the hormonal equilibrium and cause reproductive problems. Studies suggested Hibiscus sabdariffa (H. sabdariffa) possible use as alternative to hormone replacement therapy in ovarian hypofunction patients. Salvia officinali...

Background: Phytoestrogens are estrogen analogues of plant origin, allowing them to act as agonists at estrogen receptors. Objectives: This study was done to discover the effects of flaxseed and turmeric oils on male rats' fertility. Methodology: Eighteen male albino rats are divided into three groups (6 rats each). Group 1 (Control group) rats rec...

Background: Because of the growing incidence of obesity, the use of synthetic antiobesity medicines as weight-loss agents has grown in popularity, although their usefulness has yet to be established. Two of such medicines are Aplex and Venera. This study is designed to determine the potential dangers of Aplex and Venera on certain biochemical and...

Obesity poses a significant health danger. The effects of green coffee extract (GCE) and turbo slim blue (TSB) on decreasing the body weight (BW) and their impact on various physiological indicators of metabolic state in obese rats were investigated in this study. Twenty-one male rats weighing 320-360 g were distributed into three groups. Rats were...

Background: Food additives are substances used in food industry in order to improve the food's taste and appearance. Objective: To investigate the adverse effects of mixing some food additives on the biochemical parameters in male albino rats. Materials and Methods: This study was conducted on twenty-four young male albino rats. Animals were divide...

Background: Xenoestrogens are compounds like estrogens in effect but not in structure which are mimicking the action of endogenous estrogen and activate estrogen receptor. Phytoestrogens are naturally occurring non-steroidal plant chemicals that can act like the female hormone estrogen. Aphanizomenon Flos-aquae (AFA) is a blue-green microalgal spec...

Background: Xenoestrogens are chemically distinct industrial products potentially able to disrupt the endocrine system by mimicking the action of endogenous steroid hormones. Phytoestrogens are naturally occurring non-steroidal plant chemicals that can act like the female hormone estrogen. Arctium lappa (burdock) root has traditionally been recomme...

Background: Xenoestrogens are a type of xenohormone that imitates estrogen. They can be either synthetic or natural chemical compounds. Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, bisphenol A (BPA) and phthalates. "Dietary estrogen" is also called phytoestrogen, which is a plant-derived xenoestrogen not gene...

Background: phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens. They have been investigated at the epidemiological, clinical and molecular levels to determine their potential health benefits. Aim: the present study was carried out to investigate some biochemical effects of fenug...

Background: CANDEREL ® is non-nutritive artificial sweetener, which is mainly composed of aspartame and acesulfame potassium. Materials and Methods: thirty male albino rats weighing from 100 to 120 gm. The period of the experiment was 30 days. The animals were divided into three groups; group 1: control, group 2: rats received CANDEREL ® (1 tablet/...

Background: Phytoestrogen is a plant derived compound which have estrogenic effect similar to estrogen. Aim of work: The present study was carried out to investigate some pharmacological and biochemical effects of anise oil on male albino rats. Materials and methods: twelve animals were divided randomly into two groups. Group A: Control. Group B: t...

Background: the easiest method of reducing calories is to replace the high caloric food products with sweetened ones. Aim of the work: this study aimed to determine the effects of acesulfame-k or aspartame on some physiological parameters in male albino rats. Materials and methods: we used thirty male albino rats of local strain weighing from 100 t...

Background: Food additives are substances used in food industry in order to improve the food's taste and appearance by preserving its flavor and preventing it from souring. Materials and Methods: this study was conducted on twenty-four young male albino rats with an average 120-140 g body weight. Animals were divided into four groups (6 each). Grou...

Background: Food additives are substances intentionally added to food to change its characteristics, maintain and improve safety, maintain the nutrient value and to improve taste, texture, and appearance.

Background: Food additives are products added to the basic foodstuffs with an aim of improving its aspect, flavor, taste, color, texture, food value and conservation. Aim of the work: This study aimed to determine the effects of AFA against the hazardous effects of sodium benzoate, chlorophyllin and monosodium glutamate. Materials and methods: This...

Background: Süßstofftabletten is an artificial sweetener, which is mainly composed of cyclamate and saccharin. Aim of the work: clarification of Süßstofftabletten effects and the amelioration effect of vitamin E in male albino rats. Materials and methods: thirty male albino rats weighing from 100 to 120 gm. The period of the experiment was 30 days....

Background: Chlorophyllin is known as natural green. Chlorophyll derivative is used as a food additive (food–coloring agent). Mono sodium glutamate (MSG), the sodium salt of amino acid glutamate, is a food additive that popularly used all over the world as “Flavor enhancer”. Aim of the work: This study aimed to determine the hazardous effects of so...

Background: Phytoesrogenis plant derived compounds which have an estrogenic effect. Objectives: The present study was carried out to investigate some pharmacological and biochemical effects of fennel oil on male albino rats. Materials and methods: Twelve animals were divided randomly into two groups. Group A: Control. Group B: Treated rats. The rat...

Background: Non-nutritive sweeteners (NNSs) are becoming popular as sugar substitutes for diabetic patients or to decrease body weight. Aim of the work: This study was aimed to determine the effects of sucralose and sodium saccharin on some physiological parameters in male albino rats. Materials and methods: We used thirty male albino rats weighing...

Background-Burullus Lake has brackish water and agricultural, industrial and sewage drainage water represent the major inflows and it represents one of the most subjected lakes to serious pollutants at the delta’s coastline. Mugil cephalus is one of the most important food fish species for the Egyptian people. This study was conducted to explain th...

Background: Qarun and Burullus Lakes suffer from serious pollution problems owing to the enormous input of untreated agricultural, domestic and industrial effluents. This study was conducted to explain the effect of water pollution of these lakes on some physiological parameters of O. niloticus. Results: Showed clearly that water collected from bot...

Background: alterations in the level of hormones including thyroid hormones lead to physiological/ clinical abnormalities. Aim of work: this study aimed to illustrate the protective effect of Trigonella, Allium sativum or their mixture against hyperthyroidism induced by L-thyroxin in male albino rats. Materials and methods: thirty albino rats were...

Background and Objective: Amaranth dye and vanillin are food additives used in food, drugs and cosmetics. This study was designed to assess the sub-chronic effect of oral ingestion of these food additives on biochemical parameters. Materials and Methods: The animals were divided into 7 groups (5 animals/cage) and fed standard diet with tap water ad...

Background: this study aimed to illustrate the protective effect of red cabbage extract against hyperthyroidism induced by L-thyroxine in male albino rats. Materials and methods: Eighteen animals were divided randomly into three groups. Group A: healthy rats, Group B: hyperthyroidimc rats were given an oral dose of 500 μg/kg body weight/day L-thyro...

food additives are added to most junk and fast foods, especially those for kids. Sodium nitrite is an inorganic salt with widespread applications in the food industry as a color fixative and preservative in meat and fish. Annatto extract is a natural food color obtained from the outer coatings of the seeds of the Annatto tree (Bixa orellana L.). Mo...

food additives are substances used in food industry in order to improve the food’s taste, appearance by preserving its flavor and preventing it from souring. Food additives are added to the most junk and fast foods, especially food for kids. Aim of the work: this work was aimed to investigate the adverse effects of some food additives on the bioch...

Background: food additives are substances intentionally added to food to change its characteristics, to maintain and improve safety, to improve or maintain the nutrient value and to improve taste, texture, and appearance. Sodium nitrite is an inorganic salt with widespread applications in the food industry as a food preservative in meat and fish. H...

Background: the use of food additives is one of the most important problems in the human health nutrition field. Food additives are widely used for various purposes; including preservation, coloring, and sweetening, however, the physiological and biochemical changes may be produced. Aim of the work: was to investigate the protective role of royal j...

Background: food additives are substances intentionally added to food to change its characteristics, to maintain and improve safety, to improve or maintain the nutrient value and to improve taste, texture, and appearance. Sodium nitrite is an inorganic salt with widespread applications in the food industry as a food preservative in meat and fish. H...

Background: food additives are added to most junk and fast foods, especially those for kids. Sodium nitrite is an inorganic salt with widespread applications in the food industry as a color fixative and preservative in meat and fish. Annatto extract is a natural food color obtained from the outer coatings of the seeds of the Annatto tree (Bixa orel...

Background: food additives are substances used in food industry in order to improve the food's taste, appearance by preserving its flavor and preventing it from souring. Food additives are added to the most junk and fast foods, especially food for kids. Aim of the work: this work was aimed to investigate the adverse effects of some food additives o...

Background: the use of food additives is one of the most important problems in the human health nutrition field. Food additives are widely used for various purposes; including preservation, coloring, and sweetening, however, the physiological and biochemical changes may be produced. Aim of the work: was to investigate the protective role of royal j...

Objective: Oxidative stress is induced by bisphenol A (BPA) and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA. Materials and methods: 30 female albino rats were divided i...

Background: bisphenol A (BPA) is a worldwide used endocrine disruptor that is incorporated in many plastic industries. The exposure of human to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of such substances. The aim of t...

Background: The xenoestrogen, bisphenol-A (BPA), is a worldwide food contaminant with endocrine disruptor activity that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the...

Background: The xenoestrogen, bisphenol-A (BPA), is a worldwide food contaminant with endocrine disruptor activity that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the...

Objective: Salvadora persica (Miswak) is one of the folk medicinal plants commonly used by some women to delay menses. This study was conducted to evaluate the physiological effects-induced in female albino rats after administration of Salvadora persica aqueous extract. Methods: 20 female rats weighing between 160-180 g were randomized into two gro...

Background: The study on the natural herbal contraception has become one of the main interests of modern contraceptive studies. Herbs have been used by women since the beginning of time in an attempt to control their fertility. The development of new fertility regulating drugs derived from medicinal plants is an attractive proposition, Aloe Vera is...

Back ground: The use of medicinal plants for management of diabetes mellitus is an old practice which has become even more relevant in modern perspective. The present work was designed to evaluate the effect of a mixture of five medicinal plants which used in folk medicine in Egypt especially in Sinai as hypoglycemic agents on the adult male diabet...

Background:Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased responsiveness of the organs to the secreted insulin. Recently, some medicinal plants have been reported to be useful in diabetes treatment. Cleome droserifolia (Samwah) having a long history in Egyptian folk medic...

Objective: The current study aims to evaluate the potential of crude leaf extract of Artemisia judaica L. (AJE) in reducing the biochemical abnormalities accompanied to alloxan-induced diabetes in male Wistar rats. Methods: Thirty male albino rats (100-110 g) were divided equally into three groups including control, diabetic and diabetic+AJE. Diabe...

Objective: The current study aims to evaluate the potential of crude leaf extract of Artemisia judaica L. (AJE) in reducing the biochemical abnormalities accompanied to alloxan-induced diabetes in male Wistar rats. Methods: Thirty male albino rats (100-110 g) were divided equally into three groups including control, diabetic and diabetic+AJE. Diabe...

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Jasonia montana (Neheda)...

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. Different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Ambrosia maritima, L. (Damsissa)...

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. Different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Ambrosia maritima, L. (Damsissa)...

ABSTRACT Background and Objective: Diabetes is the most common endocrine disorder affecting millions of people worldwide. Nowadays, herbal drugs are gaining popularity in the treatment of diabetes and its complications. The current study was aimed at evaluating the significance of supplementation of Artemisia annua (Kaysom) extract in reducing the...

Abstract Introduction: Thalassemia is a genetic inherited blood disorder in which the body makes abnormal hemoglobin with excessive destruction of red blood cells, which leads to anemia. For many years, hepatitis B virus was a major problem for patients with thalassemia substantially contracted from blood transfusions. The development of effective...

Background: Noise and crowding are the most stressful factors which cause depressant effects on human beings, especially females.Therfore this study was aimed at clarifying their effects on hypothalamus pituitary gonadal axis hormones (luteinizing hormone (LH) and follicle-stimulating hormone (FSH), estrogen (E2)and progesterone as well as prolacti...

Some snails of Biomphalaria alexandrina can resist the infection of Schistosoma mansoni so this study aimed to clearly this mechanism by using light and electron microscopy (EM) and determine the role of Nitric oxide in this mechanism. B. alexandrina snails used in this study were exposed individually to S. mansoni infection according to their resp...

Background: Noise and crowding are the most stressful factors for human beings. Study aimed to clarify their effect on cortisol, ACTH, epinephrine, insulin and the amelioration effect of Sulpiride. Material and Methods: Thirty six female rats were divided into six groups (6/each): 1- Rats served as control, 2- Rats treated with Sulpiride drug, 3-...

Background: The internal defense system of snails consists of both cellular and humoral components. Circulating haemocytes are the principle line of cellular defense. The susceptibility of fresh water snails of genus Biomphalaria to infection by Schistosoma mansoni (S. mansoni) is linked to the haemocytes present in the haemolymph. While the humora...

Background: Infertile obese women with polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women and characterized by hyperandrogenism, chronic anovulation with either oligomenorrhea or amenorrhea and hyperandrogenism, and its morbidity may include hyperinsulinemia, insulin resistance. Lipolax was used to enhance the ovulation res...

Background: Infertile obese women with polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women and characterized by hyperandrogenism, chronic anovulation with either oligomenorrhea or amenorrhea and hyperandrogenism, and its morbidity may include hyperinsulinemia, insulin resistance. Lipolax was used to enhance the ovulation res...

Objective: The current study aims to evaluate the significance of supplementation of olive leaves extract (OLE) of Olea europaea plant in reducing the biochemical abnormalities accompanied to alloxan-induced diabetes in male Wistar rats. Methods: Thirty male albino rats were divided equally into three groups including control, diabetic and diabetic...

Background: Regular transfusion in thalassemia major patients increases life expectancy and improves quality of life. Blood transfusion is the main sources for viral transmission to Thalassemia patients. So, detection of viral antigens using more than one technique must be adopted. Iron and its binding proteins have immune regulatory properties and...

Background: Noise and crowding are the most stressful factors for human beings. This study is aimed to clarify their effect on some thyroid hormones and the amelioration effect of sulprid . Material and Methods: Thirty six female rats were divided into four groups (6/each): 1-control, 2-treated with sulpiride drug, 3- rat exposed to noise (90db...

Background: Egyptian infertile obese women with polycystic ovary syndrome (PCOS) were markedly increased in ART Unit for infertility treatment undergoing ICSI. In a trial to enhance the ovulation, fertilization response and pregnancy outcome treated patients with Metformin as insulin sensitizing drug, 3 months before ICSI processing. The aim of thi...

Background: Xenoestrogens are widely used environmental chemicals that have recently been under scrutiny because of their possible role as endocrine disrupters. Among them is digoxin that is commonly used in the treatment of heart failure and atrial dysrhythmias. Digoxin is a cardiac glycoside derived from the foxglove plant, Digitalis lanata and s...

Background: Regular transfusion in thalassemia major patients increases life expectancy and improves quality of life. Blood transfusion is the main sources for viral transmission to Thalassemia patients. So, detection of viral antigens using more than one technique must be adopted. Iron and its binding proteins have immune regulatory properties and...

Objectives: Type II diabetes mellitus is increasing health problems that negatively affect health care systems worldwide. There is a constant urge to develop new therapies with better effects, lower side effects at lower prices to treat this disease. Therefore, the present study carried out to investigate whether Balanites aegyptiaca (seeds) cou...

Objectives: The number of people suffering diabetes mellitus is increasing worldwide at an alarming rate. A huge number of populations in the world are entirely dependent on traditional medications. This practice may be due to their safety, effectiveness, and availability as well as their fewer side effects when compared to the synthetic hypoglycem...

Objectives: There is strong evidence that diabetes results a state of oxidative stress and that reactive oxygen species contribute to the production of insulin resistance, -cell dysfunction and both the microvascular and macrovascular long-term complications of diabetes. Antioxidants are used as supportive therapy in the treatment of DM, so, we...

Back ground: Xenoestrogens are compounds like estrogens in effect but not in structure which are mimicking the action of endogenous estrogen and activate estrogen receptor. Xenoestrogens are chemically distinct industrial products potentially able to disrupt the endocrine system by mimicking the action of endogenous steroid hormones. Among such com...

Objectives: The number of people suffering diabetes mellitus is increasing worldwide at an alarming rate. A huge number of populations in the world are entirely dependent on traditional medications. This practice may be due to their safety, effectiveness, and availability as well as their fewer side effects when compared to the synthetic hypogly...

Background: Xenoestrogens are widely used environmental chemicals that have recently been under scrutiny because of their possible role as endocrine disrupters. Among them is digoxin that is commonly used in the treatment of heart failure and atrial dysrhythmias. Digoxin is a cardiac glycoside derived from the foxglove plant, Digitalis lanata an...

Background: Fatty liver causes were markedly increased in Egyptian people throughout last years. People prefer to use the medicinal plants instead of using chemical compounds because they are cheap and have few side effects compared to chemical compounds. Ginger is a natural dietary rhizome with anti- oxidative, anti-inflammatory, and anti-carcin...

Back ground: Diabetes mellitus (DM) is a major health problem worldwide in recent time. Asia and Africa are the most viable areas where the disease is feared to raise 2­3 folds. Many herbal products have been recommended for the treatment of DM in ancient literature of Ayurveda in In- dia and other worldwide. Material and method: Thirty male adu...

Back ground: Diabetes is a chronic metabolic disease which affects large number of population all over the world. Such disease is associated with many complications which may leads finally to patient's mortality. Camel milk supplementation reduces the insulin requirement in Type I diabetic patients. So this study was planned to evaluate the effe...