Elisa Resende

Elisa Resende
Federal University of Minas Gerais | UFMG · Hospital das Clínicas

MD

About

50
Publications
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414
Citations

Publications

Publications (50)
Article
Background: Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory. Objectives: To investigate the specific brain regions underlying episodic memory impairment in PSP. Methods: Twenty-one...
Article
Background: The association between lifetime alcohol abuse and a higher risk to develop dementia is well known. However, it is unknown whether older adults who begin abusing alcohol late in life have an underlying neurodegenerative disease. Objective: Identify the frequency of lifelong alcohol abuse (L-AA), late-onset alcohol abuse (LO-AA), and...
Article
The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Thirty‐nine illiterate adults underwent resting state functional MRI and an episodic memory test (Free and Cued Selective Reminding Test)....
Article
Full-text available
Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including the interleukin-6 (IL-6) pathway, comprises a potential point...
Article
Background: Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's Disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some pat...
Conference Paper
Background: Mentalizing and emotion recognition are impaired in behavioral variant frontotemporal dementia (bvFTD). It is not clear whether these abilities are disturbed in progressive supranuclear palsy (PSP). Objective: To investigate social cognition (SC) between bvFTD and PSP. The neural basis of SC in PSP and bvFTD groups were also investigate...
Conference Paper
Background: Apathy is a multidimensional syndrome that impairs motivation and mechanisms of behavioural regulation. As apathy is almost ubiquitous in neurodegenerative disorders, understanding the neural basis is required to expand knowledge and ameliorate our instruments. Objective: Verify the feasibility, safety, and adherence of a remote physica...
Conference Paper
Background: The role of hippocampal connectivity for good memory performance is well known in persons with high educational level. However, it is understudied the role of hippocampal connectivity in illiterate populations. Objectives: To determine whether the hippocampal connectivity correlate with episodic memory in illiterate adults. Methods: Thi...
Conference Paper
Background: We observe Subjective Cognitive Decline (SCD) when patients perceive a decline in their cognitive functions, but this decline is not detected in neuropsychological assessments. Few studies have investigated the prevalence of SCD in the Brazilian population. Objective: Analyze the profile of 50+ years Brazilian people regarding SCD throu...
Article
Full-text available
Background Polymorphisms in TMEM106B, a gene on chromosome 7p21.3 involved in lysosomal trafficking, correlates to worse neuropathological and clinical outcomes in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) with TDP‐43 inclusions. In a small cohort of C9orf72 expansion carriers, we previously found an atypical,...
Presentation
Pathologically proven Alzheimer’s disease (AD) manifest clinically with a broad spectrum of cognitive presentations beyond the classic progressive amnestic‐predominant syndrome pointing to different patterns of selective vulnerability to AD pathology. As atypical clinical variants of AD tend to show a younger age of onset, EOAD cohorts present the...
Article
Higher education acquired through the lifespan is believed to buffer the cognitive decline associated with neurodegenerative diseases. However, whether acquiring education later in life can improve memory is unknown. We recruited illiterate adults that enroll in a late‐life literacy program to determine the impact of literacy training in adulthood...
Article
Introduction Apathy is the most common neuropsychiatric syndrome in behavioral variant frontotemporal dementia (bvFTD), and encompasses cognitive, behavioral and affective symptoms. The neural basis of apathy in bvFTD is not completely understood. Previous neuroimaging studies have poorly considered executive impairment and dementia severity as pos...
Article
Objectives: Alzheimer disease (AD) shows a broad array of clinical presentations, but the mechanisms underlying these phenotypic variants remain elusive. Aging-related astrogliopathy (ARTAG) is a relatively recent term encompassing a broad array of tau deposition in astroglia outside the range of traditional tauopathies. White matter thorn-shaped...
Article
Objectives: Late-life depression (LLD) is the most common mental disorder among the elderly, but its clinical features remain unclear, especially among older adults. We sought to investigate if age, sex and education could influence the severity or frequency of LLD symptoms. Methods: We evaluated 639 community-dwelling individuals aged 75+ years in...
Article
Full-text available
The clinical spectrum of Alzheimer’s disease (AD) extends well beyond the classic amnestic–predominant syndrome. The previous studies have suggested differential neurofibrillary tangle (NFT) burden between amnestic and logopenic primary progressive aphasia presentations of AD. In this study, we explored the regional distribution of NFT pathology an...
Article
Typical Alzheimer disease (AD) features an amnestic syndrome that reflects the progression of pathology through specific neural networks. However, a subset of patients exhibits atypical onset with prominent language, behavioral, or visuospatial deficits that are not explained by current neuropathological staging schemes. Astrogliopathy featuring ta...
Article
Full-text available
Introduction: Sleep-wake disturbances are a common and early feature in Alzheimer's disease (AD). The impact of early tau pathology in wake-promoting neurons (WPNs) remains unclear. Methods: We performed stereology in postmortem brains from AD individuals and healthy controls to identify quantitative differences in morphological metrics in WPNs....
Poster
Introduction Alzheimer’s disease (AD) and the four-repeat tauopathies, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), are neurodegenerative diseases associated with accumulation of abnormal tau protein. Despite exhibiting different patterns of sleep dysfunction, AD, CBD, and PSP all feature pathological accumulation of ta...
Article
Full-text available
Population aging will lead to a dramatic increase in dementia prevalence across the world. Dementia is the most costly illness in the United States, with an estimated yearly expenditure around $200 billion.¹ Differences in rates of dementia among diverse populations have garnered recent attention, and it is now accepted that health and socioeconomi...
Preprint
Background: Neurofibrillary tangle (NFT) pathology in Alzheimer's disease (AD) follows a stereotypic progression well-characterized by Braak staging. However, some AD cases show deviations from the Braak staging scheme. In this study, we tested the hypothesis that these variations in the regional distribution of tau pathology are linked to heteroge...
Article
OBJECTIVE: To investigate differences in white matter microstructure between illiterate and low-literate elderly Brazilians. BACKGROUND: High literacy levels are believed to partially counteract the negative effects of neurodegenerative diseases. Investigating the impact of low literacy versus illiteracy on brain structure can contribute knowledge...
Article
Full-text available
According to the cognitive reserve theory, intellectual stimuli acquired during life can prevent against developing cognitive impairment. The underlying cognitive reserve mechanisms were underexplored in low-educated individuals. Because episodic memory impairment due to hippocampal dysfunction is a key feature of Alzheimer’s dementia (AD), we soug...
Article
Full-text available
Klüver-Bucy syndrome (KBS) leads to important behavioral symptoms and social maladaptation. Rarely described, no previous study has investigated its social and affective cognitive profile. We report the case of ASP, a patient who developed a complete KBS at 9 years that evolved into an incomplete KBS. Orbitofrontal and temporal damages were evidenc...
Article
Full-text available
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate the odds of developing neuropsychiatric symptoms across increasing burdens of neurofibrillary tangle and amyloid-β pathology. Participants who passed away between 2004 and 2014...
Article
Cognitive impairment, including mild cognitive impairment (MCI) and dementia, compromises the patients' cognitive abilities and, to different extents, to carry out daily activities, accompanied by personality and behavioral changes. Studies suggest that leptin, an adipokine, has a neuroprotective role against Alzheimer's disease (AD) and that cytok...
Article
This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) levels were measured i...
Article
Full-text available
Introduction: Late-life depression (LLD) is common, but remains underdiagnosed. Validated screening tools for use with the oldest-old in clinical practice are still lacking, particularly in developing countries. Objectives: To evaluate the accuracy of a screening tool for LLD in a community-dwelling oldest-old sample. Methods: We evaluated 457...
Article
Full-text available
Methods: Thirty-one participants (22 women), 23 cognitively healthy and eight with cognitive impairment-no dementia, aged 80.4 ± 3.8 years, with 2.2 ± 1.9 years of education, underwent an MRI scan with diffusion tensor imaging (DTI) acquisition. We verified if there were correlations between the performance on the Brief Cognitive Screening Battery...
Article
Background Individuals with late-life depression (LLD) may present cognitive symptoms. We sought to determine whether a brief cognitive battery (BCB) could identify cognitive and functional deficits in oldest-old individuals with LLD and a low level of education. Methods We evaluated 639 community-dwelling individuals aged 75+ years in Caeté (MG),...
Article
Full-text available
In developing countries, cardiovascular risk factors are poorly controlled, leading to high prevalence of cerebrovascular diseases. The aim of the study was to evaluate the burden of white matter lesions in magnetic resonance through the Fazekas scale in a population aged 75 + years living in the community, and to investigate possible associations...

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Project (1)
Project
Population-based study among individuals aged 75+ years (n = 639), with the following objectives: 1. To investigate prevalence of cognitive impairment, dementia, parkinsonism and depression, as well as the association with sociodemographic characteristics, life habits, comorbidities, and genetic aspects. 2. To investigate the rate of successful brain aging (Super Aging) among this population and the association with sociodemographic and clinical characteristics. 3. To investigate neuroimaging findings with 3-Tesla MRI in a representative sample of the population and to correlate with cognitive, motor and psychiatric profiles. 4. To investigate inflammatory markers and associated genetic polymorphisms with cognitive and functional diagnoses.