Eloi Chazelas

Eloi Chazelas
Université Paris 13 Nord | Paris 13 Nord · Unité de recherche en épidémiologie nutritonnelle - UREN (UMR 557) Inserm - INRA - CNAM

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54
Publications
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Citations since 2016
54 Research Items
1086 Citations
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20162017201820192020202120220100200300400

Publications

Publications (54)
Article
Full-text available
Nitrates and nitrites occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives. The epidemiological evidence linking exposure to nitrites/nitrates with type-2 diabetes (T2D) risk is scarce. We aimed to study these associations in a large population based prospective co...
Article
Full-text available
Background Artificial sweeteners are widely used today by the food industry as sugar alternatives. Potential adverse effects of these food additives on cardiovascular disease (CVD) have been suggested in experimental studies, but data from studies involving humans remain very limited. Previous cohorts have focused on artificially sweetened beverage...
Article
Full-text available
Background Food additive emulsifiers are found in thousands of industrial foods and may exert deleterious effects on gut microbiota and carcinogenesis according to experimental studies. However, their associations with cancer risk has not been investigated yet. This study aimed to investigate these associations in a large population-based prospecti...
Article
Full-text available
Nitrates and nitrites are used as food additives in processed meats. They are also commonly ingested from water and several foods. Evidence suggests a beneficial role of dietary nitrites and nitrates in lowering blood pressure. However, associations between exposure to nitrites and nitrates from natural sources and food additives, separately, and r...
Article
Full-text available
Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease). Design Population...
Article
Full-text available
Objective To assess in 2021 the acceptance and perception of the French tax on sweetened beverages, following its revision in 2018, and factors associated with a higher level of acceptance. Design A cross-sectional survey within the NutriNet-Santé cohort study. Participants were invited to complete a self-reported questionnaire in March 2021. Weig...
Article
Full-text available
Background The food industry uses artificial sweeteners in a wide range of foods and beverages as alternatives to added sugars, for which deleterious effects on several chronic diseases are now well established. The safety of these food additives is debated, with conflicting findings regarding their role in the aetiology of various diseases. In par...
Article
Full-text available
Background Nitrates and nitrites occur naturally in water and soil. They are also used as food additives (preservatives) in processed meats. They could play a role in the carcinogenicity of processed meat. The objective was to investigate the relationship between nitrate and nitrite intakes (natural food, water and food additive sources) and cancer...
Article
Background: Added sugars’ deleterious effects have been established for several chronic diseases, leading food industries to use artificial sweeteners as alternatives in a wide range of foods and beverages. Their safety is debated and findings remain contrasted regarding their role in the etiology of various diseases. In particular, their carcinoge...
Article
Background Dietary trans fatty acids (TFAs) are either natural (from ruminant sources) or generated through industrial processes by partial hydrogenation of vegetable oils. Extended evidence demonstrated their role as cardiovascular risk factors. In contrast, their involvement in cancer etiology is suspected, but epidemiological evidence remains li...
Article
Background Nitrates and nitrites occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives in processed meats to increase shelf life and to avoid bacterial growth. These compounds could have a role in the carcinogenicity of processed meat. Objective To investigate the r...
Article
Full-text available
Aim The consumption of ultra-processed food (UPF) and its impact on diet quality has been extensively studied and reported in the literature, but only a few studies have focused on children and adolescents. The present study therefore aimed to describe UPF consumption in a representative sample of French children and adolescents and to evaluate its...
Article
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Introduction et but de l’étude Les effets délétères du sucre sur l’apparition de différentes maladies chroniques ont été établis. Les industries agro-alimentaires se sont donc tournées vers l’utilisation d’édulcorants artificiels comme alternatives au sucre dans de nombreux aliments et boissons. Toutefois, l’innocuité de ces additifs alimentaires e...
Article
Introduction et but de l’étude Les nitrates et les nitrites sont présents à l’état naturel dans l’eau et le sol et sont couramment ingérés à partir de l’eau potable et de sources alimentaires. Ils sont également utilisés comme additifs alimentaires dans les charcuteries pour augmenter la durée de conservation et éviter la croissance bactérienne. Ce...
Article
Introduction et but de l’étude Les acides gras trans (AGT) représentent une catégorie de lipides naturellement présents dans les aliments (produits dans l’estomac des ruminants) ou générés par des procédés industriels d’hydrogénation partielle des huiles végétales. Leur rôle en tant que facteurs de risque cardiovasculaire a été largement démontré....
Article
Introduction et but de l’étude Les oligosaccharides, disaccharides, monosaccharides et polyols fermentescibles (FODMAPs) ont été impliqués dans l’étiologie des troubles gastro-intestinaux. Compte tenu de leur potentiel pro-inflammatoire et de leurs interactions avec le microbiote intestinal, leur contribution au développement d’autres maladies chro...
Article
The impact of dairy product consumption for long-term health remains unclear, in particular regarding their involvement in cancer etiology for frequent locations like breast or prostate. Besides, little is known about potentially different effects of dairy producto subtypes. Our objective was therefore to evaluate the associations between dairy pro...
Article
Background Fermentable Oligosaccharides, Disaccharides and Monosaccharides And Polyols (FODMAPs) have been shown to be involved in gastrointestinal disorders. In view of their pro-inflammatory potential and their interactions with the gut microbiota, their contribution to the etiology of other chronic diseases such as cancer has been postulated. Ho...
Article
Background Added sugars' deleterious effects have been established for several chronic diseases, leading food industries to turn towards high-intensity sweeteners. Their safety is debated and findings remain contrasted regarding their role in the etiology of various diseases. In particular, their carcinogenicity has been suggested by several experi...
Article
Full-text available
Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as...
Article
Résumé Au cours des dernières décennies, l’offre agro-alimentaire s’est considérablement étoffée en matière d’aliments dits « ultra-transformés » (AUT). Il s’agit de produits ayant subi d’importants procédés de transformation impactant fortement la matrice alimentaire et/ou contenant des additifs alimentaires ou autres substances d’origine industri...
Article
Background Evidence is accumulating that high dietary glycaemic index (GI) and glycaemic load (GL) are potential risk factors for several metabolic disorders (e.g. type-2 diabetes, cardiovascular diseases), but remains limited concerning cancer risk. Although, mechanistic data suggest that consuming high-GI foods may contribute to carcinogenesis th...
Article
Full-text available
Purpose: Red and processed meats are recognized by the International Agency for Research on Cancer as probably carcinogenic and carcinogenic to humans, respectively. Heme iron has been proposed as a central factor responsible for this effect. Furthermore, anxiety affects the intestinal barrier function by increasing intestinal permeability. The ob...
Article
Introduction et but de l’étude En 2018, suite à la parution de son rapport de référence, le World Cancer Research Fund (WCRF) actualisait ses recommandations en matière de prévention des cancers basées sur les facteurs nutritionnels pour lesquels un niveau de preuve suffisant a été établi selon leur système de gradation du poids des preuves. Notre...
Article
Introduction et but de l’étude La consommation de boissons sucrées a augmenté dans le monde ces dernières années, tandis que les preuves de leur effet néfaste sur la santé cardiométabolique s’accumulent. Les boissons édulcorées, commercialisées comme une alternative plus saine, voient aussi leur impact sur la santé cardiométabolique débattu. L’obje...
Article
Full-text available
The present study aims to describe ultra-processed food (UPF) consumption in a representative sample of French adults and to evaluate the association between UPF consumption and socioeconomic characteristics and nutritional profile of the diet. This is a cross-sectional study using food consumption data from the Étude Nationale Nutrition Santé (ENN...
Conference Paper
Background: Evidence is accumulating that high dietary glycemic index (GI) and glycemic load (GL) are risk factors for several metabolic disorders, e.g. diabetes or cardiovascular diseases, but evidence on GI/GL and cancer is less consistent. However, mechanistic data suggest that food with high-GI may contribute to carcinogenesis through the insul...
Conference Paper
Background: Breast cancer remains the leading cancer in women. In 2018, following its summary report, the World Cancer Research Fund (WCRF) issued its recommendations for cancer prevention based on the nutritional risk factors with a sufficient level of evidence, several of which being related to breast cancer. Our objective was to study whether ad...
Article
Background: Excessive sugar intake is now recognized as a key risk factor for obesity, type 2 diabetes, and cardiovascular diseases. In contrast, evidence on the sugar-cancer link is less consistent. Experimental data suggest that sugars could play a role in cancer etiology through obesity but also through inflammatory and oxidative mechanisms and...
Article
During the past decades, diets have shifted towards an important increase in the degree of food processing and formulation. “Ultra-processed foods” (UPF) now represent more than 50 % of energy intakes in several Western countries. In the very last years, an impressive accumulation of evidence from large-scale epidemiological studies linked regular...
Article
Background Excessive sugar is now recognized as a key risk factor for several cardiometabolic diseases. In contrast, the associations between sugars and cancer risk in cohort studies have been less investigated, and data is lacking regarding differential effect of sugar types and sources. Experimental data suggest that sugars could play a role in c...
Article
Introduction Sugary drinks consumption has increased worldwide in recent years and evidence demonstrating their detrimental impact on cardio-metabolic health is accumulating. Artificially sweetened beverages (ASB) are marketed as a healthier alternative, but their cardio-metabolic impact is being debated in the scientific community. This study aime...
Article
Background More than 330 food additives (e.g. artificial sweeteners, emulsifiers, dyes) are authorized in Europe, with a great variability of use across food products. The objective of this study was to investigate the distribution and co-occurrence of food additives in a large-scale database of foods and beverages available on the French market....
Article
Background Cancer remains one of the leading causes of death worldwide. In 2018, following its summary report, the World Cancer Research Fund (WCRF) issued its recommendations for cancer prevention based on the nutritional risk factors with a sufficient level of evidence. Our objective was to study whether adherence to these new recommendations lea...
Article
Full-text available
Background Ultra-processed food (UPF) consumption has increased drastically worldwide and already represents 50%–60% of total daily energy intake in several high-income countries. In the meantime, the prevalence of overweight and obesity has risen continuously during the last century. The objective of this study was to investigate the associations...
Article
Introduction Previous epidemiological studies have found associations between the consumption of ultra-processed foods and the risk of obesity-related outcomes, such as post-menopausal breast cancer, cardiovascular diseases, hypertension and mortality. However, only one Spanish prospective study has explored the associations between the consumption...
Article
Introduction The consumption of ultra-processed foods has been increasing during the last decades, and has been previously associated with increased risks of mortality and several chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia. The objective of this study is to assess the prospective associations between co...
Article
Background: Mounting evidence, yet with varying levels of proof, suggests that dietary fibers (DFs) may exert a protective role against various chronic diseases, but this might depend on the DF type and source. Objectives: Our objectives were to assess the associations between the intake of DFs of different types [total (TDF), soluble (SF), inso...
Article
Introduction et but de l’étude L’impact de la consommation de sucre sur le risque de diabète et de maladies cardiovasculaires est aujourd’hui bien établi. En revanche, le niveau de preuve concernant le rôle joué par les sucres simples sur l’apparition de cancers est très limité, or ils pourraient avoir un effet délétère sur le risque de cancer via...
Article
Full-text available
Background: More than 330 food additives (e.g. artificial sweeteners, emulsifiers, dyes) are authorized in Europe, with a great variability of use across food products. Objective: The objective of this study was to investigate the distribution and co-occurrence of food additives in a large-scale database of foods and beverages available on the F...
Conference Paper
Background: The impact of sugar consumption on diabetes and cardiovascular disease risks is well established. In contrast, the level of evidence regarding the role of sugar in cancer onset is still very limited. However, simple sugars could have a deleterious effect on cancer risk via different mechanisms, such as weight gain, but also through infl...
Article
Importance Ultraprocessed foods (UPF) are widespread in Western diets. Their consumption has been associated in recent prospective studies with increased risks of all-cause mortality and chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia; however, data regarding diabetes is lacking. Objective To assess the ass...
Conference Paper
Background The objective was to assess the associations between the consumption of sugary drinks (sugar sweetened beverages and 100% fruit juices), artificially sweetened beverages and cancer risk. Methods Overall, 101,257 participants aged ≥18y (mean age: 42.2) from the French NutriNet-Santé cohort (2009-2017) were included. Consumptions of sugar...
Conference Paper
Objective The consumption of ultra-processed foods has been increasing during the last decades, and has been previously associated with increased risks of mortality and several chronic diseases. The objective of this study is to assess for the first time the prospective associations between consumption of ultra-processed foods and the risk of type...
Conference Paper
Previous epidemiological studies found associations between the consumption of ultra-processed foods (UPF) and the risk of obesity-related outcomes. The aim of this study is to investigate the associations between UPF consumption and the risk of overweight and obesity, and weight trajectories, in in the French large scale NutriNet-Santé cohort. Me...
Conference Paper
Objective To assess the prospective associations between consumption of ultra-processed foods (UPF) and the risk of cardiovascular diseases. Methods 105159 participants aged at least 18 years (median age 41.5 years) from the French NutriNet-Santé cohort (2009-2018) were included. Dietary intakes were collected using repeated 24 hour dietary record...
Article
Full-text available
Objective To assess the associations between the consumption of sugary drinks (such as sugar sweetened beverages and 100% fruit juices), artificially sweetened beverages, and the risk of cancer. Design Population based prospective cohort study. Setting and participants Overall, 101 257 participants aged 18 and over (mean age 42.2, SD 14.4; median...
Article
Full-text available
Objective To assess the prospective associations between consumption of ultra-processed foods and risk of cardiovascular diseases. Design Population based cohort study. Setting NutriNet-Santé cohort, France 2009-18. Participants 105 159 participants aged at least 18 years. Dietary intakes were collected using repeated 24 hour dietary records (5....
Conference Paper
Discipline Epidémiologie. Introduction et but de l’étude Les conséquences de l’augmentation récente de la consommation d’aliments ultra-transformés (AUT) sur la santé sont mal connues. Les AUT présentent en moyenne une moins bonne qualité nutritionnelle, contiennent des additifs alimentaires et peuvent contenir des substances provenant des emballa...
Conference Paper
Discipline Épidémiologie. Introduction et but de l’étude Selon le Global Burden of Disease, la consommation de boissons sucrées a augmentée d’environ 40 % entre 1990 et 2016. Les boissons sucrées et édulcorées ont étés associées au risque de pathologies cardiométaboliques, mais concernant le lien direct avec le cancer, les données de la littératur...
Article
OBJECTIVE To assess the associations between the consumption of sugar-containing and artificially sweetened beverages and cancer risk. DESIGN Population based prospective cohort study. SETTING AND PARTICIPANTS Overall, 101 257 participants aged ≥18y (mean age: 42.2±14.4y) from the French NutriNet-Santé cohort (2009-2017) were included. Consumptions...

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