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Introduction
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Education
October 2007 - July 2011
September 2001 - September 2005
Publications
Publications (36)
Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-day post-ligation renal tissues...
Background:
Renal fibrosis is a common histological finding present in many pathologies; however, key signaling pathways and molecular determinants involved in the development of fibrosis are not fully known yet. Previous findings have established a causative role of calreticulin's up-regulation during the development of renal fibrosis while its d...
Fibrosis is a complex and multifactorial process, affecting the structure and compromising the function of several organs. Among those, renal fibrosis is an important pathological change, eventually leading to renal failure. Proteomic analysis of the renal parenchyma in the well-established rat model of unilateral ureteral obstruction (UUO model) s...
Signaling through the B-cell receptor appears to be a major contributor to the pathogenesis of chronic lymphocytic leukemia. Toll-like receptors bridge the innate and adaptive immune responses by acting as co-stimulatory signals for B cells. The available data on the expression of Toll-like receptors in chronic lymphocytic leukemia are limited and...
We analyzed somatic hypermutation (SHM) patterns and secondary rearrangements involving the immunoglobulin (IG) light chain (LC) gene loci in 725 patients with chronic lymphocytic leukemia (CLL). Important differences regarding mutational load and targeting were identified in groups of sequences defined by IGKV/IGLV gene usage and/or K/LCDR3 featur...
Poster presentation in 53rd ERA-EDTA Congress
Poster presentation in 66th conference of Hellenic Society for Biochemistry and Molecular Biology (HSBMB),
Poster presentation in 66th conference of Hellenic Society for Biochemistry and Molecular Biology (HSBMB) and the 3rd Panhellenic Young Scientists Forum
Methodology of 2D gel electrophoresis for obtaining comparisons of renal parenchyma alterations in the UUO model. Figure S1, Expression of transgelin 1 and transgelin 2 mRNAs in the hypertensive model. Real Time PCR was performed at the different time intervals indicated with the appropriate primers. The asterisk denotes statistical significance at...
Fibrosis is a complex and multifactorial process, affecting the structure and compromising the function of several organs. Among those, renal fibrosis is an important pathological change, eventually leading to renal failure. Proteomic analysis of the renal parenchyma in the well-established rat model of unilateral ureteral obstruction (UUO model) s...
44
The role of antigen in the development of CLL is underscored by the biased immunoglobulin (IG) gene repertoire expressed by the malignant clones, the prognostic implications of B-cell receptor (BcR) structure and the identification of subsets of patients with quasi-identical, stereotyped BcRs. The structural homology of BcRs implies a role for a...
The chronic lymphocytic leukemia (CLL) immunoglobulin (IG) heavy chain repertoire is known to display biased immunoglobulin variable heavy-chain (IGHV) gene usage, remarkable complementarity determining region 3 (HCDR3) stereotypy as well as distinctive somatic hypermutation (SHM) patterns, at least for subsets of cases. Our aim in the present stud...
STUDY FOR POSSIBLE ASSOCIATION OF THE INTERLEUKIN-6 -174G/C PROMOTER POLYMORPHISM WITH PREMATURE CORONARY ARTERY DISEASE IN THE GREEK POPULATION
Arvaniti H. 1, Vasilakou M. 1, Hatzipanagi D. 1, Votteas V. 2, Kasparian H. 2, Pantazopoulos N. 2, Peste K. 3, Spyropoulou-Vlahou M. 3, Stauropoulou-Gkioka A. 3, Lamnissou K. 1
1 Dept of Biology, Univer...