Eman Abu-rish

University of Jordan | UJ · Department of Biopharmaceutics and Clinical Pharmacy

In this controlled before-and-after interventional study, the clinical pharmacist evaluated the application of performance measures (PMs) and quality measures (QMs) in the control group and the intervention group in Al-Gurayat General Hospital (GGH) in Saudi Arabia. The total number of PMs applied in the intervention group (n = 445) was significant...

This study evaluates the ability of human hybrid cells, generated by fusion of multiple myeloma (MM) primary tumor cells and im�mortalized antigen presenting cells (APC), HMy2 (EBV sensitized B-lymphoblastoid cell line), to present tumor antigens in context of MHC class I and class II, and to maintain expression of the co-stimulatory molecules to...

Background: Although we are four years into the pandemic, there is still conflicting evidence regarding the clinical outcomes of diabetic patients hospitalized with COVID-19. The primary objective of this study was to evaluate the in-hospital mortality and morbidity of diabetic versus nondiabetic patients hospitalized with COVID-19 in the Northern...

Apoptosis, programmed cell death pathway, is a vital physiological mechanism that ensures cellular homeostasis and overall cellular well-being. In the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-apoptotic proteins like Bcl2, Bcl-xL and Mcl-1 has been documented. Consequently, these proteins have emerged a...

Parkinson's disease (PD) is a prevalent neurodegenerative disorder with a poorly understood etiology. An accurate diagnosis of idiopathic PD remains challenging as misdiagnosis is common in routine clinical practice. Moreover, current therapeutics focus on symptomatic management rather than curing or slowing down disease progression. Therefore, ide...

Aims Hand hygiene (HH) is an essential practice to evade the transmission of germs and minimize community-acquired infections. This study assesses the knowledge, attitude and practice (KAP) of HH and other health and safety measures before, during, and after the COVID-19 pandemic. in university students in the United Arab Emirates (UAE). Methods A...

Background and Aim: Human monkeypox is an emerging global threat. Hundreds of publications were disseminated in the last few months. This study aimed to map, analyze, and evaluate the bibliometric indicators of the global monkeypox research output. Materials and Methods: All documents published in the past 20 years were retrieved using the Scopus...

Background The seasonal influenza vaccine is an important preventive measure against influenza and its associated complications. In Yemen, there is no seasonal influenza vaccination policy, and the influenza vaccine is excluded from the national immunization program. Data on vaccination coverage remain scarce with no previous surveillance programs...

Objectives We aimed to evaluate the levels of serum lipoprotein a, LP (a), in Jordanian patients with type 2 diabetes mellitus (DM); and to examine its relation to glycemic control, metabolic syndrome (MS) and duration of DM. The LP (a) is considered one of the independent risk factors for coronary artery disease (CAD) in the general population. M...

Background: The healthcare system in Jordan faced substantial burden during the 2020 COVID-19 pandemic including disruption of routine childhood vaccination services. Aims: We sought, for the first time, to describe the impact of the 2020 pandemic on vaccination coverage of Jordanian children in Jordan and to identify the key contributing factor...

Limited data exist regarding pneumococcal vaccination coverage among the elderly in Middle Eastern countries including Jordan. The pharmacists' role in improving vaccine acceptance has become increasingly evident. Yet, large-scale studies of the assessment of the pharmacists' role on pneumococcal vaccines acceptance among the elderly are scarce. He...

Immune system alteration has been implicated in the pathogenesis of chronic pain conditions, epilepsy and generalized anxiety disorder. Targeting cytokines has recently been proposed for the management of such conditions. Pregabalin (PGB) is an antiepileptic agent used for the management of these conditions. However, little is known about its immun...

Abstract: Aims: The optimal dosing regimen of aspirin for primary and secondary prevention of ischemic events is a topic of debate. Therefore, the aim of this study is to evaluate whether administering 100 mg aspirin in two divided dose, rather than a single daily dose, is associated with a greater degree of inhibition of platelet aggregation. Meth...

Background: Currently there is overwhelming evidence linking elevated plasma free fatty acids with insulin resistance and inflammation. Monoglyceride lipase (MGL) plays crucial metabolic role in lipolysis by mediating the release of fatty acids. Therefore, inhibiting MGL should be a promising pharmacological approach for treating type 2 diabetes an...

Objective To assess the differential cytotoxic activity of PPIs on different human cancer cell lines; namely A549 lung cancer, CACO-2 colorectal cancer, MCF-7 breast cancer, and PANC-1 pancreatic cancer, A375 skin melanoma. Methods In this study the five human cancer cell lines and human non-cancerous fibroblasts were treated with increasing conce...

Background Insulin-like growth factor-I (IGF-I) is homologous to proinsulin and possesses glucose reducing activity. The association between the level of IGF-I and diabetes has been highlighted. However, this association is controversial due to the influence of different factors including obesity. The aim of the study was to evaluate serum level of...

Introduction: Zika virus (ZIKAV) disease is a public health problem of international concern. Recent evidence has documented imported ZIKAV cases into the Middle East and the existence of ZIKAV-transmitting mosquitoes in Jordan. However, limited data exist on the role of physicians in public awareness in this regard. This study aimed to assess ZIK...

Travelers act as sentinels for the spread of Zika virus. Imported Zika cases and the presence of Zika virus-transmitting mosquitoes have been documented in the Middle East. However, data on travelers’ knowledge, attitude and practices regarding Zika and its prevention measures within the Middle East are scarce. This study aimed to address this issu...

ZIKA virus (ZIKAV) outbreak in Latin America was associated with international concerns of ZIKAV circulation. The lack of vaccine and Food and Drug Administration (FDA)-approved drugs against this virus rendered prevention as the single most effective method to control its spread. Hence, this study aimed to assess Jordanian population knowledge, at...

Tigecycline is a glycylcycline antibiotic approved by the FDA for the treatment of complicated infections. Despite its effectiveness, the FDA announced a warning of increasing mortality associated with its use. There is, however, no clear explanation for this side effect. Previous reports found a possible effect of tigecycline on leukocyte prolifer...

Purpose: The aim of the current study was to investigate the invitro antiproliferative activity of methanolic extracts of six plants regardless of their claimed ethnopharmacological application. Methods: Methanol extracts of different parts of Glycyrrhizaglabra L. (Licorice),Matricariachamomilla L. (Chamomile), Salvia triloba L. (Sage), Rheum palma...

Alteration in cytokine levels, particularly, IL-6, TNF-α, IL-1β and IL-2, has been implicated in the pathogenesis of epilepsy and bipolar disorder. Lamotrigine (LTG), an antiepileptic drug with mood stabilizing properties, has documented immunomodulatory effects. However, its effect on cytokine secretion in vivo has not been examined. Besides, stud...

Purpose: To investigate the in vitro antiproliferative activity of methanol extracts of six plants regardless of their claimed ethnopharmacological application. Methods: Methanol extracts of different parts of Glycyrrhiza glabra L. Licorice), Matricaria chamomilla L. (Chamomile), Salvia triloba L. (Sage), Rheum palmatum L. (Rhubarb), Trigonella foe...

Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug,...

Introduction: Despite the wide range of aspirin indications, there is a considerable amount of patients do not respond to aspirin, who also are referred to as aspirin non-responders or aspirin resistant patients. Aims and objectives: This study was carried out to prospectively evaluate the prevalence of aspirin resistance in Jordanian patients with...

Adoptive T-cell immunotherapy is a promising approach to manage and maintain relapse-free survival of leukemia patients, especially following allogeneic stem cell transplantation. Post-transplant adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) of the donor origin provide graft-versus-tumor effects, with or without graft-versus-host dise...

Background Influenza is an underestimated contributor to morbidity and mortality. Population knowledge regarding influenza and its vaccination has a key role in enhancing vaccination coverage. Objectives This study aimed to identify the gaps of knowledge among Jordanian population towards influenza and its vaccine, and to identify the major determ...

Purpose: To evaluate the in vitro antiproliferative activity of the extracts of the three plants against a panel of human tumor cell lines representing the most common types of cancer in Jordan, viz, breast and colorectal and skin cancers. Methods: The methanol extracts of the aerial parts of the three plants (Arbutus andrachne L., Chrysanthemum co...

Curcumin inhibited efficaciously and dose dependently the pancreatic triacylglycerol lipase (PL) activity with an IC50 value of 7.3 μg/mL (19.8 μM). Its PL-catalysis inhibition propensities have been studied to draw further on structure-potency enhancement. Enzyme kinetics study proved that curcumin inhibits PL in a competitive manner. The observed...

Objectives: Activation of TLR7 and TLR9 and high serum levels of BAFF have been implicated in the pathogenesis of SLE. However, little is known about the effects of TLR9 activation on BAFF expression by human B cells. We investigated the effect of the TLR9 agonist, CpG-ODN 2006, on the expression of BAFF and its receptors BAFF-R, TACI and BCMA, in...