Eleonora Riva

University of Ferrara | UNIFE · Sezione di Endocrinologia

Differentially expressed genes (FDR ≤ 0.05, 1.2≤ log2FC ≤−1.2) in thyrocytes sorted from tg-BRAFV600E-TOM as compared with tg-TOM in larval embryos at 5dpf.DOI: http://dx.doi.org/10.7554/eLife.20728.006

Differentially expressed genes (FDR ≤ 0.05, 1.2≤ log2FC ≤−1.2) in thyroid carcinomas isolated from adult tg-BRAFV600E-TOM zebrafish as compared with thyroid tissue from adult tg-TOM zebrafish.DOI: http://dx.doi.org/10.7554/eLife.20728.011

BRAFV600E upregulated genes (n = 85 genes; FDR ≤ 0.01, FC ≥ 1.5) identified in larval thyrocytes.DOI: http://dx.doi.org/10.7554/eLife.20728.014

Primers used for qPCR, genotyping, and gene editing. DOI: http://dx.doi.org/10.7554/eLife.20728.016

BRAFV600E downregulated genes (n = 58 genes; FDR ≤ 1×10−6, log2FC ≤1.5) identified in adult thyroid carcinomas.DOI: http://dx.doi.org/10.7554/eLife.20728.012

Introduction: It is known that growth hormone (GH) may influence neoplastic development of endometrial epithelium. GH is produced by normal and neoplastic endometrial cells and elevated levels have been observed in endometrial epithelium of patients with endometriosis and endometrial adenocarcinoma (EA). Moreover, endometrium cancer is one of the m...

Medical treatment of adrenocortical carcinoma (ACC) is still far from optimal, since even molecular targeted therapy failed to demonstrate striking results. Clinical trials enrolling ACC patients with high tissue Vascular Endothelial Growth Factor Receptor (VEGFR) expression levels showed controversial results after treatment with Sunitinib, possib...

Surgery is not feasible for infiltrating and metastatic bronchopulmonary NET(BP-NET). In those cases, medical therapy is tried with controversial results. Thus, it is important to identify new therapeutic targets to provide adequate medical treatment for patients with BP-NET. Sunitinib, is a multi-targeted receptor tyrosine kinase inhibitor (TKI),...

Background: Bronchial carcinoids (BC) are rare neoplasm, still orphan of medical therapy, which arise from neuroendocrine cells. It has been previously demonstrated that the atypical BC human cell line NCI-H720 is sensitive to everolimus (E), an m-TOR inhibitor, in terms of cell viability reduction, with a G0 cell-cycle arrest and a Cyclin D1 prote...

We found that Magmas protein (Tim16) in the MCF7 cell line is highly expressed as compared to MDA-MB231 cells and MCF12A. Our data show that treatment with compound 5 did not influences cell viability in the 3 cell lines , while Doxorubicin decrease this parameter by 20-30%. Only in MCF7 co-treatment with compound 5 enhance the antiproliferative ef...

TIM16, a protein of the translocase complex TIM23 of the mitochondrial inner membrane, is encoded by the Magmas a gene. Magmas silencing has been associated with a greater sensitivity to apoptotic stimuli in pituitary adenoma cell lines. We recently demonstrated that in a human medullary thyroid carcinoma cell line (TT) compound 5, a TIM16 inhibito...