Elena Gómez-Díaz

Elena Gómez-Díaz
Spanish National Research Council | CSIC · Institute of Parasitology and Biomedicine López-Neyra

PhD

About

81
Publications
14,079
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Introduction
Elena Gómez-Díaz currently works at the Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Spanish National Research Council. Elena does research in Molecular Biology, Parasitology and Evolutionary Biology. Their current project is 'Epigenetics of Plasmodium-mosquito interactions.'
Additional affiliations
January 2016 - present
Spanish National Research Council
Position
  • Researcher
October 2013 - December 2015
Emory University
Position
  • PostDoc Position
June 2010 - September 2013
Institute of Evolutionary Biology
Position
  • Juan de la Cierva Researcher

Publications

Publications (81)
Article
Sickle cell haemoglobin (HbS) confers protection, albeit incomplete, from severe malaria. A recent study by Band et al. in Nature on parasite genomic variation of severe malaria cases identifies parasite genomic regions with alleles associated with severe disease risk in HbS individuals. The protective effect of HbS depends therefore on parasite ge...
Preprint
Full-text available
Recent advances in long read technologies not only enable large consortia to aim to sequence all eukaryotes on Earth, but they also allow many laboratories to sequence their species of interest. Although there is a promise to obtain “perfect genomes” with long read technologies, the number of contigs often exceeds the number of chromosomes signific...
Article
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Anopheles gambiae mosquitoes are primary human malaria vectors, but we know very little about their mechanisms of transcriptional regulation. We profiled chromatin accessibility by the assay for transposase-accessible chromatin by sequencing (ATAC-seq) in laboratory-reared A. gambiae mosquitoes experimentally infected with the human malaria parasit...
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The principles and function of chromatin and nuclear architecture have been extensively studied in model organisms, such as Drosophila melanogaster . However, little is known about the role of these epigenetic processes in transcriptional regulation in other insects including mosquitoes, which are major disease vectors and a worldwide threat for hu...
Preprint
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Background: Anopheles gambiae mosquitoes are the primary vectors for the transmission of human malaria in Africa. Despite their importance from a global health perspective, we know very little about the regulatory elements controlling functional gene expression. Results: We performed genome-wide profiling of chromatin accessibility by ATAC-seq in m...
Article
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Background: Granada virus belongs to the genus Phlebovirus within the Naples serocomplex and was detected for the first time in sand flies from Spain in 2003. Seroprevalence studies have revealed that Granada virus may infect humans with most cases being asymptomatic. Moreover, recent studies in vector samples revealed that the related Massilia an...
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In an ideal world, there are equal opportunities for women to enter and progress in all scientific disciplines without bias or prejudice. Here, we share our experiences in building communities of women parasitology and offer easy-to-implement guidelines for scientists and institutions to overcome unconscious bias and create environments with better...
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Developmental conditions can impact the adult phenotype via epigenetic changes that modulate gene expression. In mammals, methylation of the glucocorticoid receptor gene Nr3c1 has been implicated as mediator of long-term effects of developmental conditions, but this evidence is limited to humans and rodents, and few studies have simultaneously test...
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Background Infection by the human malaria parasite leads to important changes in mosquito phenotypic traits related to vector competence. However, we still lack a clear understanding of the underlying mechanisms and, in particular, of the epigenetic basis for these changes. We have examined genome-wide distribution maps of H3K27ac, H3K9ac, H3K9me3...
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Feather mites are useful models for studying speciation due to their high diversity and strong degree of host specialization. However, studies to date have focused on the evolution of higher-level mite taxa while much hidden diversity likely occurs at the level of host genera and species. In this study, we examined the diversity and evolution of fe...
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Understanding the processes that shape parasite diversification, their distribution and abundance provides valuable information on the dynamics and evolution of disease. In this study, we assessed the diversity, distribution, host-specificity and infection patterns of apicomplexan parasites in amphibians and reptiles from Oman, Arabia. Using a quan...
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According to classic niche theory, species can coexist in heterogeneous environments by reducing interspecific competition via niche partitioning, e.g. trophic or spatial partitioning. However, support for the role of competition on niche partitioning remains controversial. Here, we tested for spatial and trophic partitioning in feather mites, a di...
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Q fever is a highly infectious disease with a worldwide distribution. Its causative agent, the intracellular bacterium Coxiella burnetii, infects a variety of vertebrate species, including humans. Its evolutionary origin remains almost entirely unknown and uncertainty persists regarding the identity and lifestyle of its ancestors. A few tick specie...
Article
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Correct species identification is a crucial issue in systematics with key implications for prioritising conservation effort. However, it can be particularly challenging in recently diverged species due to their strong similarity and relatedness. In such cases, species identification requires multiple and integrative approaches. In this study we use...
Article
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The epigenome of the human malaria vector Anopheles gambiae was characterized in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq. Analysis of the transcriptome of A. gambiae midgut...
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Identifying factors influencing infection patterns among hosts is critical for our understanding of the evolution and impact of parasitism in natural populations. However, the correct estimation of infection parameters depends on the performance of detection and quantification methods. In this study, we designed a quantitative PCR (qPCR) assay targ...
Article
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In recent years, a number of zoonotic flaviviruses have emerged worldwide, and wild birds serve as their major reservoirs. Epidemiological surveys of bird populations at various geographical scales can clarify key aspects of the eco-epidemiology of these viruses. In this study, we aimed at exploring the presence of flaviviruses in the western Medit...
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Three new species of the feather mite subfamily Ingrassiinae (Acariformes: Astigmata: Xolalgidae) are described from shearwaters and petrels (Procellariiformes: Procellariidae) in the North-East of Atlantic Ocean: Ingrassia calonectris sp. n. from Calonectris borealis (Cory) (type host) and Calonectris edwardsii (Oustalet), Ingrassia micronota sp....
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Background Ancient DNA has revolutionized conservation genetic studies as it allows monitoring of the genetic variability of species through time and predicting the impact of ecosystems’ threats on future population dynamics and viability. Meanwhile, the consequences of anthropogenic activities and climate change to island faunas, particularly seab...
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Microscopy has traditionally been the most common method in parasitological studies, but in recent years molecular screening has become increasingly frequent to detect protozoan parasites in a wide range of vertebrate hosts and vectors. During routine molecular screening of apicomplexan parasites in reptiles using the 18S rRNA gene, we have amplifi...
Data
Workflow on research strategies in host–parasite epigenetics. First, a phenomic (experimental) approach in laboratory or field settings can be designed to establish transgenerational phenotypic effects and fitness consequences of host or pathogen evolutionary-relevant traits for infection. Second, epigenetic and functional approaches can then be co...
Data
Methodologies for epigenetic analyses. (DOCX)
Data
Full-text available
Experimental approach to detect transgenerational epigenetic and phenotypic changes of infection in a model study involving mosquitoes. Starting from isogenic lines and controlled environmental conditions, female mosquitoes are experimentally infected for successive generations to detect adaptive traits in response to a continuous selection pressur...
Article
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A growing body of evidence points towards epigenetic mechanisms being responsible for a wide range of biological phenomena, from the plasticity of plant growth and development to the nutritional control of caste determination in honeybees and the etiology of human disease (e.g., cancer). With the (partial) elucidation of the molecular basis of epig...
Article
A new chigger mite genus and species, Arabapolonia omanensis gen. nov. et sp. nov. is described from 4 gecko species, Hemidactylus lemurinus, H. homoeolepis (Gekkonidae), Ptyodactylus hasselquistii (Phyllodactylidae), and Pristurus rupestris (Sphaerodactylidae) collected in Oman. The new genus is characterized by the simple cheliceral blade, single...
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Nine microsatellite markers were isolated from unfed larvae of Ixodes ricinus and were tested on two populations of nymphs collected on roe deer (N=21) and birds (N=39) in a French suburban forest. All markers were polymorphic, with limited evidence for deviations from linkage equilibrium. In accordance with previous markers developed for this spec...
Article
The Socotra Archipelago is an ancient continental fragment of Gondwanan origin and one of the most isolated landforms on Earth and a biodiversity hot spot. Yet, the biogeography and evolutionary history of its endemic fauna still remain largely overlooked. We investigate the origin, tempo and mode of diversification in the Hemidactylus geckos of th...
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Parasites represent ideal models for unravelling biogeographic patterns and mechanisms of diversification on islands. Both host-mediated dispersal and within-island adaptation can shape parasite island assemblages. In this study, we examined patterns of genetic diversity and structure of Ornithodoros seabird ticks within the Cape Verde Archipelago...
Article
Aim Parasites with global distributions and wide host spectra provide excellent models for exploring the factors that drive parasite diversification. Here, we tested the relative force of host and geography in shaping population structure of a widely distributed and common ectoparasite of colonial seabirds, the tick Ixodes uriae. Location Two natur...
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Seabirds act as natural reservoirs to Lyme borreliosis spirochetes and may play a significant role in the global circulation of these pathogens. While Borrelia burgdorferi sensu lato (Bbsl) has been shown to occur in ticks collected from certain locations in the North Pacific, little is known about interspecific differences in exposure within the s...
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ABSTRACT: Feeding ecology and geographic location are 2 major factors influencing animal stable isotope signatures, but their relative contributions are poorly understood, which limits the usefulness of stable isotope analysis in the study of animal ecology. To improve our knowledge of the main sources of isotopic variability at sea, we determined...
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Despite the importance of population structure for the epidemiology of pathogenic bacteria, the spatial and ecological heterogeneity of these populations is often poorly characterized. Here, we investigated the genetic diversity and population structure of the Lyme borreliosis (LB) spirochaete Borrelia garinii in its marine cycle involving colonial...
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The ubiquity of ticks and their importance in the transmission of pathogens involved in human and livestock diseases are reflected by the growing number of studies focusing on tick ecology and the epidemiology of tick-borne pathogens. Likewise, the involvement of wild birds in dispersing pathogens and their role as reservoir hosts are now well esta...
Article
Disentangling trophic interaction networks in vector-borne systems has important implications in epidemiological and evolutionary studies. Molecular methods based on bloodmeal typing in vectors have been increasingly used to identify hosts. Although most molecular approaches benefit from good specificity and sensitivity, their temporal resolution i...
Data
Isotopic composition of ectoparasite and host tissues. Stable isotopes signatures, δ13C, δ15N (‰) and C/N ratios (%), for all four ectoparasite species from different Calonectris breeding colonies and by host taxa. Values report mean and standard error. Isotopic values for blood and feathers of hosts are also indicated (Hblood and Hfeather, respect...
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Ecological studies on food webs rarely include parasites, partly due to the complexity and dimensionality of host-parasite interaction networks. Multiple co-occurring parasites can show different feeding strategies and thus lead to complex and cryptic trophic relationships, which are often difficult to disentangle by traditional methods. We analyze...
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Vector organisms are implicated in the transmission of close to a third of all infectious diseases. In many cases, multiple vectors (species or populations) can participate in transmission but may contribute differently to disease ecology and evolution. The presence of cryptic vector populations can be particularly problematic as differences in inf...
Article
The importance of understanding the population genetics and evolution of microbial pathogens is increasing as a result of the spread and re-emergence of many infectious diseases and their impact for public health. In the last few years, the development of high throughput multi-gene sequence methodologies has opened new opportunities for studying pa...
Article
Primers were developed for 10 microsatellite loci for two species of Oceanodroma storm-petrels. Variability was tested in 27 O. castro and 22 O. monteiroi from the Azores, and 24 O. leucorhoa from Norway. At least six loci amplified reliably and were polymorphic in each species. The number of alleles per locus averaged 4.6, and observed heterozygos...
Article
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Increasing evidence suggests oceanic traits may play a key role in the genetic structur- ing of marine organisms. Whereas genetic breaks in the open ocean are well known in fishes and marine invertebrates, the importance of marine habitat characteristics in seabirds remains less cer- tain. We investigated the role of oceanic transitions versus popu...
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Contamination in marine foodwebs is nowadays of great environmental concern owing to the increasing levels of pollution in marine ecosystems from different anthropogenic sources. Seabirds can be used as indicators of regional contaminant patterns across large temporal and spatial scales. We analysed Hg, Se and Pb levels as well as stable isotope ra...
Article
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The existence of two seasonally distinct breeding populations of Oceanodroma storm-petrels in the Azores islands was first documented in 1996. The discovery of morphological differences between the populations led to the suggestion that they may represent cryptic sibling species. Recent mtDNA and microsatellite analysis from storm-petrel population...