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Introduction
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Publications
Publications (35)
Microgliosis plays a critical role in diet-induced hypothalamic inflammation. A few hours after a high-fat diet (HFD), hypothalamic microglia shift to an inflammatory phenotype, and prolonged fat consumption leads to the recruitment of bone marrow-derived cells to the hypothalamus. However, the transcriptional signatures and functions of these cell...
Microgliosis is an important component of diet-induced hypothalamic inflammation in obesity. A few hours after the introduction of a high-fat diet, the mediobasal hypothalamus resident microglia undergo morphological and functional changes toward an inflammatory phenotype. If the consumption of large amounts of dietary fats persists for long period...
Objective
To estimate the point prevalence of and risk factors associated with the development of pressure ulcers at a university hospital in Brazil.
Methods
This study was conducted on 196 participants using a structured questionnaire, physical examination of the skin, and the Braden scale. The Mann-Whitney U, χ², or Fisher’s exact tests were use...
In the original publication, the authors claimed that Figure 6 reporting Western blot data was erroneous as published [...]
SARS-CoV-2 can induce vascular dysfunction and thrombotic events in patients with severe COVID-19; however, the cellular and molecular mechanisms behind these effects remain largely unknown. In this study, we used a combination of experimental and in silico approaches to explore the mechanisms behind the vascular and thrombotic events in COVID-19....
Microgliosis is an important component of diet-induced hypothalamic inflammation in obesity. A few hours after the introduction of a high-fat diet, the mediobasal hypothalamus resident microglia undergo morphological and functional changes toward an inflammatory phenotype. If the consumption of large amounts of dietary fats persists for long period...
Microgliosis plays a critical role in diet-induced hypothalamic inflammation. A few hours after a high-fat diet (HFD), hypothalamic microglia shift to an inflammatory phenotype, and prolonged fat consumption leads to the recruitment of bone marrow-derived cells to the hypothalamus. However, the transcriptional signatures and functions of these cell...
Treatment of chronic wounds is challenging, and the development of different formulations based on insulin has shown efficacy due to their ability to regulate oxidative stress and inflammatory reactions. The formulation of insulin with polysaccharides in biohybrid hydrogel systems has the advantage of synergistically combining the bioactivity of th...
Microgliosis is an important component of diet-induced hypothalamic inflammation in obesity. A few hours after the introduction of a high-fat diet, the mediobasal hypothalamus resident 38 microglia undergo morphological and functional changes toward an inflammatory phenotype. If the consumption of large amounts of dietary fats persists for long per...
Introdução: A fotobiomodulação refere-se a aplicação de luz a um sistema biológico, e tem sido utilizado no tratamento de feridas de difícil cicatrização. Contribui com resposta do sistema imune, modulação do processo de cicatrização e regeneração de tecidos, etc. Objetivo: Investigar o efeito da fotobiomodulação em feridas nos pés de pessoas com d...
Introdução: O efeito que a insulina tópica tem na cicatrização de feridas em pacientes diabéticos tem sido estudado há muitos anos. No entanto, ela é uma molécula instável e facilmente degradável. Por isso, novas formulações têm sido desenvolvidas a fim de manter sua estabilidade e bioatividade. Objetivo: Avaliar os efeitos do hidrogel de insulina...
Advances in wound treatment depend on the availability of animal models that reflect key aspects of human wound healing physiology. To this date, the accepted mouse models do not reflect defects in the healing process for chronic wounds that are associated with type two diabetic skin ulcers. The long term, systemic physiologic stress that occurs in...
Advances in wound treatment depend on the availability of suitable animal models. All animal models try to reflect human wound healing problems. For acute wounds, it is easier to obtain adequate animal models, however, for chronic wounds such as those found in individuals with diabetic foot ulcer, approximations of the clinical picture become a cha...
Epidermal growth factor (EGF) promotes cell growth, proliferation, and survival in numerous tissues. Piperonylic acid, a metabolite present in peppers (Piper nigrum L. and Piper longum L.), can bind to the epidermal growth factor receptor (EGFR) and induce an intracellular signaling cascade leading to the transcription of genes responsible for thes...
Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure. In the hippocampus, some of the beneficial actions of IL6 are attributed to its neurogenesis-inducing properties. However, in the hypothalamus, the putative neurog...
Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in...
Under high-fat feeding, the hypothalamus atypically undergoes pro-inflammatory signaling activation. Recent data from transcriptomic analysis of microglia from rodents and humans has allowed the identification of several microglial subpopulations throughout the brain. Numerous studies have clarified the roles of these cells in hypothalamic inflamma...
Este manual foi desenvolvido com o objetivo de apoiar o conteúdo prática da disciplina EN322 - Aspectos fundamentais no processo de cuidar em enfermagem, como intuito de auxiliar o aluno em relação à assistência ao paciente e nos procedimentos fundamentais que envolvem a prática diária de um enfermeiro. Esta disciplina visa capacitar o aluno para o...
Obesity is an increasing new pandemic. Currently more than 1.9 billion adults are overweight and at least 700 million of them are obese. Obesity is the result of a positive energy balance, which is conditioned by both environmental and genetic factors. Interestingly, individuals from similar ethnic-based ancestry communities, share both environment...
As the worldwide vaccination, it is imperative to minimize vaccine wastage by effectively using all doses available. Vaccine wastage can occur at multiple points during the vaccination process, but it is mainly because the device dead space and the filling process technique. However, there are no studies discussing the waste volume effect of COVID-...
Wound healing is life-dependent feature for animal survival. After a skin insult, keratinocytes, fibroblasts, and immune cells are recruited to restore the protective skin function. Immediately after injury, soluble fibrinogen is cleaved by thrombin and polymerize to insoluble fibrin clot. Immune cells infiltrate into the fibrin clot to activate th...
Glutamic Acid is the main excitatory neurotransmitter in neurons. Abnormal distributions of the glutamic acid receptors have been shown in hyper proliferative models such as psoriasis and skin regeneration. However, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed for t...
Objetivo: Avaliar o grau de suporte social percebido e sua relação com o autocuidado e o controle glicêmico dos indivíduos diabéticos tipo 2. Metodologia: Pesquisa transversal, realizada com 154 indivíduos diabéticos com idade superior a 18 anos, acompanhados em unidades de saúde. Foram analisadas variáveis sociodemográficas, antropométricas, clíni...
Polycaprolactone (PCL) is a synthetic polymer with good mechanical properties that are useful to produce biomaterials of clinical application. It can be successfully combined with chitosan, which enhances the biomaterial properties through the modulation of molecular and cellular mechanisms. The objective of this study was to evaluate the effects o...
Mounting evidence showing that local nitric oxide (NO) delivery may significantly improve the wound healing process has stimulated the development of wound dressings capable of releasing NO topically. Herein, we describe the preparation of a self‐expandable NO‐releasing hydrolyzed collagen sponge (CS), charged with the endogenously found NO donor,...
The use of specially designed wound dressings could be an important alternative to facilitate the healing process of wounds in the hyperglycemic state. Biocompatible dressings combining chitosan and alginate can speed up wound healing by modulating the inflammatory phase, stimulating fibroblast proliferation, and aiding in remodeling phases. Howeve...
The healing time of burn wounds depends on surface area and depth of the burn and associated comorbidities. Diabetes mellitus (DM) causes delays in the healing process by extending the inflammatory phase. Treatment with topical insulin can improve the inflammatory phase, restore metabolic dysregulation, and modulate impaired cellular signaling in b...
Nitric oxide (NO) donor biomaterials have great potential to promote tissue regeneration and healing. Among the materials that can be used for this purpose, collagen has high biocompatibility, low antigenic activity and is already used commercially in the form of membranes with hemostatic action for the coating of lesions to favor the regeneration...
Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to
wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) mat...
Pressure ulcers (PrUs)∗ are chronic wounds caused by a combination of factors, such as repetitive ischemia perfusion injury, bacterial colonization of the wound bed, local tissue hypoxia, or an altered cellular and systemic stress response. The objectives of this study were to analyze fragments of devitalized tissue of Stages III and IV PrUs and co...
Background and Purpose: Assessing the stress of patient with diabetes requires reliable and valid instruments. This study evaluated the measurement properties of the Brazilian version of the Diabetes Distress Scale (B-DDS). Methods: This cross-sectional study enrolled 139 patients with Type 2 diabetes mellitus (DM2) receiving outpatient treatment....
A remoção do tecido inviável da ferida é um passo importante para o processo de cicatrização. O desbridamento enzimático é um dos métodos utilizados pela equipe de enfermagem para tal fim, consistindo na aplicação de enzimas exógenas no leito da ferida, a fim de obter a degradação do tecido necrosado, sem prejuízo do viável. Dentre os produtos disp...
The objective of this updating study was to address the molecular and cellular process of the healing of cutaneous wounds in individuals with diabetes mellitus. The process of tissue repair in individuals with diabetes mellitus is slowed down; the excessive production of Reactive oxygen species, the reduction of Nitric Oxide, the reduction in the r...
