Elijah AblorsuCardiff University | CU · Cardiff Transplant Unit
Elijah Ablorsu
MD, FRCS, FEBS
About
40
Publications
91,714
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175
Citations
Introduction
Additional affiliations
January 2010 - present
January 2010 - present
Position
- Consultant in Transplant and General Surgery
Description
- Pancreas and kidney transplantation Marginal donors Machine organ preservation Hernia Surgery Gallbladder and bile duct surgery
Education
September 1993 - June 1999
Publications
Publications (40)
Objectives:
The Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were designed to assist in the evaluation of pancreases for transplant. Preprocurement Pancreas Suitability Score <17 and PancreasDonor Risk Index ≤1.57 were deemed ideal.We aimed to determine the ability ofthese scores to predict pancreas transplant outcomes....
Importance:
Continuous hypothermic machine perfusion during organ preservation has a beneficial effect on graft function and survival in kidney transplant when compared with static cold storage (SCS).
Objective:
To compare the effect of short-term oxygenated hypothermic machine perfusion preservation (end-HMPo2) after SCS vs SCS alone on 1-year...
Aim
We aimed to analyse the efficacy of the Thymoglobulin dose used for induction in controlled DCD kidneys, and its initial impact on blood cell and CD3 count, as predictors of efficacy.
Methods
140 DCD patients who received ATG induction, were analysed. Intended dose was 1.25 mg/kg/day over 5 days, rounded to nearest 25 mg and not exceeding 125...
Introduction: The number of older patients are increasing on the transplant waiting list. Donation after circulatory death (DCD) kidney transplantation has increased but there remains hesitancy in use of older DCD organs. The aim of this study was to evaluate outcomes of directing older DCD donor kidneys into older recipients.
Methods: Patients age...
Background:
Early post-operative enteral nutrition is an important part of perioperative management and is strongly supported by ESPEN Guidelines. However, there is limited evidence into the use of Early Enteral Nutrition (EEN) after combined Pancreas and Kidney Transplantation (PKT). We know malnutrition in type-1 diabetics with end stage renal f...
Background:
Reasons for declining kidney donors are older age, with or without, hypertension, kidney dysfunction, and diabetes. Implantation of both kidneys into a single recipient from such donors may improve their acceptability and outcome.
Methods:
Patients who underwent dual kidney transplantation (DKT) between June 2010 and May 2014 were id...
MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation.
Hypothermic machine perfusion is effective in improving outcome following kidney transplantation. Molecular analyses of hypothermic machine perfusate (HMP) have the potential to identify biomarkers of organ viability prior to transplantation, offering significant advantages to the transplant surgeon, and leading to a potential increase in the organ...
Background: With the increasing shortage of donor kidneys a closer look at organ quality is warranted. Getting any positive result from a potential donor is superior to rejecting the organs outright. The major reason for rejection of potential kidney donors was age coupled with a positive past medical history (especially of Diabetes Mellitus (DM) a...
Introduction: Hypothermic machine perfusion is effective in improving outcomes from kidney transplantation and molecular analyses of hypothermic machine perfusate (HMP) have the potential to identify biomarkers of organ viability prior to transplantation. The ability to predict organ-specific outcomes prior to transplantation offers enormous advant...
Background:
DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to assess quality of these kidneys prior transplantation and predict their outcomes.
Hypothermic machine perfusion (HMP) is known to improve transplant outcomes compare to static storage but...
INTRODUCTION: Peritoneal catheter malfunction is a common complication of peritoneal dialysis (PD). It has a high failure rate with conservative management. Catheter replacement was historically the standard surgical treatment of choice. Nowadays, laparoscopy has been introduced as an alternative surgical modality to rescue the malfunctioning perit...
Background:
Organ donor characteristics (presence of DM, hypertension, impaired function), length of warm ischaemia time (WIT) and cold ischaemia time (CIT) have detrimental impact on outcomes of kidney transplantation.
However, these donors remain important source to overcome persistent organ shortage. Therefore, there is increasing need to develo...
Background
Transplant recipients are known to have a significantly higher risk of surgical complications after incisional hernia repair. These patients are immunocompromised to prevent organ rejection but it increases risk of infection and impairs healing. There is enough evidence to suggest that laparoscopic incisional hernia repair (LIHR) is asso...
Introduction:
Peritoneal catheter malfunction is a common complication of peritoneal dialysis (PD). It has a high failure rate with conservative management. Catheter replacement was historically the standard surgical treatment of choice. Nowadays, laparoscopy has been introduced as an alternative surgical modality to rescue the malfunctioning peri...
Hypothermic machine preservation, Organ preservation, DCD donor, kidney transplantation
ECD donors, DCD and DBD donors, Kidney transplantation
DCD donors, kidney transplantation, old donors, marginal donors
Early Enteral Nutrition, Jejunal versus Oral nutrition, Simultaneous pancreas and kidney transplantation
Early Enteral Nutrition, Simultaneous Pancreas and Kidney Transplantation
Outcomes of transplant recipients with failed pancreas graft.
Objective
It is well known that functioning pancreas graft protects renal function, stabilise patients’ medical conditions and improves patients’ survival.
We interested what happened to patients who lost pancreas graft shortly after transplantation. The aim of this analysis was to ev...
Hypothermic machine perfusion improves outcomes in DCD kidneys with long Cold Ischemia Time.
Background (slide 1)
In recent years, utilization of kidneys donors after cardiac death (DCD) has been increased to overcome organ shortage. DCD kidneys have been shown to have the same long term outcomes as kidneys from DBD donors. However kidneys from s...
Background
Utilization of kidneys from donors after cardiac death (DCD) has been increased in recent years to overcome organ shortage. Unfortunately, these kidneys suffer from more extensive ischemic damage compared to standard criteria donors and this might have negative impact on post-transplant outcomes.
Aim of this study was to assess the effec...
Simultaneous pancreas and kidney transplantation (SPK) is the treatment of choice for insulin-dependent diabetics with end-stage renal failure. The shortage of suitable pancreata has led to the use of donors after cardiac death (DCD). Although more than 20,000 pancreas transplants have been performed worldwide, the experience of pancreas transplant...
Pancreas transplantation (PT) remains the only treatment that can restore insulin independence among insulin-dependent diabetics. An ageing population in developed countries has led to an increasing number of older patients who may be suitable for PT. Some investigators argue that PT in recipients older than 50 years has an inferior outcome compare...
Liver is the predominant location of distant metastases from colorectal cancer. The metastatic foci can be isolated or multiple. From the point of view of the liver resection as well as the overall treatment management, the metastatic liver diseases may be divided into the three groups: isolated, multiple, and non-resectable. The treatment of isola...
Questions
Questions (3)
Simultaneous pancreas and kidney transplantation is major surgery, involving quite big laparotomy and dissection. Generally, large laparotomy and major open surgery is considered to be relative (even absolute) contraindication to laparoscopy.
On the other side, laparoscopic surgery is associated with less incidence of postoperative complication compare to open approach. This benefit is even more significant in transplant patient. These patients, due to extensive co-morbidity and immunocompromised status are known to have higher incidence of postoperative complications.
Therefore, there is dilemma if in the case of need to remove gallbladder or any other elective surgery, laparoscopic option should be considered.
Laparoscopic inguinal hernia is an excellent technique with a lower complication rate and incidence of postoperative pain compared to conventional open repair. A rare complication is accumulation of fluid collection in the dead space left after removing the hernia sack. Post-operatively it presents as a lump in the groin region sometimes accompanied with groin or testicle pain. This gives quite big concerns to the patient and surgeon. As far as I know, conservative treatment is recommended. But is there any indication for surgical intervention?
Type-1 diabetics, mainly those with severe diabetic complications, suffer from chronic malnutrition. The ideal is to improve their nutritional status prior to major elective surgery.
However, it is important to know their baseline nutritional profile to target their specific needs before and after surgery. We started with nutritional assessment prior to pancreas transplantation in combination with Early Enteral Nutrition. But we found it difficult to assess this specific group of the patients.
