Eleanor Jayawant

Eleanor Jayawant
Brighton and Sussex Medical School | BSMS · Department of Clinical Medicine

PhD in Chemistry

About

4
Publications
205
Reads
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18
Citations
Additional affiliations
April 2021 - present
Brighton and Sussex Medical School
Position
  • Research Associate
October 2017 - present
The University of Warwick
Position
  • PhD Student
Description
  • Please visit my website for further details! https://warwick.ac.uk/fac/sci/chemistry/research/notman/notmangroup/people/jayawant
September 2013 - August 2014
MRC Human Nutrition Research
Position
  • Placement Student
Education
October 2017 - March 2021
The University of Warwick
Field of study
  • Chemistry
September 2015 - September 2017
University of Sussex
Field of study
  • Genetic Manipulation and Molecular Cell Biology
September 2011 - June 2015
The University of Manchester
Field of study
  • Biochemistry

Publications

Publications (4)
Article
Full-text available
Antibiotic resistance is a significant threat to human health, with natural products remaining the best source for new antimicrobial compounds. Antimicrobial peptides (AMPs) are natural products with great potential for clinical use as they are small, amenable to customization, and show broad‐spectrum activities. Lynronne‐1 is a promising AMP ident...
Article
Peptide-based drugs combine advantages of larger biological therapeutics with those of small molecule drugs, but they generally display poor permeability and metabolic stability. Recently, we introduced a new type of peptide bond isostere, in which the backbone carbonyl is replaced with a 3-amino oxetane heterocycle, into short linear peptides with...
Article
Full-text available
Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclisations are greatly improved, as measured by isolated yields, reaction rates and product distribution, by substitution of one of the backbone amide C=O bonds with an oxetane ring. The cyclisation precursors...

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