Elsa Krisanti

Elsa Krisanti
University of Indonesia | UI · Department of Chemical Engineering

Ph.D.

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58
Publications
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401
Citations

Publications

Publications (58)
Article
Full-text available
A highly stable oil-in-water nanoemulsion for topical applications, containing mangostins extracted from the pericarp of mangosteen ( Garcinia mangostana L .), is a promising strategy to protect mangostins as well as to improve penetration of these important antioxidants through the skins. Nanoemulsions consisted of virgin coconut oil as the oil ph...
Conference Paper
Cytotoxicity, antioxidant activity, and a total bioactive assay of the ethanolic extract of Annona muricata leave partitioned into water, n-hexane, and methanol fractions were investigated. The brine shrimp lethality test used for the cytotoxicity assay gave the LC50 values of 84 and 1 ppm for the n-hexane and methanol fractions, respectively. The...
Conference Paper
Full-text available
Curcuminoids, natural polyphenolic compounds extracted from the rhizomes of turmeric (Curcuma longa L), are known to have antioxidant, anti-inflammatory, anti-carcinogenic, antiviral, and antifungal actions. It is also known that the delivery of curcuminoids for local and treatment of gastric disorders, such as gastric ulcers, can use gastro-retent...
Conference Paper
Long-term drug release is needed to treat ocular diseases, especially in the posterior region where the retina is located. Dexamethasone, an anti-inflammation drug, was encapsulated in biocompatible and biodegradable polylactic acid/polylactic-co-glycolic acid (PLA, PLGA 90:10, PLGA 50:50) nanoparticles prepared using the solvent evaporation method...
Article
Full-text available
Iron fortification program relates to iron delivery through daily foods, which have a potential impact on many people. In this study, chitosan microparticle loaded with ferrous gluconate was used as fortificant, while gummy candies were selected as food vehicles. This work aimed to assess the effect of iron microparticles addition on basic nutrient...
Article
Full-text available
The aim of the study is to investigate the relationship between the phytochemical content of the fruit rind of Garcinia mangostana Linn with antioxidant activity and cytotoxicity of different fractions (ethyl acetate, n-butanol, water) of the xanthones extract. The ethyl acetate fraction showed the highest total xanthones as quercetin equivalent an...
Article
Full-text available
Steam stripping is commonly used to remove free fatty acids from crude palm oil. An alternative deacidification method, solvent extraction performed at a much lower temperature, would preserve the natural antioxidants in the refined palm oil. In this work, palmitic acid was extracted using betaine monohydrate-propionic acid and betaine monohydrate-...
Article
Full-text available
Ascorbic acid and folic acid are very important vitamins which have some crucial roles in human body’s metabolism, including enhancing iron absorption. Regardless of its roles, these vitamins are also known to be unstable and easily degraded in the processing by oxygen, pH, temperature, and UV light. Nowadays, microencapsulation may be a proper tec...
Article
Full-text available
A proper understanding of the properties of iron could increase the effectiveness of programmes for alleviating iron deficiency. Recently, encapsulation has been considered an appropriate method for protecting iron from injurious reactions. However, several events may occur during encapsulation processes, including changes in the iron’s oxidation s...
Article
Full-text available
Chitosan-alginate microparticles loaded with hydrophobic mangostins present in the mangosteen rind extract have been formulated and optimized for colon-targeted bioactive drug delivery systems. The chitosan–mangostin microparticles were prepared using the ionotropic gelation method with sodium tripolyphosphate as the cross-linking agent of chitosan...
Conference Paper
Full-text available
Benzoin absolute essential oil is a high-value oleoresin derived from the dried sap of the Styrax benzoin tree. One type of Styrax benzoin traded in Indonesia is black Sumatran incense. Reflux extraction method with ethanol is used to gain the benzoin absolute essential oil. The purpose of this study is to investigate the antioxidant activity of be...
Conference Paper
Full-text available
The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the...
Article
Full-text available
The non-volatile phenolic compounds of red ginger oleoresin are known to have high antioxidant properties to counteract a number of free radicals. Ginger oleoresin is easily degraded when exposed to air, light, water, high temperature, and low-pH conditions in the gastric area. The objective of this research was to evaluate chitosan-alginate matric...
Article
Full-text available
A simple method of encapsulation of bioactive compounds that does not involve washing, heating, and degradation of active substance is desired. The encapsulation of red ginger oleoresin in the chitosan-alginate matrix was developed using the freeze drying method to achieve higher matrix yield and loading capacity in the matrix. Bioactive substances...
Article
Full-text available
Polyvinyl alcohol (PVA)-chitosan-tripolyphosphate hydrogels were prepared using a solvent casting-evaporation method to obtain anti-TB drugs extended release formulations. X-ray diffraction and scanning electron microscope results indicated that chitosan reduced the crystallinity of PVA hydrogels and the polymers formed homogeneous mixtures. The ad...
Conference Paper
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Spent Coffee Ground (SCG) is one of the least processed domestic wastes in Indonesia, its low economic value is the main reason why this waste is not considered. Deep eutectic solvent (DES) is one of the newest, most efficient and environmentally friendly solvents, which is beginning to be widely studied as solvents for extraction of natural bioact...
Conference Paper
Full-text available
Freeze-dried chitosan matrices have been developed for sustained release of acetogenins extracted from the leaves of soursop (Annona muricata L.). The chitosan matrices were prepared by freeze drying mixtures of chitosan and acetogenin-rich extract obtained by fractionation of a soursop leaves extract solution. Freeze-dried chitosan matrices were o...
Conference Paper
Full-text available
Deacidification is one of many steps in the palm oil refining process which aims to separate free fatty acids from the oil. The deacidification process was using green solvent, known as deep eutectic solvent (DES), that consisted of betaine anhydrous and hydrogen bonding donor of 1,2-propanediol (DES-1) and 1,4-butanediol (DES-2) at a molar ratio o...
Article
Full-text available
Mangosteen pericarp contains α-mangostin, the most abundant xanthone that is useful as an antioxidant. Deep eutectic solvent (DES) was used in this study as a green solvent for extraction of α-mangostin. Our previous study shows that a DES, consisting of betaine as the hydrogen bond acceptor and 1,2-propanediol as the hydrogen bond donor, having th...
Article
Full-text available
Deep eutectic solvents (DESs) are known as alternative green solvents due to their ease of synthesis, availability, biodegradability and negligible volatility. DESs consisted of betaine as the hydrogen bond acceptor with 1,2-propanediol, levulinic acid and methyl diethanolamine (MDEA) as the hydrogen bond donors, were prepared in 1:3 and 1:6 molar...
Article
Full-text available
Freeze drying or lyophilisation method was selected for preparing chitosan-alginate matrices loaded with the extract of mangosteen pericarp for oral administration. The objective of this research was to obtain chitosan-alginate matrices for colon targeted drug delivery system that had a high content of mangostins by using a freeze drying method. Va...
Article
Full-text available
Microencapsulation using biopolymers is considered as a proper method for protecting the iron from oxidation reaction, inhibitors (fitat, tannin) and competitors (divalent metal). Chitosan and alginate are carbohydrate biopolymers commonly used in food and drug application. In order to have a carrier that can send iron to the small intestine which...
Conference Paper
Full-text available
One of the cost-effective approaches to reduce the prevalence of iron deficiency anaemia is by developing iron fortified food. However, adding iron directly into food will not only affect the organoleptic quality of the food, but will also reduce the effectiveness, stability and bioavailability of the iron added. Chitosan as linear polysaccharide,...
Conference Paper
Full-text available
Nanoemulsion of oleoresin of ginger extract (Zingiber officinale var. Roscoe) in vegetable oil was developed and characterized for the purpose to encapsulate bioactive in ginger for oral delivery formulation. Ginger extract oleoresin was known as natural antitumor, antimicrobial agents and antioxidants, but it has limited therapeutic utilization be...
Conference Paper
Full-text available
Garcinia mangostana L. (mangosteen) pericarp containing α-mangostin is predicted to have potential as an anticancer because it can induce apoptosis and has high antioxidant content. Moreover, the preliminary study showed that this extract has high antioxidant activity and cytotoxicity based on the brine shrimp lethality test. This indicates that ma...
Article
Full-text available
Deep Eutectic Solvents (DESs) are emerging as alternative green solvents. Unlike ionic liquids, DESs are more environmentally friendly and non-toxic, so that they are more suitable to be used in pharmaceutical and food production processes. Few studies reported that DESs, which are liquid at room temperature, can be applied for extracting bioactive...
Article
Full-text available
Ginger is one of the spices that well-known for the health benefit. Ginger containing 6-gingerol and other phenolic compounds that act as antioxidant activity. Bioactive compounds in ginger are sensitive to high temperature, pH, and light so encapsulation is needed for protecting the bioactive compounds from degradation and for controlling the drug...
Article
Full-text available
Mangosteen (Garcinia mangostana L.) is a fruit that is rich in xanthones, utilized as health supplements or additives in food products due to their high antioxidant activities. Choline chloride (ChCl)-based deep eutectic solvents (DESs) with polyalcohols (ethylene glycol, glycerol, propanediols, and butanediols) as hydrogen bonding donors (HBDs) we...
Article
Full-text available
Nanoemulsions containing extract of mangosteen ( Garcinia mangostana L.) rind has been developed and characterized as a topical formulation. The encapsulation of mangosteen extract in nanoemulsions is considered a promising strategy to utilize the available bioactive compounds, particularly α-mangostin. In this study, a high-speed homogenization me...
Article
Full-text available
In the palm oil refining processes, the free fatty acid content is reduced to an acceptable level by using steam-stripping that causes, also, the loss of nutraceuticals such as tocopherols and carotenoids. An alternative method, such as solvent extraction, to separate free fatty acids, especially palmitic acid as the major free fatty acid present i...
Article
Full-text available
The pericarp of mangosteen (Garcinia mangostana L.) contains bioactive xanthones, with α-mangostin being the major component, has been known to possess antitumor, antiviral, and other pharmacological activities. In this study, the effect of elevated temperature during the preparation step of fresh mangosteen pericarp juice and mangosteen extract, o...
Article
Full-text available
The problem to overcome in oral drug administration is the significant pH changes present in the human digestive system. In this study, ionotropic gelation method employing 2-8% (w/v) tripolyphosphate solutions were used to crosslink chitosan microspheres for a controlled release of paracetamol as a model drug. The release profiles of paracetamol f...
Article
Full-text available
A hydrogel of nanoemulsion system containing mangosteen extract of mangosteen rind was developed and characterized for the purpose of topical formulation. Mangostins, the bioactive in the extract, has been known to have biological activities such as antifungal, antibacterial, antioxidant, antiviral and antitumoral. Due to the hydrophobic nature of...
Article
Full-text available
Deep eutectic solvents (DESs) consisting of betaine as the hydrogen donor acceptor and a propanediol or a butanediol as the hydrogen bonding donor were used to extract vitexin from the leaves of Anredera cordifolia (Ten.) Steenis, known in Indonesia as binahong used traditionally to treat wounds. The vitexin extraction yields depend strongly on the...
Conference Paper
Full-text available
Dietary modification, supplementation and food fortification are common strategies to alleviate iron deficiencies. Fortification of food is an effective long-term approach to improve iron status of populations. Fortification by adding iron directly to food will cause sensory problems and decrease its bioavailability. The purpose of iron encapsulati...
Article
In the palm oil industry, the deacidification process is performed by steam stripping which causes the loss of most of palm oil’s natural antioxidants due to high temperature. The liquid-liquid extraction process which is carried out at low temperature is preferable in order to preserve these compounds. The use of hydrated ethanol can reduce the lo...
Conference Paper
Full-text available
The mucoadhesive properties of chitosan is suitable for extending the residence time of chitosan microparticles in the small intestine and colon. Microparticles prepared using the lowest molecular weight chitosan (62 kDa) showed the highest mucin adsorption of 55-84% and the highest zeta potential of +35.1 mV. Alginate-modified chitosan micropartic...
Conference Paper
Full-text available
The usage of red ginger rhizome (Zingiber officinale var. Rubrum) oleoresin extract as the preservative for fresh milk has not been studied yet. The aim of this research was to compare the inhibition effect of oleoresin extract-loaded chitosan-alginate microparticles, and various ginger-based preservatives added into fresh milk, on the growth of ba...
Conference Paper
In application of intravitreal injection, an extended drug delivery system is desired so that the frequency of injection to treat diabetic retinopathy may be reduced. Poly(lactic-co-glycolic acid)polymer (PLGA) was used to encapsulate a model drug in the form of microspheres. The zeta potential of dimethyldioctadecylammonium bromide (DDAB)-modified...
Conference Paper
The common treatment for diabetic retinopathy is corticosteroids intravitreal injection that sometimes lead to complications. Dexamethasone-loaded polylactic co-glycolic acid (PLGA) nanospheres, modified with dioctadecyldimethylammonium bromide (DDAB) as the cationic surfactant, is expected to prolong drug retention time. Zeta potential of the PLGA...
Conference Paper
Full-text available
The leaves of binahong (Anredera cordifolia (Ten) Steenis) contain flavonoids as bioactive substances that have efficacy to treat wounds and diseases caused by bacteria. One of the flavonoids contained in the leaves is 8-glucopyranosyl-4'5'7-trihydroxyflavone or vitexin. Conventional extraction of flavonoids from leaves of binahong has been develop...
Conference Paper
Full-text available
This study was conducted to determine the effectiveness of Natural Deep Eutectic Solvent (NADES), consisting of choline chloride and a hydrogen bonding donor (HBD) compound, in terms of carbon dioxide absorption. Solubility of carbon dioxide in NADES was found to be influenced HBD compound used and choline chloride to HBD ratio, carbon dioxide pres...
Conference Paper
Full-text available
Preparation of mangostin-loaded chitosan-alginate microparticles, chemical and physical characterization of the particles, and mangostin release profiles, are described herein. Mangostin rich fraction was obtained from Garcinia mangostana L. pericarp by extraction followed by fractionation. Mangostin-loaded chitosan-alginate microparticles were pre...
Article
Full-text available
Herein is described the selective polar-guided extraction and column chromatography separation of annonaceous acetogenins from the leaves of Annona muricata L., commonly known as soursop. The objective of this study is to obtain an acetogenin-rich fraction, containing mainly annonacin, known to be present in the highest amount in soursop leaves. So...
Article
Full-text available
This research considers the application of Natural Deep Eutectic Solvents (NADES) as green solvents for the extraction of bioactive compounds, mainly α-mangostin, from the pericarp of mangosteen (Garcinia mangostana L.). Extractions were carried out using NADES consisting of choline chloride, a quarternary ammonium salt, and four hydrogen bond dono...
Article
Full-text available
A communication skills course for chemical engineering students has been updated to enhance the students' presentation and proposal writing skills, including summarizing journal papers, teaching note writing, and memo writing. All of these skills will help prepare these students for undertaking courses in the subsequent semesters that emphasize sma...
Article
Full-text available
Annonaceous acetogenins are bioactive compounds present in the leaves of Annona muricata (soursop) with significant anti-cancer activities. In this study, acetogenin-rich ethanol fraction extracted from soursop leaves was further separated and isolated using a simple open column chromatography technique with silica gel as the stationary phase. The...
Article
The present work explores the combined production of hemicellulose-derived carbohydrates and an upgraded solid residue from wheat straw using a dilute-acid pretreatment at mild temperature. Dilute aqueous HCl solutions were studied at temperatures of 100 and 120°C, and they were compared to dilute FeCl(3) under the same conditions. Comparable yield...
Article
Full-text available
There are two most widely reported mechanisms to study the effect of magnetic fields on calcium car-bonate (CaCO 3) precipitate, namely ionic and particle mechanisms. The effects are most debatable because they are contrary to each other. This study explored the effects of both mechanisms in CaCO 3 deposit and total CaCO 3 pre-cipitation using ioni...
Article
Full-text available
Magnetic Field Effects on CaCO3 Precipitation Process in Hard Water. Magnetic treatment is applied as physical water treatment for scale prevention especially CaCO3, from hard water in piping equipment by reducing its hardness. Na2CO3 and CaCl2 solution sample was used in to investigate the magnetic fields influence on the formation of particle of...
Article
H2S removal from natural gas or from gases produced by the petroleum industry typically involves air oxidation of HS into elemental sulfur and water. The rate of the anthraquinone reduction and sulfur formation reaction in the first stage of the HysulfSM process was studied. Details of the 2-tert-butylanthraquinone (TBAQ) to H2TBAQ reaction mechani...

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Projects (2)
Project
Application of ionic liquid as a green solvent to extracting secondary metabolite from herbal plants