Eleni Ladikou

Eleni Ladikou
Brighton and Sussex Medical School | BSMS · Department of Medicine

iBSc(Hons) MBChB MRCP MRes
PhD Clinical Fellow investigating the role of Bone Marrow microenvironment in Acute Myeloid Leukaemia.

About

20
Publications
2,493
Reads
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306
Citations
Introduction
Skills and Expertise
Additional affiliations
September 2017 - present
Brighton and Sussex University Hospitals NHS Trust
Position
  • Fellow
Description
  • Targeting MCL-1 increases apoptosis by BET inhibition in AML cells
September 2016 - September 2017
University of Leicester
Position
  • NIHR Academic Foundation Programme
Description
  • The role of cTfh cells in low grade lymphoma
September 2012 - September 2013
University of Leicester
Position
  • Student
Description
  • The role of oestradiol in modulating B-cell receptor (BCR) signalling in B-cell lymphomas and leukaemias
Education
August 2017 - November 2019
September 2012 - September 2013
University of Leicester
Field of study
  • Science
September 2009 - September 2015
University of Leicester
Field of study
  • Medicine

Publications

Publications (20)
Article
Acute myeloid leukaemia (AML) is the most common adult acute leukaemia with the lowest survival rate. It is characterised by a build‐up of immature myeloid cells anchored in the protective niche of the bone marrow (BM) microenvironment. The CXCL12/CXCR4 axis is central to the pathogenesis of AML as it has fundamental control over AML cell adhesion...
Article
Full-text available
Purpose of review: Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic strategies to be developed in order to improve treatment outcomes for patients. Recent findings: Recent evidence has hig...
Article
Full-text available
CD4⁺ T-cell subsets are found in the tumour microenvironment (TME) of low-grade B-cell non-Hodgkin’s lymphomas such as marginal zone lymphoma (MZL) or follicular lymphoma (FL). Both numbers and architecture of activating follicular helper T-cells (Tfh) and suppressive Treg in the TME of FL are associated with clinical outcomes. There has been almos...
Article
Full-text available
Increasing evidence implicates a role of estrogens in hematological malignancies. We reviewed current knowledge on the emerging role of estrogens and estrogen receptors in normal B-cell function, chronic lymphocytic leukemia, and B-cell lymphoma. Data support that (1) normal human peripheral blood cells (mononuclear cells, total lymphocytes, T as w...
Article
Full-text available
Background Some high-income countries have deployed fourth doses of COVID-19 vaccines, but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We aimed to investigate the safety, reactogenicity, and immunogenicity of fourth-dose boosters against COVID-19. Methods The COV-BOOST trial is a multicentre, blinded, phas...
Article
Lymphocytosis is a common blood-test finding. Establishing whether the cause of lymphocytosis is benign or malignant is key to managing patients appropriately. A lymphocytosis should always prompt clinical review including a thorough history, examination and appropriate preliminary investigations (blood tests, blood film). The majority of patients...
Article
Acute leukaemia is characterised by uncontrolled expansion of immature leukocytes, either myeloid or lymphoid progenitors, leading to acute myeloid leukaemia (AML) and acute lymphoid leukaemia (ALL), respectively. If left untreated, it is life-threatening and can lead to death within weeks. When acute leukaemia is suspected, urgent haematology inpu...
Article
Full-text available
The retention and re-migration of Chronic Lymphocytic Leukemia cells into cytoprotective and proliferative lymphoid niches is thought to contribute to the development of resistance, leading to subsequent disease relapse. The aim of this study was to elucidate the molecular processes that govern CLL cell migration to elicit a more complete inhibitio...
Article
Full-text available
In this study, we evaluated an NF-κB inducing kinase (NIK) inhibitor, CW15337, in primary chronic lymphocytic leukemia (CLL) cells, CLL and multiple myeloma (MM) cell lines and normal B- and T-lymphocytes. Basal NF-κB subunit activity was characterized using an enzyme linked immunosorbent assay (ELISA), and the effects of NIK inhibition were then a...
Article
Full-text available
Background: COVID-19 infection is characterised, among other features, by a prothrombotic state with high rate of venous thromboembolism (VTE), D-dimer, and fibrinogen levels. Clinical observations have also highlighted that these patients have elevated von Willebrand factor (vWF) and factor VIIIc. Methods: 24 consecutive COVID-19 positive patie...
Article
Full-text available
Coagulopathy (Tang, et al 2020) and a prothrombotic diathesis with high D‐dimer and fibrinogen levels (Al‐Samkari, et al 2020) are associated with coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Extensive thrombosis in small vessels and the microvasculature in lungs and extrapulmonary orga...
Article
Background: A possible association between COVID-19 infection and thrombosis, either as a direct consequence of the virus or as a complication of inflammation, is emerging in the literature. Data on the incidence of venous thromboembolism (VTE) are extremely limited. Methods: We describe three cases of thromboembolism refractory to heparin treat...
Poster
Full-text available
Background: Current prognostic scoring systems in multiple myeloma lack consensus and are often clinically impractical. The key diagnostic features known as CRAB; hypercalcaemia (C), renal impairment (R), anaemia (A), and bone lesions (B), are known to represent end organ damage in myeloma. Aims: We aimed to produce a simplified and practical prog...
Data
Genes and oligonucleotide primer pairs employed in microfluidic RT-qPCR. (DOCX)
Data
Comparison of gene expression between normal subjects and patients with MZL. Heat maps show gene expression levels (rows) from normal subjects (n = 5) and MZL patients (n = 4) in (A) cTfh PD1+ cells and (B) cTfh1 PD1+ cells. There are significant differences in gene expression between normal subjects and lymphoma patients for CCL4 and JAK3 as indic...
Data
Gene expression in tonsillar Tfh and non-Tfh cells. (A) Heat map showing gene expression levels (rows) in sorted Tfh cells (CD4+CXCR5+) (n = 2) and non-Tfh cells (CD4+CXCR5-) (n = 2). Arrow-heads indicate the position of genes whose fold-change in expression levels are indicated in (B). (B) Fold-change in expression levels of individual genes invol...

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