Elisa Deriu

Elisa Deriu
HD Biosciences (Wuxi AppTec) San Diego

PhD

About

21
Publications
4,494
Reads
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1,131
Citations
Additional affiliations
January 2015 - December 2016
University of California, Los Angeles
Position
  • Associate Specialist

Publications

Publications (21)
Article
Full-text available
Intensive research is underway to find new agents that can successfully mitigate the acute effects of radiation exposure. This is primarily in response to potential counterthreats of radiological terrorism and nuclear accidents but there is some hope that they might also be of value for cancer patients treated with radiation therapy. Research into...
Article
Full-text available
Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the inte...
Data
Influenza-induced IFN-Is enhance host sensitivity to secondary S. Typhimurium infection. A) Lung PR8 was measured by qPCR at 8 dpi, and its relative expression to L32 was calculated in WT and Ifnar1-/- mice that were infected with either PR8-only or secondarily infected with S. Typhimurium. One representative experiment is shown. N of mice used in...
Data
Poly I:C-induced IFN-Is promote S. Typhimurium intestinal colonization and systemic dissemination (i.p. model). A) Schematic of the i.p. pIC model. B, C, D, E) Colon content, MLN, lungs and spleen were harvested 72 h (day 3) post bacterial infection for enumeration of S. Typhimurium. P values were calculated by two-tailed Mann-Whitney test. *p valu...
Data
Poly I:C reduces cecal histopathology in WT mice, but not in Ifnar1-/- mice during S. Typhimurium infection (non-surgical intratracheal instillation model). Blinded histopathology scores of cecal samples from WT (A, B and C) and Ifnar1–/- (A, C and D) mice at 72 h post S. Typhimurium or mock infection, treated or not with pIC through non-surgical i...
Data
Poly I:C-induced IFN-Is promote S. Typhimurium intestinal colonization and systemic dissemination (non-surgical intratracheal instillation model). A) Schematic of the non-surgical intratracheal instillation pIC model. B, C, D, E) Colon content, MLN, lungs and spleen were harvested 72 h (day 3) post bacterial infection for enumeration of S. Typhimur...
Data
Poly I:C-induced IFN-Is inhibit host immunity during S. Typhimurium infection. A, B, C) S100A9, Lcn2 and Ifnγ transcript levels were detected by qPCR in the i.p. pIC model from cecum of WT and Ifnar1–/–mice 72 h post infection. D) Serum Ifnγ protein was assessed by ELISA in the i.p. pIC model from cecum of WT and Ifnar1–/–mice 72 h post infection....
Data
Poly I:C reduces cecal histopathology in WT mice, but not in Ifnar1-/- mice during S. Typhimurium infection (i.p. model). Blinded histopathology scores of cecal samples from WT (A, B and C) and Ifnar1–/- (A, C and, D) mice at 72 h post S. Typhimurium or mock infection, i.p. pIC- or mock- treated. The score of individual mice (circles) and the geome...
Data
Real-time qPCR primers used in this study. (DOCX)
Data
Strains and plasmids used in this study. (DOCX)
Data
Supplemental references cited only in the supporting information files. (DOCX)
Data
Changes in the fecal microbiota after PR8 infection and poly I:C treatment are mediated by IFN-Is. A and B) WT and Ifnar1-/- mice (n = 4 WT, n = 4 Ifnar1-/-) were infected with PR8 (n = 3 WT, n = 3 Ifnar1-/-) or PBS (n = 1 WT, n = 1 Ifnar1-/-) on day 0 through non-surgical intratracheal instillation. Viral titer was determined by plaque assay in lu...
Article
Full-text available
Salmonella enterica serovar Abortusovis is a pathogen strictly adapted to ovines, in which it causes abortion. To enhance our understanding of this pathogen, we assembled the first draft sequence of an S. Abortusovis genome (strain SS44). The obtained genomic data might facilitate the study of S. enterica evolution and host adaptation.
Article
Host inflammation alters the availability of nutrients such as iron to limit microbial growth. However, Salmonella enterica serovar Typhimurium thrives in the inflamed gut by scavenging for iron with siderophores. By administering Escherichia coli strain Nissle 1917, which assimilates iron by similar mechanisms, we show that this nonpathogenic bact...
Article
Full-text available
Organisms adapt to day-night cycles through highly specialized circadian machinery, whose molecular components anticipate and drive changes in organism behavior and metabolism. Although many effectors of the immune system are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections is not unders...
Article
Full-text available
Probiotics are beneficial components of the microbiota that have been used for centuries because of the health benefits they confer to the host. Only recently, however, has the contribution of probiotics to modulation of immunological, respiratory, and gastrointestinal functions started to be fully appreciated and scientifically evaluated. Probioti...
Article
Full-text available
A genome-wide association scan of approximately 6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants with disease, which was confirmed in 1,775 cases and 2,005 controls (rs9657904, overall P = 1.60 x 10(-10), OR = 1.40). CBLB encodes a neg...
Article
Full-text available
Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after...
Article
Full-text available
A variety of signal transduction events are controlled by the opposing, balanced activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Until recently scientists have focused on PTKs, but recent findings have recognized that PTPs play specific and active roles in the regulation of many physiological processes. CD148...

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