Elena Nikolaevna Zaitceva

Samara State Medical University · Department of Pharmacology

Salinization of cultivated soil is an important negative factor that reduces crop yields. Obtaining accurate and timely data on the salinity of soil horizons allows for planning the agrotechnical measures to reduce this negative impact. The method of soil salinity mapping of the 0–30 cm layer on irrigated arable land with the help of multispectral...

Spreading marigold (Tagetes patula L.) is a valuable source of biologically active compounds, including flavonoids. The aim of the present work was to study the diuretic activity of a dense extract from spreading marigold flowers and the dominant flavonoids of this type of raw material, i.e., patulitrin and patuletin. The two flavonoids patuletin (...

Oregano (Origanum vulgare L.) is a valuable source of biologically active substances, including phenolic compounds. The aim of this study was the isolation of 3′,4′-dihydroxybenzylprotocatechoic acid 4′-O-β-D-glucopyranoside from O. vulgare herb and subsequent analysis of its nephrotropic and neurotropic activity. Pure 3′,4′-dihydroxybenzylprotocat...

Aim to study the effect of the hawthorn shoots on kidney excretory function. Material and methods. We used the shoots of Crataegus sanguinea Pall., Crataegus monogina Jacq. and Crataegus submollis Sarg. harvested during the flowering period in the arboretum of the Botanical Garden of Samara University in 2021. The raw material of each type, separat...

Objectives comparative study of the diuretic activity of a thick extract of Filipendula ulmaria (L.) Maxim. fruits and flavonoids spireoside and quercetin isolated from Filipendula ulmaria (L.) Maxim. fruits by column chromatography. Material and methods. The extractum spissum was obtained by extracting the fruits of Filipendula ulmaria (L.) Maxim....

Objective: to analyse of medicines prescriptions for federal beneficiaries with circulatory system diseases and to identify the main trends in the implementation of the federal program for the provision of necessary medicines in the Samara Region in 2014–2017. Material and methods. The authors reviewed the nomenclature of medicines used to treat ci...

The flavonoids quercetin and spireoside (quercetin 4′-O-β-D-glucopyranoside) were isolated for the first time from fruit of meadowsweet [Filipendula ulmaria (L.) Maxim.] and identified using UV spectrophotometry, NMR spectroscopy, mass spectrometry, and acid hydrolysis. The isolated flavonoids and the thick extract of meadowsweet fruit possessed pr...

Objectives - a comparative study of antidepressant activity and diuretic action of water and water-alcohol preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. Materials and methods. The study covers the water and alcohol-water extracts from the fruits of hawthorn blood-red (Crataegus sanguinea Pall.) and Quebec haw...

The flowers and fruits of various species of the hawthorn genus (Crataegus L.) are widely used in domestic and foreign medical practice as cardiotonic agents. A perspective species for collecting of the raw material is Crataegus submollis Sarg. It was determined that 70% ethanol is an optimal extragent for the extraction of flavonoids from Crataegu...

Objectives - to perform a comparative study of the antidepressant action and diuretic activity of liquid extract and decoction of the fruits of Crataegus submollis Sarg. Material and methods. The study of the antidepressant activity was performed using the behavioral despair test. The diuretic activity of the liquid extract and decoction from the C...

The purpose of the study is to study the urinative and antidepressant activities of liquid extracts based on flowers, shoots, leaves and fruits of Crataegus sanguinea Pall. to substantiate their use in the development and manufacture of drugs for the complex treatment of cardiovascular diseases. Materials and methods. The comparative study of the d...

Aim - study of the effect of agonist and antagonists of adenosine receptors on the excretory function of the kidneys. Materials and methods. The experiments were carried out on white outbread rats. Experimental animals were injected subcutaneously with a pharmacological agent (natrii adenosinetriphosphate, natrii coffeinum-benzoate, euphyllinum, pe...

Aim - to analyze the effect of rutin on the renal excretory function in the conditions of normogravity and hypergravity. Materials and methods. 9 series of experiments were conducted, including 4 series with the use of a centrifuge of ultra-short radius. The effect of rutin in the dose of 10 mg/kg on the renal excretory function was studied in norm...

The diuretic and saluretic activities of aqueous and aqueous-alcoholic extracts of bilberry (Vaccinium myrtillus L.) fruits and shoots were studied in laboratory animals. The results obtained here showed that aqueous extracts of shoots and preparations based on fresh bilberry fruits had moderate diuretic and saluretic activities. Aqueous-alcoholic...

The flowers of the pot marigold (Calendula officinalis L.) are part of combination herbal medicinal preparations which applied in the treatment of diseases of the hepatobiliary system, gastrointestinal tract, diseases of kidneys and the urinary tract, such as «Fitonephrol» («Urological tea»). Calendula flowers make a contribution in the total thera...

The effective diuretic dose of 5-HT3 receptor blocker RU-63 (1 mg/kg) was found in experiments on white rats. It is established that the diuretic and saluretic effects of compound RU-63 increase on the background of impact of the gravitational factor. Compound RU-63 (1 mg/kg, subcutaneously) administered daily under hypergravity conditions (3 g in...

Aim. The search for new effective method of treatment of acute renal failure (ARF). Methods. The experiments were performed on albino rats subject to the provisions of the European Convention for the protection of vertebrate animals used for experimental and scientific purposes (Strasbourg, 02.01.1991 g). The impact of hydrochlorothiazide, hypergra...

Cherula and sticklewort tinctures exhibit rapid and short-lasting diuretic effect. Tinctures of tansy and immortelle are featured by rapid onset of the effect and prolonged action, while the tincture of common bearberry has a long latency period and prolonged action. Under normal conditions of gravity, flavonoid rutin stimulates diuresis only throu...

In experiments on white rats that humate of magnesium (at a dose of 5 mg/kg, subcutaneously) daily introduction on the background of 3% of the water load in parallel with the gravitational influence (3g in the direction of the vector of the centrifugal acceleration to the kidneys of the animal) in the development of ischemic acute renal failure inc...

The utility model relates to experimental medicine and physiology. The purpose of creating useful models is to obtain the possibility of measuring gravitational loads in real time. The device comprises a load mechanism on the platform of which is placed cells the canisters. On one of the walls of the cell foam is fixed the vertical rod, the upper e...

The utility model relates to the field of experimental medicine. The purpose of the utility model – increasing ease of use. The device comprises a container of flexible material, is cylindrical in shape with bellows and a shut-off element in the form of a ball, located on the rod mounted on the bottom of the tank. 2 p. f., 1 Fig.

The utility model relates to the field of experimental medicine. The purpose of the utility model – increasing the ease of performing surgical operations on laboratory animals. The apparatus comprises a support frame, mesh bed to accommodate the animal and elements of its fixation, 3 p. f., 1 Fig.

The utility model relates to the field of experimental medicine. The purpose of the utility model – the opportunity of conducting research to study the effects of increased stress on blood pressure in laboratory animals. The device comprises a load mechanism in the form of a platform with the axis of rotation and fixed on the platform of the cell-h...

The utility model relates to the field of experimental medicine. The purpose of the useful model – improving the efficiency, reducing the aeration time, prolongation of time of viability of isolated biological objects. The device comprises a rack in which cells are consistently capacity with a nutrient solution and biological objects. In the aerati...

The utility model relates to the field of experimental medicine. The purpose of the utility model is the possibility of exposure to centrifugal force on the body of the animal at different distances from the center of rotation. The device comprises a platform with an axis of rotation that is connected to the actuator. On the platform fixed cell hol...