Elsadig Mohamed Ahmed

• PhD in Clinical chemistry
• Professor (Associate) at University of El Imam El Mahdi

L-asparaginase is an amidohydrolase enzyme that is widely identified as one of the most potential anti cancerous drugs. Nevertheless, this drug is poorly bioavailable and hence its pharmaceutical uses are limited. To improve its bioactivity, L-asparaginase was loaded on gold nanoparticles (GNPs) along with Arg-Gly-Asp (RGD) peptide that direct the...

The integration of advanced computational methods into precision medicine represents a transformative advancement in healthcare, enabling highly personalized treatment strategies based on individual genetic, environmental, and lifestyle factors. These methodologies have significantly enhanced disease diagnostics, genomic analysis, and drug discover...

The study aims to evaluate the significant role of interleukin 15 (IL-15), IL-22, IL-37, and Caspase 9 gene expression in polycystic ovary syndrome (PCOS), focusing on the underlying mechanisms and potential diagnostic or therapeutic implications. Peripheral blood has been collected, and serum was separated for the evaluation of the serum IL-15, IL...

Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca²⁺ pathways have been identified as potential pathways regulating insulin synthesis by preserving pancreatic β-cell functioning. The current study aime...

Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease. In addition to the very bad socioeconomic impacts, it influences patients and their families and communities. The global costs of DM and its complications are huge and expe...

Insulin gene mutations affect the structure of insulin and are considered a leading cause of neonatal diabetes and permanent neonatal diabetes mellitus PNDM. These mutations can affect the production and secretion of insulin, resulting in inadequate insulin levels and subsequent hyperglycemia. Early discovery or prediction of PNDM can aid in better...

Insulin gene mutations affect the structure of insulin and are considered a leading cause of neonatal diabetes and permanent neonatal diabetes mellitus PNDM. These mutations can affect the production and secretion of insulin, resulting in inadequate insulin levels and subsequent hyperglycemia. Early discovery or prediction of PNDM can aid in better...

Alpha synuclein (α-Syn) is a neuronal protein encoded by the SNCA gene and is involved in the development of Parkinson’s disease (PD). The objective of this study was to examine in silico the functional implications of non-synonymous single nucleotide polymorphisms (nsSNPs) in the SNCA gene. We used a range of computational algorithms such as seque...

The study planned to estimate biological parameters linked to rheumatoid arthritis (RA) patients, detecting the influence of MTX and biotherapy treatments on these parameters and synthesizing methotrexate bovine serum albumin nanoparticles linked to folate (FA-MTX-BSA NPs) to reduce the overwhelming expression of inflammatory cytokines. Inflammator...

Citation: Elkhalifa, A.M.E.; Shah, N.N.; Khan, Z.; Ali, S.I.; Nabi, S.U.; Bashir, S.M.; Mir, M.S.; Bazie, E.A.; Elderdery, A.Y.; Alanazi, A.; et al. Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19. Healthcare 2023, 11, 944. Abstract: The present study evaluated the clinical presentation and outcome of C...

The goal of the current work was to create an antibacterial agent by using polycaprolactone/chitosan (PCL/CH) nanofibers loaded with Cordia myxa fruit extract (CMFE) as an antimicrobial agent for wound dressing. Several characteristics, including morphological, physicomechanical, and mechanical characteristics, surface wettability, antibacterial ac...

Single-walled carbon nanotubes (SWCNTs) involving polyethylene glycol (PEG) and polyethyleneimine (PEI), which contain amines, were produced and analyzed using X-ray diffraction (XRD), UV–vis spectroscopy, Raman spectroscopy (RS), and transmission electron microscopy (TEM) for the spectral and structural analyses of PEG-PEI-SWCNTs. PEG-PEI-SWCNTs d...

In this work, bismuth oxide nanoparticles (Bi2O3 NP) were prepared by laser ablation of a solid target in distilled water. The optical and structural properties of Bi2O3 NPs were studied using UV–VIS spectroscopy, energy-dispersive X-ray spectroscopy (EDS), transmission electron microscope (TEM), scanning electron microscopy (SEM), and Fourier tran...

Colorectal cancer (CRC) is considered as the fourth prevalent reason of cancer deaths. Interleukin 10 (IL10) and interleukin 17A (IL-17A) act as anti-inflammatory and pro-inflammatory cytokines, respectively, both being able to exert antitumor or pro-tumor roles in cancer. Serum levels for IL-10, IL-17A, and calcitriol were measured by ELISA. The C...

Colorectal cancer (CRC) is considered as the fourth prevalent reason of cancer deaths. Interleukin 10 (IL10) and interleukin 17A (IL-17A) act as anti-inflammatory and pro-inflammatory cytokines, respectively, both being able to exert antitumor or pro-tumor roles in cancer. Serum levels for IL-10, IL-17A, and calcitriol were measured by ELISA. The C...

Background: Thyroid dysfunction is a public health problem in White Nile State in Sudan. It is majorly caused by iodine deficiency. Hyperprolactinemia, the clinical condition associated with infertilityis resulted from a number of causes. Objectives: This study aimed to assess the relationship between thyroid hormone and prolactin serum level in Su...

In this study, we developed a new, efficient targeting and pH-responsive formulation using folate (FA)-conjugated human serum albumin (HSA) nanoparticles to deliver doxorubicin (DOX) drug to renal cell carcinoma. FA was conjugated to HSA, and DOX was loaded into obtained FA-HSA NP using the desolvation method. FA-HSA-DOX NPs were examined using zet...

L-asparaginase is an amidohydrolase enzyme that is widely identified as one of the most potential anti cancerous drugs. Nevertheless, this drug is poorly bioavailable and hence its pharmaceutical uses are limited. To improve its bioactivity, L-asparaginase was loaded on gold nanoparticles (GNPs) along with Arg-Gly-Asp (RGD) peptide that direct the...

Background: This study aimed to observe the lipid profile in diabeticpatients and to find out correlation between glycated hemoglobin (HbA 1C) and lipid profile. Methods: Lipid profiles, fasting blood sugar and HbA 1C values of 100 diabetic patients were studied. Blood samples of 41 male and 59 female diabetic patients were assessed for fasting blo...

Background: This study aimed to observe the lipid profile in diabeticpatients and to find out correlation between glycated hemoglobin (HbA1C) and lipid profile. Methods: Lipid profiles, fasting blood sugar and HbA1C values of 100 diabetic patients were studied. Blood samples of 41 male and 59 female diabetic patients were assessed for fasting blood...

Background: Human pathogens have been recognized as having a considerable possible effect on male infertility. Recent studies have shown the role of viral infections as an idiopathic pathogenesis of male infertility including cytomegalovirus. This study aimed to detect human cytomegalovirus antibody in serum among infertile male and to find out the...

Insulin resistance is the pathophysiological basis of dyslipidemia and hyperglycemia.Most lipid abnormalities in type 2 diabetes can be explained by reduced action of insulin at the tissue level.This cross sectional study was carried out to assess the impact of diabetes mellitus on lipid profile of Sudanese diabetic patients treated with insulin an...

Background and objectives:The objective of this study was to assess the necessity of regular monitoring of thyroid function status during mid and late stages of pregnancy. Patients and method: Maternal thyroid function was investigated in 50 normal pregnant women in their second and third trimester and 50 age-matched non-pregnant women, attending t...

ABSTRACT: The Sudanese diabetic patients may have high frequency of dyslipidaemia, which contribute to accelerated coronary atherosclerosis. This study aims to assess Lp (a) and HbA1C in blood samples of Sudanese diabetic patients. In this cross-sectional prospective study, blood samples of 150 Sudanese diabetic patients were collected. Diabetic pa...

This study aimed to determine cholesterol serum levels among pregnant Sudanese women during their third gestational period. In this cross-sectional study, samples were collected from pregnant ladies during the period of September 2012 to April, 2013. The serum concentration of cholesterol was estimated in 120 cases and in a control group of 240 non...

Original Article Background: Diabetes mellitus (DM) is the most common endocrine-metabolic disorder in children and adolescents. It is characterized by high incidence of cardiovascular disease (CVD). The cause of increased risk of CVD in diabetes is multi-factorial, important factors include dyslipidaemia and poor glycaemic control. Problem: The Su...

Original Article Background: Diabetes mellitus (DM) is the most common endocrine-metabolic disorder in children and adults. Cardio Vascular Disease (CVD) is a common complication of diabetes mellitus. The cause of the increased risk of CVD in diabetes is multi-factorial, including poor glycaemic control and dyslipidaemia. Aim of Study: This study w...

The objective of this study was to find out possible relationship between thyroid hormones and lipids profile levels in Elobeid city, North Kordofan State, during the period from March 2011 to March 2012. A total of 250 subjects were selected for this study. Out of 250 subjects, 150 were patients, Female to Male ratio was 2.75: 1.0 (100 patients we...