Eman Abdelzaher

Alexandria University | AU · Faculty of Medicine, Department of Pathology

Background Non-neoplastic brain lesions can be misdiagnosed as low-grade gliomas. Conventional magnetic resonance (MR) imaging may be non-specific. Additional imaging modalities such as spectroscopy (MRS), perfusion and diffusion imaging aid in diagnosis of such lesions. However, contradictory and overlapping results are still present. Hence, our p...

Urothelial carcinoma (UC) of the urinary bladder is the ninth most common cancer worldwide. The majority of these patients present with non-muscle invasive bladder cancer (NMIBC). GATA3 has recently emerged as one of the diagnostically helpful immunohistochemical markers for UC. The published literature, however, lacks comprehensive studies on the...

Multiple myeloma is a monoclonal proliferation of plasma cells with common involvement of vertebrae, ribs and skull vault. However, involvement of skull base is relatively uncommon and myeloma manifesting initially as a petrous apex mass is distinctly rare. We report a rare case of non-secretory multiple myeloma in a 52-year-old Egyptian male prese...

Malignant peripheral nerve sheath tumour (MPNST) with perineurial differentiation is a rare variant of MPNST. The pathological features and clinical significance of this variant remain to be characterised. We reported the clinicoradiological and pathological features of a case of recurrent right arm mass related to the ulnar nerve in a 42-year-old...

Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic le...

Background The conventional osteosarcoma (OS) is the commonest primary malignant, bone tumor with complex genomic profiles and poor survival. Runt-related transcription factor 2 (RUNX2) and WW domain containing oxidoreductase (WWOX) genes are implicated in normal osteogenesis as well as in the development of primary conventional OS. Methods We retr...

Fibroblast growth factor 18 (FGF18) has been suggested to play important roles in promoting progression of ovarian high-grade serous carcinoma. Our aim was to investigate FGF18 expression in the whole spectrum of serous and mucinous ovarian tumors, highlighting differences in expression within the adenoma-carcinoma sequence and differences between...

Facial tumors are a major form of human suffering. The face is our main tool in social interaction, and this poses a great responsibility on the plastic surgeon to maintain a fine balance between adequate tumor resection and aesthetic functional reconstruction. The main prognostic factor is the magnitude of resection, but the choice and execution o...

Conventional prognostic factors for bladder cancer are inadequate to predict tumor recurrence and/or progression successfully; thus, the identification of adjunctive novel prognostic biomarkers is of paramount importance. In this study, the immunohistochemical expression patterns and clinical significance of RUNX2, WWOX, and p53 were investigated i...

Breast cancer is the most common cancer in women worldwide. Aberrant lipid metabolism is an established hallmark of cancer cells. The recently isolated lysophosphatidylcholine acyltransferase 1 (LPCAT1), the most important enzyme in membrane biogenesis, has been currently implicated in cancer development and progression. The published literature la...

Objective: The data on the frequency and pattern of human epidermal growth factor receptor 2 (HER2) expression in colorectal carcinoma (CRC) and its clinical significance are ambiguous. In addition, little is known about HER2 status in CRC variants and its relation with proliferative activity and clinical outcome. Such knowledge may be of potential...

Background: Wilms’ tumor is a common pediatric malignancy of the kidney. In all, 5–10% of tumors are fatal because of the occurrence of metastases and drug resistance. In solid tumors, it has been suggested that angiogenesis plays an important role in tumor progression and metastatic spread. Vascular endothelial growth factor (VEGF) is an angiogen...

Papillary glioneuronal tumor (PGNT) is a recently recognized member of the mixed glioneuronal group of central nervous system tumors with a favorable clinical outcome. To date, approximately 40 cases of PGNT have been reported. We report the clinical, radiologic, and pathologic features of PGNT in 3 Egyptian patients.

We explored the expression of the stem cell markers OCT4 and nestin in laryngeal squamous cell carcinoma (LSCC) and investigated their relationship to survivin expression. Eighty-five LSCC, and 62 non-neoplastic laryngeal tissues were analyzed immunohistochemically for the presence of OCT4, nestin and survivin. Marker expression was correlated to c...

Background. Meningiomas are common intracranial tumors. Recently, histogenetic and phenotypic similarities between meningiomas and mesotheliomas have been proposed. We were interested in whether these similarities are reflected on the immunohistochemical level, which would add new potentially diagnostic markers for meningiomas. Methods. The expres...

Anaplastic meningiomas are uncommon. We report the clinical, radiological and pathological features of an anaplastic meningioma in a young male Egyptian patient presenting as a suprasellar solid/cystic enhancing mass resembling a craniopharyngioma.

Objectives: Follicular thyroid lesions represent a heterogeneous group with variable biological behavior. Discrimination between benign and malignant follicular thyroid lesions by histologic examination poses a significant challenge to pathologists. Recently, CD56 has attracted attention as a potential diagnostic marker in follicular thyroid lesion...

Background Data: Schistosomiasis affects over 200 million people worldwide. Involvement of the CNS is a rare occurrence. Spinal cord involvement is a rare manifestation of schistosomiasis, the conus medullaris being the primary site of spinal involvement. Purpose: We describe the clinical presentation and the MRI findings of spinal cord schistosomi...

Primary CNS lymphoma is difficult to diagnose with conventional imaging modalities. Magnetic resonance proton spectroscopy, dynamic susceptibility contrast DSC perfusion and diffusion weighted images have been recently investigated as a problem-solving tool for evaluation of primary CNS lymphoma with favorable results.Aim of the workTo assess the v...

Gastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of i...

Objective: This work was designed to study the biological and demographic characteristics of meningiomas and their impact on tumor recurrence in Egyptian patients. Material and methods: A cohort of 265 Egyptian patients with meningioma was studied. Immunohistochemistry for VEGF, Ki67, PR, CD20, and CD3 was performed. Statistical analysis was use...

Colonic carcinoma is one of the most common cancers worldwide. Recently, the possible involvement of claudin-1, one of the major tight junction proteins, in the process of tumorigenesis has been suggested. Also, claudin-1 has emerged as a potential prognostic factor in different types of tumors. The aim of this study was to detect caludin-1 express...

The biological behaviour of meningiomas and the risk of recurrence in individual cases cannot be predicted by using conventional histological criteria alone. A number of histologically benign meningiomas may recur, even after gross complete surgical removal. A retrospective immunohistochemical and statistical analysis of 60 patients with benign int...

Certain subtypes of Renal cell carcinomas (RCCs) are diagnostically challenging owing to their overlapping histopathological features. Recently, c-KIT (CD117) has come into focus as a potential diagnostic marker of some renal tumors. c-KIT also provides a potentially suitable for targeted tumor therapy. The present study was designed to investigate...

Objective: The temporal lobe is a complex part of the brain which contains eloquent structures that perform many higher cerebral functions. Several pathologies can affect the temporal lobes and have different clinical presentations. Temporal lobe surgery includes several approaches with varying outcome results. The aim of this study was to identify...

Introduction: Current primary treatment options for esophageal cancer are surgery only or concomitant chemo-radiotherapy (CRT) and the long–term survival of patients with locally-advanced disease is rare. Pre-operative concomitant CRT seems to be beneficial, mostly in patients who achieve a complete pathologic response (pCR) after CRT. Objectives:...