Elvar Theodorsson

Elvar Theodorsson
Linköping University | LiU · Department of Clinical and Experimental Medicine (IKE)

MD, PhD

About

614
Publications
117,360
Reads
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22,081
Citations
Introduction
Medical school at the University of Iceland, PhD Karolinska Institute (Pharmacology), Specialist Clinical Chemistry/Pathology, Karolinska Hospital, Professor of Neurochemistry, Linköping University since 1995 H-index (SCOPUS, ORCID=0000-0003-0756-7723, https://www.scopus.com/authid/detail.uri?authorId=56488383600) of 71. Main research interests: 1) The neuroendocrinology of regulatory peptides, 2) Metrology and quality control
Additional affiliations
April 1995 - present
Linkoping University
Position
  • Research, teaching and administration
April 1983 - April 1995
Karolinska University Hospital
Position
  • PhD
January 1980 - April 1995
Karolinska Institutet
Position
  • Research and teaching
Education
January 1980 - October 1983
Karolinska Institutet
Field of study
  • Medicine
January 1972 - June 1978
University of Iceland
Field of study
  • Medicine

Publications

Publications (614)
Preprint
Background Testosterone is thought to be incorporated in growing hair strands so that specific hair segments reflect average free hormone concentrations from the corresponding time period. However, the exact mechanisms of hormone integration in scalp hair have not yet been established and it is not known how testosterone is stored in the hair segme...
Article
Background Few studies are available on how to optimize time points for sampling and how to estimate effects of analytical uncertainty when glomerular filtration rate (GFR) is calculated. Methods We explored the underlying regression mathematics of how analytical variation of a kidney filtration marker affects 1-compartment, slope-and-intercept GF...
Article
Uncertainty is an inseparable part of all kinds of measurements performed in clinical laboratories. Accreditation standards including the ISO/IEC 17025:2017 and ISO 15189:2012 require that laboratories have routines for calculating the measurement uncertainty of reported results. Various guidelines such as CLSI EP29, Nordest 537, and ISO 20914:2019...
Article
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Current studies indicate that robotic-assisted surgery is not inferior to laparoscopic or open surgery regarding oncologic or functional outcomes. An exception may be uterine cervix cancer, where the survival after minimal invasive surgery might not be as good as after open surgery. There is less bleeding and need for blood transfusion after roboti...
Article
Background: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods: A secondary analysis was conducted of saliva cortisol measured...
Article
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Objective To determine if preterm birth is associated with adaptation of the hypothalamic–pituitary–adrenal (HPA) axis and whether HPA axis programming relates to the degree of prematurity (defined as extremely preterm birth at <28 weeks or very preterm birth at 28–32 weeks gestation). Design This study reports findings from a prospective birth co...
Article
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Background Increased cortisol exposure is a risk factor for coronary artery disease (CAD). It is not clear to what degree this risk is independent from the standard modifiable risk factors (SMuRFs) dyslipidemia, hypertension, and diabetes. Aim To use path analysis to test the direct and indirect association, mediated by SMuRFs, between long-term c...
Article
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During pregnancy, the immune system is modified to allow developmental developmental tolerance of the semi-allogeneic fetus and placenta to term. Pregnant women suffering from stress, anxiety and depression show dysfunctions of their immune system that may be responsible for fetal and/or newborn disorders, provided that provided that placental gene...
Technical Report
The problem of evaluating and expressing uncertainty in qualitative chemical analysis has received much less coverage in the literature than that afforded to uncertainty for quantitative analysis (i.e., measurements). While some authors have addressed this area, general guidance on the assessment of performance in qualitative analysis or the evalua...
Article
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The pathogenesis of paediatric appendicitis is still an enigma. In recent years, it has become more evident that our inherent immunological responses affect the trajectory of the disease course. Long-term stress has an impact on our immune system; however, it is practically and ethically challenging to prospectively track blood measurements of cort...
Article
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Hepatic nerves have a complex role in synchronizing liver metabolism. Here, we used three-dimensional (3D) immunoimaging to explore the integrity of the hepatic nervous system in experimental and human nonalcoholic fatty liver disease (NAFLD). We demonstrate parallel signs of mild degeneration and axonal sprouting of sympathetic innervations in ear...
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Previously, we found that dogs belonging to the herding breed group, selected for human cooperation, synchronise their long-term stress levels with their owners. The aim of the current study was to investigate features that could influence long-term stress levels in ancient dog breeds, genetically closer to wolves, and dogs specifically selected to...
Article
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Objective: To investigate hair cortisol concentrations (HCC) monthly in pregnant women and to explore the effect of parity. Design: Prospective cohort study from gestational week (GW) 26, at childbirth and postpartum. Setting: An antenatal care clinic in southeast Sweden. Sample: 390 pregnant women. Methods: Cortisol was measured using rad...
Article
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Long term stress exposure is typical for modern societies and might trigger different diseases. This case–control study reveals that persons who had suffered an acute myocardial infarction (AMI) had elevated cortisol concentrations in the month before the acute event. Middle-aged patients admitted to cardiology clinics with acute myocardial infarct...
Article
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Background The global financial crisis emerging in 2008 struck Greece especially hard, whereas Scandinavian countries were less affected. This has created a unique opportunity to study the long-term effect of community stress on populations. Increasing frequencies of mental health issues and poorer perceived health among the Greek population have b...
Article
Studies show that very low birthweight can be an important risk factor for mental problems, disturbed fertility and neuroendocrine dysregulation. In a regional long-term study 56 of 86 adult individuals 27 to 28 years of age with a very low birthweight were compared with normal birthweight controls. Analyses of self-reported mental health, socio-de...
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Background: Diastasis of the rectus abdominis muscle is a common condition. There are no generally accepted criteria for diagnosis or treatment of diastasis of the rectus abdominis muscle, which causes uncertainty for the patient and healthcare providers alike. Methods: The consensus document was created by a group of Swedish surgeons and based...
Article
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Anxiety, chronical stress, and depression during pregnancy are considered to affect the offspring, presumably through placental dysregulation. We have studied the term placentae of pregnancies clinically monitored with the Beck’s Anxiety Inventory (BAI) and Edinburgh Postnatal Depression Scale (EPDS). A cutoff threshold for BAI/EPDS of 10 classed p...
Preprint
Full-text available
Anxiety, chronical stress and depression during pregnancy are considered to affect the offspring, presumably through placental dysregulation. We have studied the term placentae of pregnancies clinically monitored with the Beck’s Anxiety Inventory (BAI) and Edinburgh Postnatal Depression Scale (EPDS). A cutoff threshold for BAI/EPDS of 10 classed pa...
Article
Full-text available
Granulocyte transfusions have been administered to patients with life-threatening infections for more than five decades. However, to what extent this should be the case is far from established. On the one hand, the clinical effects of these transfusions are difficult to prove in clinical studies, and the donors of granulocytes may be exposed to cer...
Article
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The aim of this study was to analyse the dynamics of tissue damage and inflammatory response markers perioperatively and whether these differ between women operated with robotic and abdominal hysterectomy in treating early-stage endometrial cancer. At a Swedish university hospital fifty women with early-stage low-risk endometrial cancer were alloca...
Preprint
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Background: Health behavior varies highly across European countries, and stress and stress-related disorders are commonly seen in European Primary Health Care. Greece has suffered deeply from the 2008 international financial crisis, whereas Scandinavian countries were less affected. Several reports of increasing mental health issues and poorer perc...
Article
Hair cortisol is a promising biomarker to measure long-term stress since cortisol is incorporated into the hair shaft as it grows. However, few studies have previously assessed hair cortisol concentrations (HCC) in horses. In this study, HCC was evaluated in both mane hair from the neck and body hair from the withers in 153 horses of different bree...
Article
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Measurement uncertainties in clinical chemistry are commonly regarded as heteroscedastic – having a constant relative standard deviation irrespective of the concentration of the measurand. The uncertainty is usually determined at two concentrations using stabilized control materials and assumed to represent the analytical goal. The purpose of the p...
Article
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Measurement imprecision is usually calculated from measurement results of the same stabilized control material(s) obtained over time, and is therefore, principally, only valid at the concentration(s) of the selected control material(s). The resulting uncertainty has been obtained under reproducibility conditions and corresponds to the conventional...
Article
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Measurement uncertainty (MU) can be estimated and calculated by different procedures, representing different aspects and intended use. It is appropriate to distinguish between uncertainty determined under repeatability and reproducibility conditions, and to distinguish causes of variation using analysis of variance components. The intra-laboratory...
Article
Objective: Satisfactory anabolic reactions, including the activation of the hypothalamic-pituitary-adrenal (HPA) axis, are essential following severe traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH). Many factors may influence this activation. This study aimed to investigate whether individuals who reported chronic disease...
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Background Individuals born very preterm or with very low birth weight (VLBW) have a reduced likelihood to reproduce according to population-based register studies. Extremely low-birth weight born adults had a lower reproduction rate for both men and women in a follow-up study. Aim To investigate if being born with VLBW is associated with differen...
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Extensive research has been devoted to developing methods for assessing core body temperature, and to determine which method is most accurate. A number of wireless dermal thermometers for home use are presently available, but their relation to core body temperature and suitability for use in clinical research has hitherto not been assessed. The cur...
Article
Background Myocardial infarction (MI) is more likely if the heart damage biomarker cardiac troponin T (cTnT) is elevated in a blood sample from a patient with chest pain. There is no conventional method to estimate the risk of MI at a specific cTnT concentration. The purpose of this study was to evaluate the performance of a novel method that conve...
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Hot flushes are common and troublesome symptoms of menopause. The neuropeptide calcitonin gene-related peptide (CGRP) is increased in plasma during hot flushes but it has not been clear if CGRP is causally involved in the mechanism underpinning the flushes. Here, we examined the effect of interventions with CGRP in a mouse model of hot flushes base...
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Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with one or more small molecule (classic) neurotransmitters. Neuropeptides act both as transmitters and trophic factors, and play a role particularly when the nervous system is challenged, as by injury, pain or stress. Here neuropeptides and coexistence in mammals a...
Article
Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less than 32 weeks of gestational age admitted to St Olavs University Hospital, Trondheim, Norway, between January 2014 and J...
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Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract w...
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Objective: The effect of combined oral contraceptives (COC) on female sexuality has long been a matter of discussion, but placebo-controlled studies are lacking. Thus, the aim of the present study was to investigate if an estradiol-containing COC influences sexual function. Design: Investigator-initiated, randomised, double-blinded, placebo-control...
Article
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Background: It has not yet been established whether men in heterosexual relationships adapt their hormone levels to their female partner's menstrual cycle to allocate reproductive resources to the period when the female is actually fertile. Aim: This prospective observational study tested the hypothesis that some males have peaks in testosterone...
Article
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The pathogenesis of acne vulgaris has only been partially elucidated. Various hormones, especially androgens, are likely to play a role, but results of studies are still inconclusive. The objective of the current study was to investigate whether day to day variation in salivary testosterone correlates with acne in males. Saliva samples were collect...
Article
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Background: Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeutic options are few. Several factors have been suggested to explain this translational difficulty, particularly concerning methodo...
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Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consi...
Data
Global TPH1KO mice still synthesize 5-HT in the intestine. (A) Example of genotype analysis results of TPH1KO +/+ (Wt), TPH1KO +/− (Hz) and TPH1KO −/− (KO). (B) HPLC-ECD measurements of 5-HT concentration in homogenized tissue from duodenum and colon (n = 7). (C) Representative images from immunohistochemistry on intestinal segments marked with 5-H...
Data
Main Nutrient and Microbial metabolites which are being recognized by GPCR sensors and which are probed for expression in EC cells in the present study. Sensing of triglycerides is mainly performed by FFAR1 and GPR119, which recognize LCFAs and 2-acyl glycerol, respectively, and TGR5 recognizing primary bile acids required for triglyceride micelle...
Data
qPCR and histological analysis of co-expressed peptides and granins in colonic EC cells. (A) qPCR analysis targeting the expression of 88 common peptide hormones, neuropeptides and granins in 5-HT positive cells (y-axis) versus 5-HT negative cells (x-axis) in colon. The enriched peptide transcripts are depicted as green dots whereas the rest are gr...
Data
qPCR analysis of various receptors on ChgA-GFP positive colon cells (A) qPCR analysis expression data for main nutrient metabolite 7TM GPCRs and microbiota metabolite in ChgA-GFP positive cells (y-axis) compared with surrounding negative cells (x-axis) isolated from colon. (B) qPCR analysis expression data for main gut hormone 7TM GPCRs in ChgA-GFP...
Data
Immunohistochemistry (A and B) Representative fluorescent microscopy picture with monoclonal GLP-1R antibody (green) in combination with Somatostatin antibody (red) in duodenum.
Article
Objectives: 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract. However, the molecular mechanism through which EC cells sense nutrients and gut microbiota is still uncl...
Article
The TARGIT-A (TARGeted Intraoperative radioTherapy) multicentre study of early breast cancer compared intraoperative radiotherapy with external radiotherapy. While the intraoperative radiotherapy was standardised, the external postoperative comparison treatment followed established routines in the participating treatment centres resulting in substa...
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The concentrations of testosterone deposited in hair during hair growth may provide a retrospective reflection of the concentrations of bioactive testosterone in plasma. The objective of this study was to develop a radioimmunoassay with a sufficiently low limit of detection to measure the testosterone-like immunoreactivity in smaller hair samples (...
Article
Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus, stress and anxiety. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical...
Article
Full-text available
Clinical chemistry is subject to the same principles and standards used in all branches of metrology in chemistry for validation of measurement methods. The use of measuring systems in clinical chemistry is, however, of exceptionally high volume, diverse and involves many laboratories and systems. Samples for measuring the same measurand from a cer...
Article
Healthy infants establish a salivary cortisol circadian rhythm (SCCR) at one month of age (1). This study investigated the development of SCCR in infants at high psychosocial risk, by measuring salivary cortisol levels during their first year of life and evaluating whether those were related to behavioural regularity. This article is protected by c...
Article
Full-text available
Objectives To investigate at what age preterm infants develop a salivary cortisol circadian rhythm and identify whether it is dependent on gestational age and/or postnatal age. To evaluate whether salivary cortisol circadian rhythm development is related to behavioral regularity. To elucidate salivary cortisol levels in preterm infants during the f...
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Student rating of teaching is essential for attaining and maintaining high educational quality. A quality improvement system, SKURT, based on digital online weekly combined quantitative, ten-graded scale, and qualitative, open-ended free text, group feedback from medical students was developed. Students rated all educational, non-clerkship, items t...