Elif Keskin

• Yıldız Technical University

Background: Uterine carcinosarcomas (UCS) constitute 3-4% of all uterine malignancies and 16% of deaths caused due to uterine neoplasms. Aim: In this study, we aimed to perform DNA-based mutation analysis in 12 genes (KRAS, NRAS, EGFR, C-KIT, BRAF, PDGFRA, ALK, ERBB2, ERBB3, ESR1, RAF1, PIK3CA) to determine the molecular subtypes of UCS using ne...

Disclosed are naphthalimide derivatives and in particular e.g. N - aryl - substituted naphthalimidopropylamine deriva tives ( i.e. 2- [ 3- ( amino ) propyl ) -1H - benz [ de ] isoquinoline - 1,3 ( 2H ) -dione derivatives ) such as e.g. such as e.g. ( Formula I ) or ( Formula III ) as anti - parasitic agents for the treatment of Leishmaniasis . The...

Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on macrophages plus poor aqueous solubility and poor bioavailability of the compounds limit their application in therapies. Address...

Objectives: The aim of this study was to investigate the relationship between scoliosis and upper extremity functions in patients with Duchenne muscular dystrophy (DMD). Patients and methods: Between January 2018 and July 2018, a total of 55 patients (54 males, 1 female; mean age: 9.9±2.9 years; range, 6 to 15 years) who were diagnosed with DMD...

Pseudoxanthoma elasticum (PXE) is an inherited multisystem disorder with ectopic mineralization of connective tissues and characteristic clinical manifestations in the skin, eyes and cardiovascular system. A 46-year-old woman was admitted to dermatology clinic with whitish/yellow papules that coalesce into cobblestone patterned plaques at the later...

Objective: The purpose of our study was to find out the frequency of incidental carcinomas, dysplasias and adenomas of the gallbladder in patients who underwent laparoscopic cholecystec-tomy. Methods: We reviewed pathology records of 5063 cholecystectomy specimens Hematoxylin-eosin stained sections of the patients having dysplasia, adenoma, gallbla...

Objective: Triple-negative-breast-cancer that accounts for 10-20% of all breast carcinomas is defined by the lack of estrogen receptor, progesterone receptor, HER2 expression, and agressive clinical behavior. Triple-negative-breast-cancer is categorized into basal like and other types. The basal-like subtype is characterized by the expression of my...

New di- or triamide organocatalysts derived from (L)-proline were synthesized and successfully used in the direct asymmetric aldol reaction of aliphatic ketones and aromatic aldehydes in water at 0 °C in the presence of benzoic acid as co-catalyst. (S)-methyl-2-((S)-3-hydroxy-2-((S)-3-pyrrolidine-2-carboxamido)propanamido)-3-phenylpropanoate (7c) a...

Background: EFECE Systems are newly-defined internal fixation systems, which are suitable for patella fracture fixation. The aim of this study was to compare the fixation strength of EFECE Systems with tension band wiring for transverse patellar fracture simulation on fresh frozen cadaver models. Methods: Quadriceps tendon-patella-patellar tendon (...

Background Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease and is characterized by self-limiting episodes of fever and polyserositis. The aim of this study was to determine the atopic clinical findings associated with the MEFV gene. Methods A retrospective chart review was conducted of pediatric patients who had rec...

Autoimmune diseases are pathological conditions caused by abnormal autoimmune responses. They are characterized by auto-antibodies and T-cell responses to self-molecules by immune system reactivity. Autoimmune diseases (AD) affect more than 5% of the human population worldwide and load a significant burden of morbidity and mortality on the human po...

Background EFECE Systems are newly-defined internal fixation systems, which are suitable for patella fracture fixation. The aim of this study was to compare the fixation strength of EFECE Systems with tension band wiring for transverse patellar fracture simulation on fresh frozen cadaver models. Methods Quadriceps tendon-patella-patellar tendon (QT...

Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, including pentavalent antimonials—i.e., sodium stibogluconate (Pentostan) and meglumine antimoniate (Glucantim), pentamidine...

Ganglioneuromas (GNs) are benign, slow growing and well differentiated neuroectodermal neoplasias. They are derived from developing neuronal cells of the sympathetic nervous system. They occur mostly in children and are located in the posterior mediastinum, retroperitoneum. We present a case of incidental polypoid ganglioneuroma of the colon. A 70...

The present invention relates to the use of novel drug molecules and,use of said novel drug molecules in the treatment of neurodegenerative diseases, such as Parkinson's disease. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2019004970&tab=PCTDESCRIPTION

HETEROBIVALENT LIGANDS SUITABLE FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE

The perspective of this study describes a new concept for ammonia borane (NH3BH3, AB) in the form of pellet composited with Co–B catalyst to use as a hydrogen storage medium. For the purpose of this, hydrogen storage capacity and physical-chemical properties of composite pellet are examined and tested to investigate effects of specified environment...

Melanotic Schwannoma (MS) is rarely seen and potentially malignant neoplasm that is categorized as a variant of Schwannoma. MS most frequently involves intracranial structures followed by posterior nerve roots in the spinal canal. Approximately 50% of the cases with MS have psammomatous calcifications and this type of MS is related to Carney comple...

Amonyum Boran Pelletlerinin Farklı Koşullar Altında Depolanmasının İncelenmesi: Fiziksel, Stabilite ve Performans Testleri

The parotid duct can be damaged in traumatic injuries and surgical interventions. Early diagnosis and treatment of a duct injury is of great importance because complications such as sialocele and salivary gland fistula may develop if the duct is not surgically repaired. We think the cuff of an intubation tube is an ideal material in parotid duct re...

Observation: Malignant melanoma is a cutaneous cancer which has been seen more frequently in the recent years with increasing mortality. Primary focus cannot be detected in some patients. This delays the diagnosis and the patient is noticed in the later stage. In this study, a case whose primary focus is not known, whose treatment is continuing, wh...

Triple negative breast cancer (TNBC), an agressive subtype accounts nearly 15 % of all breast carcinomas. Conventional chemotherapy is the only treatment modality thus new, effective targeted therapy methods have been investigated. Epidermal growth factor receptor (EGFR) inhibitors give hope according to the recent studies results. Also therapeutic...

In this research, it is aimed to analysis the effect of the Project-Based Learning Method in success degree and motivation of 6th grade students while learning the unit called “Electricity in life”. Pre-test and post-test control group experimental model is applied to the study. Research is implemented in the first period of 2010-2011 academic year...

Results: Female/ male ratio was 2/1, mean age was 59.5. Meningothelial (58.4%), transitional (16%), fibrous (4.8%) subtypes were most frequent ones. Of the 125 cases, 64.8% were located in cerebral convexity, 12% were in sphenoid wing. Grade distrubution was as follows: grade I (89.6%), grade II (9.6%), grade III (0.8%). We found statistically sign...

Objective: Meningiomas are extremely common tumors originating from meningeal coverings of the brain and spinal cord. Histopathological examination and grading of meningiomas give valuable prognostic information. The aim of this study was to evaluate clinical and histopathological parameters in meningiomas, find out significant factors impact on re...

Objective: Triple-negative-breast-cancer that accounts for 10-20% of all breast carcinomas is defined by the lack of estrogen receptor, progesterone receptor, HER2 expression, and agressive clinical behavior. Triple-negative-breast-cancer is categorized into basal like and other types. The basal-like subtype is characterized by the expression of m...