About
14
Publications
2,548
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Introduction
I investigate audio-visual change detection in healthy humans and children with a genetic high risk of developing schizophrenia. I use simple audiovisual/auditory paradigms that allow me to quantitatively test the brains implementation of probabilistic models and to specifically probe the involvement of the frontal cortex and its interaction with primary sensory regions. By combining fMRI &TMS, I am aiming to identify the neuroanatomical loci of this probabilistic coding and their causal role.
Additional affiliations
February 2014 - present
February 2013 - January 2014
Copenhagen University Hospital Hvidovre; Skt Hans Hospital
Position
- PostDoc Position
Description
- MMN, auditory, multisensory integration, fMRI
Position
- PostDoc Position
Education
July 2007 - June 2011
September 2005 - July 2007
September 2001 - December 2003
Publications
Publications (14)
Background
Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories.
Methods
Sixty-nine male refugees (PTSD = 38) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Sc...
One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11...
Background
One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals w...
22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change dete...
Attention allows our brain to focus its limited resources on a given task. It does so by selective modulation of neural activity and of functional connectivity (FC) across brain-wide networks. While there is extensive literature on activity changes, surprisingly few studies examined brain-wide FC modulations that can be cleanly attributed to attent...
Background:
Neurodevelopmental brain disorders such as schizophrenia, autism and attention deficit hyperactivity disorder are complex disorders with heterogeneous etiologies. Schizophrenia and autism are difficult to treat and often cause major individual suffering largely owing to our limited understanding of the disease biology. Thus our underst...
Little is known about mechanisms mediating a stable perception of the world during pursuit eye movements. Here, we used fMRI to determine to what extent human motion-responsive areas integrate planar retinal motion with nonretinal eye movement signals in order to discard self-induced planar retinal motion and to respond to objective ("real") motion...
Motion processing regions apart from V5+/MT+ are still relatively poorly understood. Here, we used functional magnetic resonance
imaging to perform a detailed functional analysis of the recently described cingulate sulcus visual area (CSv) in the dorsal
posterior cingulate cortex. We used distinct types of visual motion stimuli to compare CSv with...
Trichromatic color vision is a fundamental aspect of the visual system shared by humans and non-human primates. In human observers, color has been shown to facilitate object identification. However, little is known about the role that color plays in higher level vision of non-human primates. Here, we addressed this question and studied the interact...
Ataxia telangiectasia (AT) is a hereditary human disorder resulting in a wide variety of clinical manifestations, including progressive neurodegeneration, immunodeficiency, and high incidence of lymphoid tumors. Cells from patients with AT show genetic instability, hypersensitivity to radiation, and a continuous state of oxidative stress. Oxidative...
Introduction and Motivation: fMRI is a natural source of high-dimensional time series data. Recordings are typically acquired in several hour sessions, with processing and analysis done of-fline. Due to the short amount of recording time available from any session, there is an imbalance between the comparatively small number of time slices and the...