Elyse Caron-Beaudoin

Elyse Caron-Beaudoin
  • PhD
  • Professor (Assistant) at University of Toronto

About

54
Publications
4,825
Reads
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789
Citations
Introduction
I am an Assistant Professor in environmental health at the University of Toronto – Scarborough. My research is focused on the development of transdisciplinary research projects in partnership with communities to assess the impacts of anthropogenic pressures on health by combining information from multiple levels of biological organization. My research interests are at the nexus of toxicology, molecular biology, public and environmental health, and community-based research.
Current institution
University of Toronto
Current position
  • Professor (Assistant)
Additional affiliations
December 2016 - present
Université de Montréal
Position
  • Research Officer
April 2016 - present
Université de Montréal
Position
  • Co-Investigator
Description
  • Gestational exposure to environmental contaminants related to unconventional natural gas exploitation in aboriginal communities of Northern British Columbia, Canada.
March 2013 - present
University of Quebec in Montreal
Position
  • Lecturer
Education
September 2012 - December 2017
May 2010 - September 2012
September 2007 - May 2010
University of Quebec in Montreal
Field of study
  • Biology, environmental toxicology

Publications

Publications (54)
Article
Full-text available
The enzyme aromatase (CYP19; cytochrome P450 19) in humans undergoes highly tissue- and promoter-specific regulation. In hormone-dependent breast cancer, aromatase is over-expressed via several normally inactive promoters (PII, I.3, I.7). Aromatase biosynthesizes estrogens, which stimulate breast cancer cell proliferation. The placenta produces est...
Article
Full-text available
The Arctic Monitoring Assessment Program (AMAP) is tasked with monitoring and assessing the status of environmental contaminants in the Arctic, documenting levels and trends, and producing science-based assessments. The objectives of this paper are to present the current levels of persistent organic pollutants (POPs) across the Arctic, and to ident...
Article
Full-text available
The 2021 Arctic Monitoring Assessment Program (AMAP)’s Human Health Assessment report presents a summary of the presence of contaminants in human populations across the circumpolar Arctic and provides an update to the previous assessment released in 2015. The primary objective of this paper is to summarise some of these findings by describing the c...
Article
Many chemicals associated with unconventional oil and natural gas (UOG) are known toxicants, leading to health concerns about the effects of UOG. Our objective was to conduct a scoping review of the toxicological literature to assess the effects of UOG chemical exposures in models relevant to human health. We searched databases for primary research...
Article
Full-text available
In Brief Unconventional oil and natural gas (UOG) operations, particularly hydraulic fracturing, have revolutionized oil and gas production, using and containing complex mixtures of chemicals that may impact reproductive health. While there is growing evidence for effects on births in hydraulic fracturing/UOG regions and good mechanistic evidence f...
Article
Northeastern British Columbia is a region of prolific unconventional oil and gas (UOG) activity. UOG activity can release volatile organic compounds (VOCs) which can elevate oxidative stress and disrupt antioxidant activity in exposed pregnant individuals, potentially increasing the risk of adverse pregnancy outcomes. This study measured biomarkers...
Article
Full-text available
Objective Unconventional oil and gas development (UOGD, sometimes termed “fracking” or “hydraulic fracturing”) is an industrial process to extract methane gas and/or oil deposits. Many chemicals used in UOGD have known adverse human health effects. Canada is a major producer of UOGD-derived gas with wells frequently located in and around rural and...
Article
Northeastern British Columbia (Canada) is an area of oil and gas exploitation, which may result in release of fine (PM2.5) and inhalable (PM10) particulate matter. The aims of this study were to: 1) apply extrapolation methods to estimate exposure to PM2.5 and PM10 concentrations among EXPERIVA (Exposures in the Peace River Valley study) participan...
Article
Full-text available
Background Located in Northeastern British Columbia, the Montney formation is an important area of unconventional oil and gas exploitation, which can release contaminants like trace elements. Gestational exposure to these contaminants may lead to deleterious developmental effects. Objectives Our study aimed to (1) assess gestational exposure to tr...
Article
Perfluoroalkyl acids (PFAAs), a subset of per- and poly-fluoroalkyl substances (PFAS), are environmentally stable, mobile and bioaccumulative compounds. This leads to high concentrations in wildlife species essential to the cultural identity and subsistence of Arctic populations. Our objective was to characterize the distribution and exposure deter...
Article
Background Perfluoroalkyl acids (PFAAs), a subset of perfluoroalkyl substances (PFAS), are synthetic chemicals used in industrial and consumer applications. They are exceptionally stable and highly mobile in the environment, and were detected in high concentrations in Arctic wildlife and Nunavik Inuit. The study's objective was to study the associa...
Article
Full-text available
Background Hydraulic fracturing (fracking) is a method used to extract unconventional natural gas (UNG). Living near UNG operations has been associated with various health outcomes, but few have explored the association between UNG and mental health and substance use. Our objective was to evaluate the association between metrics of residential UNG...
Article
Full-text available
Background Persistent organic pollutant exposures are well-documented in the Arctic, but fewer studies examined non-persistent chemicals, despite increased market food and consumer product consumption. Objective To measure phenol, paraben, phthalate, and alternative plasticizer concentrations in Inuit adults. Methods The study included 30 pooled...
Article
Full-text available
Objective To document perfluoroalkyl acids (PFAAs) and bisphenol-A (BPA) exposure in four First Nation communities in northern Quebec compared to the Canadian Health Measures Survey (CHMS Cycle 5 2016-2017) and examine the associations between dietary consumption and chemical exposure. Design We used cross-sectional data from the JES-YEH! project...
Article
There are numerous volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) that Inuit may be exposed to from combustion, cooking, heating, vehicle exhaust, active and passive smoking and other local sources of contaminants such as oil spills or open-air burning in landfills. To better assess the levels of exposure to these non...
Article
Background Northeastern British Columbia (Canada) is an area of unconventional natural gas (UNG) exploitation by hydraulic fracturing, which can release several contaminants, including volatile organic compounds (VOCs). To evaluate gestational exposure to contaminants in this region, we undertook the Exposures in the Peace River Valley (EXPERIVA) s...
Article
Full-text available
Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the endocrine system and cause adverse effects. We aimed to classify the effects of 24 known EDCs, prevalent in certain occupations, according to four modes of action (estrogenic, antiestrogenic, androgenic, and/or antiandrogenic). A literature search, stratified int...
Article
Full-text available
Hydraulic fracturing, a method used in Northeastern British Columbia (Canada) to extract natural gas, can release contaminants with potential deleterious health effects on fetal development. To date, the association between hydraulic fracturing activity and birth outcomes has not been evaluated in this region. To evaluate the association between th...
Article
Full-text available
Background Perfluoroalkyl acids (PFAAs) are persistent and ubiquitous environmental contaminants that potentially disrupt endocrine system functions. While some PFAAs (perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA)) are regulated, currently used fluorotelomer alcohols (FTOHs) can be transported to the Arctic and are degraded in a n...
Article
Full-text available
Background: Northeastern British Columbia (Canada) is an area of intense natural gas exploitation by hydraulic fracturing. Hydraulic fracturing can release contaminants, including trace metals, many of which are known developmental toxicants. To date, there is limited data on human exposure to contaminants in this region. Objective: We aimed to...
Article
Background Perfluoroalkyl substances (PFASs) are found in several consumer goods. Exposure to PFASs in children has been associated with alteration in thyroid hormones, which have critical roles in brain function. Objective In 2015, 198 children and youth (3–19 y) were recruited as part of the pilot project Jeunes, Environnement et Santé/Youth, En...
Article
Ethnobiology is well positioned to work in tandem with biomonitoring research to create a more complete understanding of how people experience and are affected by contaminated environments. Indigenous communities in proximity to unconventional natural gas (“fracking”) facilities face potential health risks that are often poorly assessed or not asse...
Article
Full-text available
Background: Aromatase (CYP19) is a key enzyme in estrogens biosynthesis. In the mammary gland, CYP19 gene is expressed at low levels under the regulation of its I.4 promoter. In hormone-dependent breast cancer, fibroblast cells surrounding the tumor express increased levels of CYP19 mRNA due to a decrease of I.4 promoter activity and an increase o...
Poster
The preliminary steps involved in the development of the new co-culture model. Each cell type were profiled and assessed separately for their different properties. The evaluations confirmed the relevance of our chosen models.
Article
Background: Northeastern British Columbia (Canada) is an area of intense hydraulic fracturing for unconventional natural gas exploitation. There have been multiple reports of air and water contamination by volatile organic compounds in the vicinity of gas wells. Although these chemicals are known developmental toxicants, no biomonitoring effort ha...
Article
Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the enzyme aromatase (CYP19). Disruption of estrogen production by contaminants may result in serious pregnancy outcomes. We used our recently developed in vitro co-culture model of fetoplacental...
Article
Full-text available
Aromatase (CYP19) is the key enzyme in the biosynthesis of estrogens. In humans, it is expressed in a tissue-and promoter-specific manner. In hormone-dependent breast cancer, CYP19 is overexpressed through the activation of several additional promoters (PII, I.3 and I.7) that are normally inactive in the healthy mammary gland. In the normal mammary...
Article
Full-text available
The enzyme aromatase (CYP19; cytochrome P450 19) in humans undergoes highly tissue- and promoter-specific regulation. In hormone-dependent breast cancer, aromatase is over-expressed via several normally inactive promoters (PII, I.3, I.7). Aromatase biosynthesizes estrogens, which stimulate breast cancer cell proliferation. The placenta produces est...
Article
Full-text available
The aim of the present study was to investigate the feeding ecology of an omnivorous bird, the Ring-billed Gull (Larus delawarensis Ord, 1815), breeding in a highly urbanized and heterogeneous landscape (Montréal area, Quebec, Canada). We used gastrointestinal (G.I.) tract content analysis, GPS-based tracking information, and stable isotope profile...
Article
This study investigated the occurrence of a comprehensive suite of polybrominated diphenyl ethers (PBDEs) and current-use flame retardants (FRs) in ring-billed gulls breeding in a highly industrialized section of the St. Lawrence River, downstream from Montreal (QC, Canada). Despite major point-sources and diffuse contamination by FRs, nearly no FR...

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