Elke O Kreps

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Verified

Elke verified their affiliation via an institutional email.

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• MD PhD
• Ophthalmologist at Ghent University

Purpose Congenital cutis laxa (CL) syndromes encompass a diverse group of inherited connective tissue disorders characterized by redundant, wrinkled, and inelastic skin, often with systemic involvement. Ocular involvement in CL has sporadically been reported albeit without systematic, comprehensive ocular assessment. The purpose of this study was t...

Introduction Orbital inflammation has a variety of underlying causes and warrants comprehensive work-up including extensive blood work and imaging studies. This case report highlights a rare presentation of multiple myeloma presenting as recurrent orbital inflammatory syndrome. Case Report A 61-year-old woman experienced brief episodes of recurren...

Purpose To report on a rare case of intermediate uveitis occurring in a patient with common variable immunodeficiency (CVID) and a heterozygous TNFRSF13B variant. Methods Observational case report. Results A 23-year-old male presented with a 3-month history of increasing floaters and blurred vision to both eyes. He had been treated with topical a...

Purpose To investigate the anterior scleral thickness (AST) in patients with Marfan syndrome (MFS). Methods A prospective, cross‐sectional study was conducted at the Department of Ophthalmology, Ghent University Hospital, Ghent, including patients with a genetically confirmed clinical diagnosis of MFS and age‐, gender‐ and axial length‐matched con...

This study investigates the changes in the optical properties of the cornea after laser in situ keratomileusis (LASIK) based on Scheimpflug light intensity distribution. Retrospective data from patients who had undergone uneventful LASIK surgery were eligible. Scheimpflug images obtained with the Pentacam(6.10r59) HR device prior to the LASIK treat...

Purpose: To document the long-term visual outcomes in patients with Blau syndrome. Methods: A retrospective institutional cohort study was conducted, and 13 patients with genetically confirmed Blau syndrome were included. Demographic and clinical data were collected from standardised medical charts. Baseline was defined as the first detected uve...

Background Adalimumab is currently considered the most efficacious anti-TNFα agent for childhood noninfectious uveitis (NIU). The objective of this study was to define a therapeutic range for adalimumab trough levels in the treatment of childhood NIU. Methods A retrospective, observational, pilot study of 36 children with NIU aged < 18 years, trea...

Objectives To examine the outcome of infliximab treatment in patients with non-infectious paediatric uveitis who have previously failed biologic treatment. Methods A retrospective cohort study was performed at Bristol Eye Hospital, UK. Paediatric patients with chronic non-infectious uveitis who had been switched to infliximab due to inadequate uve...

Purpose There is currently no consensus on which keratoconus need cross-linking nor on how to establish progression. This study assessed the performance of diverse progression criteria and compared them with our clinical knowledge of keratoconus evolution. Methods This was a retrospective, longitudinal, observational study. Habitual progression cr...

Toxoplasma gondii, an obligate intracellular parasitic protozoon, usually causes a mild, acute infection followed by a latent asymptomatic phase with tissue cysts or a chronic form with recurrent retinochoroiditis. However, immunocompromised patients can cause disseminated disease due to the reactivation of the latent tissue cysts or due to a prima...

Purpose: The purpose of the study was to investigate the optical and visual determinants of vision-related quality of life (VR-QoL) in patients with keratoconus. Methods: A cross-sectional case-control study was conducted at the Department of Ophthalmology, Antwerp University Hospital, Belgium. Patients previously diagnosed with keratoconus and...

Purpose: We report an atypical case of combined acute syphilitic necrotizing retinitis and a contiguous acute syphilitic posterior placoid chorioretinitis (ASPPC) in an HIV-negative, immunocompetent patient. Method: Observational case report. Results: A 56-year-old male presented with a one-week history of pain and blurred vision in the left e...

Objective: To evaluate the effect of specialty contact lens (CL) wear on posterior corneal tomography in keratoconus subjects. Methods: Patients with keratoconus who were wearing specialty CL were included in this retrospective cohort study. Tomographic parameters were evaluated with Scheimpflug imaging (Pentacam HR) before lens fitting and imme...

Background: Ligneous conjunctivitis is a very rare form of pseudomembranous conjunctivitis with few published cases in literature. We aim to describe the ocular findings and treatment in an infant with ligneous conjunctivitis resembling preseptal cellulitis on presentation. Materials and methods: Case report of a 3-month-old girl who was referre...

A woman presented with cough, fever and dyspnea during a twin pregnancy following a thirteenth in vitro fertilization procedure. Ultimately, miliary tuberculosis was diagnosed and tuberculostatic treatment was initiated, complicated by drug-induced hepatotoxicity. In retrospect, previous pelvic tuberculosis had likely been overlooked. This case rep...

Purpose : To investigate the gender gap in first/last authors in vision science and whether gender affects manuscript review times. Design : Observational retrospective database study. Methods : First/last author's gender and country were assigned to 30438 PubMed records (data derived from Q1-Q2 ‘Ophthalmology’ journals for 2016–2020). Using mixe...

Hans De Loof,1 Ellen De Win,1 Nathalie Moens,1 Veronique Verhoeven,2 Paul Van Royen,2 Elke O Kreps,3 Hilde Philips2 1Laboratory of Physiopharmacology, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium; 2Research Group, Primary and Interdisciplinary Care (ELIZA), Department Family Medicine and Population Health (FAMPOP)...

Purpose: We sought to investigate corneal reflectivity in Marfan syndrome (MFS) on the basis of Scheimpflug light intensity distribution. Methods: In a retrospective case-control analysis, the left eyes of 40 MFS patients and 40 age- and refraction-matched healthy controls were investigated. Patients with MFS meeting the Ghent II diagnostic crit...

Abstract: Early and accurate detection of keratoconus progression is particularly important for the prudent, cost-effective use of corneal cross-linking and judicious timing of clinical follow-up visits. The aim of this study was to verify whether a progression could be predicted based on two prior tomography measurements and to verify the accuracy...

Objectives: To identify the most suitable parameters to describe keratoconus progression. Methods: Longitudinal retrospective cohort study. Monotonicity and consistency of over 250 parameters extracted from the Pentacam tomographies (Oculus, Germany) of 743 patients was analyzed. Repeatability was calculated for 69 patients (published elsewhere)...

Background: Traboulsi syndrome is a very rare, syndromic form of ectopia lentis that is potentially sight-threatening at a young age. It is characterized by typical facial, skeletal and ocular signs. Materials and Methods: Two siblings, born to consanguineous parents, with a clinical phenotype consistent with Traboulsi syndrome, underwent extensive...

Background Uveitis is one of the most frequent ophthalmologic manifestations in rheumatology. Uveal inflammation can underlie a systemic inflammatory rheumatic disease (SIRD) in approximately 30 % of cases with a significant burden on the quality of life since it represents a cause of blindness in up to 20 % of cases in Western countries. Methods...

Objectives: To report the clinical outcome of hybrid contact lens fitting in keratoconus. Methods: A retrospective chart review was performed of keratoconus patients who had been fitted with hybrid contact lenses in one or both eyes. Patients with a history of previous intraocular surgery (except for corneal crosslinking) and relevant concurrent...

Purpose: To evaluate the effects of mini-scleral lenses on visual acuity (VA) and visual functioning in patients with keratoconus. Methods: This prospective, interventional study examined the effects of mini-scleral lenses on VA and visual functioning in patients with keratoconus. Patients younger than 18 years or with a history of refractive su...

Purpose: To assess the correlation of the scleral shape and corneal tomographic parameters in keratoconus. Methods: Twenty eyes of 15 keratoconus patients with no previous specialty lens wear or ocular surgery were included in this study. Corneal imaging was obtained with the Pentacam HR and three-dimensional (3D) corneoscleral maps were acquire...

Purpose: To investigate the corneoscleral shape in Marfan syndrome (MFS) patients. Methods: Thirty eyes of 15 participants with molecularly proven MFS were included in this prospective, cross-sectional study. Optical biometry, Scheimpflug imaging, and corneoscleral topography (Eye Surface Profiler) were performed in all patients. Topographic dat...

Purpose To evaluate differences in corneoscleral shape in keratoconus patients with and without specialty lenses compared to controls. Methods A cross-sectional study was performed comparing three groups of keratoconus eyes: 24 lens-naïve keratoconus eyes (17 patients; group 1), 7 eyes with corneal lens wear (7 patients; group 2) and 7 eyes with s...

Purpose To evaluate the repeatability of an extensive number of relevant indices with the Pentacam HR in keratoconus of varying severity and normal eyes. Design Reliability analysis Methods This study was performed at Antwerp University Hospital, Belgium, and enrolled 20 healthy volunteers (20 eyes) and 69 patients (69 eyes) with keratoconus. Thr...

Purpose To develop an objective severity scoring system for keratoconus for the use in clinical practice. Methods Corneal elevation and minimum thickness data of 812 subjects were retrospectively collected and divided into two groups: one control group with normal topography in both eyes (304 eyes), and one keratoconus group (508 eyes). Keratoconu...

Purpose To investigate the current patterns of diagnosis and referral in keratoconus. Methods A retrospective chart review was performed of patients who had recently been diagnosed with keratoconus and attended dedicated clinics at Antwerp University Hospital, Belgium and Maria Middelares General Hospital, Ghent, Belgium between June 2013 and Febr...

Purpose: To investigate the success and failure of scleral lens fitting in patients with keratoconus with resolved hydrops. Methods: Retrospective case series of patients with keratoconus who attended the Ophthalmology Department at Antwerp University Hospital, Belgium, and developed acute hydrops between January 1, 2015, and June 30, 2018. The...

Purpose Ado-trastuzumab emtansine (T-DM1/Kadcyla®;Genentech) is an antibody-drug conjugate used in the treatment of human epidermal growth factor receptor-2-positive metastasized breast cancer. Few studies report a spectrum of corneal changes in patients treated with this drug. Our aim is to specify the nature and prevalence of corneal features of...

Objectives: Systemic sclerosis (SSc) is a rare and complex autoimmune disorder characterized by microvascular damage and progressive fibrosis which affects the skin and multiple other organs. Much of the published data concerning SSc and the eye consists of single case reports or small case studies. This systematic review aims to provide an overvi...

Background: To describe ocular and vascular findings in a patient with multiple endocrine neoplasia type 2B. Materials and methods: Case report of a 31-year-old male who was referred for ocular assessment following diagnosis of a carotid artery dissection and multiple vascular anomalies. Results: Clinical examination revealed a marfanoid habitus, m...

Purpose: To investigate the success and failure rates of scleral lens correction in severe keratoconus. Design: Retrospective case series. Methods: Study population: Patients with keratoconus who attended the keratoconus clinic at the Antwerp University Hospital, Belgium between 01/01/2010 and 12/31/2014. The included eyes had maximal keratome...

Oral poster presentation

Objective: To describe a patient with peripheral retinal ischaemia and neovascularisation who was diagnosed with streptococcus mitis-induced bacterial endocarditis. Methods: Retrospective analysis of case report. A 57-year-old man presented with a history of a rapidly progressive, bilateral, painless visual loss. He also suffered from pain in the n...

The aim of this study was to investigate the clinical features in endogenous endophthalmitis cases. We conducted a retrospective chart review of patients treated for endogenous endophthalmitis at Royal Hallamshire Hospital, Sheffield, UK between January 2013 and August 2015.

Purpose To investigate the accuracy of recognizing female heterozygotes for X‐linked retinitis pigmentosa ( XLRP ) and choroideraemia ( CHM ) using fundoscopy and blue‐light fundus autofluorescence ( FAF ). Methods Retrospective analysis revealed 26 female XLRP heterozygotes from 17 different families (age 3–77 years) and 8 CHM heterozygotes from...

Rubella virus (RV) has a central role in the etiopathogenesis of Fuchs' uveitis syndrome (FUS). We aim to offer new insights by comprehensive analysis of recent laboratory and epidemiologic data. We conducted a literature search for laboratory data and papers on etiopathogenesis. Aqueous humour samples of FUS patients show immunoreactivity to RV, i...

Remnant of the hyaloid artery in the left eye of an asymptomatic man in his early 60s. It supplies blood to the developing lens during embryological development and usually regresses during fetal life. In rare cases, its anterior part remains as an occluded, cicatricial tuft. A, Diffuse illumination. B and C, Narrow-slit illumination. D, Retroillum...

Objective and importance: We report on a rare case of septic arthritis of the sacroiliac joint in a young patient without apparent predisposing factors. Clinical presentation: A 22-year-old female presented with severe right pelvic and gluteal pain and systemic illness. She had a recent diagnosis of bilateral sacroiliitis. Intervention: System...