Elham Vahdat

Elham Vahdat
University of Grenoble Alpes · Department of Physics

Doctor of Philosophy

About

8
Publications
1,563
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31
Citations

Publications

Publications (8)
Thesis
Membrane proteins are potential targets for drug design due to their vital biological functions. Investigating the 3D structure of proteins is essential to understand their function. Macromolecular X-ray crystallography is the most widely used technique to determine the structure of proteins. However, obtaining high diffraction quality crystals of...
Article
The use of neutron macromolecular crystallography (NMX) is expanding rapidly with most structures determined in the last decade thanks to new NMX beamlines having been built and increased availability of structure refinement software. However, the neutron sources currently available for NMX are significantly weaker than equivalent sources for X-ray...
Article
Full-text available
A rational way to find the appropriate conditions to grow crystal samples for bio-crystallography is to determine the crystallization phase diagram, which allows precise control of the parameters affecting the crystal growth process. First, the nucleation is induced at supersaturated conditions close to the solubility boundary between the nucleatio...
Article
Lag phase as the initial stage of protein aggregation has an important role in fibril formation and contributes to pathogenesis of many human diseases. Harsh environments provided by some additives can change the rate and the amounts of protein abnormalities. Here we studied the lag phase as the first stage of fibrillation process of bovine serum a...
Article
Protein fibrillation is a challenging issue in medicine, causing many diseases, and an impediment to pharmaceutics and protein industry. Many chemicals, especially polyphenol compounds and aromatic small molecules, have been widely used as an effective strategy to combat protein fibril formation. Hence, understanding mechanisms of fibrillation inhi...
Article
Full-text available
Obesity and increased blood pressure are identified as risk factors for cardiac and pulmonary disorders. On the other hand, iron deficiency (another preventable disease) is common in adolescence and considered as associated with health impairment. The present study evaluates body mass index (BMI) and its association with blood pressure and hematolo...

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