Elizabeth Longphre Elliott

Elizabeth Longphre Elliott
University of North Carolina at Wilmington | UNCW · Center for Marine Science

Master of Science

About

9
Publications
1,038
Reads
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427
Citations
Additional affiliations
April 2007 - October 2015
University of North Carolina at Wilmington
Position
  • Researcher
August 2003 - July 2006
Georgia Southern University
Position
  • Laboratory Supervisor
June 1999 - June 2003
University of Virginia
Position
  • Research Specialist Senior

Publications

Publications (9)
Article
Full-text available
During an investigation of new actinomycete species from Caribbean sponges for novel bioactive natural products, frigocyclinone (1), dimethyldehydrorabelomycin (3) and six new angucyclinone derivatives were isolated from Streptomyces sp. strain M7_15 associated with the sponge Scopalina ruetzleri. Of these, monacyclinones A–B (4–5) contain the core...
Article
Full-text available
Brevetoxins are a family of ladder-framed polyether toxins produced during blooms of the marine dinoflagellate, Karenia brevis. Consumption of shellfish or finfish exposed to brevetoxins can lead to the development of neurotoxic shellfish poisoning. The toxic effects of brevetoxins are believed to be due to the activation of voltage-sensitive sodiu...
Article
Full-text available
Focal adhesions attach cultured cells to the extracellular matrix, and we found endogenous protein phosphatase-1alpha isoform (PP1alpha) localized in adhesions across the entire area of adherent fibroblasts. However, in fibroblasts migrating into a scrape wound or spreading after replating PP1alpha did not appear in adhesions near the leading edge...
Article
In this study the pattern of arthrodial membrane deposition in Callinectes sapidus was determined by histological and ultrastructural examination of tissues from the carpus joint of the cheliped collected during premolt, ecdysis, postmolt, and intermolt. Apolysis in the arthrodial membrane occurs at stage D0 and is synchronous with apolysis of the...
Article
Full-text available
Centrosome separation is regulated by balance of in situ protein kinase/phosphatase activities during the cell cycle. The mammalian NimA-related kinase Nek2 forms a complex with the catalytic subunit of protein phosphatase-1 (PP1C). This complex is located at centrosomes and has been implicated in regulation of the cycle of duplication and separati...
Article
Full-text available
Neurabin I, a neuronal actin-binding protein, binds protein phosphatase 1 (PP1) and p70 ribosomal S6 protein kinase (p70S6K), both proteins implicated in cytoskeletal dynamics. We expressed wild-type and mutant neurabins fused to green fluorescent protein in Cos7, HEK293, and hippocampal neurons. Biochemical and cellular studies showed that an N-te...
Article
Full-text available
Fluorescence microscopy is an exceptional tool for looking inside cells and tissues. Recent advances in fluorescence microscopy, including improved optics, sensitive fluorescent dyes, and high-sensitivity cameras, coupled with technological advances in computers and sophisticated software now permit quantitative measurement and noninvasive acquisit...
Article
Full-text available
Opitz syndrome (OS) is a human genetic disease characterized by deformities such as cleft palate that are attributable to defects in embryonic development at the midline. Gene mapping has identified OS mutations within a protein called Mid1. Wild-type Mid1 predominantly colocalizes with microtubules, in contrast to mutant versions of Mid1 that appe...
Article
The noncalcified inner branchiostegal cuticle, which lines the branchial chamber, was examined histologically and ultrastructurally over the molt cycle in the blue crab, Callinectes sapidus. In intermolt crabs (stage C4) the epithelium underlying the inner cuticle is cuboidal and has abundant intercellular spaces and a prominent basement membrane....

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