Elzbieta Kaja

Elzbieta Kaja
Poznan University of Medical Sciences · Department of Medical Chemistry and Laboratory Medicine,

PhD

About

20
Publications
3,843
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
174
Citations
Citations since 2017
12 Research Items
146 Citations
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050

Publications

Publications (20)
Article
Full-text available
Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare vari...
Article
Full-text available
Background: Severe outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. Methods: In this study, a subset of 747 samples from unrelated individuals coll...
Article
Full-text available
Although Slavic populations account for over 4.5% of world inhabitants, no centralised, open-source reference database of genetic variation of any Slavic population exists to date. Such data are crucial for clinical genetics, biomedical research, as well as archeological and historical studies. The Polish population, which is homogenous and sedenta...
Preprint
Full-text available
Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare vari...
Article
Full-text available
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological de...
Preprint
Full-text available
Although Slavic populations account for over 3.5% of world inhabitants, no centralized, open source reference database of genetic variation of any Slavic population exists to date. Such data are crucial for either biomedical research and genetic counseling and are essential for archeological and historical studies. Polish population, homogenous and...
Preprint
Full-text available
Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork progression and for the overall unlinking of the two duplex DNA strands, as well as for ongoing transcription. To...
Preprint
Full-text available
Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork progression and for the overall unlinking of the two duplex DNA strands, as well as for ongoing transcription. To...
Article
Full-text available
Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork progression and for the overall unlinking of the two duplex DNA strands, as well as for ongoing transcription. To...
Article
Full-text available
MicroRNAs (miRNAs) are key players in multiple biological processes; therefore, analysis and characterization of these small regulatory RNAs is a critical step toward a better understanding of animal and plant biology. In apple (Malus domestica), 200 microRNAs are known, which most probably represent only a fraction of miRNAome diversity. As a resu...
Article
Full-text available
Background MicroRNAs (miRNAs) regulate gene expression via mRNA cleavage or translation inhibition. In spite of barley being a cereal of great economic importance, very little data is available concerning its miRNA biogenesis. There are 69 barley miRNA and 67 pre-miRNA sequences available in the miRBase (release 19). However, no barley pri-miRNA an...
Data
Growth stages studied in barley, cultivar Rolap. (A) 1-week-old plants. (B) 2-week-old plants. (C) 3-week-old plants. (D) 6-week-old plants. (E) 68-day-old plants.
Data
Full-text available
RT-PCR detection of MIR genes transcripts studied in two additional biological replicates (B and C). 1w: 1-week-old seedlings, 2w: 2-week-old seedlings, 3w: 3-week-old plants, 6w: 6-week-old plants, 68d: 68-day-old plants, gDNA: genomic DNA, H: no template control, M: GeneRuler 100 bp Plus or 1kb Plus DNA Ladder.
Data
Full-text available
The purity of RNA and cDNA samples depleted of gDNA in three biological replicates. (A) RNA samples after DNase treatment. The purity of RNA samples depleted of DNA traces was controlled by PCR amplification of the barley MIR171 gene. In a positive control reaction, 1 ng of gDNA was used. (B) cDNA samples. The purity of cDNA samples containing no g...
Data
Full-text available
Gene structure and composition of fully spliced and alternatively spliced variants of MIR156g and MIR1126 gene transcripts. The longest ORF detected in each variant is defined by the length of the encoding sequence, position of the ORF within the sequence, numbers of amino acids, and the lowest E-value in blastp analysis. The lengths of the spliced...
Data
List of primers and hybridization probes used in the experiments.
Article
microRNAs (miRNAs) are small RNAs that play key roles in regulation of cellular processes and therefore could largely contribute to solving many problems in medicine, biotechnology, and other biological sciences. As a result, the numbers of research projects and publications on miRNAs are constantly growing, which is accompanied by increasing amoun...

Network

Cited By