Elke Dopp

Elke Dopp
University of Duisburg-Essen | uni-due · Medical Faculty

Prof. Dr. agr. habil.

About

174
Publications
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3,307
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Publications

Publications (174)
Article
Full-text available
The biochemical modification of the metals and metalloids mercury, tin, arsenic, antimony, bismuth, selenium, and tellurium via formation of volatile metal hydrides and alkylated species (volatile and involatile) performs a fundamental role in determining the environmental processing of these elements. In most instances, the formation of such speci...
Article
Full-text available
Nanomaterials are extensively used in industry and daily life, but little is known about possible health effects. An intensified research regarding toxicity of nanomaterials is urgently needed. Several studies have demonstrated that nanoparticles (NPs; diameter < 100 nm) can be transported to the central nervous system; however, interference of NPs...
Article
The aim of this interdisciplinary research project in North Rhine-Westphalia (NRW), Germany, entitled “Elimination of pharmaceuticals and organic micropollutants from waste water” involved the conception of cost-effective and innovative waste-water cleaning methods. In this project in vitro assays, in vivo assays and chemical analyses were performe...
Poster
Full-text available
The broad use of plastics and the persistence of the material result in plastic residues being found practically everywhere in the environment. Increasing contamination of rivers and lakes by plastics has already been demonstrated, as has their presence in drinking water and food. Substances added to plastic can leach into their surroundings, but l...
Presentation
Weitere Information zur Veranstaltung sowie ein Link zum Sonderheft finden sie unter: https://iww-online.de/veranstaltung/4-wasseranalytisches-seminar-mwas-2020/
Article
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Röntgenkontrastmittel, die in der medizinischen Diagnostik eingesetzt werden, werden über den Abwasserpfad entsorgt. Für Röntgenuntersuchungen kann der Einsatz von Kontrastmitteln notwendig sein, die vom Körper innerhalb von 24 h mit dem Urin wieder entsorgt werden. Diese werden dann in Kläranlagen nur geringfügig entfernt und gelangen somit in den...
Cover Page
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Editorial of the Special Issue "Water and Health"
Preprint
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Pannekens, H, Gottschlich, A, Hollert, H, and Dopp, E (2019). Evaluation of mixture effects of endocrine active substances in wastewater using CALUX reporter-gene assays. International Journal of Hygiene and Environmental Health. Volume 222, Issue 4, pp 670-677. Endocrine active substances (EAS), which are commonly used in pharmaceuticals and pers...
Article
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Correction Authorship: Linda Gehrmann and Helena Bielak contributed equally to this work and are regarded as joint first authors.
Preprint
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Complex mixtures of chemicals in waste and finally in surface water may pose a risk to the environment and also to human health. This contamination of surface water cannot be addressed with chemical analysis alone. Tools are required to detect and assess these micropollutants which might cause adverse effects. Effect-directed analysis (EDA) with ef...
Poster
Full-text available
Many of the organic micropollutants (OMPs) present in municipal wastewater cannot be eliminated with conventional treatment. OMP adsorption on granular activated carbon (GAC) can be used to upgrade existing wastewater treatment plants (WWTPs). The desorption that may occur in GAC filters releasing OMPs in the effluent is still not investigated. We...
Article
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Die klassische instrumentelle Analytik kann gezielt Einzelstoffe im Wasser detektieren. Eine Aussage über die Wirkung aller im Wasser vorkommenden Stoffe als Ganzes ist damit jedoch nicht möglich. Biotestbatterien, als Instrument der wirkungsbezogenen Analytik, erlauben durch den Einsatz verschiedener Bioassays letztendlich eine differenzierte Beur...
Article
Full-text available
(Anti-)Estrogenic and (anti-)androgenic effects in wastewater during advanced treatment: Comparison of three in vitro bioassays L. Gehrmann & H. Bielak et al., 2016 Endocrine disrupting chemicals, which are discharged into the environment mainly by wastewater treatment plants (WWTP), have been shown to induce adverse effects in aquatic life and t...
Chapter
Full-text available
Moderne Kläranlagen reinigen Abwasser effizient von leicht abbaubaren organischen Stoffen und Nährstoffen. Sie sind aber nicht für die Eliminierung von Mikroschadstoffen konzipiert, so dass viele dieser Stoffe im Abwasser kaum abgebaut werden und somit über die Vorflut in Oberflächengewässer gelangen. Dieser Artikel geht unter anderem der Frage nac...
Presentation
Full-text available
The aim of this study was to investigate the impact of ozone treatment on substances with endocrine activity in wastewater. More precisely, the degradation of substances with known endocrine potentials was related to the analysis of the biological activity after ozonation. Therefor wastewater samples were spiked with model substances, degradation w...
Article
Full-text available
Effluents from municipal wastewater treatment plants (WWTPs) are known to be point sources of micropollutants for surface waters. The aim of this study was to examine a reconstructed full-scale ozonation equipped with a pump-injector system for ozone (O3) dosage and a fluidized moving-bed reactor as biological posttreatment at a municipal WWTP util...
Article
The viable but non-culturable (VBNC) state of the opportunistic bacterium Pseudomonas aeruginosa was previously shown to be induced by copper ions in concentrations relevant to those in drinking water plumbing systems. This decrease of bacterial culturability without loss of viability might have an influence on human health due to an underestimatio...
Poster
Full-text available
Die Untersuchungen dieser Studie befassen sich mit jenen Kombinationseffekten, die auftreten können, wenn Arzneimittel mit unterschiedlichen hormonellen Wirkungen in einem Gemisch auftreten. Um nachvollziehen zu können, ob Transformationsprodukte durch den Einsatz von Ozon zu einem auftretenden Effekt beitragen, wurde der Abbau von Modellsubstanzen...
Presentation
Endocrine active substances (EAS), which are commonly used in pharmaceuticals and person-al care products, cannot be completely removed during conventional treatment in wastewater treatment plants (WWTPs) and are consequently released into surface water through WWTP effluents. EAS have been shown to cause adverse effects in aquatic organisms. Hence...
Chapter
Full-text available
Article
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The Taihu (Tai lake) region is one of the most economically prospering areas of China. Due to its location within this district of high anthropogenic activities, Taihu represents a drastic example of water pollution with nutrients (nitrogen, phosphate), organic contaminants and heavy metals. High nutrient levels combined with very shallow water cre...
Chapter
Full-text available
To gain biologically and chemically safe conditions in aquatic systems, as required by the EU Water Framework Directive, advanced oxidation processes are the only conceivable possibility to remove pharmaceuticals and their metabolites from waste water. Water treatment plants are not designed for the complete mineralization of these substances, so t...
Article
Full-text available
Epidemiological and experimental studies have suggested the enhancement of asbestos-induced disease processes by simultaneous exposure to kerosene, its soot, and cigarette smoke in asbestos-exposed animals as well as in humans. To determine the influence of these factors on the genotoxic potential of asbestos, a micronucleus test was performed in S...
Data
Full-text available
Editorial to the Special Issue
Research
Special Issue of the Journal of Toxicology
Research
Special Issue of the Journal of Toxicology
Research
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Special Issue of the Journal of Toxicology
Book
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The incorporation of nanomaterials into products can improve performance, efficiency, and durability in various fields ranging from construction, energy management, catalysis, microelectronics, plastics, coatings, and paints to consumer articles such as foods and cosmetics. But innovation never comes at zero risk. The potential hazards resulting fr...
Poster
Full-text available
Pharmaceuticals and their metabolites enter the hydrological cycle mainly through hospital effluents and private households. They were detected in surface and ground water in concentrations to μg/L and even after the water treatment process in drinking water. To gain biologically and chemically save conditions in aquatic systems, as required by the...
Poster
Full-text available
In case problematic organic substances, like pharmaceuticals and personal care products, cannot be eliminated during wastewater treatment, they can reach surface waters and harm the environment and have adverse effects on human health already at low concentrations of the substance. The amount of micropollutants in surface waters is steadily growing...
Article
Full-text available
Arsenic, a common poison, is known to react with sulfide in vivo, forming thioarsenates. The acute toxicity of the inorganic thioarsenates is currently unknown. Our experiments showed that a fourfold sulfide excess reduced acute arsenite cytotoxicity in human hepatocytes (HepG2) and urothelial cells (UROtsa) significantly, but had little effect on...
Chapter
Full-text available
This chapter will provide an overview on the effects of metal oxide nanomaterials and review data published in the literature as well as data obtained in the German projects nanoGEM and NanoCARE. Initially, in vitro results will be summarized focusing on biological effects of metal oxide nanoparticles on cultured cell lines with respect to differen...
Article
Thousands of organic micropollutants and their transformation products occur in water. Although often present at low concentrations, individual compounds contribute to mixture effects. Cell-based bioassays that target health-relevant biological endpoints may therefore complement chemical analysis for water quality assessment. The objective of this...
Article
The entry of pharmaceuticals into the water cycle from sewage treatment plants is of growing concern because environmental effects are evident at trace levels. Ozonation, UV- and UV/H2O2-treatment were tested as an additional step in waste water treatment because they have been proven to be effective in eliminating aqueous organic contaminants. The...
Article
Natural and synthetic fibres and particles are being introduced into the workplace and environment daily. Comparative analyses of the induced signalling pathways are essential in order to understand the potential hazards of these particles. To identify the molecular characteristics of particles and fibres, we selected crocidolite and chrysotile asb...
Article
The fate in wastewater treatment of gadolinium chelates used in increasing amounts as contrast agents in magnetic resonance imaging recently got into the focus of research. Oxidative processes, in particular the application of ozone, are currently discussed or even implemented for advanced wastewater treatment. However, reactions of the gadolinium...
Article
Full-text available
UROtsa is an authentic, immortalized human urothelial cell line that is used to study the effects of metals and other toxic substances, mostly in the context of bladder cancer carcinogenesis. Unusual properties on the molecular level of a provided UROtsa cell line stock prompted us to verify its identity. UROtsa cell line stocks from different sour...
Data
Full-text available
STR profile analysis of the cell line stocks UROtsa-1, UROtsa-4, UROtsa-3/T24, and the cell line T24. (PDF)
Data
Real-Time PCR results of the mRNA expression analysis of eleven different genes and the expression analysis of members of the miR-200 family. (XLSX)
Data
Time course of mRNA expression in UROtsa-3/T24 cells. Shown are the normalized mRNA levels of VIM (green), HRAS (pink), RB1 (blue), ZEB1 (dark blue), TP53 (light blue), NOTCH1 (grey), and KRT17 (orange) as determined by Real-Time PCR. GAPDH was used for normalization. CDH1, KRT20 and TP63 were not detectable. For UPK1A only a few time points were d...
Data
Time course of miRNA expression (miR-200 family) in UROtsa-3/T24 cells. The normalized levels of miR-200a (red), miR-200b (green), miR-200c (blue), and miR-429 (orange) are shown as determined by Real-Time PCR. RNU44 and RNU48 levels were used for normalization. MiR-141 was not detectable. (TIF)
Data
Time course of DNA methylation of several genes in UROtsa-3/T24 cells. The degree of promoter methylation of the genes PGR, RASSF1, RARB, LINE1, FHIT, ESR1, CDH1, C1QTNF6, MGMT, PTGS2, and SOCS3 was determined by pyrosequencing. Samples were taken every four weeks during long-term culturing of UROtsa-3 cells. (TIF)
Data
Details of PCR conditions and primer sequences for the DNA methylation analysis. (XLSX)
Chapter
Full-text available
SynonymsOrganotin; Tin; ToxicityDefinitionTin (Sn, from stannum) is the 49th most abundant element in the Earth’s crust, where it occurs primarily as a mineral containing tin dioxide (SnO2). In its elemental form, tin is a soft, silver-white metal which is relatively inert toward air and water. Tin is a main group metal (atomic number 50) and appea...
Article
Full-text available
The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bioaccumulation of the nonbiodegradable nanoscale particles in a biological system and are a cause for concern....
Article
Full-text available
The specific properties of nanoscale particles, large surface-to-mass ratios and highly reactive surfaces, have increased their commercial application in many fields. However, the same properties are also important for the interaction and bioaccumulation of the nonbiodegradable nanoscale particles in a biological system and are a cause for concern....
Article
Triclosan is an antimicrobial agent widely used in many household and personal care products. Widespread use of this compound has led to the elevated concentrations of triclosan in wastewater, wastewater treatment plants and receiving waters. In this study removal of triclosan by aqueous ozone was investigated and the degradation products formed du...
Article
In contrast to the temporary administration of arsenic in cancer therapy (e.g. in the form of arsenic trioxide), chronic exposure to low doses can cause bladder cancer and other cancers. Especially the trivalent arsenic species MMA(III) (monomethylarsonous acid) and DMA(III) (dimethylarsinous acid) are known to be highly toxic. In the present study...